Ubiquitin-60S ribosomal protein L40

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin/ribosomal protein S27a, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAC2_LEIDO

TriTrypDb:

LdBPK_360660.1 , LdCL_360011500 , LDHU3_14.1690

Length:

152

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ubiquitin/ribosomal S27a

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 50

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 40

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005840	ribosome	5	16
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	16

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7XAC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAC2

PDB structure(s): 6az1_f

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006508	proteolysis	4	2
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009987	cellular process	1	16

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0005488	binding	1	16
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031386	protein tag	1	2
GO:0031625	ubiquitin protein ligase binding	5	2
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0044389	ubiquitin-like protein ligase binding	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	13	19	PF00089	0.382
CLV_PCSK_KEX2_1	77	79	PF00082	0.737
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.748
CLV_PCSK_SKI1_1	77	81	PF00082	0.609
CLV_PCSK_SKI1_1	96	100	PF00082	0.337
DEG_APCC_DBOX_1	88	96	PF00400	0.591
DEG_Nend_UBRbox_3	1	3	PF02207	0.551
DOC_MAPK_MEF2A_6	57	65	PF00069	0.549
DOC_PP4_FxxP_1	80	83	PF00568	0.602
DOC_USP7_MATH_1	9	13	PF00917	0.523

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IIY9	Bodo saltans	57%	100%
A0A1X0P981	Trypanosomatidae	67%	100%
A0A3Q8IIG2	Leishmania donovani	99%	100%
A0A422P284	Trypanosoma rangeli	72%	100%
A4H7U7	Leishmania braziliensis	92%	100%
A4HNS0	Leishmania braziliensis	95%	100%
A4HW73	Leishmania infantum	99%	100%
A4ICS4	Leishmania infantum	100%	100%
C9ZSU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
D0A2N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	89%

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