PUB domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA96_LEIDO

TriTrypDb:

LdBPK_360140.1 , LdCL_360006200 , LDHU3_36.0200

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XA96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.706
CLV_C14_Caspase3-7	31	35	PF00656	0.728
CLV_NRD_NRD_1	120	122	PF00675	0.616
CLV_NRD_NRD_1	131	133	PF00675	0.470
CLV_NRD_NRD_1	141	143	PF00675	0.431
CLV_NRD_NRD_1	155	157	PF00675	0.496
CLV_NRD_NRD_1	164	166	PF00675	0.483
CLV_NRD_NRD_1	175	177	PF00675	0.269
CLV_NRD_NRD_1	188	190	PF00675	0.496
CLV_NRD_NRD_1	274	276	PF00675	0.510
CLV_NRD_NRD_1	355	357	PF00675	0.524
CLV_PCSK_FUR_1	118	122	PF00082	0.624
CLV_PCSK_KEX2_1	100	102	PF00082	0.572
CLV_PCSK_KEX2_1	120	122	PF00082	0.293
CLV_PCSK_KEX2_1	155	157	PF00082	0.557
CLV_PCSK_KEX2_1	164	166	PF00082	0.483
CLV_PCSK_KEX2_1	174	176	PF00082	0.386
CLV_PCSK_KEX2_1	188	190	PF00082	0.519
CLV_PCSK_KEX2_1	276	278	PF00082	0.640
CLV_PCSK_KEX2_1	306	308	PF00082	0.315
CLV_PCSK_KEX2_1	355	357	PF00082	0.549
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.572
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.640
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.315
CLV_PCSK_SKI1_1	100	104	PF00082	0.539
CLV_PCSK_SKI1_1	108	112	PF00082	0.490
CLV_PCSK_SKI1_1	142	146	PF00082	0.521
CLV_PCSK_SKI1_1	175	179	PF00082	0.496
CLV_PCSK_SKI1_1	291	295	PF00082	0.355
DEG_APCC_DBOX_1	290	298	PF00400	0.413
DEG_SPOP_SBC_1	232	236	PF00917	0.614
DEG_SPOP_SBC_1	25	29	PF00917	0.717
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.184
DOC_MAPK_gen_1	120	130	PF00069	0.600
DOC_MAPK_gen_1	132	140	PF00069	0.587
DOC_MAPK_gen_1	174	181	PF00069	0.456
DOC_MAPK_gen_1	305	311	PF00069	0.449
DOC_MAPK_gen_1	314	323	PF00069	0.449
DOC_MAPK_gen_1	355	363	PF00069	0.499
DOC_MAPK_MEF2A_6	174	181	PF00069	0.454
DOC_PP1_RVXF_1	326	333	PF00149	0.387
DOC_USP7_MATH_1	232	236	PF00917	0.592
DOC_USP7_UBL2_3	123	127	PF12436	0.511
DOC_WW_Pin1_4	7	12	PF00397	0.627
LIG_14-3-3_CanoR_1	146	154	PF00244	0.611
LIG_14-3-3_CanoR_1	310	316	PF00244	0.385
LIG_14-3-3_CanoR_1	51	58	PF00244	0.602
LIG_AP2alpha_2	300	302	PF02296	0.449
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BRCT_BRCA1_1	298	302	PF00533	0.398
LIG_FHA_1	237	243	PF00498	0.661
LIG_FHA_1	287	293	PF00498	0.449
LIG_FHA_1	306	312	PF00498	0.263
LIG_FHA_1	344	350	PF00498	0.376
LIG_FHA_1	35	41	PF00498	0.557
LIG_FHA_1	71	77	PF00498	0.450
LIG_FHA_2	102	108	PF00498	0.512
LIG_FHA_2	190	196	PF00498	0.554
LIG_FHA_2	31	37	PF00498	0.659
LIG_FHA_2	41	47	PF00498	0.467
LIG_FHA_2	85	91	PF00498	0.573
LIG_GBD_Chelix_1	353	361	PF00786	0.467
LIG_LIR_Gen_1	43	53	PF02991	0.483
LIG_LIR_Gen_1	73	83	PF02991	0.515
LIG_LIR_Nem_3	43	48	PF02991	0.471
LIG_PCNA_PIPBox_1	252	261	PF02747	0.612
LIG_RPA_C_Fungi	207	219	PF08784	0.618
