LeishMANIAdb
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Enriched in surface-labeled proteome protein 18

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Enriched in surface-labeled proteome protein 18
Gene product:
Enriched in surface-labeled proteome protein 18
Species:
Leishmania donovani
UniProt:
A0A3S7XAF9_LEIDO
TriTrypDb:
LdBPK_360720.1 * , LdCL_360012100 , LDHU3_36.0880
Length:
202

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 3
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005768 endosome 7 1
GO:0009986 cell surface 2 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7XAF9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAF9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 149 153 PF00656 0.434
CLV_NRD_NRD_1 113 115 PF00675 0.654
CLV_PCSK_KEX2_1 113 115 PF00082 0.655
CLV_PCSK_SKI1_1 103 107 PF00082 0.589
CLV_PCSK_SKI1_1 113 117 PF00082 0.598
CLV_PCSK_SKI1_1 17 21 PF00082 0.270
CLV_PCSK_SKI1_1 57 61 PF00082 0.781
CLV_PCSK_SKI1_1 6 10 PF00082 0.553
DEG_APCC_DBOX_1 153 161 PF00400 0.355
DEG_APCC_DBOX_1 16 24 PF00400 0.184
DEG_SPOP_SBC_1 59 63 PF00917 0.561
DOC_CDC14_PxL_1 157 165 PF14671 0.453
DOC_CYCLIN_yCln2_LP_2 4 10 PF00134 0.533
DOC_MAPK_MEF2A_6 158 165 PF00069 0.456
DOC_PP2B_LxvP_1 163 166 PF13499 0.417
DOC_WW_Pin1_4 43 48 PF00397 0.446
DOC_WW_Pin1_4 62 67 PF00397 0.561
DOC_WW_Pin1_4 89 94 PF00397 0.463
LIG_14-3-3_CanoR_1 113 123 PF00244 0.452
LIG_14-3-3_CanoR_1 57 66 PF00244 0.533
LIG_BRCT_BRCA1_1 15 19 PF00533 0.402
LIG_eIF4E_1 175 181 PF01652 0.373
LIG_FHA_1 114 120 PF00498 0.494
LIG_FHA_1 54 60 PF00498 0.587
LIG_GBD_Chelix_1 24 32 PF00786 0.441
LIG_LIR_Gen_1 117 128 PF02991 0.452
LIG_LIR_Gen_1 172 183 PF02991 0.372
LIG_LIR_Nem_3 117 123 PF02991 0.472
LIG_LIR_Nem_3 172 178 PF02991 0.330
LIG_MLH1_MIPbox_1 15 19 PF16413 0.402
LIG_NBox_RRM_1 19 29 PF00076 0.424
LIG_Pex14_2 9 13 PF04695 0.711
LIG_SH2_STAT5 85 88 PF00017 0.417
LIG_SH3_2 90 95 PF14604 0.473
LIG_SH3_3 65 71 PF00018 0.439
LIG_SH3_3 87 93 PF00018 0.458
LIG_SUMO_SIM_par_1 70 76 PF11976 0.457
LIG_TRAF2_1 73 76 PF00917 0.476
MOD_CDC14_SPxK_1 92 95 PF00782 0.458
MOD_CDK_SPxK_1 89 95 PF00069 0.472
MOD_CK1_1 33 39 PF00069 0.438
MOD_CK2_1 104 110 PF00069 0.463
MOD_CK2_1 70 76 PF00069 0.460
MOD_GlcNHglycan 116 119 PF01048 0.650
MOD_GlcNHglycan 171 174 PF01048 0.570
MOD_GlcNHglycan 32 35 PF01048 0.435
MOD_GlcNHglycan 47 50 PF01048 0.680
MOD_GSK3_1 114 121 PF00069 0.416
MOD_GSK3_1 33 40 PF00069 0.414
MOD_GSK3_1 53 60 PF00069 0.553
MOD_GSK3_1 9 16 PF00069 0.693
MOD_N-GLC_1 52 57 PF02516 0.761
MOD_NEK2_1 30 35 PF00069 0.351
MOD_NEK2_1 37 42 PF00069 0.555
MOD_NEK2_1 9 14 PF00069 0.680
MOD_NEK2_2 174 179 PF00069 0.430
MOD_PKA_1 113 119 PF00069 0.501
MOD_PKA_2 113 119 PF00069 0.471
MOD_Plk_4 123 129 PF00069 0.384
MOD_ProDKin_1 43 49 PF00069 0.448
MOD_ProDKin_1 62 68 PF00069 0.556
MOD_ProDKin_1 89 95 PF00069 0.463
MOD_SUMO_rev_2 76 84 PF00179 0.428
TRG_DiLeu_BaEn_1 176 181 PF01217 0.410
TRG_DiLeu_BaEn_4 110 116 PF01217 0.363
TRG_DiLeu_BaLyEn_6 192 197 PF01217 0.486
TRG_ENDOCYTIC_2 120 123 PF00928 0.458
TRG_ENDOCYTIC_2 175 178 PF00928 0.334
TRG_ER_diArg_1 112 114 PF00400 0.490
TRG_ER_diArg_1 193 196 PF00400 0.490
TRG_Pf-PMV_PEXEL_1 195 199 PF00026 0.661
TRG_Pf-PMV_PEXEL_1 95 99 PF00026 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8L4 Leptomonas seymouri 49% 97%
A0A1X0P888 Trypanosomatidae 28% 100%
A4HNS6 Leishmania braziliensis 72% 100%
A4ICR8 Leishmania infantum 96% 100%
D0A2N6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9ASI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q210 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS