Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAI3_LEIDO

TriTrypDb:

LdBPK_361270.1 , LdCL_360017800 , LDHU3_36.1610

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.577
CLV_C14_Caspase3-7	205	209	PF00656	0.668
CLV_PCSK_SKI1_1	113	117	PF00082	0.452
CLV_PCSK_SKI1_1	125	129	PF00082	0.452
CLV_PCSK_SKI1_1	211	215	PF00082	0.698
CLV_PCSK_SKI1_1	60	64	PF00082	0.550
DEG_SPOP_SBC_1	191	195	PF00917	0.684
DEG_SPOP_SBC_1	9	13	PF00917	0.659
DOC_USP7_MATH_1	107	111	PF00917	0.520
DOC_USP7_MATH_1	187	191	PF00917	0.726
DOC_USP7_MATH_1	9	13	PF00917	0.646
DOC_WW_Pin1_4	181	186	PF00397	0.765
DOC_WW_Pin1_4	2	7	PF00397	0.636
LIG_14-3-3_CanoR_1	188	196	PF00244	0.747
LIG_14-3-3_CanoR_1	245	250	PF00244	0.607
LIG_14-3-3_CanoR_1	7	16	PF00244	0.671
LIG_14-3-3_CanoR_1	82	88	PF00244	0.551
LIG_14-3-3_CanoR_1	91	97	PF00244	0.477
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_BRCT_BRCA1_1	151	155	PF00533	0.523
LIG_DLG_GKlike_1	245	253	PF00625	0.486
LIG_FHA_1	191	197	PF00498	0.627
LIG_FHA_1	56	62	PF00498	0.450
LIG_FHA_1	84	90	PF00498	0.629
LIG_FHA_1	99	105	PF00498	0.443
LIG_FHA_2	169	175	PF00498	0.762
LIG_FHA_2	193	199	PF00498	0.653
LIG_FHA_2	218	224	PF00498	0.543
LIG_LIR_Gen_1	131	140	PF02991	0.440
LIG_LIR_Gen_1	167	175	PF02991	0.580
LIG_LIR_Gen_1	85	93	PF02991	0.537
LIG_LIR_Nem_3	131	137	PF02991	0.424
LIG_LIR_Nem_3	167	172	PF02991	0.621
LIG_LIR_Nem_3	220	225	PF02991	0.437
LIG_LIR_Nem_3	53	59	PF02991	0.429
LIG_LIR_Nem_3	85	90	PF02991	0.524
LIG_PCNA_PIPBox_1	112	121	PF02747	0.544
LIG_PCNA_PIPBox_1	240	249	PF02747	0.620
LIG_PCNA_yPIPBox_3	240	250	PF02747	0.650
LIG_SH2_CRK	222	226	PF00017	0.560
LIG_SH2_NCK_1	146	150	PF00017	0.407
LIG_SH2_STAP1	146	150	PF00017	0.407
LIG_SH2_STAP1	247	251	PF00017	0.478
LIG_SH2_STAP1	57	61	PF00017	0.567
LIG_SH2_STAT3	19	22	PF00017	0.612
LIG_SH2_STAT3	237	240	PF00017	0.592
LIG_SH2_STAT5	118	121	PF00017	0.482
LIG_SH2_STAT5	19	22	PF00017	0.570
LIG_SH2_STAT5	237	240	PF00017	0.503
LIG_SH2_STAT5	36	39	PF00017	0.244
LIG_SH2_STAT5	57	60	PF00017	0.540
LIG_SH3_3	236	242	PF00018	0.482
LIG_SUMO_SIM_anti_2	208	216	PF11976	0.519
LIG_TYR_ITSM	218	225	PF00017	0.568
MOD_CDK_SPK_2	2	7	PF00069	0.631
MOD_CDK_SPxxK_3	181	188	PF00069	0.666
MOD_CK1_1	138	144	PF00069	0.572
MOD_CK1_1	190	196	PF00069	0.642
MOD_CK1_1	48	54	PF00069	0.487
MOD_CK1_1	5	11	PF00069	0.618
MOD_CK1_1	85	91	PF00069	0.552
MOD_CK2_1	168	174	PF00069	0.755
MOD_GlcNHglycan	109	112	PF01048	0.501
MOD_GlcNHglycan	13	16	PF01048	0.673
MOD_GlcNHglycan	189	192	PF01048	0.715
MOD_GlcNHglycan	50	53	PF01048	0.509
MOD_GSK3_1	1	8	PF00069	0.669
MOD_GSK3_1	138	145	PF00069	0.495
MOD_GSK3_1	187	194	PF00069	0.671
MOD_GSK3_1	202	209	PF00069	0.633
MOD_N-GLC_1	156	161	PF02516	0.579
MOD_NEK2_1	1	6	PF00069	0.714
MOD_NEK2_1	106	111	PF00069	0.369
MOD_NEK2_1	150	155	PF00069	0.527
MOD_NEK2_1	229	234	PF00069	0.450
MOD_NEK2_1	50	55	PF00069	0.477
MOD_NEK2_1	98	103	PF00069	0.460
MOD_NEK2_2	168	173	PF00069	0.701
MOD_NEK2_2	45	50	PF00069	0.545
MOD_NEK2_2	55	60	PF00069	0.384
MOD_PIKK_1	179	185	PF00454	0.767
MOD_PIKK_1	92	98	PF00454	0.567
MOD_PKA_2	187	193	PF00069	0.768
MOD_PKB_1	80	88	PF00069	0.507
MOD_Plk_4	150	156	PF00069	0.577
MOD_Plk_4	217	223	PF00069	0.484
MOD_Plk_4	229	235	PF00069	0.446
MOD_Plk_4	45	51	PF00069	0.510
MOD_ProDKin_1	181	187	PF00069	0.762
MOD_ProDKin_1	2	8	PF00069	0.634
TRG_AP2beta_CARGO_1	167	176	PF09066	0.584
TRG_DiLeu_BaEn_1	210	215	PF01217	0.627
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.542
TRG_ENDOCYTIC_2	222	225	PF00928	0.559
TRG_ENDOCYTIC_2	246	249	PF00928	0.496
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB2	Leptomonas seymouri	51%	91%
A0A0S4JAI8	Bodo saltans	31%	100%
A0A1X0P886	Trypanosomatidae	37%	100%
A4ICL3	Leishmania infantum	100%	100%
D0A2U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ASP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q1V5	Leishmania major	85%	100%
V5B9R5	Trypanosoma cruzi	36%	100%