LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7XAF2_LEIDO
TriTrypDb:
LdBPK_361020.1 * , LdCL_360015300 , LDHU3_36.1350
Length:
916

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3S7XAF2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAF2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 239 243 PF00656 0.714
CLV_C14_Caspase3-7 323 327 PF00656 0.441
CLV_C14_Caspase3-7 643 647 PF00656 0.690
CLV_C14_Caspase3-7 747 751 PF00656 0.778
CLV_NRD_NRD_1 163 165 PF00675 0.678
CLV_NRD_NRD_1 30 32 PF00675 0.542
CLV_NRD_NRD_1 36 38 PF00675 0.466
CLV_NRD_NRD_1 387 389 PF00675 0.510
CLV_NRD_NRD_1 407 409 PF00675 0.605
CLV_NRD_NRD_1 446 448 PF00675 0.609
CLV_NRD_NRD_1 458 460 PF00675 0.473
CLV_NRD_NRD_1 589 591 PF00675 0.491
CLV_NRD_NRD_1 617 619 PF00675 0.626
CLV_NRD_NRD_1 665 667 PF00675 0.578
CLV_NRD_NRD_1 906 908 PF00675 0.518
CLV_NRD_NRD_1 909 911 PF00675 0.489
CLV_PCSK_FUR_1 587 591 PF00082 0.486
CLV_PCSK_FUR_1 614 618 PF00082 0.558
CLV_PCSK_FUR_1 907 911 PF00082 0.511
CLV_PCSK_KEX2_1 163 165 PF00082 0.707
CLV_PCSK_KEX2_1 36 38 PF00082 0.387
CLV_PCSK_KEX2_1 387 389 PF00082 0.510
CLV_PCSK_KEX2_1 407 409 PF00082 0.605
CLV_PCSK_KEX2_1 445 447 PF00082 0.612
CLV_PCSK_KEX2_1 458 460 PF00082 0.466
CLV_PCSK_KEX2_1 589 591 PF00082 0.491
CLV_PCSK_KEX2_1 616 618 PF00082 0.628
CLV_PCSK_KEX2_1 665 667 PF00082 0.578
CLV_PCSK_KEX2_1 869 871 PF00082 0.465
CLV_PCSK_KEX2_1 908 910 PF00082 0.511
CLV_PCSK_PC1ET2_1 869 871 PF00082 0.465
CLV_PCSK_PC1ET2_1 908 910 PF00082 0.511
CLV_PCSK_PC7_1 383 389 PF00082 0.486
CLV_PCSK_PC7_1 403 409 PF00082 0.523
CLV_PCSK_SKI1_1 387 391 PF00082 0.466
CLV_PCSK_SKI1_1 41 45 PF00082 0.502
CLV_PCSK_SKI1_1 471 475 PF00082 0.494
CLV_PCSK_SKI1_1 652 656 PF00082 0.572
DEG_APCC_DBOX_1 142 150 PF00400 0.514
DEG_APCC_DBOX_1 382 390 PF00400 0.679
DEG_APCC_KENBOX_2 767 771 PF00400 0.672
DEG_SCF_FBW7_1 15 22 PF00400 0.761
DEG_SPOP_SBC_1 413 417 PF00917 0.655
DEG_SPOP_SBC_1 673 677 PF00917 0.807
DEG_SPOP_SBC_1 794 798 PF00917 0.836
DEG_SPOP_SBC_1 810 814 PF00917 0.645
DOC_CKS1_1 16 21 PF01111 0.756
DOC_CKS1_1 270 275 PF01111 0.644
DOC_CYCLIN_yCln2_LP_2 253 259 PF00134 0.734
DOC_MAPK_gen_1 266 276 PF00069 0.641
DOC_MAPK_gen_1 684 691 PF00069 0.757
DOC_MAPK_gen_1 766 775 PF00069 0.674
DOC_PP2B_LxvP_1 14 17 PF13499 0.741
DOC_PP2B_LxvP_1 253 256 PF13499 0.659
DOC_PP4_FxxP_1 449 452 PF00568 0.777
DOC_PP4_FxxP_1 522 525 PF00568 0.673
DOC_PP4_FxxP_1 679 682 PF00568 0.777
DOC_USP7_MATH_1 102 106 PF00917 0.575
