Phosphatidylinositol-4-phosphate 5-kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XA92_LEIDO

TriTrypDb:

LdBPK_360400.1 , LdCL_360008800 , LDHU3_36.0520

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XA92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA92

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016307	phosphatidylinositol phosphate kinase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.346
CLV_NRD_NRD_1	292	294	PF00675	0.341
CLV_PCSK_KEX2_1	294	296	PF00082	0.384
CLV_PCSK_KEX2_1	333	335	PF00082	0.331
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.388
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.331
CLV_PCSK_PC7_1	290	296	PF00082	0.263
CLV_PCSK_PC7_1	329	335	PF00082	0.187
CLV_PCSK_SKI1_1	12	16	PF00082	0.409
CLV_PCSK_SKI1_1	135	139	PF00082	0.407
CLV_PCSK_SKI1_1	150	154	PF00082	0.421
CLV_PCSK_SKI1_1	280	284	PF00082	0.243
CLV_PCSK_SKI1_1	358	362	PF00082	0.293
CLV_PCSK_SKI1_1	416	420	PF00082	0.246
CLV_PCSK_SKI1_1	56	60	PF00082	0.522
CLV_PCSK_SKI1_1	79	83	PF00082	0.531
CLV_PCSK_SKI1_1	97	101	PF00082	0.349
CLV_Separin_Metazoa	299	303	PF03568	0.241
DEG_APCC_DBOX_1	149	157	PF00400	0.230
DEG_SPOP_SBC_1	342	346	PF00917	0.255
DEG_SPOP_SBC_1	350	354	PF00917	0.215
DEG_SPOP_SBC_1	36	40	PF00917	0.446
DOC_MAPK_gen_1	154	163	PF00069	0.209
DOC_MAPK_gen_1	77	85	PF00069	0.559
DOC_MAPK_HePTP_8	170	182	PF00069	0.276
DOC_MAPK_MEF2A_6	173	182	PF00069	0.246
DOC_MAPK_MEF2A_6	77	85	PF00069	0.576
DOC_MAPK_NFAT4_5	173	181	PF00069	0.247
DOC_PP1_RVXF_1	282	288	PF00149	0.223
DOC_PP1_RVXF_1	414	421	PF00149	0.263
DOC_PP2B_LxvP_1	69	72	PF13499	0.416
DOC_PP4_FxxP_1	286	289	PF00568	0.388
DOC_USP7_MATH_1	165	169	PF00917	0.369
DOC_USP7_MATH_1	343	347	PF00917	0.271
DOC_USP7_MATH_1	36	40	PF00917	0.499
DOC_USP7_MATH_1	43	47	PF00917	0.559
DOC_USP7_MATH_1	52	56	PF00917	0.421
DOC_USP7_UBL2_3	205	209	PF12436	0.257
DOC_USP7_UBL2_3	237	241	PF12436	0.446
LIG_14-3-3_CanoR_1	12	19	PF00244	0.425
LIG_14-3-3_CanoR_1	157	162	PF00244	0.318
LIG_14-3-3_CanoR_1	24	31	PF00244	0.564
LIG_14-3-3_CanoR_1	358	363	PF00244	0.417
LIG_14-3-3_CanoR_1	372	381	PF00244	0.253
LIG_14-3-3_CanoR_1	436	441	PF00244	0.386
LIG_14-3-3_CanoR_1	84	92	PF00244	0.314
LIG_Actin_WH2_1	293	310	PF00022	0.263
LIG_Actin_WH2_2	10	26	PF00022	0.401
LIG_Actin_WH2_2	294	310	PF00022	0.263
LIG_AP2alpha_1	192	196	PF02296	0.233
LIG_BRCT_BRCA1_1	126	130	PF00533	0.392
LIG_DLG_GKlike_1	436	443	PF00625	0.388
LIG_FHA_1	141	147	PF00498	0.395
LIG_FHA_1	158	164	PF00498	0.180
LIG_FHA_1	402	408	PF00498	0.417
