Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAI1_LEIDO

TriTrypDb:

LdBPK_361280.1 , LdCL_360017900 , LDHU3_36.1620

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.637
CLV_C14_Caspase3-7	343	347	PF00656	0.593
CLV_C14_Caspase3-7	360	364	PF00656	0.654
CLV_NRD_NRD_1	388	390	PF00675	0.554
CLV_NRD_NRD_1	451	453	PF00675	0.573
CLV_PCSK_KEX2_1	388	390	PF00082	0.558
CLV_PCSK_SKI1_1	333	337	PF00082	0.620
DEG_Nend_UBRbox_2	1	3	PF02207	0.656
DEG_SPOP_SBC_1	286	290	PF00917	0.638
DOC_CKS1_1	233	238	PF01111	0.640
DOC_CKS1_1	382	387	PF01111	0.688
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.585
DOC_MAPK_MEF2A_6	130	139	PF00069	0.787
DOC_PP1_RVXF_1	331	338	PF00149	0.620
DOC_USP7_MATH_1	286	290	PF00917	0.682
DOC_USP7_MATH_1	322	326	PF00917	0.558
DOC_USP7_MATH_1	338	342	PF00917	0.733
DOC_USP7_MATH_1	344	348	PF00917	0.696
DOC_USP7_MATH_1	54	58	PF00917	0.622
DOC_USP7_UBL2_3	136	140	PF12436	0.565
DOC_WW_Pin1_4	179	184	PF00397	0.566
DOC_WW_Pin1_4	187	192	PF00397	0.541
DOC_WW_Pin1_4	232	237	PF00397	0.640
DOC_WW_Pin1_4	255	260	PF00397	0.617
DOC_WW_Pin1_4	34	39	PF00397	0.646
DOC_WW_Pin1_4	369	374	PF00397	0.694
DOC_WW_Pin1_4	381	386	PF00397	0.605
LIG_14-3-3_CanoR_1	113	119	PF00244	0.603
LIG_14-3-3_CanoR_1	249	254	PF00244	0.610
LIG_14-3-3_CanoR_1	271	275	PF00244	0.587
LIG_14-3-3_CanoR_1	389	399	PF00244	0.637
LIG_14-3-3_CanoR_1	440	448	PF00244	0.589
LIG_14-3-3_CanoR_1	452	456	PF00244	0.516
LIG_14-3-3_CanoR_1	7	13	PF00244	0.669
LIG_Actin_WH2_2	257	273	PF00022	0.613
LIG_APCC_ABBA_1	297	302	PF00400	0.578
LIG_BIR_III_2	195	199	PF00653	0.635
LIG_BRCT_BRCA1_1	256	260	PF00533	0.624
LIG_BRCT_BRCA1_1	265	269	PF00533	0.530
LIG_BRCT_BRCA1_1	280	284	PF00533	0.491
LIG_CSL_BTD_1	180	183	PF09270	0.565
LIG_FHA_1	165	171	PF00498	0.642
LIG_FHA_1	23	29	PF00498	0.552
LIG_FHA_1	233	239	PF00498	0.641
LIG_FHA_1	316	322	PF00498	0.735
LIG_FHA_1	405	411	PF00498	0.548
LIG_FHA_1	46	52	PF00498	0.623
LIG_FHA_1	8	14	PF00498	0.673
LIG_FHA_2	107	113	PF00498	0.564
LIG_FHA_2	161	167	PF00498	0.600
LIG_FHA_2	365	371	PF00498	0.657
LIG_FHA_2	391	397	PF00498	0.600
LIG_GBD_Chelix_1	237	245	PF00786	0.601
LIG_LIR_Apic_2	224	229	PF02991	0.581
LIG_LIR_Gen_1	251	260	PF02991	0.578
LIG_LIR_Gen_1	415	425	PF02991	0.639
LIG_LIR_Nem_3	251	256	PF02991	0.585
LIG_LIR_Nem_3	415	420	PF02991	0.646
