Myb-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAH7_LEIDO

TriTrypDb:

LdBPK_360420.1 , LdCL_360009000 , LDHU3_36.0550

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.668
CLV_C14_Caspase3-7	39	43	PF00656	0.671
CLV_C14_Caspase3-7	546	550	PF00656	0.594
CLV_C14_Caspase3-7	55	59	PF00656	0.668
CLV_NRD_NRD_1	15	17	PF00675	0.802
CLV_NRD_NRD_1	266	268	PF00675	0.393
CLV_NRD_NRD_1	457	459	PF00675	0.347
CLV_NRD_NRD_1	502	504	PF00675	0.553
CLV_NRD_NRD_1	555	557	PF00675	0.707
CLV_PCSK_KEX2_1	128	130	PF00082	0.440
CLV_PCSK_KEX2_1	15	17	PF00082	0.720
CLV_PCSK_KEX2_1	157	159	PF00082	0.484
CLV_PCSK_KEX2_1	266	268	PF00082	0.393
CLV_PCSK_KEX2_1	4	6	PF00082	0.728
CLV_PCSK_KEX2_1	457	459	PF00082	0.332
CLV_PCSK_KEX2_1	502	504	PF00082	0.501
CLV_PCSK_KEX2_1	520	522	PF00082	0.551
CLV_PCSK_KEX2_1	553	555	PF00082	0.609
CLV_PCSK_KEX2_1	614	616	PF00082	0.501
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.472
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.548
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.630
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.536
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.606
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.534
CLV_PCSK_PC7_1	153	159	PF00082	0.384
CLV_PCSK_SKI1_1	118	122	PF00082	0.538
CLV_PCSK_SKI1_1	266	270	PF00082	0.451
CLV_PCSK_SKI1_1	385	389	PF00082	0.575
CLV_PCSK_SKI1_1	534	538	PF00082	0.444
DEG_APCC_DBOX_1	625	633	PF00400	0.523
DEG_SPOP_SBC_1	287	291	PF00917	0.544
DEG_SPOP_SBC_1	437	441	PF00917	0.425
DOC_CDC14_PxL_1	104	112	PF14671	0.569
DOC_CDC14_PxL_1	410	418	PF14671	0.558
DOC_CYCLIN_RxL_1	115	126	PF00134	0.471
DOC_MAPK_DCC_7	576	584	PF00069	0.669
DOC_MAPK_gen_1	502	510	PF00069	0.455
DOC_MAPK_gen_1	553	561	PF00069	0.684
DOC_MAPK_gen_1	99	107	PF00069	0.618
DOC_MAPK_MEF2A_6	176	185	PF00069	0.352
DOC_MAPK_MEF2A_6	345	352	PF00069	0.807
DOC_MAPK_MEF2A_6	553	561	PF00069	0.525
DOC_MAPK_MEF2A_6	576	584	PF00069	0.669
DOC_MAPK_MEF2A_6	589	596	PF00069	0.627
DOC_PP1_RVXF_1	116	122	PF00149	0.470
DOC_PP1_RVXF_1	383	390	PF00149	0.472
DOC_PP1_RVXF_1	503	510	PF00149	0.518
DOC_PP2B_LxvP_1	594	597	PF13499	0.523
DOC_PP2B_LxvP_1	63	66	PF13499	0.545
DOC_PP4_FxxP_1	537	540	PF00568	0.565
DOC_PP4_FxxP_1	97	100	PF00568	0.461
DOC_USP7_MATH_1	163	167	PF00917	0.475
DOC_USP7_MATH_1	20	24	PF00917	0.636
DOC_USP7_MATH_1	303	307	PF00917	0.683
DOC_USP7_MATH_1	36	40	PF00917	0.723
DOC_USP7_MATH_1	360	364	PF00917	0.704
DOC_USP7_MATH_1	371	375	PF00917	0.724
DOC_USP7_MATH_1	437	441	PF00917	0.493
DOC_USP7_MATH_1	47	51	PF00917	0.775
DOC_USP7_MATH_1	486	490	PF00917	0.407
DOC_USP7_MATH_1	548	552	PF00917	0.589
DOC_USP7_UBL2_3	349	353	PF12436	0.630
DOC_WW_Pin1_4	61	66	PF00397	0.777
DOC_WW_Pin1_4	657	662	PF00397	0.613
LIG_14-3-3_CanoR_1	134	139	PF00244	0.494
