Zinc finger protein family member, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAD2_LEIDO

TriTrypDb:

LdBPK_360800.1 , LdCL_360012900 , LDHU3_36.1020

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAD2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.609
CLV_C14_Caspase3-7	358	362	PF00656	0.398
CLV_C14_Caspase3-7	503	507	PF00656	0.501
CLV_C14_Caspase3-7	533	537	PF00656	0.556
CLV_NRD_NRD_1	467	469	PF00675	0.475
CLV_NRD_NRD_1	503	505	PF00675	0.471
CLV_PCSK_KEX2_1	469	471	PF00082	0.427
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.427
CLV_PCSK_SKI1_1	272	276	PF00082	0.379
CLV_PCSK_SKI1_1	309	313	PF00082	0.468
DEG_ODPH_VHL_1	262	275	PF01847	0.408
DOC_CDC14_PxL_1	414	422	PF14671	0.419
DOC_MAPK_gen_1	201	208	PF00069	0.421
DOC_MAPK_gen_1	269	279	PF00069	0.371
DOC_MAPK_MEF2A_6	201	208	PF00069	0.421
DOC_MAPK_MEF2A_6	269	277	PF00069	0.375
DOC_MAPK_MEF2A_6	419	428	PF00069	0.399
DOC_MAPK_NFAT4_5	272	280	PF00069	0.396
DOC_MAPK_RevD_3	492	505	PF00069	0.424
DOC_PP2B_LxvP_1	369	372	PF13499	0.434
DOC_PP4_FxxP_1	279	282	PF00568	0.397
DOC_USP7_MATH_1	231	235	PF00917	0.722
DOC_USP7_MATH_1	339	343	PF00917	0.370
DOC_USP7_MATH_1	61	65	PF00917	0.686
DOC_USP7_UBL2_3	265	269	PF12436	0.476
DOC_USP7_UBL2_3	309	313	PF12436	0.459
DOC_USP7_UBL2_3	364	368	PF12436	0.467
DOC_USP7_UBL2_3	452	456	PF12436	0.413
DOC_USP7_UBL2_3	531	535	PF12436	0.556
DOC_WW_Pin1_4	187	192	PF00397	0.518
DOC_WW_Pin1_4	97	102	PF00397	0.660
LIG_14-3-3_CanoR_1	210	216	PF00244	0.476
LIG_APCC_ABBA_1	353	358	PF00400	0.388
LIG_BRCT_BRCA1_1	319	323	PF00533	0.418
LIG_BRCT_BRCA1_1	487	491	PF00533	0.404
LIG_eIF4E_1	440	446	PF01652	0.453
LIG_FHA_1	188	194	PF00498	0.492
LIG_FHA_1	198	204	PF00498	0.481
LIG_FHA_1	268	274	PF00498	0.433
LIG_FHA_1	423	429	PF00498	0.390
LIG_FHA_2	212	218	PF00498	0.510
LIG_FHA_2	434	440	PF00498	0.423
LIG_FHA_2	495	501	PF00498	0.424
LIG_LIR_Apic_2	278	282	PF02991	0.398
LIG_LIR_Apic_2	300	304	PF02991	0.496
LIG_LIR_Apic_2	333	339	PF02991	0.378
LIG_LIR_Gen_1	349	356	PF02991	0.382
LIG_LIR_Gen_1	488	496	PF02991	0.382
LIG_LIR_Nem_3	300	306	PF02991	0.415
LIG_LIR_Nem_3	333	338	PF02991	0.375
LIG_LIR_Nem_3	435	440	PF02991	0.419
LIG_LIR_Nem_3	488	494	PF02991	0.385
LIG_Pex14_2	363	367	PF04695	0.389
LIG_PTB_Apo_2	167	174	PF02174	0.565
LIG_SH2_CRK	336	340	PF00017	0.373
LIG_SH2_GRB2like	352	355	PF00017	0.412
LIG_SH2_STAP1	212	216	PF00017	0.499
LIG_SH2_STAP1	458	462	PF00017	0.525
LIG_SH2_STAT3	124	127	PF00017	0.657
LIG_SH2_STAT3	160	163	PF00017	0.708
LIG_SH2_STAT3	174	177	PF00017	0.488
LIG_SH2_STAT3	454	457	PF00017	0.411
LIG_SH2_STAT3	52	55	PF00017	0.703
LIG_SH2_STAT3	83	86	PF00017	0.593
LIG_SH2_STAT3	94	97	PF00017	0.624
