LeishMANIAdb
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SNF1-related protein kinase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SNF1-related protein kinase, putative
Gene product:
SNF1-related protein kinases, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XAF4_LEIDO
TriTrypDb:
LdBPK_360960.1 , LdCL_360014600 , LDHU3_36.1270
Length:
790

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAF4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 10
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0016310 phosphorylation 5 10
GO:0019538 protein metabolic process 3 10
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004672 protein kinase activity 3 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:0140096 catalytic activity, acting on a protein 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 467 471 PF00656 0.660
CLV_MEL_PAP_1 14 20 PF00089 0.491
CLV_NRD_NRD_1 356 358 PF00675 0.587
CLV_NRD_NRD_1 53 55 PF00675 0.280
CLV_NRD_NRD_1 553 555 PF00675 0.647
CLV_PCSK_KEX2_1 356 358 PF00082 0.584
CLV_PCSK_KEX2_1 553 555 PF00082 0.647
CLV_PCSK_KEX2_1 68 70 PF00082 0.346
CLV_PCSK_KEX2_1 772 774 PF00082 0.462
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.346
CLV_PCSK_PC1ET2_1 772 774 PF00082 0.446
CLV_PCSK_PC7_1 768 774 PF00082 0.523
CLV_PCSK_SKI1_1 123 127 PF00082 0.272
CLV_PCSK_SKI1_1 144 148 PF00082 0.294
CLV_PCSK_SKI1_1 249 253 PF00082 0.248
CLV_PCSK_SKI1_1 281 285 PF00082 0.476
CLV_PCSK_SKI1_1 46 50 PF00082 0.290
CLV_PCSK_SKI1_1 529 533 PF00082 0.616
CLV_PCSK_SKI1_1 553 557 PF00082 0.665
CLV_PCSK_SKI1_1 558 562 PF00082 0.675
CLV_PCSK_SKI1_1 62 66 PF00082 0.243
CLV_PCSK_SKI1_1 69 73 PF00082 0.258
CLV_Separin_Metazoa 311 315 PF03568 0.483
DEG_APCC_DBOX_1 248 256 PF00400 0.331
DEG_APCC_DBOX_1 45 53 PF00400 0.404
DEG_SCF_FBW7_1 785 790 PF00400 0.546
DEG_SPOP_SBC_1 688 692 PF00917 0.500
DOC_CKS1_1 376 381 PF01111 0.653
DOC_CYCLIN_RxL_1 120 130 PF00134 0.382
DOC_CYCLIN_RxL_1 276 285 PF00134 0.504
DOC_CYCLIN_yCln2_LP_2 491 497 PF00134 0.602
DOC_MAPK_DCC_7 374 382 PF00069 0.515
DOC_MAPK_gen_1 44 51 PF00069 0.338
DOC_MAPK_gen_1 66 76 PF00069 0.309
DOC_MAPK_gen_1 90 98 PF00069 0.404
DOC_MAPK_MEF2A_6 281 288 PF00069 0.352
DOC_MAPK_MEF2A_6 44 51 PF00069 0.315
DOC_MAPK_MEF2A_6 541 549 PF00069 0.579