LIG_14-3-3_CanoR_1	172	176	PF00244	0.451
LIG_14-3-3_CanoR_1	76	83	PF00244	0.804
LIG_BIR_II_1	1	5	PF00653	0.750
LIG_BRCT_BRCA1_1	401	405	PF00533	0.515
LIG_Clathr_ClatBox_1	528	532	PF01394	0.480
LIG_CtBP_PxDLS_1	591	595	PF00389	0.619
LIG_eIF4E_1	650	656	PF01652	0.465
LIG_FHA_1	253	259	PF00498	0.604
LIG_FHA_1	328	334	PF00498	0.591
LIG_FHA_1	502	508	PF00498	0.539
LIG_FHA_1	510	516	PF00498	0.519
LIG_FHA_1	78	84	PF00498	0.707
LIG_FHA_2	29	35	PF00498	0.771
LIG_FHA_2	443	449	PF00498	0.420
LIG_FHA_2	544	550	PF00498	0.735
LIG_FHA_2	599	605	PF00498	0.643
LIG_FHA_2	622	628	PF00498	0.468
LIG_FHA_2	7	13	PF00498	0.627
LIG_LIR_Apic_2	94	100	PF02991	0.490
LIG_LIR_Gen_1	445	454	PF02991	0.475
LIG_LIR_Gen_1	651	661	PF02991	0.455
LIG_LIR_Nem_3	101	107	PF02991	0.440
LIG_LIR_Nem_3	137	143	PF02991	0.368
LIG_LIR_Nem_3	445	450	PF02991	0.491
LIG_LIR_Nem_3	455	459	PF02991	0.521
LIG_LIR_Nem_3	651	656	PF02991	0.471
LIG_NRBOX	449	455	PF00104	0.494
LIG_PCNA_yPIPBox_3	571	581	PF02747	0.607
LIG_Pex14_1	649	653	PF04695	0.461
LIG_Pex14_2	459	463	PF04695	0.404
LIG_Rb_pABgroove_1	190	198	PF01858	0.348
LIG_RPA_C_Fungi	453	465	PF08784	0.475
LIG_SH2_CRK	196	200	PF00017	0.430
LIG_SH2_CRK	653	657	PF00017	0.524
LIG_SH2_PTP2	104	107	PF00017	0.623
LIG_SH2_STAP1	617	621	PF00017	0.503
LIG_SH2_STAT3	156	159	PF00017	0.399
LIG_SH2_STAT5	104	107	PF00017	0.575
LIG_SH2_STAT5	140	143	PF00017	0.367
LIG_SH2_STAT5	273	276	PF00017	0.374
LIG_SH2_STAT5	535	538	PF00017	0.409
LIG_SH3_1	511	517	PF00018	0.503
LIG_SH3_2	106	111	PF14604	0.527
LIG_SH3_2	344	349	PF14604	0.665
LIG_SH3_3	103	109	PF00018	0.576
LIG_SH3_3	200	206	PF00018	0.464
LIG_SH3_3	255	261	PF00018	0.466
LIG_SH3_3	330	336	PF00018	0.613
LIG_SH3_3	338	344	PF00018	0.588
LIG_SH3_3	345	351	PF00018	0.572
LIG_SH3_3	511	517	PF00018	0.488
LIG_SH3_3	585	591	PF00018	0.524
LIG_SH3_3	59	65	PF00018	0.720
LIG_SH3_3	634	640	PF00018	0.545
LIG_SH3_3	641	647	PF00018	0.487
LIG_SH3_3	655	661	PF00018	0.476
LIG_SUMO_SIM_par_1	217	223	PF11976	0.483
LIG_SUMO_SIM_par_1	526	532	PF11976	0.458
LIG_SUMO_SIM_par_1	654	660	PF11976	0.589
LIG_TRAF2_1	11	14	PF00917	0.632
LIG_TYR_ITIM	138	143	PF00017	0.387
LIG_TYR_ITIM	194	199	PF00017	0.379
LIG_UBA3_1	120	128	PF00899	0.445
LIG_WRC_WIRS_1	453	458	PF05994	0.471
MOD_CDK_SPxxK_3	61	68	PF00069	0.550
MOD_CK1_1	19	25	PF00069	0.621
MOD_CK1_1	231	237	PF00069	0.513
MOD_CK1_1	26	32	PF00069	0.604
MOD_CK1_1	3	9	PF00069	0.693
MOD_CK1_1	38	44	PF00069	0.503
MOD_CK1_1	45	51	PF00069	0.478
MOD_CK1_1	54	60	PF00069	0.626
MOD_CK1_1	657	663	PF00069	0.598
MOD_CK2_1	28	34	PF00069	0.742
MOD_CK2_1	442	448	PF00069	0.482
MOD_CK2_1	49	55	PF00069	0.680
MOD_CK2_1	598	604	PF00069	0.526
MOD_CK2_1	610	616	PF00069	0.479
MOD_CK2_1	621	627	PF00069	0.553
MOD_DYRK1A_RPxSP_1	61	65	PF00069	0.593
MOD_GlcNHglycan	165	168	PF01048	0.564