DOC_USP7_MATH_1 342 346 PF00917 0.431
DOC_USP7_MATH_1 413 417 PF00917 0.746
DOC_USP7_MATH_1 43 47 PF00917 0.733
DOC_USP7_MATH_1 489 493 PF00917 0.607
DOC_USP7_MATH_1 596 600 PF00917 0.728
DOC_USP7_MATH_1 622 626 PF00917 0.727
DOC_USP7_MATH_1 673 677 PF00917 0.812
DOC_USP7_MATH_1 682 686 PF00917 0.744
DOC_USP7_MATH_1 702 706 PF00917 0.677
DOC_USP7_MATH_1 714 718 PF00917 0.792
DOC_USP7_MATH_1 743 747 PF00917 0.772
DOC_USP7_MATH_1 801 805 PF00917 0.788
DOC_USP7_MATH_1 809 813 PF00917 0.725
DOC_USP7_UBL2_3 762 766 PF12436 0.769
DOC_USP7_UBL2_3 858 862 PF12436 0.665
DOC_WW_Pin1_4 114 119 PF00397 0.499
DOC_WW_Pin1_4 15 20 PF00397 0.763
DOC_WW_Pin1_4 189 194 PF00397 0.509
DOC_WW_Pin1_4 269 274 PF00397 0.658
DOC_WW_Pin1_4 421 426 PF00397 0.669
DOC_WW_Pin1_4 448 453 PF00397 0.719
DOC_WW_Pin1_4 618 623 PF00397 0.771
DOC_WW_Pin1_4 678 683 PF00397 0.765
DOC_WW_Pin1_4 892 897 PF00397 0.716
LIG_14-3-3_CanoR_1 126 130 PF00244 0.416
LIG_14-3-3_CanoR_1 387 395 PF00244 0.679
LIG_14-3-3_CanoR_1 458 464 PF00244 0.764
LIG_14-3-3_CanoR_1 626 635 PF00244 0.733
LIG_14-3-3_CanoR_1 778 785 PF00244 0.712
LIG_14-3-3_CanoR_1 788 794 PF00244 0.733
LIG_14-3-3_CanoR_1 870 875 PF00244 0.699
LIG_BIR_II_1 1 5 PF00653 0.665
LIG_BIR_III_4 106 110 PF00653 0.475
LIG_BRCT_BRCA1_1 363 367 PF00533 0.397
LIG_BRCT_BRCA1_1 434 438 PF00533 0.677
LIG_BRCT_BRCA1_1 491 495 PF00533 0.700
LIG_BRCT_BRCA1_1 598 602 PF00533 0.715
LIG_BRCT_BRCA1_1 675 679 PF00533 0.803
LIG_deltaCOP1_diTrp_1 847 852 PF00928 0.682
LIG_EVH1_1 16 20 PF00568 0.759
LIG_FHA_1 126 132 PF00498 0.418
LIG_FHA_1 195 201 PF00498 0.438
LIG_FHA_1 20 26 PF00498 0.718
LIG_FHA_1 207 213 PF00498 0.308
LIG_FHA_1 230 236 PF00498 0.662
LIG_FHA_1 270 276 PF00498 0.563
LIG_FHA_1 290 296 PF00498 0.286
LIG_FHA_1 413 419 PF00498 0.683
LIG_FHA_1 488 494 PF00498 0.658
LIG_FHA_1 50 56 PF00498 0.636
LIG_FHA_1 502 508 PF00498 0.611
LIG_FHA_1 547 553 PF00498 0.765
LIG_FHA_1 707 713 PF00498 0.700
LIG_FHA_1 782 788 PF00498 0.843
LIG_FHA_2 237 243 PF00498 0.708
LIG_FHA_2 646 652 PF00498 0.679
LIG_FHA_2 862 868 PF00498 0.679
LIG_LIR_Apic_2 676 682 PF02991 0.791
LIG_LIR_Apic_2 719 724 PF02991 0.753
LIG_LIR_Apic_2 873 877 PF02991 0.697
LIG_LIR_Gen_1 175 186 PF02991 0.458
LIG_LIR_Gen_1 344 353 PF02991 0.419
LIG_LIR_Gen_1 426 437 PF02991 0.719
LIG_LIR_Gen_1 492 501 PF02991 0.660
LIG_LIR_Gen_1 769 776 PF02991 0.736
LIG_LIR_Gen_1 847 855 PF02991 0.782
LIG_LIR_Nem_3 119 125 PF02991 0.512
LIG_LIR_Nem_3 175 181 PF02991 0.448
LIG_LIR_Nem_3 319 324 PF02991 0.416
