ER membrane protein complex subunit 3

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Integral membrane protein DUF106, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAB1_LEIDO

TriTrypDb:

LdBPK_360390.1 , LdCL_360008700 , LDHU3_36.0510

Length:

259

Annotations

LeishMANIAdb annotations

A very conserved component of the ER translocon. Localization: ER (by homology)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0032991	protein-containing complex	1	1
GO:0072546	EMC complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

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Expansion

Sequence features

A0A3S7XAB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAB1

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	249	251	PF00082	0.626
CLV_PCSK_KEX2_1	257	259	PF00082	0.721
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.629
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.721
CLV_PCSK_SKI1_1	214	218	PF00082	0.503
CLV_PCSK_SKI1_1	249	253	PF00082	0.611
CLV_PCSK_SKI1_1	60	64	PF00082	0.459
DOC_CYCLIN_RxL_1	57	64	PF00134	0.272
DOC_MAPK_DCC_7	14	24	PF00069	0.357
DOC_MAPK_FxFP_2	138	141	PF00069	0.552

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P702	Leptomonas seymouri	78%	100%
A0A0S4JI82	Bodo saltans	52%	100%
A0A1X0P9P9	Trypanosomatidae	62%	100%
A0A422P2C0	Trypanosoma rangeli	60%	100%
A4HNP4	Leishmania braziliensis	89%	100%
A4ICV1	Leishmania infantum	100%	100%
A7A082	Saccharomyces cerevisiae (strain YJM789)	30%	100%
B3LQQ2	Saccharomyces cerevisiae (strain RM11-1a)	28%	100%
B5VLV9	Saccharomyces cerevisiae (strain AWRI1631)	28%	100%
D0A2K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%

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