Vacuolar protein sorting-associated protein 45, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-associated protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAA1_LEIDO

TriTrypDb:

LdBPK_360490.1 , LdCL_360009800 , LDHU3_36.0640

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7XAA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAA1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	19
GO:0016192	vesicle-mediated transport	4	19
GO:0051179	localization	1	19
GO:0051234	establishment of localization	2	19
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	130	136	PF00089	0.391
CLV_NRD_NRD_1	13	15	PF00675	0.532
CLV_NRD_NRD_1	195	197	PF00675	0.272
CLV_NRD_NRD_1	240	242	PF00675	0.417
CLV_NRD_NRD_1	343	345	PF00675	0.315
CLV_NRD_NRD_1	574	576	PF00675	0.300
CLV_PCSK_FUR_1	11	15	PF00082	0.582
CLV_PCSK_KEX2_1	13	15	PF00082	0.532
CLV_PCSK_KEX2_1	195	197	PF00082	0.281
CLV_PCSK_SKI1_1	35	39	PF00082	0.322
CLV_PCSK_SKI1_1	367	371	PF00082	0.333
CLV_PCSK_SKI1_1	390	394	PF00082	0.340
CLV_PCSK_SKI1_1	44	48	PF00082	0.309
DEG_APCC_DBOX_1	389	397	PF00400	0.418
DOC_CKS1_1	245	250	PF01111	0.345
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.319
DOC_MAPK_DCC_7	241	251	PF00069	0.418
DOC_MAPK_gen_1	344	350	PF00069	0.317
DOC_MAPK_gen_1	531	540	PF00069	0.251
DOC_MAPK_MEF2A_6	206	215	PF00069	0.454
DOC_MAPK_MEF2A_6	230	239	PF00069	0.312
DOC_MAPK_MEF2A_6	531	540	PF00069	0.314
DOC_PP2B_LxvP_1	249	252	PF13499	0.340
DOC_PP4_FxxP_1	165	168	PF00568	0.402
DOC_USP7_MATH_1	231	235	PF00917	0.314
DOC_USP7_MATH_1	355	359	PF00917	0.341
DOC_USP7_MATH_1	596	600	PF00917	0.430
DOC_USP7_UBL2_3	206	210	PF12436	0.315
DOC_USP7_UBL2_3	471	475	PF12436	0.315
DOC_WW_Pin1_4	153	158	PF00397	0.373
DOC_WW_Pin1_4	160	165	PF00397	0.369
DOC_WW_Pin1_4	244	249	PF00397	0.338
LIG_14-3-3_CanoR_1	181	189	PF00244	0.295
LIG_14-3-3_CanoR_1	218	223	PF00244	0.407
LIG_14-3-3_CanoR_1	325	331	PF00244	0.315
LIG_14-3-3_CanoR_1	344	349	PF00244	0.315
LIG_14-3-3_CanoR_1	371	375	PF00244	0.308
LIG_14-3-3_CanoR_1	463	470	PF00244	0.323
LIG_Actin_WH2_2	141	156	PF00022	0.315
LIG_Actin_WH2_2	215	232	PF00022	0.395
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	607	611	PF00533	0.256
LIG_Clathr_ClatBox_1	236	240	PF01394	0.326
LIG_deltaCOP1_diTrp_1	18	28	PF00928	0.476
LIG_eIF4E_1	51	57	PF01652	0.295
LIG_FHA_1	109	115	PF00498	0.373
LIG_FHA_1	143	149	PF00498	0.328
LIG_FHA_1	230	236	PF00498	0.401
LIG_FHA_1	245	251	PF00498	0.272
LIG_FHA_1	29	35	PF00498	0.385
LIG_FHA_1	325	331	PF00498	0.367
LIG_FHA_1	355	361	PF00498	0.438
LIG_FHA_1	41	47	PF00498	0.252
LIG_FHA_1	487	493	PF00498	0.314
LIG_FHA_1	504	510	PF00498	0.418
LIG_FHA_1	577	583	PF00498	0.345
LIG_FHA_1	589	595	PF00498	0.292
LIG_FHA_1	601	607	PF00498	0.229
LIG_FHA_2	223	229	PF00498	0.418
LIG_FHA_2	399	405	PF00498	0.355
LIG_FHA_2	542	548	PF00498	0.325
LIG_GBD_Chelix_1	420	428	PF00786	0.406
LIG_Integrin_isoDGR_2	365	367	PF01839	0.315
LIG_LIR_Apic_2	163	168	PF02991	0.402
LIG_LIR_Apic_2	274	280	PF02991	0.144
LIG_LIR_Gen_1	107	118	PF02991	0.401
LIG_LIR_Gen_1	145	155	PF02991	0.323
LIG_LIR_Gen_1	18	28	PF02991	0.352