MOD_GlcNHglycan	177	180	PF01048	0.501
MOD_GlcNHglycan	18	21	PF01048	0.699
MOD_GlcNHglycan	22	25	PF01048	0.690
MOD_GlcNHglycan	275	278	PF01048	0.421
MOD_GlcNHglycan	290	293	PF01048	0.607
MOD_GlcNHglycan	440	443	PF01048	0.425
MOD_GlcNHglycan	45	48	PF01048	0.604
MOD_GlcNHglycan	51	54	PF01048	0.657
MOD_GlcNHglycan	585	588	PF01048	0.628
MOD_GlcNHglycan	633	636	PF01048	0.545
MOD_GlcNHglycan	69	72	PF01048	0.575
MOD_GSK3_1	15	22	PF00069	0.608
MOD_GSK3_1	171	178	PF00069	0.547
MOD_GSK3_1	225	232	PF00069	0.508
MOD_GSK3_1	23	30	PF00069	0.583
MOD_GSK3_1	269	276	PF00069	0.404
MOD_GSK3_1	34	41	PF00069	0.472
MOD_GSK3_1	43	50	PF00069	0.476
MOD_GSK3_1	438	445	PF00069	0.491
MOD_GSK3_1	544	551	PF00069	0.621
MOD_GSK3_1	67	74	PF00069	0.633
MOD_NEK2_1	195	200	PF00069	0.504
MOD_NEK2_1	229	234	PF00069	0.499
MOD_NEK2_1	372	377	PF00069	0.684
MOD_NEK2_1	388	393	PF00069	0.605
MOD_NEK2_1	436	441	PF00069	0.406
MOD_NEK2_1	610	615	PF00069	0.491
MOD_NEK2_2	329	334	PF00069	0.546
MOD_NEK2_2	373	378	PF00069	0.673
MOD_NEK2_2	442	447	PF00069	0.515
MOD_NEK2_2	452	457	PF00069	0.429
MOD_NEK2_2	548	553	PF00069	0.477
MOD_PIKK_1	229	235	PF00454	0.539
MOD_PIKK_1	488	494	PF00454	0.406
MOD_PIKK_1	77	83	PF00454	0.668
MOD_PK_1	259	265	PF00069	0.450
MOD_PKA_1	15	21	PF00069	0.623
MOD_PKA_2	15	21	PF00069	0.734
MOD_PKA_2	171	177	PF00069	0.454
MOD_PKA_2	303	309	PF00069	0.735
MOD_PKA_2	501	507	PF00069	0.580
MOD_PKA_2	67	73	PF00069	0.776
MOD_PKA_2	75	81	PF00069	0.768
MOD_Plk_1	548	554	PF00069	0.523
MOD_Plk_1	604	610	PF00069	0.605
MOD_Plk_4	225	231	PF00069	0.439
MOD_Plk_4	269	275	PF00069	0.378
MOD_Plk_4	388	394	PF00069	0.525
MOD_Plk_4	442	448	PF00069	0.509
MOD_ProDKin_1	61	67	PF00069	0.780
MOD_ProDKin_1	657	663	PF00069	0.621
MOD_SUMO_for_1	268	271	PF00179	0.409
TRG_DiLeu_BaEn_1	428	433	PF01217	0.480
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.503
TRG_ENDOCYTIC_2	104	107	PF00928	0.578
TRG_ENDOCYTIC_2	140	143	PF00928	0.344
TRG_ENDOCYTIC_2	196	199	PF00928	0.404
TRG_ENDOCYTIC_2	653	656	PF00928	0.458
TRG_ER_diArg_1	266	268	PF00400	0.438
TRG_ER_diArg_1	456	458	PF00400	0.345
TRG_ER_diArg_1	502	505	PF00400	0.556
TRG_ER_diArg_1	554	556	PF00400	0.669
TRG_NES_CRM1_1	112	126	PF08389	0.426
TRG_NES_CRM1_1	506	518	PF08389	0.398
TRG_NES_CRM1_1	563	575	PF08389	0.653
TRG_NLS_MonoCore_2	552	557	PF00514	0.647
TRG_NLS_MonoExtC_3	552	557	PF00514	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z4	Leptomonas seymouri	70%	100%
A0A0S4JPG4	Bodo saltans	29%	100%
A0A1X0P8L9	Trypanosomatidae	40%	100%
A0A422P299	Trypanosoma rangeli	39%	100%
A4HNP7	Leishmania braziliensis	85%	100%
A4ICU8	Leishmania infantum	100%	100%
D0A2K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9ASF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4Q239	Leishmania major	96%	100%
V5BZZ1	Trypanosoma cruzi	41%	100%