SAP domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAP domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA97_LEIDO

TriTrypDb:

LdBPK_360070.1 , LdCL_360005500 , LDHU3_36.0120

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.633
CLV_NRD_NRD_1	263	265	PF00675	0.731
CLV_NRD_NRD_1	318	320	PF00675	0.630
CLV_NRD_NRD_1	6	8	PF00675	0.558
CLV_PCSK_KEX2_1	208	210	PF00082	0.482
CLV_PCSK_KEX2_1	317	319	PF00082	0.653
CLV_PCSK_KEX2_1	5	7	PF00082	0.559
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.482
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.559
CLV_PCSK_SKI1_1	105	109	PF00082	0.530
CLV_PCSK_SKI1_1	112	116	PF00082	0.488
CLV_PCSK_SKI1_1	189	193	PF00082	0.357
CLV_PCSK_SKI1_1	74	78	PF00082	0.639
CLV_Separin_Metazoa	190	194	PF03568	0.369
DEG_Nend_UBRbox_2	1	3	PF02207	0.660
DEG_SPOP_SBC_1	136	140	PF00917	0.733
DEG_SPOP_SBC_1	42	46	PF00917	0.717
DOC_CKS1_1	92	97	PF01111	0.595
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.733
DOC_MAPK_gen_1	29	38	PF00069	0.646
DOC_MAPK_gen_1	5	11	PF00069	0.556
DOC_MAPK_MEF2A_6	32	40	PF00069	0.685
DOC_PP2B_LxvP_1	253	256	PF13499	0.563
DOC_PP2B_LxvP_1	36	39	PF13499	0.689
DOC_PP2B_LxvP_1	40	43	PF13499	0.682
DOC_PP4_FxxP_1	92	95	PF00568	0.647
DOC_USP7_MATH_1	136	140	PF00917	0.733
DOC_USP7_MATH_1	215	219	PF00917	0.689
DOC_USP7_MATH_1	259	263	PF00917	0.766
DOC_USP7_MATH_1	295	299	PF00917	0.681
DOC_USP7_MATH_1	43	47	PF00917	0.709
DOC_USP7_UBL2_3	208	212	PF12436	0.492
DOC_WW_Pin1_4	154	159	PF00397	0.751
DOC_WW_Pin1_4	22	27	PF00397	0.594
DOC_WW_Pin1_4	251	256	PF00397	0.688
DOC_WW_Pin1_4	263	268	PF00397	0.683
DOC_WW_Pin1_4	38	43	PF00397	0.606
DOC_WW_Pin1_4	46	51	PF00397	0.680
DOC_WW_Pin1_4	91	96	PF00397	0.609
LIG_14-3-3_CanoR_1	171	180	PF00244	0.690
LIG_14-3-3_CanoR_1	296	300	PF00244	0.607
LIG_14-3-3_CanoR_1	32	40	PF00244	0.657
LIG_14-3-3_CanoR_1	91	95	PF00244	0.721
LIG_14-3-3_CterR_2	317	322	PF00244	0.618
LIG_BRCT_BRCA1_1	287	291	PF00533	0.528
LIG_BRCT_BRCA1_1	297	301	PF00533	0.631
LIG_BRCT_BRCA1_1	88	92	PF00533	0.654
LIG_FHA_1	222	228	PF00498	0.772
LIG_FHA_1	32	38	PF00498	0.785
LIG_FHA_2	138	144	PF00498	0.689
LIG_FHA_2	150	156	PF00498	0.749
LIG_FHA_2	182	188	PF00498	0.326
LIG_FHA_2	269	275	PF00498	0.718
LIG_FHA_2	92	98	PF00498	0.639
LIG_LIR_Apic_2	89	95	PF02991	0.640
LIG_LIR_Nem_3	278	283	PF02991	0.531
LIG_LIR_Nem_3	79	83	PF02991	0.596
LIG_MYND_1	255	259	PF01753	0.699
LIG_NRBOX	187	193	PF00104	0.369
LIG_PDZ_Class_2	317	322	PF00595	0.699
LIG_Pex14_2	114	118	PF04695	0.581
LIG_SH2_STAT5	10	13	PF00017	0.541
LIG_SH3_3	156	162	PF00018	0.702
LIG_SH3_3	249	255	PF00018	0.683
LIG_SH3_3	36	42	PF00018	0.733
LIG_SH3_3	50	56	PF00018	0.751