DOC_MAPK_MEF2A_6 722 730 PF00069 0.561
DOC_MAPK_MEF2A_6 90 99 PF00069 0.321
DOC_MAPK_NFAT4_5 281 289 PF00069 0.356
DOC_MAPK_NFAT4_5 92 100 PF00069 0.350
DOC_MAPK_RevD_3 540 554 PF00069 0.608
DOC_PP4_FxxP_1 569 572 PF00568 0.594
DOC_SPAK_OSR1_1 319 323 PF12202 0.515
DOC_USP7_MATH_1 239 243 PF00917 0.327
DOC_USP7_MATH_1 418 422 PF00917 0.624
DOC_USP7_MATH_1 511 515 PF00917 0.683
DOC_USP7_MATH_1 643 647 PF00917 0.709
DOC_USP7_MATH_2 324 330 PF00917 0.487
DOC_USP7_UBL2_3 406 410 PF12436 0.663
DOC_USP7_UBL2_3 558 562 PF12436 0.666
DOC_USP7_UBL2_3 68 72 PF12436 0.425
DOC_USP7_UBL2_3 727 731 PF12436 0.456
DOC_WW_Pin1_4 180 185 PF00397 0.276
DOC_WW_Pin1_4 320 325 PF00397 0.567
DOC_WW_Pin1_4 375 380 PF00397 0.594
DOC_WW_Pin1_4 471 476 PF00397 0.763
DOC_WW_Pin1_4 490 495 PF00397 0.617
DOC_WW_Pin1_4 568 573 PF00397 0.656
DOC_WW_Pin1_4 575 580 PF00397 0.711
DOC_WW_Pin1_4 605 610 PF00397 0.686
DOC_WW_Pin1_4 633 638 PF00397 0.747
DOC_WW_Pin1_4 783 788 PF00397 0.688
LIG_14-3-3_CanoR_1 138 148 PF00244 0.411
LIG_14-3-3_CanoR_1 263 267 PF00244 0.288
LIG_14-3-3_CanoR_1 281 287 PF00244 0.326
LIG_14-3-3_CanoR_1 296 302 PF00244 0.488
LIG_14-3-3_CanoR_1 342 351 PF00244 0.675
LIG_14-3-3_CanoR_1 466 475 PF00244 0.526
LIG_14-3-3_CanoR_1 553 558 PF00244 0.606
LIG_14-3-3_CanoR_1 612 621 PF00244 0.798
LIG_AP2alpha_2 510 512 PF02296 0.707
LIG_BIR_II_1 1 5 PF00653 0.703
LIG_BRCT_BRCA1_1 284 288 PF00533 0.486
LIG_BRCT_BRCA1_1 565 569 PF00533 0.593
LIG_FHA_1 128 134 PF00498 0.362
LIG_FHA_1 298 304 PF00498 0.623
LIG_FHA_1 40 46 PF00498 0.346
LIG_FHA_1 530 536 PF00498 0.607
LIG_FHA_1 565 571 PF00498 0.597
LIG_FHA_1 765 771 PF00498 0.528
LIG_FHA_2 140 146 PF00498 0.404
LIG_FHA_2 376 382 PF00498 0.650
LIG_FHA_2 660 666 PF00498 0.665
LIG_FHA_2 689 695 PF00498 0.554
LIG_FHA_2 733 739 PF00498 0.573
LIG_FHA_2 89 95 PF00498 0.272
LIG_GBD_Chelix_1 757 765 PF00786 0.449
LIG_LIR_Apic_2 183 189 PF02991 0.272
LIG_LIR_Apic_2 235 241 PF02991 0.273
LIG_LIR_Apic_2 373 379 PF02991 0.646
LIG_LIR_Apic_2 566 572 PF02991 0.594
LIG_LIR_Gen_1 285 292 PF02991 0.458
LIG_LIR_Gen_1 31 39 PF02991 0.350
LIG_LIR_Gen_1 365 375 PF02991 0.578
LIG_LIR_Gen_1 514 524 PF02991 0.606
LIG_LIR_Gen_1 578 589 PF02991 0.703
LIG_LIR_Gen_1 698 708 PF02991 0.596
LIG_LIR_Gen_1 715 726 PF02991 0.369
LIG_LIR_Nem_3 106 111 PF02991 0.294
