ADP-ribosylation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XAE0_LEIDO

TriTrypDb:

LdBPK_360880.1 , LdCL_360013800 , LDHU3_36.1150

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAE0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	271	273	PF00082	0.498
CLV_PCSK_KEX2_1	95	97	PF00082	0.407
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.498
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.414
CLV_PCSK_SKI1_1	201	205	PF00082	0.310
CLV_PCSK_SKI1_1	26	30	PF00082	0.557
CLV_PCSK_SKI1_1	272	276	PF00082	0.510
CLV_PCSK_SKI1_1	40	44	PF00082	0.395
CLV_PCSK_SKI1_1	96	100	PF00082	0.322
DEG_APCC_DBOX_1	39	47	PF00400	0.481
DOC_CYCLIN_RxL_1	23	33	PF00134	0.571
DOC_CYCLIN_RxL_1	37	47	PF00134	0.410
DOC_MAPK_gen_1	107	116	PF00069	0.414
DOC_MAPK_gen_1	124	132	PF00069	0.213
DOC_MAPK_gen_1	199	206	PF00069	0.347
DOC_MAPK_gen_1	92	100	PF00069	0.411
DOC_MAPK_MEF2A_6	124	132	PF00069	0.374
DOC_MAPK_MEF2A_6	199	206	PF00069	0.319
DOC_USP7_MATH_1	274	278	PF00917	0.528
DOC_USP7_MATH_1	72	76	PF00917	0.639
DOC_USP7_MATH_1	87	91	PF00917	0.156
DOC_USP7_UBL2_3	271	275	PF12436	0.542
DOC_WW_Pin1_4	124	129	PF00397	0.343
LIG_14-3-3_CanoR_1	107	117	PF00244	0.365
LIG_14-3-3_CanoR_1	96	101	PF00244	0.376
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_EH_1	33	37	PF12763	0.509
LIG_FHA_1	109	115	PF00498	0.290
LIG_FHA_1	125	131	PF00498	0.300
LIG_FHA_1	23	29	PF00498	0.522
LIG_FHA_1	240	246	PF00498	0.376
LIG_FHA_1	95	101	PF00498	0.306
LIG_GBD_Chelix_1	251	259	PF00786	0.412
LIG_LIR_Gen_1	263	274	PF02991	0.418
LIG_LIR_Gen_1	33	43	PF02991	0.482
LIG_LIR_Nem_3	129	135	PF02991	0.412
LIG_LIR_Nem_3	165	170	PF02991	0.443
LIG_LIR_Nem_3	263	269	PF02991	0.398
LIG_LIR_Nem_3	33	39	PF02991	0.483
LIG_NRBOX	38	44	PF00104	0.550
LIG_Pex14_1	159	163	PF04695	0.292
LIG_Pex14_2	155	159	PF04695	0.300
LIG_SH2_CRK	266	270	PF00017	0.528
LIG_SH2_STAP1	266	270	PF00017	0.477
LIG_SH2_STAT5	126	129	PF00017	0.444
LIG_SH2_STAT5	171	174	PF00017	0.338
LIG_SH2_STAT5	197	200	PF00017	0.343
LIG_SH2_STAT5	38	41	PF00017	0.481
LIG_SH3_3	29	35	PF00018	0.524
LIG_SH3_3	52	58	PF00018	0.568
LIG_SH3_5	138	142	PF00018	0.409
LIG_SUMO_SIM_par_1	96	102	PF11976	0.446
LIG_UBA3_1	19	26	PF00899	0.536
LIG_UBA3_1	203	210	PF00899	0.343
LIG_WRC_WIRS_1	100	105	PF05994	0.296
MOD_CK1_1	175	181	PF00069	0.403
MOD_CK1_1	76	82	PF00069	0.710
MOD_CK2_1	112	118	PF00069	0.452
MOD_GlcNHglycan	118	121	PF01048	0.296
MOD_GlcNHglycan	174	177	PF01048	0.309
MOD_GlcNHglycan	232	235	PF01048	0.440
MOD_GlcNHglycan	75	78	PF01048	0.645
MOD_GlcNHglycan	89	92	PF01048	0.375
MOD_GSK3_1	108	115	PF00069	0.319
MOD_GSK3_1	72	79	PF00069	0.659
MOD_N-GLC_2	143	145	PF02516	0.412
MOD_NEK2_1	189	194	PF00069	0.428
MOD_NEK2_1	22	27	PF00069	0.483
MOD_NEK2_1	230	235	PF00069	0.231
MOD_PIKK_1	56	62	PF00454	0.613
MOD_Plk_1	4	10	PF00069	0.581
MOD_Plk_4	112	118	PF00069	0.355
MOD_ProDKin_1	124	130	PF00069	0.343
MOD_SUMO_for_1	280	283	PF00179	0.496
MOD_SUMO_for_1	91	94	PF00179	0.347
MOD_SUMO_rev_2	118	127	PF00179	0.444
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.343
TRG_ENDOCYTIC_2	266	269	PF00928	0.383
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	40	45	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P886	Leptomonas seymouri	68%	99%
A0A0S4JWF1	Bodo saltans	42%	100%
A0A1X0P850	Trypanosomatidae	51%	100%
A0A422NK26	Trypanosoma rangeli	52%	93%
A4HNU2	Leishmania braziliensis	81%	96%
A4ICQ2	Leishmania infantum	100%	100%
D0A2Q7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ASK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q3SXY8	Homo sapiens	35%	70%
Q4Q1Z4	Leishmania major	96%	100%
Q640N2	Mus musculus	37%	70%