TPR-repeat-containing_chaperone_protein_DNAJ_puta tive/GeneDB:LmjF.36.0500

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat-containing chaperone protein DNAJ, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAC9_LEIDO

TriTrypDb:

LdBPK_360530.1 , LdCL_360010200 , LDHU3_36.0690

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAC9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.388
CLV_C14_Caspase3-7	389	393	PF00656	0.369
CLV_NRD_NRD_1	331	333	PF00675	0.242
CLV_NRD_NRD_1	374	376	PF00675	0.369
CLV_NRD_NRD_1	501	503	PF00675	0.573
CLV_PCSK_FUR_1	369	373	PF00082	0.398
CLV_PCSK_KEX2_1	249	251	PF00082	0.446
CLV_PCSK_KEX2_1	331	333	PF00082	0.242
CLV_PCSK_KEX2_1	371	373	PF00082	0.404
CLV_PCSK_KEX2_1	374	376	PF00082	0.410
CLV_PCSK_KEX2_1	395	397	PF00082	0.269
CLV_PCSK_KEX2_1	441	443	PF00082	0.257
CLV_PCSK_KEX2_1	500	502	PF00082	0.584
CLV_PCSK_KEX2_1	63	65	PF00082	0.413
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.446
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.404
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.410
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.269
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.257
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.391
CLV_PCSK_PC7_1	245	251	PF00082	0.307
CLV_PCSK_SKI1_1	130	134	PF00082	0.457
CLV_PCSK_SKI1_1	245	249	PF00082	0.315
CLV_PCSK_SKI1_1	268	272	PF00082	0.336
CLV_PCSK_SKI1_1	309	313	PF00082	0.496
CLV_PCSK_SKI1_1	364	368	PF00082	0.403
CLV_PCSK_SKI1_1	371	375	PF00082	0.358
CLV_PCSK_SKI1_1	76	80	PF00082	0.461
DEG_APCC_DBOX_1	244	252	PF00400	0.336
DEG_SPOP_SBC_1	114	118	PF00917	0.421
DEG_SPOP_SBC_1	170	174	PF00917	0.364
DEG_SPOP_SBC_1	8	12	PF00917	0.543
DOC_CYCLIN_RxL_1	127	137	PF00134	0.404
DOC_CYCLIN_RxL_1	374	388	PF00134	0.258
DOC_MAPK_gen_1	266	274	PF00069	0.459
DOC_MAPK_gen_1	295	305	PF00069	0.465
DOC_PP2B_LxvP_1	382	385	PF13499	0.278
DOC_USP7_MATH_1	170	174	PF00917	0.431
DOC_USP7_MATH_1	253	257	PF00917	0.358
DOC_USP7_MATH_1	27	31	PF00917	0.134
DOC_USP7_MATH_1	330	334	PF00917	0.301
DOC_USP7_MATH_1	411	415	PF00917	0.276
DOC_USP7_MATH_1	7	11	PF00917	0.673
DOC_USP7_UBL2_3	367	371	PF12436	0.349
DOC_USP7_UBL2_3	376	380	PF12436	0.248
DOC_USP7_UBL2_3	395	399	PF12436	0.311
DOC_WW_Pin1_4	115	120	PF00397	0.478
DOC_WW_Pin1_4	184	189	PF00397	0.471
DOC_WW_Pin1_4	193	198	PF00397	0.486
LIG_14-3-3_CanoR_1	289	295	PF00244	0.382
LIG_14-3-3_CanoR_1	90	98	PF00244	0.493
LIG_BRCT_BRCA1_1	29	33	PF00533	0.307
LIG_FHA_1	276	282	PF00498	0.335
LIG_FHA_2	120	126	PF00498	0.501
LIG_FXI_DFP_1	166	170	PF00024	0.389
LIG_Integrin_isoDGR_2	498	500	PF01839	0.623
LIG_LIR_Gen_1	205	216	PF02991	0.315
LIG_LIR_Nem_3	204	210	PF02991	0.329
LIG_LIR_Nem_3	377	382	PF02991	0.222
LIG_LIR_Nem_3	422	428	PF02991	0.242
LIG_LIR_Nem_3	430	435	PF02991	0.242
LIG_NRBOX	128	134	PF00104	0.474
LIG_Pex14_2	489	493	PF04695	0.668
LIG_PTB_Apo_2	473	480	PF02174	0.445
LIG_RPA_C_Fungi	52	64	PF08784	0.388
LIG_SH2_CRK	379	383	PF00017	0.276
LIG_SH2_CRK	88	92	PF00017	0.294
LIG_SH2_GRB2like	54	57	PF00017	0.388
LIG_SH2_SRC	179	182	PF00017	0.440
LIG_SH2_SRC	317	320	PF00017	0.332
LIG_SH2_SRC	67	70	PF00017	0.336
LIG_SH2_STAP1	277	281	PF00017	0.294
LIG_SH2_STAP1	40	44	PF00017	0.258
LIG_SH2_STAT3	218	221	PF00017	0.257
LIG_SH2_STAT5	200	203	PF00017	0.379
LIG_SH2_STAT5	208	211	PF00017	0.229
LIG_SH2_STAT5	277	280	PF00017	0.336
LIG_SH2_STAT5	61	64	PF00017	0.276
LIG_SH3_3	182	188	PF00018	0.377
LIG_SH3_3	191	197	PF00018	0.375
LIG_SH3_3	45	51	PF00018	0.388
LIG_SUMO_SIM_anti_2	469	476	PF11976	0.508
LIG_TRAF2_1	352	355	PF00917	0.307
LIG_TRAF2_1	413	416	PF00917	0.257
LIG_TRAF2_1	466	469	PF00917	0.628
MOD_CDK_SPK_2	115	120	PF00069	0.403
MOD_CK1_1	55	61	PF00069	0.257
MOD_CK2_1	184	190	PF00069	0.490
MOD_CK2_1	411	417	PF00069	0.250
MOD_Cter_Amidation	498	501	PF01082	0.617
MOD_DYRK1A_RPxSP_1	193	197	PF00069	0.369
MOD_GlcNHglycan	11	14	PF01048	0.608
MOD_GlcNHglycan	134	137	PF01048	0.448
MOD_GlcNHglycan	225	228	PF01048	0.351
MOD_GlcNHglycan	324	327	PF01048	0.392
MOD_GlcNHglycan	40	43	PF01048	0.324
MOD_GlcNHglycan	445	448	PF01048	0.463
MOD_GlcNHglycan	459	462	PF01048	0.494
MOD_GlcNHglycan	57	60	PF01048	0.151
MOD_GlcNHglycan	92	95	PF01048	0.337
MOD_GSK3_1	110	117	PF00069	0.416
MOD_GSK3_1	189	196	PF00069	0.487
MOD_GSK3_1	317	324	PF00069	0.360
MOD_GSK3_1	416	423	PF00069	0.263
MOD_GSK3_1	76	83	PF00069	0.464
MOD_GSK3_1	86	93	PF00069	0.414
MOD_N-GLC_1	290	295	PF02516	0.492
MOD_N-GLC_1	55	60	PF02516	0.242
MOD_NEK2_1	149	154	PF00069	0.452
MOD_NEK2_1	198	203	PF00069	0.476
MOD_NEK2_1	231	236	PF00069	0.353
MOD_NEK2_1	290	295	PF00069	0.345
MOD_NEK2_1	443	448	PF00069	0.488
MOD_NEK2_1	80	85	PF00069	0.528
MOD_PIKK_1	275	281	PF00454	0.363
MOD_PIKK_1	420	426	PF00454	0.406
MOD_PIKK_1	464	470	PF00454	0.616
MOD_PKA_2	102	108	PF00069	0.463
MOD_PKA_2	231	237	PF00069	0.301
MOD_PKA_2	330	336	PF00069	0.349
MOD_Plk_1	189	195	PF00069	0.405
MOD_Plk_1	290	296	PF00069	0.392
MOD_Plk_1	80	86	PF00069	0.343
MOD_Plk_4	470	476	PF00069	0.500
MOD_ProDKin_1	115	121	PF00069	0.475
MOD_ProDKin_1	184	190	PF00069	0.473
MOD_ProDKin_1	193	199	PF00069	0.484
MOD_SUMO_rev_2	304	311	PF00179	0.332
MOD_SUMO_rev_2	414	419	PF00179	0.279
TRG_DiLeu_BaEn_3	354	360	PF01217	0.263
TRG_ENDOCYTIC_2	166	169	PF00928	0.414
TRG_ENDOCYTIC_2	208	211	PF00928	0.260
TRG_ENDOCYTIC_2	378	381	PF00928	0.242
TRG_ENDOCYTIC_2	88	91	PF00928	0.282
TRG_ER_diArg_1	144	147	PF00400	0.443
TRG_ER_diArg_1	331	334	PF00400	0.242
TRG_ER_diArg_1	500	502	PF00400	0.615
TRG_NLS_MonoCore_2	438	443	PF00514	0.336
TRG_NLS_MonoExtC_3	370	375	PF00514	0.375
TRG_NLS_MonoExtC_3	439	445	PF00514	0.257
TRG_NLS_MonoExtN_4	369	375	PF00514	0.453
TRG_NLS_MonoExtN_4	438	444	PF00514	0.243
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.204

