HORMA domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HORMA domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAH4_LEIDO

TriTrypDb:

LdBPK_361170.1 , LdCL_360016800 , LDHU3_36.1510

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7XAH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAH4

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.436
CLV_NRD_NRD_1	144	146	PF00675	0.424
CLV_NRD_NRD_1	147	149	PF00675	0.398
CLV_NRD_NRD_1	385	387	PF00675	0.615
CLV_NRD_NRD_1	524	526	PF00675	0.697
CLV_NRD_NRD_1	534	536	PF00675	0.616
CLV_PCSK_FUR_1	145	149	PF00082	0.411
CLV_PCSK_KEX2_1	146	148	PF00082	0.416
CLV_PCSK_KEX2_1	385	387	PF00082	0.615
CLV_PCSK_KEX2_1	524	526	PF00082	0.697

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U4	Leptomonas seymouri	53%	99%
A4HNX1	Leishmania braziliensis	73%	100%
A4ICM3	Leishmania infantum	99%	100%
E9ASN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1W5	Leishmania major	90%	100%

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