Enriched in surface-labeled proteome protein 18

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 18

Species:

Leishmania donovani

UniProt:

A0A3S7XAF9_LEIDO

TriTrypDb:

LdBPK_360720.1 , LdCL_360012100 , LDHU3_36.0880

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 3
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0009986	cell surface	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.434
CLV_NRD_NRD_1	113	115	PF00675	0.654
CLV_PCSK_KEX2_1	113	115	PF00082	0.655
CLV_PCSK_SKI1_1	103	107	PF00082	0.589
CLV_PCSK_SKI1_1	113	117	PF00082	0.598
CLV_PCSK_SKI1_1	17	21	PF00082	0.270
CLV_PCSK_SKI1_1	57	61	PF00082	0.781
CLV_PCSK_SKI1_1	6	10	PF00082	0.553
DEG_APCC_DBOX_1	153	161	PF00400	0.355
DEG_APCC_DBOX_1	16	24	PF00400	0.184
DEG_SPOP_SBC_1	59	63	PF00917	0.561
DOC_CDC14_PxL_1	157	165	PF14671	0.453
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.533
DOC_MAPK_MEF2A_6	158	165	PF00069	0.456
DOC_PP2B_LxvP_1	163	166	PF13499	0.417
DOC_WW_Pin1_4	43	48	PF00397	0.446
DOC_WW_Pin1_4	62	67	PF00397	0.561
DOC_WW_Pin1_4	89	94	PF00397	0.463
LIG_14-3-3_CanoR_1	113	123	PF00244	0.452
LIG_14-3-3_CanoR_1	57	66	PF00244	0.533
LIG_BRCT_BRCA1_1	15	19	PF00533	0.402
LIG_eIF4E_1	175	181	PF01652	0.373
LIG_FHA_1	114	120	PF00498	0.494
LIG_FHA_1	54	60	PF00498	0.587
LIG_GBD_Chelix_1	24	32	PF00786	0.441
LIG_LIR_Gen_1	117	128	PF02991	0.452
LIG_LIR_Gen_1	172	183	PF02991	0.372
LIG_LIR_Nem_3	117	123	PF02991	0.472
LIG_LIR_Nem_3	172	178	PF02991	0.330
LIG_MLH1_MIPbox_1	15	19	PF16413	0.402
LIG_NBox_RRM_1	19	29	PF00076	0.424
LIG_Pex14_2	9	13	PF04695	0.711
LIG_SH2_STAT5	85	88	PF00017	0.417
LIG_SH3_2	90	95	PF14604	0.473
LIG_SH3_3	65	71	PF00018	0.439
LIG_SH3_3	87	93	PF00018	0.458
LIG_SUMO_SIM_par_1	70	76	PF11976	0.457
LIG_TRAF2_1	73	76	PF00917	0.476
MOD_CDC14_SPxK_1	92	95	PF00782	0.458
MOD_CDK_SPxK_1	89	95	PF00069	0.472
MOD_CK1_1	33	39	PF00069	0.438
MOD_CK2_1	104	110	PF00069	0.463
MOD_CK2_1	70	76	PF00069	0.460
MOD_GlcNHglycan	116	119	PF01048	0.650
MOD_GlcNHglycan	171	174	PF01048	0.570
MOD_GlcNHglycan	32	35	PF01048	0.435
MOD_GlcNHglycan	47	50	PF01048	0.680
MOD_GSK3_1	114	121	PF00069	0.416
MOD_GSK3_1	33	40	PF00069	0.414
MOD_GSK3_1	53	60	PF00069	0.553
MOD_GSK3_1	9	16	PF00069	0.693
MOD_N-GLC_1	52	57	PF02516	0.761
MOD_NEK2_1	30	35	PF00069	0.351
MOD_NEK2_1	37	42	PF00069	0.555
MOD_NEK2_1	9	14	PF00069	0.680
MOD_NEK2_2	174	179	PF00069	0.430
MOD_PKA_1	113	119	PF00069	0.501
MOD_PKA_2	113	119	PF00069	0.471
MOD_Plk_4	123	129	PF00069	0.384
MOD_ProDKin_1	43	49	PF00069	0.448
MOD_ProDKin_1	62	68	PF00069	0.556
MOD_ProDKin_1	89	95	PF00069	0.463
MOD_SUMO_rev_2	76	84	PF00179	0.428
TRG_DiLeu_BaEn_1	176	181	PF01217	0.410
TRG_DiLeu_BaEn_4	110	116	PF01217	0.363
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.486
TRG_ENDOCYTIC_2	120	123	PF00928	0.458
TRG_ENDOCYTIC_2	175	178	PF00928	0.334
TRG_ER_diArg_1	112	114	PF00400	0.490
TRG_ER_diArg_1	193	196	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L4	Leptomonas seymouri	49%	97%
A0A1X0P888	Trypanosomatidae	28%	100%
A4HNS6	Leishmania braziliensis	72%	100%
A4ICR8	Leishmania infantum	96%	100%
D0A2N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q210	Leishmania major	88%	100%