LIG_SH2_NCK_1	204	208	PF00017	0.580
LIG_SH2_SRC	204	207	PF00017	0.526
LIG_SH2_STAP1	204	208	PF00017	0.523
LIG_SH2_STAT5	38	41	PF00017	0.529
LIG_SH3_3	17	23	PF00018	0.753
LIG_SH3_3	242	248	PF00018	0.489
LIG_TRAF2_1	192	195	PF00917	0.432
LIG_UBA3_1	144	148	PF00899	0.589
MOD_CK1_1	236	242	PF00069	0.673
MOD_CK1_1	24	30	PF00069	0.650
MOD_CK1_1	243	249	PF00069	0.631
MOD_CK1_1	343	349	PF00069	0.385
MOD_CK2_1	101	107	PF00069	0.435
MOD_CK2_1	146	152	PF00069	0.541
MOD_CK2_1	189	195	PF00069	0.517
MOD_CK2_1	25	31	PF00069	0.656
MOD_CK2_1	266	272	PF00069	0.418
MOD_CK2_1	84	90	PF00069	0.586
MOD_Cter_Amidation	140	143	PF01082	0.528
MOD_GlcNHglycan	242	245	PF01048	0.674
MOD_GlcNHglycan	249	252	PF01048	0.601
MOD_GlcNHglycan	278	281	PF01048	0.629
MOD_GSK3_1	21	28	PF00069	0.664
MOD_GSK3_1	228	235	PF00069	0.579
MOD_GSK3_1	236	243	PF00069	0.586
MOD_GSK3_1	247	254	PF00069	0.511
MOD_GSK3_1	262	269	PF00069	0.548
MOD_GSK3_1	276	283	PF00069	0.351
MOD_GSK3_1	30	37	PF00069	0.612
MOD_GSK3_1	305	312	PF00069	0.360
MOD_GSK3_1	336	343	PF00069	0.356
MOD_N-GLC_1	240	245	PF02516	0.691
MOD_N-GLC_1	25	30	PF02516	0.746
MOD_N-GLC_1	343	348	PF02516	0.367
MOD_NEK2_1	309	314	PF00069	0.365
MOD_NEK2_1	347	352	PF00069	0.406
MOD_NEK2_2	286	291	PF00069	0.413
MOD_OFUCOSY	66	72	PF10250	0.448
MOD_PIKK_1	38	44	PF00454	0.460
MOD_PIKK_1	70	76	PF00454	0.462
MOD_PK_1	21	27	PF00069	0.560
MOD_PKA_1	276	282	PF00069	0.424
MOD_PKA_1	305	311	PF00069	0.385
MOD_PKA_2	276	282	PF00069	0.424
MOD_PKA_2	309	315	PF00069	0.449
MOD_Plk_1	240	246	PF00069	0.669
MOD_Plk_1	343	349	PF00069	0.394
MOD_Plk_4	251	257	PF00069	0.572
MOD_Plk_4	266	272	PF00069	0.467
MOD_Plk_4	348	354	PF00069	0.340
MOD_Plk_4	40	46	PF00069	0.448
MOD_Plk_4	58	64	PF00069	0.423
MOD_ProDKin_1	7	13	PF00069	0.627
MOD_SUMO_for_1	147	150	PF00179	0.553
MOD_SUMO_for_1	217	220	PF00179	0.555
MOD_SUMO_rev_2	105	112	PF00179	0.501
MOD_SUMO_rev_2	124	128	PF00179	0.504
MOD_SUMO_rev_2	2	8	PF00179	0.699
TRG_DiLeu_BaEn_1	325	330	PF01217	0.475
TRG_DiLeu_BaEn_4	125	131	PF01217	0.539
TRG_DiLeu_BaEn_4	194	200	PF01217	0.393
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.445
TRG_DiLeu_LyEn_5	325	330	PF01217	0.398
TRG_ER_diArg_1	118	121	PF00400	0.624
TRG_ER_diArg_1	154	156	PF00400	0.554
TRG_ER_diArg_1	174	176	PF00400	0.274
TRG_ER_diArg_1	274	277	PF00400	0.528
TRG_ER_diArg_1	354	356	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I208	Leptomonas seymouri	63%	100%
A0A0S4JLL2	Bodo saltans	42%	94%
A0A1X0P8K7	Trypanosomatidae	48%	100%
A0A3S5IQV7	Trypanosoma rangeli	48%	100%
A4HNM0	Leishmania braziliensis	78%	100%
A4ICX4	Leishmania infantum	99%	100%
D0A2H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	89%
E9ASD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q265	Leishmania major	91%	100%
V5BQK6	Trypanosoma cruzi	44%	100%