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.572
LIG_WW_3	55	59	PF00397	0.725
MOD_CDK_SPK_2	91	96	PF00069	0.711
MOD_CDK_SPxxK_3	154	161	PF00069	0.752
MOD_CDK_SPxxK_3	22	29	PF00069	0.617
MOD_CDK_SPxxK_3	51	58	PF00069	0.747
MOD_CK1_1	126	132	PF00069	0.632
MOD_CK1_1	134	140	PF00069	0.641
MOD_CK1_1	154	160	PF00069	0.704
MOD_CK1_1	20	26	PF00069	0.612
MOD_CK1_1	248	254	PF00069	0.697
MOD_CK1_1	31	37	PF00069	0.632
MOD_CK1_1	41	47	PF00069	0.626
MOD_CK1_1	49	55	PF00069	0.562
MOD_CK2_1	137	143	PF00069	0.664
MOD_CK2_1	144	150	PF00069	0.657
MOD_CK2_1	181	187	PF00069	0.343
MOD_CK2_1	268	274	PF00069	0.633
MOD_GlcNHglycan	133	136	PF01048	0.750
MOD_GlcNHglycan	21	25	PF01048	0.646
MOD_GlcNHglycan	247	250	PF01048	0.714
MOD_GlcNHglycan	88	91	PF01048	0.569
MOD_GSK3_1	126	133	PF00069	0.668
MOD_GSK3_1	150	157	PF00069	0.653
MOD_GSK3_1	232	239	PF00069	0.617
MOD_GSK3_1	241	248	PF00069	0.623
MOD_GSK3_1	251	258	PF00069	0.675
MOD_GSK3_1	259	266	PF00069	0.714
MOD_GSK3_1	38	45	PF00069	0.694
MOD_GSK3_1	86	93	PF00069	0.675
MOD_N-GLC_1	275	280	PF02516	0.632
MOD_NEK2_1	149	154	PF00069	0.778
MOD_NEK2_1	236	241	PF00069	0.733
MOD_NEK2_1	83	88	PF00069	0.451
MOD_NEK2_2	107	112	PF00069	0.546
MOD_PIKK_1	178	184	PF00454	0.524
MOD_PIKK_1	259	265	PF00454	0.727
MOD_PIKK_1	31	37	PF00454	0.752
MOD_PIKK_1	43	49	PF00454	0.738
MOD_PK_1	195	201	PF00069	0.415
MOD_PK_1	275	281	PF00069	0.618
MOD_PKA_2	162	168	PF00069	0.663
MOD_PKA_2	28	34	PF00069	0.641
MOD_PKA_2	295	301	PF00069	0.636
MOD_PKA_2	90	96	PF00069	0.711
MOD_PKB_1	193	201	PF00069	0.415
MOD_Plk_1	275	281	PF00069	0.625
MOD_Plk_2-3	144	150	PF00069	0.710
MOD_Plk_2-3	151	157	PF00069	0.679
MOD_Plk_4	137	143	PF00069	0.725
MOD_Plk_4	248	254	PF00069	0.580
MOD_Plk_4	275	281	PF00069	0.572
MOD_ProDKin_1	154	160	PF00069	0.750
MOD_ProDKin_1	22	28	PF00069	0.594
MOD_ProDKin_1	251	257	PF00069	0.692
MOD_ProDKin_1	263	269	PF00069	0.683
MOD_ProDKin_1	38	44	PF00069	0.608
MOD_ProDKin_1	46	52	PF00069	0.682
MOD_ProDKin_1	91	97	PF00069	0.602
MOD_SUMO_rev_2	239	246	PF00179	0.780
TRG_DiLeu_BaEn_1	14	19	PF01217	0.563
TRG_DiLeu_BaEn_1	187	192	PF01217	0.326
TRG_DiLeu_BaEn_4	144	150	PF01217	0.795
TRG_ENDOCYTIC_2	80	83	PF00928	0.660
TRG_ER_diArg_1	169	172	PF00400	0.723
TRG_ER_diArg_1	192	195	PF00400	0.425
TRG_ER_diArg_1	317	319	PF00400	0.659
TRG_ER_diArg_1	6	8	PF00400	0.558
TRG_NLS_MonoExtN_4	3	9	PF00514	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II75	Leptomonas seymouri	52%	100%
A0A1X0P8R1	Trypanosomatidae	31%	100%
A0A422NB21	Trypanosoma rangeli	31%	100%
A4HNL1	Leishmania braziliensis	67%	100%
A4ICY1	Leishmania infantum	99%	100%
E9ASC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q272	Leishmania major	89%	100%