Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAD3_LEIDO

TriTrypDb:

LdBPK_360580.1 , LdCL_360010700 , LDHU3_36.0740

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7XAD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.646
CLV_C14_Caspase3-7	15	19	PF00656	0.452
CLV_PCSK_SKI1_1	119	123	PF00082	0.381
CLV_PCSK_SKI1_1	133	137	PF00082	0.233
CLV_PCSK_SKI1_1	174	178	PF00082	0.402
CLV_PCSK_SKI1_1	187	191	PF00082	0.433
CLV_PCSK_SKI1_1	87	91	PF00082	0.408
DEG_APCC_DBOX_1	149	157	PF00400	0.500
DOC_MAPK_gen_1	167	177	PF00069	0.583
DOC_MAPK_MEF2A_6	59	66	PF00069	0.619
DOC_MAPK_NFAT4_5	59	67	PF00069	0.599
DOC_PP1_RVXF_1	172	178	PF00149	0.594
DOC_USP7_MATH_1	113	117	PF00917	0.661
DOC_USP7_MATH_1	8	12	PF00917	0.425
LIG_14-3-3_CanoR_1	26	32	PF00244	0.384
LIG_14-3-3_CanoR_1	55	63	PF00244	0.604
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BRCT_BRCA1_1	164	168	PF00533	0.561
LIG_FHA_1	155	161	PF00498	0.554
LIG_FHA_2	188	194	PF00498	0.569
LIG_FHA_2	28	34	PF00498	0.370
LIG_FHA_2	68	74	PF00498	0.666
LIG_LIR_Gen_1	165	176	PF02991	0.486
LIG_LIR_Nem_3	165	171	PF02991	0.500
LIG_LIR_Nem_3	2	6	PF02991	0.389
LIG_NRBOX	48	54	PF00104	0.397
LIG_SH2_CRK	107	111	PF00017	0.717
LIG_SH2_CRK	202	206	PF00017	0.575
LIG_SH2_GRB2like	201	204	PF00017	0.563
LIG_SH2_STAP1	107	111	PF00017	0.693
LIG_SH2_STAP1	172	176	PF00017	0.500
LIG_SH2_STAP1	31	35	PF00017	0.244
LIG_SH2_STAT5	76	79	PF00017	0.643
LIG_SUMO_SIM_par_1	33	40	PF11976	0.321
LIG_SUMO_SIM_par_1	45	51	PF11976	0.276
LIG_WW_1	104	107	PF00397	0.677
MOD_CK1_1	134	140	PF00069	0.638
MOD_CK1_1	14	20	PF00069	0.497
MOD_CK1_1	37	43	PF00069	0.281
MOD_CK1_1	7	13	PF00069	0.482
MOD_CK2_1	27	33	PF00069	0.501
MOD_CK2_1	6	12	PF00069	0.405
MOD_GlcNHglycan	5	9	PF01048	0.620
MOD_GSK3_1	127	134	PF00069	0.553
MOD_GSK3_1	14	21	PF00069	0.513
MOD_GSK3_1	27	34	PF00069	0.396
MOD_GSK3_1	4	11	PF00069	0.472
MOD_N-GLC_1	18	23	PF02516	0.693
MOD_NEK2_1	136	141	PF00069	0.562
MOD_NEK2_1	176	181	PF00069	0.638
MOD_NEK2_1	4	9	PF00069	0.465
MOD_NEK2_1	53	58	PF00069	0.418
MOD_PIKK_1	12	18	PF00454	0.550
MOD_PK_1	131	137	PF00069	0.490
MOD_PKA_2	54	60	PF00069	0.525
MOD_PKA_2	67	73	PF00069	0.682
MOD_Plk_4	31	37	PF00069	0.340
MOD_SUMO_rev_2	179	189	PF00179	0.592
TRG_ENDOCYTIC_2	107	110	PF00928	0.720
TRG_ENDOCYTIC_2	172	175	PF00928	0.499
TRG_ENDOCYTIC_2	202	205	PF00928	0.544
TRG_ER_diArg_1	85	88	PF00400	0.621
TRG_ER_diArg_1	99	102	PF00400	0.703
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z6	Leptomonas seymouri	78%	100%
A0A0S4JAJ7	Bodo saltans	32%	100%
A0A1X0P877	Trypanosomatidae	52%	100%
A0A3R7MV99	Trypanosoma rangeli	49%	100%
A4HNR3	Leishmania braziliensis	94%	100%
A4ICT2	Leishmania infantum	100%	100%
D0A2M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q223	Leishmania major	98%	100%