Mitochondrial ATP synthase epsilon chain, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAE3_LEIDO

TriTrypDb:

LdBPK_360680.1 , LdCL_360011700 , LDHU3_36.0840

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

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Cellular components
Term	Name	Level	Count
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	4
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	4
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	4
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	4
GO:0098796	membrane protein complex	2	4
GO:0098798	mitochondrial protein-containing complex	2	4
GO:0098800	inner mitochondrial membrane protein complex	3	4
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S7XAE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAE3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0005215	transporter activity	1	4
GO:0005216	monoatomic ion channel activity	4	4
GO:0005261	monoatomic cation channel activity	5	4
GO:0008324	monoatomic cation transmembrane transporter activity	4	4
GO:0015075	monoatomic ion transmembrane transporter activity	3	4
GO:0015078	proton transmembrane transporter activity	5	4
GO:0015252	proton channel activity	6	4
GO:0015267	channel activity	4	4
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	115	121	PF00089	0.721
CLV_NRD_NRD_1	179	181	PF00675	0.760
CLV_NRD_NRD_1	196	198	PF00675	0.540
CLV_PCSK_FUR_1	146	150	PF00082	0.749
CLV_PCSK_KEX2_1	148	150	PF00082	0.791
CLV_PCSK_KEX2_1	179	181	PF00082	0.760
CLV_PCSK_KEX2_1	196	198	PF00082	0.540
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.748
CLV_PCSK_SKI1_1	166	170	PF00082	0.756
DEG_APCC_DBOX_1	186	194	PF00400	0.523

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4ICS2	Leishmania infantum	99%	100%
Q4Q214	Leishmania major	85%	100%

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