Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAD8_LEIDO

TriTrypDb:

LdBPK_360030.1 , LdCL_360005100 , LDHU3_36.0060

Length:

152

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.642
CLV_PCSK_KEX2_1	51	53	PF00082	0.630
CLV_PCSK_SKI1_1	89	93	PF00082	0.481
DOC_USP7_MATH_1	54	58	PF00917	0.707
DOC_WW_Pin1_4	131	136	PF00397	0.769
DOC_WW_Pin1_4	7	12	PF00397	0.823
LIG_APCC_ABBA_1	142	147	PF00400	0.602
LIG_deltaCOP1_diTrp_1	40	45	PF00928	0.494
LIG_FHA_1	137	143	PF00498	0.545
LIG_FHA_2	132	138	PF00498	0.721
LIG_LIR_Gen_1	40	50	PF02991	0.560
LIG_LIR_Nem_3	21	26	PF02991	0.543
LIG_LIR_Nem_3	40	45	PF02991	0.361
LIG_PCNA_yPIPBox_3	31	43	PF02747	0.419
LIG_PCNA_yPIPBox_3	61	71	PF02747	0.522
LIG_Pex14_1	104	108	PF04695	0.519
LIG_SH2_CRK	146	150	PF00017	0.592
LIG_SH2_NCK_1	24	28	PF00017	0.559
LIG_SH2_STAT5	86	89	PF00017	0.539
LIG_SH2_STAT5	94	97	PF00017	0.474
LIG_TRAF2_1	134	137	PF00917	0.750
LIG_TYR_ITIM	144	149	PF00017	0.561
MOD_CK2_1	131	137	PF00069	0.722
MOD_GlcNHglycan	56	60	PF01048	0.611
MOD_GSK3_1	1	8	PF00069	0.845
MOD_GSK3_1	145	152	PF00069	0.589
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NMyristoyl	1	7	PF02799	0.735
MOD_PIKK_1	114	120	PF00454	0.640
MOD_Plk_1	136	142	PF00069	0.594
MOD_Plk_2-3	136	142	PF00069	0.639
MOD_ProDKin_1	131	137	PF00069	0.764
MOD_ProDKin_1	7	13	PF00069	0.820
MOD_SPalmitoyl_4	1	7	PF01529	0.783
MOD_SUMO_rev_2	136	144	PF00179	0.544
TRG_DiLeu_BaEn_3	40	46	PF01217	0.505
TRG_ENDOCYTIC_2	146	149	PF00928	0.574
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T3	Leptomonas seymouri	75%	100%
A0A0S4JM37	Bodo saltans	49%	94%
A0A1X0P8L8	Trypanosomatidae	48%	97%
A0A3R7M3R0	Trypanosoma rangeli	46%	100%
A0A3R7M9B9	Trypanosoma rangeli	44%	77%
A4HNL4	Leishmania braziliensis	84%	100%
A4ICY5	Leishmania infantum	100%	100%
D0A2G5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	68%
E9ASC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q276	Leishmania major	97%	100%
V5BQL8	Trypanosoma cruzi	44%	100%