LIG_LIR_Nem_3 278 282 PF02991 0.455
LIG_LIR_Nem_3 285 291 PF02991 0.427
LIG_LIR_Nem_3 31 35 PF02991 0.272
LIG_LIR_Nem_3 365 370 PF02991 0.524
LIG_LIR_Nem_3 395 400 PF02991 0.485
LIG_LIR_Nem_3 453 458 PF02991 0.761
LIG_LIR_Nem_3 514 519 PF02991 0.595
LIG_LIR_Nem_3 578 584 PF02991 0.695
LIG_LIR_Nem_3 715 721 PF02991 0.535
LIG_LIR_Nem_3 83 89 PF02991 0.431
LIG_LYPXL_SIV_4 754 762 PF13949 0.450
LIG_LYPXL_yS_3 723 726 PF13949 0.524
LIG_MYND_1 273 277 PF01753 0.350
LIG_NRBOX 535 541 PF00104 0.517
LIG_Pex14_1 512 516 PF04695 0.710
LIG_Pex14_1 710 714 PF04695 0.596
LIG_Pex14_2 676 680 PF04695 0.511
LIG_PTAP_UEV_1 594 599 PF05743 0.548
LIG_PTB_Apo_2 416 423 PF02174 0.603
LIG_Rb_pABgroove_1 80 88 PF01858 0.290
LIG_SH2_CRK 212 216 PF00017 0.312
LIG_SH2_CRK 238 242 PF00017 0.288
LIG_SH2_CRK 367 371 PF00017 0.575
LIG_SH2_CRK 438 442 PF00017 0.579
LIG_SH2_CRK 516 520 PF00017 0.624
LIG_SH2_CRK 86 90 PF00017 0.272
LIG_SH2_GRB2like 367 370 PF00017 0.538
LIG_SH2_GRB2like 5 8 PF00017 0.576
LIG_SH2_NCK_1 186 190 PF00017 0.272
LIG_SH2_NCK_1 238 242 PF00017 0.324
LIG_SH2_NCK_1 516 520 PF00017 0.709
LIG_SH2_PTP2 400 403 PF00017 0.567
LIG_SH2_SRC 238 241 PF00017 0.404
LIG_SH2_STAP1 367 371 PF00017 0.544
LIG_SH2_STAP1 714 718 PF00017 0.592
LIG_SH2_STAP1 755 759 PF00017 0.462
LIG_SH2_STAT5 101 104 PF00017 0.279
LIG_SH2_STAT5 110 113 PF00017 0.315
LIG_SH2_STAT5 135 138 PF00017 0.272
LIG_SH2_STAT5 282 285 PF00017 0.430
LIG_SH2_STAT5 302 305 PF00017 0.373
LIG_SH2_STAT5 363 366 PF00017 0.565
LIG_SH2_STAT5 397 400 PF00017 0.501
LIG_SH2_STAT5 717 720 PF00017 0.529
LIG_SH3_3 254 260 PF00018 0.272
LIG_SH3_3 274 280 PF00018 0.223
LIG_SH3_3 501 507 PF00018 0.717
LIG_SH3_3 516 522 PF00018 0.621
LIG_SH3_3 569 575 PF00018 0.518
LIG_SH3_3 592 598 PF00018 0.539
LIG_SH3_3 6 12 PF00018 0.562
LIG_SH3_3 631 637 PF00018 0.703
LIG_SH3_3 718 724 PF00018 0.451
LIG_SH3_4 558 565 PF00018 0.523
LIG_SUMO_SIM_anti_2 222 230 PF11976 0.346
LIG_SUMO_SIM_anti_2 94 100 PF11976 0.278
LIG_SUMO_SIM_par_1 94 100 PF11976 0.278
LIG_TRAF2_1 323 326 PF00917 0.519
LIG_TRAF2_1 333 336 PF00917 0.502
LIG_TRAF2_1 412 415 PF00917 0.716
LIG_TRAF2_1 695 698 PF00917 0.469
LIG_TRAF2_2 20 25 PF00917 0.382
LIG_TYR_ITIM 210 215 PF00017 0.272
LIG_TYR_ITIM 398 403 PF00017 0.487
LIG_TYR_ITIM 721 726 PF00017 0.528