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1E2P6	Ustilago maydis (strain 521 / FGSC 9021)	25%	88%
A0A0D2XVZ5	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	26%	98%
A0A0N1PF59	Leptomonas seymouri	79%	97%
A0A0S4JLZ7	Bodo saltans	53%	100%
A0A1X0P8B2	Trypanosomatidae	56%	100%
A0A1X0P9Z7	Trypanosomatidae	31%	74%
A0A422NFP3	Trypanosoma rangeli	26%	97%
A0A422P0G2	Trypanosoma rangeli	32%	73%
A0A422P289	Trypanosoma rangeli	52%	100%
A4H7V3	Leishmania braziliensis	26%	100%
A4HNQ8	Leishmania braziliensis	91%	100%
A4ICT7	Leishmania infantum	100%	100%
A6ZRW3	Saccharomyces cerevisiae (strain YJM789)	24%	83%
C9ZML0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	72%
C9ZST7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
D0A2L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D0A549	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	88%
E9ASG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
F4IXE4	Arabidopsis thaliana	28%	70%
J9VKM5	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	26%	98%
P07213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	83%
Q13217	Homo sapiens	24%	100%
Q27968	Bos taurus	24%	100%
Q4Q228	Leishmania major	97%	100%
Q54IP0	Dictyostelium discoideum	35%	95%
Q54M21	Dictyostelium discoideum	24%	100%
Q5R8D8	Pongo abelii	33%	100%
Q5ZI13	Gallus gallus	25%	100%
Q84JR9	Arabidopsis thaliana	26%	75%
Q91YW3	Mus musculus	24%	100%
Q99615	Homo sapiens	33%	100%
Q9HGM9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9LYW9	Arabidopsis thaliana	27%	100%
Q9MAH1	Arabidopsis thaliana	24%	73%
Q9QYI3	Mus musculus	33%	100%
Q9R0T3	Rattus norvegicus	24%	100%
Q9SIN1	Arabidopsis thaliana	24%	74%
V5BKG1	Trypanosoma cruzi	32%	73%
V5BZY4	Trypanosoma cruzi	53%	100%
V5DRP2	Trypanosoma cruzi	24%	69%