LIG_LIR_Nem_3 344 349 PF02991 0.419
LIG_LIR_Nem_3 364 370 PF02991 0.183
LIG_LIR_Nem_3 468 473 PF02991 0.752
LIG_LIR_Nem_3 492 498 PF02991 0.666
LIG_LIR_Nem_3 769 775 PF02991 0.736
LIG_LIR_Nem_3 847 851 PF02991 0.777
LIG_MLH1_MIPbox_1 434 438 PF16413 0.675
LIG_OCRL_FandH_1 367 379 PF00620 0.529
LIG_PCNA_PIPBox_1 261 270 PF02747 0.629
LIG_Pex14_1 40 44 PF04695 0.743
LIG_Pex14_1 848 852 PF04695 0.711
LIG_REV1ctd_RIR_1 365 375 PF16727 0.514
LIG_SH2_CRK 178 182 PF00017 0.426
LIG_SH2_CRK 470 474 PF00017 0.696
LIG_SH2_CRK 721 725 PF00017 0.697
LIG_SH2_GRB2like 96 99 PF00017 0.527
LIG_SH2_NCK_1 173 177 PF00017 0.498
LIG_SH2_NCK_1 322 326 PF00017 0.486
LIG_SH2_NCK_1 721 725 PF00017 0.697
LIG_SH2_PTP2 346 349 PF00017 0.436
LIG_SH2_PTP2 76 79 PF00017 0.474
LIG_SH2_SRC 173 176 PF00017 0.501
LIG_SH2_SRC 178 181 PF00017 0.449
LIG_SH2_SRC 721 724 PF00017 0.725
LIG_SH2_STAT3 725 728 PF00017 0.772
LIG_SH2_STAT3 86 89 PF00017 0.446
LIG_SH2_STAT5 180 183 PF00017 0.503
LIG_SH2_STAT5 346 349 PF00017 0.513
LIG_SH2_STAT5 57 60 PF00017 0.566
LIG_SH2_STAT5 76 79 PF00017 0.273
LIG_SH2_STAT5 772 775 PF00017 0.678
LIG_SH3_1 616 622 PF00018 0.739
LIG_SH3_3 14 20 PF00018 0.761
LIG_SH3_3 252 258 PF00018 0.646
LIG_SH3_3 329 335 PF00018 0.448
LIG_SH3_3 419 425 PF00018 0.654
LIG_SH3_3 560 566 PF00018 0.720
LIG_SH3_3 616 622 PF00018 0.739
LIG_SH3_3 788 794 PF00018 0.710
LIG_SUMO_SIM_anti_2 209 215 PF11976 0.502
LIG_SUMO_SIM_par_1 272 277 PF11976 0.563
LIG_SUMO_SIM_par_1 415 424 PF11976 0.750
LIG_TRAF2_1 172 175 PF00917 0.505
LIG_TRAF2_1 478 481 PF00917 0.767
LIG_WRC_WIRS_1 200 205 PF05994 0.472
LIG_WRC_WIRS_1 350 355 PF05994 0.436
LIG_WW_3 662 666 PF00397 0.727
MOD_CDC14_SPxK_1 681 684 PF00782 0.714
MOD_CDK_SPxK_1 678 684 PF00069 0.719
MOD_CDK_SPxxK_3 189 196 PF00069 0.583
MOD_CK1_1 144 150 PF00069 0.689
MOD_CK1_1 199 205 PF00069 0.564
MOD_CK1_1 237 243 PF00069 0.677
MOD_CK1_1 289 295 PF00069 0.457
MOD_CK1_1 421 427 PF00069 0.629
MOD_CK1_1 678 684 PF00069 0.707
MOD_CK1_1 69 75 PF00069 0.513
MOD_CK1_1 780 786 PF00069 0.637
MOD_CK1_1 836 842 PF00069 0.730
MOD_CK1_1 880 886 PF00069 0.645
MOD_CK1_1 892 898 PF00069 0.555
MOD_CK1_1 97 103 PF00069 0.692
MOD_CK2_1 448 454 PF00069 0.605
MOD_CK2_1 551 557 PF00069 0.618
MOD_CK2_1 655 661 PF00069 0.675
MOD_CK2_1 853 859 PF00069 0.601
MOD_Cter_Amidation 161 164 PF01082 0.518
MOD_DYRK1A_RPxSP_1 618 622 PF00069 0.679
MOD_GlcNHglycan 149 152 PF01048 0.697
MOD_GlcNHglycan 154 157 PF01048 0.614
MOD_GlcNHglycan 27 30 PF01048 0.633