LIG_LIR_Nem_3	482	487	PF02991	0.539
LIG_Pex14_1	92	96	PF04695	0.558
LIG_Pex14_2	177	181	PF04695	0.651
LIG_SH2_CRK	247	251	PF00017	0.554
LIG_SH2_CRK	484	488	PF00017	0.494
LIG_SH2_NCK_1	247	251	PF00017	0.611
LIG_SH2_NCK_1	96	100	PF00017	0.516
LIG_SH2_SRC	96	99	PF00017	0.521
LIG_SH2_STAP1	96	100	PF00017	0.516
LIG_SH2_STAT3	107	110	PF00017	0.653
LIG_SH2_STAT5	107	110	PF00017	0.609
LIG_SH2_STAT5	226	229	PF00017	0.617
LIG_SH2_STAT5	247	250	PF00017	0.612
LIG_SH2_STAT5	428	431	PF00017	0.587
LIG_SH3_1	230	236	PF00018	0.643
LIG_SH3_3	136	142	PF00018	0.655
LIG_SH3_3	167	173	PF00018	0.597
LIG_SH3_3	217	223	PF00018	0.652
LIG_SH3_3	230	236	PF00018	0.554
LIG_SH3_3	370	376	PF00018	0.703
LIG_SH3_3	379	385	PF00018	0.620
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.634
LIG_TRAF2_1	367	370	PF00917	0.663
LIG_TRAF2_1	454	457	PF00917	0.563
LIG_TYR_ITIM	245	250	PF00017	0.555
LIG_WRC_WIRS_1	250	255	PF05994	0.554
MOD_CDK_SPxxK_3	381	388	PF00069	0.576
MOD_CK1_1	117	123	PF00069	0.647
MOD_CK1_1	160	166	PF00069	0.588
MOD_CK1_1	224	230	PF00069	0.646
MOD_CK1_1	231	237	PF00069	0.602
MOD_CK1_1	252	258	PF00069	0.631
MOD_CK1_1	263	269	PF00069	0.514
MOD_CK1_1	287	293	PF00069	0.631
MOD_CK1_1	357	363	PF00069	0.674
MOD_CK1_1	57	63	PF00069	0.661
MOD_CK2_1	106	112	PF00069	0.569
MOD_CK2_1	311	317	PF00069	0.641
MOD_CK2_1	322	328	PF00069	0.558
MOD_CK2_1	337	343	PF00069	0.644
MOD_CK2_1	364	370	PF00069	0.654
MOD_CK2_1	390	396	PF00069	0.610
MOD_CK2_1	412	418	PF00069	0.664
MOD_CK2_1	451	457	PF00069	0.573
MOD_CK2_1	50	56	PF00069	0.721
MOD_GlcNHglycan	176	180	PF01048	0.653
MOD_GlcNHglycan	223	226	PF01048	0.640
MOD_GlcNHglycan	260	263	PF01048	0.689
MOD_GlcNHglycan	324	327	PF01048	0.677
MOD_GlcNHglycan	355	359	PF01048	0.646
MOD_GlcNHglycan	414	417	PF01048	0.678
MOD_GlcNHglycan	424	428	PF01048	0.565
MOD_GlcNHglycan	493	496	PF01048	0.587
MOD_GlcNHglycan	52	55	PF01048	0.647
MOD_GlcNHglycan	59	62	PF01048	0.581
MOD_GlcNHglycan	92	95	PF01048	0.615
MOD_GSK3_1	160	167	PF00069	0.651
MOD_GSK3_1	171	178	PF00069	0.615
MOD_GSK3_1	2	9	PF00069	0.656
MOD_GSK3_1	224	231	PF00069	0.651
MOD_GSK3_1	245	252	PF00069	0.600
MOD_GSK3_1	254	261	PF00069	0.618
MOD_GSK3_1	265	272	PF00069	0.583
MOD_GSK3_1	311	318	PF00069	0.641
MOD_GSK3_1	333	340	PF00069	0.644
MOD_GSK3_1	377	384	PF00069	0.700