LIG_LIR_Gen_1	254	263	PF02991	0.315
LIG_LIR_Nem_3	100	106	PF02991	0.338
LIG_LIR_Nem_3	107	112	PF02991	0.361
LIG_LIR_Nem_3	145	150	PF02991	0.323
LIG_LIR_Nem_3	18	24	PF02991	0.363
LIG_LIR_Nem_3	225	229	PF02991	0.315
LIG_LIR_Nem_3	301	306	PF02991	0.298
LIG_MYND_1	248	252	PF01753	0.393
LIG_NRBOX	33	39	PF00104	0.295
LIG_PCNA_yPIPBox_3	124	133	PF02747	0.241
LIG_PCNA_yPIPBox_3	60	72	PF02747	0.336
LIG_Pex14_2	336	340	PF04695	0.295
LIG_PTB_Apo_2	22	29	PF02174	0.474
LIG_PTB_Apo_2	497	504	PF02174	0.295
LIG_PTB_Phospho_1	497	503	PF10480	0.295
LIG_SH2_GRB2like	138	141	PF00017	0.440
LIG_SH2_GRB2like	23	26	PF00017	0.484
LIG_SH2_NCK_1	277	281	PF00017	0.144
LIG_SH2_NCK_1	417	421	PF00017	0.342
LIG_SH2_SRC	138	141	PF00017	0.325
LIG_SH2_STAP1	106	110	PF00017	0.301
LIG_SH2_STAP1	255	259	PF00017	0.295
LIG_SH2_STAP1	417	421	PF00017	0.318
LIG_SH2_STAP1	590	594	PF00017	0.291
LIG_SH2_STAT3	451	454	PF00017	0.418
LIG_SH2_STAT3	512	515	PF00017	0.310
LIG_SH2_STAT5	109	112	PF00017	0.344
LIG_SH2_STAT5	138	141	PF00017	0.315
LIG_SH2_STAT5	23	26	PF00017	0.322
LIG_SH2_STAT5	539	542	PF00017	0.396
LIG_SH2_STAT5	543	546	PF00017	0.391
LIG_SH2_STAT5	590	593	PF00017	0.317
LIG_SH3_1	242	248	PF00018	0.418
LIG_SH3_3	242	248	PF00018	0.366
LIG_SH3_3	283	289	PF00018	0.340
LIG_SH3_3	393	399	PF00018	0.295
LIG_SH3_3	515	521	PF00018	0.326
LIG_SH3_3	579	585	PF00018	0.261
LIG_SH3_3	80	86	PF00018	0.418
LIG_SUMO_SIM_anti_2	232	240	PF11976	0.318
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.325
LIG_SUMO_SIM_anti_2	534	539	PF11976	0.307
LIG_SUMO_SIM_par_1	232	240	PF11976	0.316
LIG_SUMO_SIM_par_1	326	332	PF11976	0.418
LIG_SUMO_SIM_par_1	505	510	PF11976	0.418
LIG_SUMO_SIM_par_1	60	65	PF11976	0.310
LIG_TRAF2_1	68	71	PF00917	0.300
LIG_TYR_ITIM	415	420	PF00017	0.317
LIG_UBA3_1	150	154	PF00899	0.300
LIG_UBA3_1	424	429	PF00899	0.346
MOD_CDK_SPxxK_3	153	160	PF00069	0.385
MOD_CK1_1	2	8	PF00069	0.698
MOD_CK1_1	205	211	PF00069	0.420
MOD_CK1_1	599	605	PF00069	0.403
MOD_CK1_1	87	93	PF00069	0.392
MOD_CK2_1	326	332	PF00069	0.319
MOD_CK2_1	370	376	PF00069	0.315
MOD_CK2_1	541	547	PF00069	0.315
MOD_Cter_Amidation	11	14	PF01082	0.489
MOD_GlcNHglycan	28	31	PF01048	0.473
MOD_GlcNHglycan	86	89	PF01048	0.458
MOD_GSK3_1	114	121	PF00069	0.365
MOD_GSK3_1	138	145	PF00069	0.324
MOD_GSK3_1	185	192	PF00069	0.365
MOD_GSK3_1	218	225	PF00069	0.329
MOD_GSK3_1	344	351	PF00069	0.303
MOD_GSK3_1	45	52	PF00069	0.280
MOD_GSK3_1	576	583	PF00069	0.382
MOD_GSK3_1	584	591	PF00069	0.283
MOD_GSK3_1	596	603	PF00069	0.302
MOD_N-GLC_1	367	372	PF02516	0.303
MOD_N-GLC_1	383	388	PF02516	0.216
MOD_N-GLC_1	503	508	PF02516	0.292
MOD_NEK2_1	113	118	PF00069	0.336
MOD_NEK2_1	189	194	PF00069	0.322
MOD_NEK2_1	28	33	PF00069	0.449
MOD_NEK2_1	462	467	PF00069	0.321
MOD_NEK2_1	469	474	PF00069	0.311
MOD_NEK2_1	600	605	PF00069	0.256
MOD_NEK2_1	611	616	PF00069	0.353
MOD_PIKK_1	169	175	PF00454	0.332
MOD_PIKK_1	486	492	PF00454	0.319
MOD_PIKK_1	49	55	PF00454	0.326
MOD_PIKK_1	522	528	PF00454	0.280
MOD_PK_1	218	224	PF00069	0.411
MOD_PK_1	344	350	PF00069	0.329
MOD_PKA_1	344	350	PF00069	0.295
MOD_PKA_2	180	186	PF00069	0.315