MOD_GlcNHglycan 276 279 PF01048 0.472
MOD_GlcNHglycan 355 358 PF01048 0.513
MOD_GlcNHglycan 363 366 PF01048 0.381
MOD_GlcNHglycan 691 694 PF01048 0.737
MOD_GlcNHglycan 71 74 PF01048 0.513
MOD_GlcNHglycan 712 715 PF01048 0.736
MOD_GlcNHglycan 716 719 PF01048 0.719
MOD_GlcNHglycan 754 758 PF01048 0.804
MOD_GlcNHglycan 779 782 PF01048 0.743
MOD_GlcNHglycan 842 845 PF01048 0.798
MOD_GlcNHglycan 880 883 PF01048 0.645
MOD_GSK3_1 15 22 PF00069 0.702
MOD_GSK3_1 192 199 PF00069 0.627
MOD_GSK3_1 208 215 PF00069 0.233
MOD_GSK3_1 285 292 PF00069 0.455
MOD_GSK3_1 330 337 PF00069 0.601
MOD_GSK3_1 349 356 PF00069 0.289
MOD_GSK3_1 403 410 PF00069 0.705
MOD_GSK3_1 414 421 PF00069 0.641
MOD_GSK3_1 423 430 PF00069 0.485
MOD_GSK3_1 49 56 PF00069 0.583
MOD_GSK3_1 598 605 PF00069 0.659
MOD_GSK3_1 618 625 PF00069 0.668
MOD_GSK3_1 673 680 PF00069 0.784
MOD_GSK3_1 689 696 PF00069 0.690
MOD_GSK3_1 702 709 PF00069 0.527
MOD_GSK3_1 710 717 PF00069 0.708
MOD_GSK3_1 776 783 PF00069 0.698
MOD_GSK3_1 789 796 PF00069 0.541
MOD_GSK3_1 799 806 PF00069 0.688
MOD_GSK3_1 809 816 PF00069 0.549
MOD_GSK3_1 836 843 PF00069 0.730
MOD_GSK3_1 84 91 PF00069 0.670
MOD_GSK3_1 877 884 PF00069 0.640
MOD_LATS_1 624 630 PF00433 0.724
MOD_N-GLC_1 237 242 PF02516 0.540
MOD_N-GLC_1 299 304 PF02516 0.586
MOD_N-GLC_1 330 335 PF02516 0.653
MOD_N-GLC_1 413 418 PF02516 0.605
MOD_N-GLC_1 840 845 PF02516 0.727
MOD_N-GLC_1 97 102 PF02516 0.718
MOD_N-GLC_2 706 708 PF02516 0.730
MOD_NEK2_1 108 113 PF00069 0.752
MOD_NEK2_1 125 130 PF00069 0.431
MOD_NEK2_1 152 157 PF00069 0.571
MOD_NEK2_1 208 213 PF00069 0.438
MOD_NEK2_1 219 224 PF00069 0.394
MOD_NEK2_1 234 239 PF00069 0.621
MOD_NEK2_1 245 250 PF00069 0.587
MOD_NEK2_1 274 279 PF00069 0.408
MOD_NEK2_1 286 291 PF00069 0.402
MOD_NEK2_1 293 298 PF00069 0.485
MOD_NEK2_1 299 304 PF00069 0.518
MOD_NEK2_1 324 329 PF00069 0.575
MOD_NEK2_1 353 358 PF00069 0.507
MOD_NEK2_1 412 417 PF00069 0.713
MOD_NEK2_1 418 423 PF00069 0.745
MOD_NEK2_1 501 506 PF00069 0.563
MOD_NEK2_1 598 603 PF00069 0.714
MOD_NEK2_1 645 650 PF00069 0.553
MOD_NEK2_1 655 660 PF00069 0.617
MOD_NEK2_1 753 758 PF00069 0.726
MOD_NEK2_1 776 781 PF00069 0.652
MOD_NEK2_1 787 792 PF00069 0.650
MOD_NEK2_2 489 494 PF00069 0.496
MOD_PIKK_1 194 200 PF00454 0.483
MOD_PIKK_1 423 429 PF00454 0.697
MOD_PIKK_1 531 537 PF00454 0.643
MOD_PIKK_1 561 567 PF00454 0.713
MOD_PIKK_1 801 807 PF00454 0.757
MOD_PIKK_1 815 821 PF00454 0.580
MOD_PIKK_1 88 94 PF00454 0.651
MOD_PK_1 459 465 PF00069 0.678
MOD_PKA_1 36 42 PF00069 0.461