MOD_GSK3_1	41	48	PF00069	0.653
MOD_GSK3_1	412	419	PF00069	0.768
MOD_GSK3_1	50	57	PF00069	0.508
MOD_GSK3_1	59	66	PF00069	0.604
MOD_GSK3_1	84	91	PF00069	0.638
MOD_N-GLC_1	363	368	PF02516	0.701
MOD_N-GLC_1	391	396	PF02516	0.519
MOD_N-GLC_1	72	77	PF02516	0.583
MOD_NEK2_1	116	121	PF00069	0.660
MOD_NEK2_1	177	182	PF00069	0.644
MOD_NEK2_1	237	242	PF00069	0.623
MOD_NEK2_1	245	250	PF00069	0.580
MOD_NEK2_1	254	259	PF00069	0.516
MOD_NEK2_1	260	265	PF00069	0.492
MOD_NEK2_1	269	274	PF00069	0.474
MOD_NEK2_1	278	283	PF00069	0.455
MOD_NEK2_1	284	289	PF00069	0.510
MOD_NEK2_1	311	316	PF00069	0.642
MOD_NEK2_1	337	342	PF00069	0.617
MOD_NEK2_1	41	46	PF00069	0.679
MOD_NEK2_1	429	434	PF00069	0.596
MOD_NEK2_1	462	467	PF00069	0.567
MOD_PIKK_1	106	112	PF00454	0.546
MOD_PIKK_1	278	284	PF00454	0.622
MOD_PIKK_1	457	463	PF00454	0.531
MOD_PKA_2	105	111	PF00069	0.551
MOD_PKA_2	22	28	PF00069	0.663
MOD_PKA_2	248	254	PF00069	0.610
MOD_PKA_2	270	276	PF00069	0.575
MOD_PKA_2	344	350	PF00069	0.588
MOD_PKA_2	451	457	PF00069	0.573
MOD_PKA_2	6	12	PF00069	0.669
MOD_Plk_1	165	171	PF00069	0.620
MOD_Plk_1	201	207	PF00069	0.631
MOD_Plk_1	333	339	PF00069	0.645
MOD_Plk_1	391	397	PF00069	0.510
MOD_Plk_1	41	47	PF00069	0.573
MOD_Plk_1	423	429	PF00069	0.525
MOD_Plk_1	457	463	PF00069	0.531
MOD_Plk_1	72	78	PF00069	0.605
MOD_Plk_2-3	27	33	PF00069	0.646
MOD_Plk_4	145	151	PF00069	0.576
MOD_Plk_4	202	208	PF00069	0.631
MOD_Plk_4	249	255	PF00069	0.647
MOD_Plk_4	416	422	PF00069	0.747
MOD_ProDKin_1	179	185	PF00069	0.565
MOD_ProDKin_1	187	193	PF00069	0.542
MOD_ProDKin_1	232	238	PF00069	0.639
MOD_ProDKin_1	255	261	PF00069	0.614
MOD_ProDKin_1	34	40	PF00069	0.646
MOD_ProDKin_1	369	375	PF00069	0.694
MOD_ProDKin_1	381	387	PF00069	0.602
TRG_DiLeu_BaEn_1	405	410	PF01217	0.713
TRG_DiLeu_BaEn_2	475	481	PF01217	0.566
TRG_DiLeu_BaEn_4	457	463	PF01217	0.531
TRG_DiLeu_LyEn_5	349	354	PF01217	0.651
TRG_ENDOCYTIC_2	247	250	PF00928	0.555
TRG_ENDOCYTIC_2	428	431	PF00928	0.587
TRG_ENDOCYTIC_2	484	487	PF00928	0.604
TRG_ER_diArg_1	466	469	PF00400	0.554
TRG_NES_CRM1_1	461	476	PF08389	0.511
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HNY2	Leishmania braziliensis	53%	100%
A4ICL2	Leishmania infantum	99%	100%
E9ASP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q1V4	Leishmania major	81%	100%