LIG_FHA_1	439	445	PF00498	0.257
LIG_FHA_2	274	280	PF00498	0.242
LIG_FHA_2	351	357	PF00498	0.263
LIG_FHA_2	375	381	PF00498	0.388
LIG_LIR_Apic_2	109	114	PF02991	0.356
LIG_LIR_Apic_2	283	289	PF02991	0.388
LIG_LIR_Gen_1	303	312	PF02991	0.302
LIG_LIR_Gen_1	314	323	PF02991	0.245
LIG_LIR_Gen_1	438	448	PF02991	0.377
LIG_LIR_Gen_1	91	99	PF02991	0.411
LIG_LIR_Nem_3	303	307	PF02991	0.301
LIG_LIR_Nem_3	314	318	PF02991	0.260
LIG_LIR_Nem_3	376	381	PF02991	0.273
LIG_LIR_Nem_3	392	398	PF02991	0.225
LIG_LIR_Nem_3	438	443	PF02991	0.301
LIG_LIR_Nem_3	91	96	PF02991	0.255
LIG_LYPXL_yS_3	221	224	PF13949	0.241
LIG_Pex14_2	107	111	PF04695	0.329
LIG_Pex14_2	192	196	PF04695	0.245
LIG_REV1ctd_RIR_1	128	137	PF16727	0.230
LIG_REV1ctd_RIR_1	412	420	PF16727	0.301
LIG_SH2_CRK	175	179	PF00017	0.388
LIG_SH2_CRK	304	308	PF00017	0.281
LIG_SH2_CRK	315	319	PF00017	0.200
LIG_SH2_PTP2	395	398	PF00017	0.242
LIG_SH2_STAP1	159	163	PF00017	0.222
LIG_SH2_STAP1	315	319	PF00017	0.250
LIG_SH2_STAP1	433	437	PF00017	0.303
LIG_SH2_STAT5	159	162	PF00017	0.283
LIG_SH2_STAT5	188	191	PF00017	0.257
LIG_SH2_STAT5	395	398	PF00017	0.242
LIG_SH2_STAT5	405	408	PF00017	0.242
LIG_SH3_3	99	105	PF00018	0.334
LIG_SUMO_SIM_par_1	142	148	PF11976	0.285
LIG_SUMO_SIM_par_1	397	404	PF11976	0.388
LIG_TRAF2_1	145	148	PF00917	0.336
LIG_TYR_ITIM	219	224	PF00017	0.241
LIG_TYR_ITIM	393	398	PF00017	0.230
LIG_UBA3_1	137	142	PF00899	0.359
LIG_WRC_WIRS_1	385	390	PF05994	0.263
LIG_WRC_WIRS_1	437	442	PF05994	0.388
LIG_WRC_WIRS_1	92	97	PF05994	0.424
MOD_CK2_1	109	115	PF00069	0.426
MOD_CK2_1	142	148	PF00069	0.283
MOD_CK2_1	224	230	PF00069	0.377
MOD_CK2_1	350	356	PF00069	0.412
MOD_CK2_1	374	380	PF00069	0.423
MOD_CK2_1	436	442	PF00069	0.352
MOD_CK2_1	47	53	PF00069	0.613
MOD_GlcNHglycan	226	229	PF01048	0.263
MOD_GlcNHglycan	260	263	PF01048	0.409
MOD_GlcNHglycan	345	348	PF01048	0.371
MOD_GlcNHglycan	353	356	PF01048	0.226
MOD_GlcNHglycan	61	66	PF01048	0.404
MOD_GlcNHglycan	9	12	PF01048	0.422
MOD_GSK3_1	157	164	PF00069	0.265
MOD_GSK3_1	337	344	PF00069	0.307
MOD_GSK3_1	370	377	PF00069	0.418
MOD_GSK3_1	43	50	PF00069	0.581
MOD_GSK3_1	67	74	PF00069	0.555
MOD_LATS_1	278	284	PF00433	0.388
MOD_NEK2_1	131	136	PF00069	0.285
MOD_NEK2_1	140	145	PF00069	0.279
MOD_NEK2_1	161	166	PF00069	0.370
MOD_NEK2_1	178	183	PF00069	0.298
MOD_NEK2_1	224	229	PF00069	0.275
MOD_NEK2_1	23	28	PF00069	0.456
MOD_NEK2_1	313	318	PF00069	0.253
MOD_NEK2_1	414	419	PF00069	0.283
MOD_NEK2_1	44	49	PF00069	0.591
MOD_NMyristoyl	1	7	PF02799	0.550
MOD_PIKK_1	124	130	PF00454	0.388
