Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAG8_LEIDO

TriTrypDb:

LdBPK_360310.1 , LdCL_360008100 , LDHU3_36.0430

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7XAG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.608
CLV_NRD_NRD_1	138	140	PF00675	0.632
CLV_NRD_NRD_1	205	207	PF00675	0.685
CLV_NRD_NRD_1	3	5	PF00675	0.488
CLV_NRD_NRD_1	94	96	PF00675	0.696
CLV_PCSK_KEX2_1	102	104	PF00082	0.608
CLV_PCSK_KEX2_1	138	140	PF00082	0.632
CLV_PCSK_KEX2_1	2	4	PF00082	0.496
CLV_PCSK_KEX2_1	204	206	PF00082	0.639
CLV_PCSK_KEX2_1	94	96	PF00082	0.711
CLV_PCSK_PC7_1	98	104	PF00082	0.689
CLV_PCSK_SKI1_1	236	240	PF00082	0.736
DEG_MDM2_SWIB_1	300	308	PF02201	0.391
DEG_Nend_UBRbox_1	1	4	PF02207	0.725
DOC_CYCLIN_yCln2_LP_2	251	254	PF00134	0.568
DOC_MAPK_gen_1	102	111	PF00069	0.468
DOC_MAPK_MEF2A_6	166	173	PF00069	0.410
DOC_PP2B_LxvP_1	251	254	PF13499	0.568
DOC_PP4_FxxP_1	35	38	PF00568	0.551
DOC_USP7_MATH_1	142	146	PF00917	0.515
DOC_USP7_MATH_1	194	198	PF00917	0.509
DOC_USP7_MATH_1	306	310	PF00917	0.562
DOC_WW_Pin1_4	214	219	PF00397	0.541
DOC_WW_Pin1_4	34	39	PF00397	0.464
LIG_14-3-3_CanoR_1	102	108	PF00244	0.418
LIG_14-3-3_CanoR_1	206	216	PF00244	0.485
LIG_AP2alpha_2	242	244	PF02296	0.509
LIG_APCC_ABBA_1	216	221	PF00400	0.601
LIG_EH1_1	11	19	PF00400	0.440
LIG_eIF4E_1	13	19	PF01652	0.514
LIG_FHA_1	104	110	PF00498	0.362
LIG_FHA_1	208	214	PF00498	0.514
LIG_FHA_1	254	260	PF00498	0.485
LIG_FHA_1	294	300	PF00498	0.485
LIG_FHA_2	158	164	PF00498	0.500
LIG_FHA_2	66	72	PF00498	0.487
LIG_GBD_Chelix_1	18	26	PF00786	0.382
LIG_LIR_Apic_2	135	140	PF02991	0.439
LIG_LIR_Gen_1	273	280	PF02991	0.528
LIG_LIR_Nem_3	241	247	PF02991	0.580
LIG_LIR_Nem_3	273	277	PF02991	0.481
LIG_LIR_Nem_3	309	313	PF02991	0.686
LIG_LIR_Nem_3	31	35	PF02991	0.373
LIG_MYND_1	249	253	PF01753	0.571
LIG_NRBOX	17	23	PF00104	0.497
LIG_Pex14_1	240	244	PF04695	0.510
LIG_Pex14_1	311	315	PF04695	0.649
LIG_Pex14_2	300	304	PF04695	0.412
LIG_PTB_Apo_2	258	265	PF02174	0.489
LIG_PTB_Phospho_1	258	264	PF10480	0.494
LIG_RPA_C_Fungi	193	205	PF08784	0.517
LIG_SH2_CRK	274	278	PF00017	0.696
LIG_SH2_NCK_1	127	131	PF00017	0.599
LIG_SH2_SRC	113	116	PF00017	0.638
LIG_SH2_STAP1	155	159	PF00017	0.500
LIG_SH2_STAT5	174	177	PF00017	0.508
LIG_SH2_STAT5	264	267	PF00017	0.604
LIG_SH2_STAT5	274	277	PF00017	0.535
LIG_SH3_3	240	246	PF00018	0.627
LIG_SH3_3	256	262	PF00018	0.511
LIG_TRAF2_1	145	148	PF00917	0.629
LIG_TYR_ITIM	272	277	PF00017	0.697
LIG_TYR_ITIM	308	313	PF00017	0.572
LIG_WW_3	252	256	PF00397	0.621
MOD_CDK_SPxK_1	214	220	PF00069	0.685
MOD_CK1_1	157	163	PF00069	0.519
MOD_CK1_1	62	68	PF00069	0.627
MOD_CK2_1	142	148	PF00069	0.604
MOD_CK2_1	157	163	PF00069	0.440
MOD_CK2_1	194	200	PF00069	0.509
MOD_CK2_1	34	40	PF00069	0.567
MOD_GlcNHglycan	7	10	PF01048	0.677
MOD_GSK3_1	155	162	PF00069	0.541
MOD_GSK3_1	219	226	PF00069	0.763
MOD_GSK3_1	24	31	PF00069	0.429
MOD_N-GLC_1	142	147	PF02516	0.505
MOD_N-GLC_1	65	70	PF02516	0.528
MOD_NEK2_1	24	29	PF00069	0.457
MOD_NEK2_1	272	277	PF00069	0.566
MOD_NEK2_1	280	285	PF00069	0.520
MOD_NEK2_1	300	305	PF00069	0.265
MOD_NEK2_1	59	64	PF00069	0.511
MOD_NEK2_2	231	236	PF00069	0.657
MOD_PIKK_1	207	213	PF00454	0.586
MOD_PKA_2	219	225	PF00069	0.658
MOD_PKB_1	190	198	PF00069	0.558
MOD_Plk_2-3	87	93	PF00069	0.671
MOD_Plk_4	272	278	PF00069	0.692
MOD_Plk_4	282	288	PF00069	0.370
MOD_Plk_4	306	312	PF00069	0.525
MOD_Plk_4	59	65	PF00069	0.592
MOD_ProDKin_1	214	220	PF00069	0.685
MOD_ProDKin_1	34	40	PF00069	0.567
TRG_DiLeu_BaEn_3	91	97	PF01217	0.636
TRG_ENDOCYTIC_2	274	277	PF00928	0.598
TRG_ENDOCYTIC_2	310	313	PF00928	0.653
TRG_ER_diArg_1	1	4	PF00400	0.630
TRG_ER_diArg_1	102	104	PF00400	0.498
TRG_ER_diArg_1	137	139	PF00400	0.486
TRG_ER_diArg_1	181	184	PF00400	0.489
TRG_ER_diArg_1	203	206	PF00400	0.540
TRG_ER_diArg_1	94	96	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z7	Leptomonas seymouri	46%	99%
A4HNN7	Leishmania braziliensis	76%	100%
A4ICV8	Leishmania infantum	99%	100%
E9ASE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q249	Leishmania major	94%	100%