MOD_CDK_SPxxK_3 471 478 PF00069 0.628
MOD_CDK_SPxxK_3 605 612 PF00069 0.708
MOD_CK1_1 168 174 PF00069 0.324
MOD_CK1_1 180 186 PF00069 0.225
MOD_CK1_1 242 248 PF00069 0.384
MOD_CK1_1 425 431 PF00069 0.646
MOD_CK1_1 453 459 PF00069 0.573
MOD_CK1_1 464 470 PF00069 0.609
MOD_CK1_1 474 480 PF00069 0.814
MOD_CK1_1 593 599 PF00069 0.726
MOD_CK1_1 608 614 PF00069 0.664
MOD_CK1_1 692 698 PF00069 0.574
MOD_CK1_1 747 753 PF00069 0.463
MOD_CK1_1 780 786 PF00069 0.582
MOD_CK2_1 100 106 PF00069 0.272
MOD_CK2_1 320 326 PF00069 0.515
MOD_CK2_1 330 336 PF00069 0.549
MOD_CK2_1 375 381 PF00069 0.644
MOD_CK2_1 418 424 PF00069 0.715
MOD_CK2_1 456 462 PF00069 0.713
MOD_CK2_1 622 628 PF00069 0.672
MOD_CK2_1 688 694 PF00069 0.561
MOD_CK2_1 757 763 PF00069 0.446
MOD_GlcNHglycan 102 105 PF01048 0.272
MOD_GlcNHglycan 192 195 PF01048 0.290
MOD_GlcNHglycan 244 247 PF01048 0.357
MOD_GlcNHglycan 424 427 PF01048 0.752
MOD_GlcNHglycan 513 516 PF01048 0.767
MOD_GlcNHglycan 614 617 PF01048 0.717
MOD_GlcNHglycan 62 65 PF01048 0.424
MOD_GlcNHglycan 746 749 PF01048 0.469
MOD_GlcNHglycan 782 785 PF01048 0.525
MOD_GSK3_1 156 163 PF00069 0.404
MOD_GSK3_1 176 183 PF00069 0.144
MOD_GSK3_1 292 299 PF00069 0.518
MOD_GSK3_1 326 333 PF00069 0.523
MOD_GSK3_1 418 425 PF00069 0.600
MOD_GSK3_1 447 454 PF00069 0.572
MOD_GSK3_1 456 463 PF00069 0.574
MOD_GSK3_1 466 473 PF00069 0.686
MOD_GSK3_1 549 556 PF00069 0.578
MOD_GSK3_1 56 63 PF00069 0.274
MOD_GSK3_1 564 571 PF00069 0.578
MOD_GSK3_1 589 596 PF00069 0.717
MOD_GSK3_1 608 615 PF00069 0.683
MOD_GSK3_1 629 636 PF00069 0.631
MOD_GSK3_1 659 666 PF00069 0.572
MOD_GSK3_1 688 695 PF00069 0.465
MOD_GSK3_1 783 790 PF00069 0.655
MOD_LATS_1 527 533 PF00433 0.645
MOD_N-GLC_1 451 456 PF02516 0.654
MOD_N-GLC_1 489 494 PF02516 0.568
MOD_N-GLC_1 499 504 PF02516 0.648
MOD_N-GLC_1 688 693 PF02516 0.503
MOD_NEK2_1 165 170 PF00069 0.290
MOD_NEK2_1 176 181 PF00069 0.255
MOD_NEK2_1 215 220 PF00069 0.321
MOD_NEK2_1 221 226 PF00069 0.261
MOD_NEK2_1 297 302 PF00069 0.566
MOD_NEK2_1 422 427 PF00069 0.623
MOD_NEK2_1 429 434 PF00069 0.562
MOD_NEK2_1 460 465 PF00069 0.649
MOD_NEK2_1 499 504 PF00069 0.631
MOD_NEK2_1 549 554 PF00069 0.643
MOD_NEK2_1 687 692 PF00069 0.550
MOD_NEK2_2 156 161 PF00069 0.315
MOD_NEK2_2 282 287 PF00069 0.432
MOD_NEK2_2 564 569 PF00069 0.592
MOD_NEK2_2 663 668 PF00069 0.630