LIG_SH2_STAT5	172	175	PF00017	0.640
LIG_SH2_STAT5	301	304	PF00017	0.433
LIG_SH2_STAT5	344	347	PF00017	0.393
LIG_SH2_STAT5	352	355	PF00017	0.403
LIG_SH2_STAT5	59	62	PF00017	0.617
LIG_SH2_STAT5	94	97	PF00017	0.651
LIG_SH3_2	118	123	PF14604	0.657
LIG_SH3_3	107	113	PF00018	0.658
LIG_SH3_3	114	120	PF00018	0.591
LIG_SH3_3	415	421	PF00018	0.421
LIG_TRAF2_1	497	500	PF00917	0.443
LIG_TYR_ITSM	331	338	PF00017	0.378
LIG_UBA3_1	203	207	PF00899	0.376
MOD_CK1_1	130	136	PF00069	0.625
MOD_CK1_1	245	251	PF00069	0.704
MOD_CK1_1	433	439	PF00069	0.489
MOD_CK2_1	235	241	PF00069	0.681
MOD_CK2_1	246	252	PF00069	0.607
MOD_CK2_1	390	396	PF00069	0.423
MOD_CK2_1	494	500	PF00069	0.413
MOD_Cter_Amidation	314	317	PF01082	0.439
MOD_GlcNHglycan	157	160	PF01048	0.660
MOD_GlcNHglycan	231	234	PF01048	0.758
MOD_GlcNHglycan	288	291	PF01048	0.401
MOD_GlcNHglycan	319	322	PF01048	0.425
MOD_GlcNHglycan	339	342	PF01048	0.453
MOD_GlcNHglycan	348	351	PF01048	0.358
MOD_GlcNHglycan	400	404	PF01048	0.501
MOD_GlcNHglycan	8	11	PF01048	0.625
MOD_GSK3_1	225	232	PF00069	0.657
MOD_GSK3_1	242	249	PF00069	0.662
MOD_GSK3_1	339	346	PF00069	0.364
MOD_GSK3_1	399	406	PF00069	0.462
MOD_N-GLC_1	130	135	PF02516	0.643
MOD_N-GLC_1	257	262	PF02516	0.551
MOD_N-GLC_1	403	408	PF02516	0.419
MOD_NEK2_1	275	280	PF00069	0.381
MOD_NEK2_1	286	291	PF00069	0.430
MOD_NEK2_1	299	304	PF00069	0.408
MOD_NEK2_1	485	490	PF00069	0.391
MOD_NEK2_2	339	344	PF00069	0.368
MOD_NEK2_2	422	427	PF00069	0.439
MOD_OFUCOSY	483	489	PF10250	0.377
MOD_PIKK_1	112	118	PF00454	0.747
MOD_PIKK_1	47	53	PF00454	0.735
MOD_PIKK_1	77	83	PF00454	0.744
MOD_PIKK_1	92	98	PF00454	0.540
MOD_PK_1	202	208	PF00069	0.415
MOD_Plk_1	257	263	PF00069	0.583
MOD_Plk_1	299	305	PF00069	0.422
MOD_Plk_1	403	409	PF00069	0.414
MOD_Plk_1	422	428	PF00069	0.276
MOD_Plk_4	106	112	PF00069	0.708
MOD_Plk_4	235	241	PF00069	0.633
MOD_Plk_4	275	281	PF00069	0.412
MOD_Plk_4	339	345	PF00069	0.390
MOD_ProDKin_1	187	193	PF00069	0.506
MOD_ProDKin_1	97	103	PF00069	0.659
MOD_SUMO_for_1	311	314	PF00179	0.472
MOD_SUMO_rev_2	238	245	PF00179	0.696
MOD_SUMO_rev_2	261	271	PF00179	0.580
MOD_SUMO_rev_2	310	318	PF00179	0.437
MOD_SUMO_rev_2	498	507	PF00179	0.464
MOD_SUMO_rev_2	527	537	PF00179	0.557
TRG_DiLeu_BaEn_2	486	492	PF01217	0.388
TRG_ENDOCYTIC_2	212	215	PF00928	0.489
TRG_ENDOCYTIC_2	335	338	PF00928	0.407
TRG_ENDOCYTIC_2	352	355	PF00928	0.424
TRG_ER_diArg_1	468	471	PF00400	0.446
TRG_NLS_MonoExtN_4	466	472	PF00514	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W2	Leptomonas seymouri	67%	100%
A4HNT4	Leishmania braziliensis	84%	100%
A4ICR0	Leishmania infantum	100%	100%
E9ASJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4Q202	Leishmania major	96%	100%