MOD_PIKK_1	250	256	PF00454	0.342
MOD_PIKK_1	38	44	PF00454	0.550
MOD_PK_1	142	148	PF00069	0.285
MOD_PKA_2	23	29	PF00069	0.560
MOD_PKA_2	258	264	PF00069	0.457
MOD_PKA_2	265	271	PF00069	0.297
MOD_PKA_2	371	377	PF00069	0.302
MOD_PKA_2	435	441	PF00069	0.286
MOD_PKA_2	83	89	PF00069	0.318
MOD_Plk_1	109	115	PF00069	0.439
MOD_Plk_1	280	286	PF00069	0.241
MOD_Plk_1	313	319	PF00069	0.242
MOD_Plk_1	61	67	PF00069	0.458
MOD_Plk_2-3	109	115	PF00069	0.419
MOD_Plk_4	133	139	PF00069	0.357
MOD_Plk_4	166	172	PF00069	0.242
MOD_Plk_4	197	203	PF00069	0.413
MOD_Plk_4	313	319	PF00069	0.242
MOD_Plk_4	414	420	PF00069	0.257
MOD_SUMO_for_1	118	121	PF00179	0.313
MOD_SUMO_for_1	448	451	PF00179	0.432
MOD_SUMO_for_1	58	61	PF00179	0.392
TRG_DiLeu_BaEn_1	148	153	PF01217	0.242
TRG_DiLeu_BaEn_2	90	96	PF01217	0.349
TRG_DiLeu_BaEn_4	185	191	PF01217	0.241
TRG_ENDOCYTIC_2	175	178	PF00928	0.369
TRG_ENDOCYTIC_2	221	224	PF00928	0.234
TRG_ENDOCYTIC_2	304	307	PF00928	0.266
TRG_ENDOCYTIC_2	315	318	PF00928	0.217
TRG_ENDOCYTIC_2	395	398	PF00928	0.242
TRG_ER_diArg_1	293	296	PF00400	0.387
TRG_NLS_MonoExtC_3	292	298	PF00514	0.307
TRG_NLS_MonoExtN_4	237	243	PF00514	0.165
TRG_NLS_MonoExtN_4	290	297	PF00514	0.263
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT9	Leptomonas seymouri	23%	83%
A0A0N1PE70	Leptomonas seymouri	56%	100%
A0A0S4IZA7	Bodo saltans	25%	99%
A0A0S4JRR3	Bodo saltans	40%	98%
A0A1X0P9B0	Trypanosomatidae	48%	100%
A0A1X0PB79	Trypanosomatidae	22%	95%
A0A3R7KQW9	Trypanosoma rangeli	45%	100%
A0A422N247	Trypanosoma rangeli	22%	95%
A4HNP5	Leishmania braziliensis	68%	100%
A4ICV0	Leishmania infantum	100%	100%
C9ZM20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
D0A2K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D3ZSI8	Rattus norvegicus	25%	83%
E9ASF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O13010	Sus scrofa	24%	100%
O60331	Homo sapiens	24%	68%
O70161	Mus musculus	26%	69%
O70172	Mus musculus	24%	100%
O88377	Rattus norvegicus	24%	100%
P48426	Homo sapiens	24%	100%
P70182	Mus musculus	24%	83%
P78356	Homo sapiens	24%	100%
Q0P5F7	Bos taurus	25%	100%
Q4Q241	Leishmania major	91%	100%
Q5F356	Gallus gallus	24%	100%
Q5I6B8	Rattus norvegicus	25%	66%
Q5PQ01	Xenopus laevis	26%	100%
Q5R488	Pongo abelii	26%	100%
Q6GL14	Xenopus tropicalis	26%	100%
Q6IQE1	Danio rerio	25%	100%
Q80XI4	Mus musculus	24%	100%
Q8TBX8	Homo sapiens	26%	100%
Q91XU3	Mus musculus	26%	100%
Q99755	Homo sapiens	24%	81%
Q9R0I8	Rattus norvegicus	24%	100%
V5BA13	Trypanosoma cruzi	46%	100%
V5BV28	Trypanosoma cruzi	22%	96%