MOD_PIKK_1 401 407 PF00454 0.629
MOD_PIKK_1 429 435 PF00454 0.625
MOD_PIKK_1 772 778 PF00454 0.494
MOD_PKA_1 553 559 PF00069 0.641
MOD_PKA_1 772 778 PF00069 0.584
MOD_PKA_2 139 145 PF00069 0.430
MOD_PKA_2 262 268 PF00069 0.288
MOD_PKA_2 28 34 PF00069 0.272
MOD_PKA_2 553 559 PF00069 0.716
MOD_PKA_2 772 778 PF00069 0.464
MOD_Plk_1 292 298 PF00069 0.572
MOD_Plk_1 451 457 PF00069 0.674
MOD_Plk_1 499 505 PF00069 0.632
MOD_Plk_2-3 262 268 PF00069 0.272
MOD_Plk_4 297 303 PF00069 0.592
MOD_Plk_4 326 332 PF00069 0.596
MOD_Plk_4 396 402 PF00069 0.516
MOD_Plk_4 425 431 PF00069 0.617
MOD_Plk_4 531 537 PF00069 0.516
MOD_Plk_4 564 570 PF00069 0.594
MOD_Plk_4 616 622 PF00069 0.698
MOD_Plk_4 663 669 PF00069 0.648
MOD_Plk_4 757 763 PF00069 0.504
MOD_ProDKin_1 180 186 PF00069 0.276
MOD_ProDKin_1 320 326 PF00069 0.569
MOD_ProDKin_1 375 381 PF00069 0.598
MOD_ProDKin_1 471 477 PF00069 0.762
MOD_ProDKin_1 490 496 PF00069 0.616
MOD_ProDKin_1 568 574 PF00069 0.655
MOD_ProDKin_1 575 581 PF00069 0.717
MOD_ProDKin_1 605 611 PF00069 0.686
MOD_ProDKin_1 633 639 PF00069 0.741
MOD_ProDKin_1 783 789 PF00069 0.692
MOD_SUMO_for_1 146 149 PF00179 0.272
MOD_SUMO_for_1 560 563 PF00179 0.649
MOD_SUMO_for_1 67 70 PF00179 0.346
MOD_SUMO_for_1 703 706 PF00179 0.428
MOD_SUMO_rev_2 368 375 PF00179 0.639
MOD_SUMO_rev_2 737 747 PF00179 0.431
TRG_ENDOCYTIC_2 212 215 PF00928 0.312
TRG_ENDOCYTIC_2 363 366 PF00928 0.557
TRG_ENDOCYTIC_2 367 370 PF00928 0.532
TRG_ENDOCYTIC_2 400 403 PF00928 0.494
TRG_ENDOCYTIC_2 438 441 PF00928 0.581
TRG_ENDOCYTIC_2 516 519 PF00928 0.567
TRG_ENDOCYTIC_2 700 703 PF00928 0.376
TRG_ENDOCYTIC_2 717 720 PF00928 0.450
TRG_ENDOCYTIC_2 723 726 PF00928 0.493
TRG_ENDOCYTIC_2 86 89 PF00928 0.272
TRG_ER_diArg_1 356 358 PF00400 0.627
TRG_ER_diArg_1 553 555 PF00400 0.647
TRG_ER_diArg_1 765 768 PF00400 0.432
TRG_Pf-PMV_PEXEL_1 123 127 PF00026 0.272
TRG_Pf-PMV_PEXEL_1 54 58 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7V2 Leptomonas seymouri 71% 97%
A0A1X0P956 Trypanosomatidae 50% 100%
A0A3R7KDE9 Trypanosoma rangeli 47% 100%
A4HNV0 Leishmania braziliensis 81% 100%
A4ICP4 Leishmania infantum 100% 100%
D0A2R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
Q4Q1Y6 Leishmania major 95% 100%
V5BQE9 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS