Mitochondrial ATP synthase epsilon chain, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAE3_LEIDO

TriTrypDb:

LdBPK_360680.1 , LdCL_360011700 , LDHU3_36.0840

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	4
GO:0032991	protein-containing complex	1	4
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	4
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	4
GO:0098796	membrane protein complex	2	4
GO:0098798	mitochondrial protein-containing complex	2	4
GO:0098800	inner mitochondrial membrane protein complex	3	4
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7XAE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAE3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0005215	transporter activity	1	4
GO:0005216	monoatomic ion channel activity	4	4
GO:0005261	monoatomic cation channel activity	5	4
GO:0008324	monoatomic cation transmembrane transporter activity	4	4
GO:0015075	monoatomic ion transmembrane transporter activity	3	4
GO:0015078	proton transmembrane transporter activity	5	4
GO:0015252	proton channel activity	6	4
GO:0015267	channel activity	4	4
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	4
GO:0016874	ligase activity	2	4
GO:0022803	passive transmembrane transporter activity	3	4
GO:0022857	transmembrane transporter activity	2	4
GO:0022890	inorganic cation transmembrane transporter activity	4	4
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	115	121	PF00089	0.721
CLV_NRD_NRD_1	179	181	PF00675	0.760
CLV_NRD_NRD_1	196	198	PF00675	0.540
CLV_PCSK_FUR_1	146	150	PF00082	0.749
CLV_PCSK_KEX2_1	148	150	PF00082	0.791
CLV_PCSK_KEX2_1	179	181	PF00082	0.760
CLV_PCSK_KEX2_1	196	198	PF00082	0.540
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.748
CLV_PCSK_SKI1_1	166	170	PF00082	0.756
DEG_APCC_DBOX_1	186	194	PF00400	0.523
DEG_APCC_DBOX_1	195	203	PF00400	0.454
DEG_SPOP_SBC_1	81	85	PF00917	0.514
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.524
DOC_MAPK_DCC_7	44	53	PF00069	0.502
DOC_MAPK_gen_1	196	202	PF00069	0.549
DOC_MAPK_HePTP_8	119	131	PF00069	0.522
DOC_MAPK_HePTP_8	41	53	PF00069	0.502
DOC_MAPK_JIP1_4	6	12	PF00069	0.542
DOC_MAPK_MEF2A_6	122	131	PF00069	0.524
DOC_MAPK_MEF2A_6	44	53	PF00069	0.450
DOC_PP1_RVXF_1	170	177	PF00149	0.483
DOC_PP2B_LxvP_1	123	126	PF13499	0.525
DOC_PP2B_LxvP_1	139	142	PF13499	0.484
DOC_PP2B_LxvP_1	56	59	PF13499	0.512
DOC_PP4_FxxP_1	237	240	PF00568	0.495
DOC_PP4_FxxP_1	67	70	PF00568	0.519
DOC_USP7_MATH_1	152	156	PF00917	0.611
DOC_USP7_MATH_1	158	162	PF00917	0.522
DOC_USP7_MATH_1	71	75	PF00917	0.529
DOC_USP7_UBL2_3	229	233	PF12436	0.512
DOC_WW_Pin1_4	121	126	PF00397	0.613
DOC_WW_Pin1_4	13	18	PF00397	0.399
DOC_WW_Pin1_4	137	142	PF00397	0.418
DOC_WW_Pin1_4	188	193	PF00397	0.560
DOC_WW_Pin1_4	82	87	PF00397	0.515
LIG_14-3-3_CanoR_1	118	126	PF00244	0.520
LIG_14-3-3_CanoR_1	146	156	PF00244	0.577
LIG_14-3-3_CanoR_1	157	165	PF00244	0.504
LIG_14-3-3_CanoR_1	179	184	PF00244	0.529
LIG_14-3-3_CanoR_1	196	200	PF00244	0.410
LIG_14-3-3_CanoR_1	236	240	PF00244	0.499
LIG_BRCT_BRCA1_1	30	34	PF00533	0.503
LIG_FHA_1	148	154	PF00498	0.617
LIG_FHA_1	217	223	PF00498	0.482
LIG_FHA_2	131	137	PF00498	0.533
LIG_GSK3_LRP6_1	141	146	PF00069	0.480
LIG_LIR_Apic_2	235	240	PF02991	0.500
LIG_LIR_Apic_2	66	70	PF02991	0.519
LIG_LIR_Nem_3	110	115	PF02991	0.517
LIG_LIR_Nem_3	162	168	PF02991	0.563
LIG_LIR_Nem_3	210	214	PF02991	0.478
LIG_Pex14_2	169	173	PF04695	0.474
LIG_Pex14_2	50	54	PF04695	0.506
LIG_SH2_CRK	165	169	PF00017	0.560
LIG_SH2_CRK	46	50	PF00017	0.502
LIG_SH2_GRB2like	214	217	PF00017	0.478
LIG_SH2_GRB2like	89	92	PF00017	0.520
LIG_SH2_SRC	214	217	PF00017	0.478
LIG_SH2_STAP1	89	93	PF00017	0.521
LIG_SH2_STAT3	108	111	PF00017	0.511
LIG_SH2_STAT5	128	131	PF00017	0.528
LIG_SH2_STAT5	211	214	PF00017	0.478
LIG_SH2_STAT5	242	245	PF00017	0.514
LIG_SH3_3	11	17	PF00018	0.399
LIG_SH3_3	135	141	PF00018	0.598
LIG_SH3_3	75	81	PF00018	0.498
LIG_SH3_3	99	105	PF00018	0.522
LIG_SUMO_SIM_par_1	6	11	PF11976	0.542
LIG_TRAF2_1	107	110	PF00917	0.510
LIG_TRAF2_1	252	255	PF00917	0.403
LIG_TYR_ITIM	212	217	PF00017	0.477
LIG_UBA3_1	53	57	PF00899	0.461
LIG_WRC_WIRS_1	9	14	PF05994	0.399
LIG_WW_1	125	128	PF00397	0.524
MOD_CDK_SPK_2	141	146	PF00069	0.480
MOD_CDK_SPxxK_3	141	148	PF00069	0.479
MOD_CK1_1	121	127	PF00069	0.521
MOD_CK1_1	13	19	PF00069	0.399
MOD_CK1_1	140	146	PF00069	0.569
MOD_CK1_1	161	167	PF00069	0.545
MOD_CK1_1	235	241	PF00069	0.406
MOD_CK1_1	85	91	PF00069	0.514
MOD_GlcNHglycan	237	240	PF01048	0.606
MOD_GSK3_1	113	120	PF00069	0.593
MOD_GSK3_1	130	137	PF00069	0.420
MOD_GSK3_1	8	15	PF00069	0.399
MOD_GSK3_1	81	88	PF00069	0.480
MOD_LATS_1	177	183	PF00433	0.483
MOD_N-GLC_1	215	220	PF02516	0.678
MOD_N-GLC_1	246	251	PF02516	0.658
MOD_NEK2_1	117	122	PF00069	0.542
MOD_NEK2_1	195	200	PF00069	0.477
MOD_NEK2_1	8	13	PF00069	0.357
MOD_NEK2_2	113	118	PF00069	0.488
MOD_NEK2_2	152	157	PF00069	0.539
MOD_PK_1	179	185	PF00069	0.490
MOD_PKA_1	179	185	PF00069	0.490
MOD_PKA_2	117	123	PF00069	0.522
MOD_PKA_2	159	165	PF00069	0.564
MOD_PKA_2	179	185	PF00069	0.390
MOD_PKA_2	186	192	PF00069	0.464
MOD_PKA_2	195	201	PF00069	0.371
MOD_PKA_2	235	241	PF00069	0.505
MOD_PKA_2	94	100	PF00069	0.520
MOD_Plk_4	134	140	PF00069	0.539
MOD_Plk_4	179	185	PF00069	0.564
MOD_ProDKin_1	121	127	PF00069	0.613
MOD_ProDKin_1	13	19	PF00069	0.399
MOD_ProDKin_1	137	143	PF00069	0.419
MOD_ProDKin_1	188	194	PF00069	0.560
MOD_ProDKin_1	82	88	PF00069	0.514
MOD_SUMO_rev_2	249	259	PF00179	0.516
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.711
TRG_ENDOCYTIC_2	128	131	PF00928	0.528
TRG_ENDOCYTIC_2	165	168	PF00928	0.558
TRG_ENDOCYTIC_2	214	217	PF00928	0.478
TRG_ENDOCYTIC_2	234	237	PF00928	0.293
TRG_ENDOCYTIC_2	242	245	PF00928	0.310
TRG_ER_diArg_1	169	172	PF00400	0.563
TRG_ER_diArg_1	178	180	PF00400	0.460
TRG_ER_diArg_1	195	197	PF00400	0.337
TRG_NES_CRM1_1	207	220	PF08389	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4ICS2	Leishmania infantum	99%	100%
Q4Q214	Leishmania major	85%	100%