MOD_PKA_2	324	330	PF00069	0.340
MOD_PKA_2	370	376	PF00069	0.347
MOD_PKA_2	462	468	PF00069	0.310
MOD_PKA_2	84	90	PF00069	0.385
MOD_PKB_1	200	208	PF00069	0.418
MOD_Plk_1	114	120	PF00069	0.444
MOD_Plk_1	367	373	PF00069	0.325
MOD_Plk_1	386	392	PF00069	0.334
MOD_Plk_2-3	175	181	PF00069	0.340
MOD_Plk_2-3	398	404	PF00069	0.315
MOD_Plk_4	114	120	PF00069	0.443
MOD_Plk_4	231	237	PF00069	0.310
MOD_Plk_4	370	376	PF00069	0.323
MOD_Plk_4	562	568	PF00069	0.276
MOD_Plk_4	596	602	PF00069	0.309
MOD_ProDKin_1	153	159	PF00069	0.373
MOD_ProDKin_1	160	166	PF00069	0.369
MOD_ProDKin_1	244	250	PF00069	0.338
MOD_SUMO_for_1	278	281	PF00179	0.340
MOD_SUMO_for_1	428	431	PF00179	0.385
MOD_SUMO_for_1	592	595	PF00179	0.418
MOD_SUMO_rev_2	172	179	PF00179	0.402
MOD_SUMO_rev_2	329	336	PF00179	0.330
MOD_SUMO_rev_2	394	401	PF00179	0.315
TRG_DiLeu_BaEn_1	146	151	PF01217	0.300
TRG_DiLeu_BaEn_1	387	392	PF01217	0.418
TRG_DiLeu_BaEn_1	440	445	PF01217	0.373
TRG_DiLeu_BaEn_2	331	337	PF01217	0.295
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.355
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.373
TRG_ENDOCYTIC_2	255	258	PF00928	0.315
TRG_ENDOCYTIC_2	317	320	PF00928	0.365
TRG_ENDOCYTIC_2	417	420	PF00928	0.317
TRG_ENDOCYTIC_2	95	98	PF00928	0.323
TRG_ER_diArg_1	11	14	PF00400	0.486
TRG_NES_CRM1_1	55	70	PF08389	0.193
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D5	Leptomonas seymouri	84%	100%
A0A0N0P7P1	Leptomonas seymouri	31%	100%
A0A0S4J1J9	Bodo saltans	22%	100%
A0A0S4JI94	Bodo saltans	50%	94%
A0A1X0P7Y3	Trypanosomatidae	29%	100%
A0A1X0P895	Trypanosomatidae	67%	100%
A0A3Q8IG36	Leishmania donovani	32%	100%
A0A422P2E3	Trypanosoma rangeli	67%	100%
A4HNQ4	Leishmania braziliensis	90%	100%
A4HP92	Leishmania braziliensis	32%	100%
A4ICU1	Leishmania infantum	100%	100%
A4IDJ7	Leishmania infantum	32%	100%
D0A395	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ASG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AT00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O00186	Homo sapiens	22%	100%
O08599	Mus musculus	20%	100%
O08700	Rattus norvegicus	30%	100%
O49048	Arabidopsis thaliana	29%	100%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	97%
P22213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	93%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P61763	Bos taurus	20%	100%
P61764	Homo sapiens	20%	100%
P61765	Rattus norvegicus	20%	100%
P97390	Mus musculus	30%	100%
Q09805	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q24179	Drosophila melanogaster	21%	97%
Q28288	Canis lupus familiaris	21%	100%
Q4Q1J8	Leishmania major	32%	100%
Q4Q232	Leishmania major	97%	100%
Q54GE3	Dictyostelium discoideum	29%	100%
Q5R6D2	Pongo abelii	20%	100%
Q5VNU3	Oryza sativa subsp. japonica	21%	94%
Q60770	Mus musculus	23%	100%
Q62753	Rattus norvegicus	21%	100%
Q64324	Mus musculus	21%	100%
Q6R748	Gallus gallus	20%	100%
Q851W1	Oryza sativa subsp. japonica	21%	99%
Q9C5P7	Arabidopsis thaliana	21%	92%
Q9NRW7	Homo sapiens	30%	100%
Q9SZ77	Arabidopsis thaliana	22%	93%
V5BV59	Trypanosoma cruzi	67%	100%
V5DCK0	Trypanosoma cruzi	31%	100%