MOD_PKA_1 387 393 PF00069 0.590
MOD_PKA_1 407 413 PF00069 0.770
MOD_PKA_1 617 623 PF00069 0.719
MOD_PKA_2 125 131 PF00069 0.505
MOD_PKA_2 144 150 PF00069 0.408
MOD_PKA_2 36 42 PF00069 0.685
MOD_PKA_2 370 376 PF00069 0.530
MOD_PKA_2 387 393 PF00069 0.408
MOD_PKA_2 407 413 PF00069 0.770
MOD_PKA_2 617 623 PF00069 0.706
MOD_PKA_2 777 783 PF00069 0.640
MOD_PKA_2 787 793 PF00069 0.676
MOD_PKB_1 870 878 PF00069 0.622
MOD_Plk_1 174 180 PF00069 0.556
MOD_Plk_1 330 336 PF00069 0.591
MOD_Plk_1 413 419 PF00069 0.565
MOD_Plk_1 645 651 PF00069 0.662
MOD_Plk_1 887 893 PF00069 0.646
MOD_Plk_1 97 103 PF00069 0.720
MOD_Plk_2-3 646 652 PF00069 0.635
MOD_Plk_2-3 861 867 PF00069 0.596
MOD_Plk_4 10 16 PF00069 0.723
MOD_Plk_4 116 122 PF00069 0.669
MOD_Plk_4 208 214 PF00069 0.411
MOD_Plk_4 342 348 PF00069 0.506
MOD_Plk_4 414 420 PF00069 0.664
MOD_Plk_4 501 507 PF00069 0.587
MOD_Plk_4 53 59 PF00069 0.536
MOD_Plk_4 861 867 PF00069 0.608
MOD_ProDKin_1 114 120 PF00069 0.615
MOD_ProDKin_1 15 21 PF00069 0.711
MOD_ProDKin_1 189 195 PF00069 0.643
MOD_ProDKin_1 269 275 PF00069 0.558
MOD_ProDKin_1 421 427 PF00069 0.585
MOD_ProDKin_1 448 454 PF00069 0.656
MOD_ProDKin_1 618 624 PF00069 0.727
MOD_ProDKin_1 678 684 PF00069 0.719
MOD_ProDKin_1 892 898 PF00069 0.648
MOD_SUMO_rev_2 746 751 PF00179 0.525
MOD_SUMO_rev_2 861 871 PF00179 0.557
TRG_DiLeu_BaEn_1 116 121 PF01217 0.638
TRG_DiLeu_BaEn_1 468 473 PF01217 0.650
TRG_DiLeu_BaLyEn_6 270 275 PF01217 0.529
TRG_DiLeu_LyEn_5 468 473 PF01217 0.650
TRG_ENDOCYTIC_2 178 181 PF00928 0.561
TRG_ENDOCYTIC_2 346 349 PF00928 0.513
TRG_ENDOCYTIC_2 429 432 PF00928 0.702
TRG_ENDOCYTIC_2 470 473 PF00928 0.703
TRG_ENDOCYTIC_2 76 79 PF00928 0.402
TRG_ENDOCYTIC_2 772 775 PF00928 0.623
TRG_ER_diArg_1 142 145 PF00400 0.650
TRG_ER_diArg_1 163 165 PF00400 0.591
TRG_ER_diArg_1 386 388 PF00400 0.631
TRG_ER_diArg_1 445 447 PF00400 0.682
TRG_ER_diArg_1 458 461 PF00400 0.602
TRG_ER_diArg_1 587 590 PF00400 0.607
TRG_ER_diArg_1 614 617 PF00400 0.785
TRG_ER_diArg_1 664 666 PF00400 0.729
TRG_ER_diArg_1 906 909 PF00400 0.651
TRG_Pf-PMV_PEXEL_1 163 168 PF00026 0.592
TRG_Pf-PMV_PEXEL_1 387 391 PF00026 0.579
TRG_Pf-PMV_PEXEL_1 471 475 PF00026 0.619

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1X5 Leptomonas seymouri 32% 100%
A4HNV5 Leishmania braziliensis 50% 100%
A4ICN8 Leishmania infantum 99% 100%
E9ASL6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q1Y0 Leishmania major 84% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS