N-acetylglucosamine-6-phosphate_deacetylase-like_ protein/GeneDB:LmjF.36.0040

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetylglucosamine-6-phosphate deacetylase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XA87_LEIDO

TriTrypDb:

LdBPK_360040.1 , LdCL_360005200 , LDHU3_36.0080

Length:

432

Annotations

Annotations by Jardim et al.

Carbohydrate metabolism, N-acetylglucosamine-6-phosphate deacetylase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA87

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	1
GO:0006044	N-acetylglucosamine metabolic process	6	1
GO:0006046	N-acetylglucosamine catabolic process	7	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0046348	amino sugar catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901071	glucosamine-containing compound metabolic process	5	1
GO:1901072	glucosamine-containing compound catabolic process	6	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity	4	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	2
GO:0019213	deacetylase activity	3	2
GO:0047419	N-acetylgalactosamine-6-phosphate deacetylase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.426
CLV_MEL_PAP_1	126	132	PF00089	0.224
CLV_NRD_NRD_1	391	393	PF00675	0.350
CLV_NRD_NRD_1	40	42	PF00675	0.471
CLV_PCSK_KEX2_1	128	130	PF00082	0.242
CLV_PCSK_KEX2_1	169	171	PF00082	0.257
CLV_PCSK_KEX2_1	409	411	PF00082	0.308
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.242
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.257
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.308
CLV_PCSK_SKI1_1	117	121	PF00082	0.234
CLV_PCSK_SKI1_1	179	183	PF00082	0.217
CLV_PCSK_SKI1_1	197	201	PF00082	0.319
CLV_PCSK_SKI1_1	205	209	PF00082	0.250
CLV_PCSK_SKI1_1	224	228	PF00082	0.124
DEG_APCC_DBOX_1	40	48	PF00400	0.369
DOC_CYCLIN_RxL_1	194	201	PF00134	0.459
DOC_MAPK_DCC_7	267	276	PF00069	0.450
DOC_MAPK_gen_1	202	208	PF00069	0.478
DOC_MAPK_gen_1	267	276	PF00069	0.426
DOC_MAPK_gen_1	392	400	PF00069	0.412
DOC_MAPK_MEF2A_6	267	276	PF00069	0.426
DOC_MAPK_RevD_3	378	393	PF00069	0.371
DOC_PP4_FxxP_1	64	67	PF00568	0.411
DOC_USP7_MATH_1	214	218	PF00917	0.457
DOC_USP7_MATH_1	293	297	PF00917	0.488
DOC_WW_Pin1_4	181	186	PF00397	0.411
LIG_14-3-3_CanoR_1	247	252	PF00244	0.459
LIG_14-3-3_CanoR_1	339	345	PF00244	0.464
LIG_APCC_ABBA_1	183	188	PF00400	0.424
LIG_BRCT_BRCA1_1	107	111	PF00533	0.411
LIG_Clathr_ClatBox_1	280	284	PF01394	0.467
LIG_Clathr_ClatBox_1	397	401	PF01394	0.457
LIG_FHA_1	118	124	PF00498	0.468
LIG_FHA_1	12	18	PF00498	0.415
LIG_FHA_1	271	277	PF00498	0.461
LIG_FHA_1	302	308	PF00498	0.443
LIG_FHA_1	346	352	PF00498	0.420
LIG_FHA_1	371	377	PF00498	0.478
LIG_FHA_2	225	231	PF00498	0.418
LIG_FHA_2	56	62	PF00498	0.454
LIG_Integrin_isoDGR_2	319	321	PF01839	0.211
LIG_LIR_Apic_2	61	67	PF02991	0.246
LIG_LIR_Gen_1	353	362	PF02991	0.412
LIG_LIR_Nem_3	167	171	PF02991	0.431
LIG_LIR_Nem_3	353	358	PF02991	0.412
LIG_PDZ_Class_1	427	432	PF00595	0.461
LIG_PTB_Apo_2	86	93	PF02174	0.424
LIG_PTB_Phospho_1	86	92	PF10480	0.442
LIG_SH2_CRK	422	426	PF00017	0.341
LIG_SH2_NCK_1	60	64	PF00017	0.464
LIG_SH2_STAP1	60	64	PF00017	0.295
LIG_SH2_STAT5	133	136	PF00017	0.474
LIG_SH2_STAT5	332	335	PF00017	0.442
LIG_SH2_STAT5	422	425	PF00017	0.271
LIG_SH3_3	255	261	PF00018	0.457
LIG_Sin3_3	395	402	PF02671	0.426
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.468
LIG_SUMO_SIM_anti_2	298	305	PF11976	0.427
LIG_SUMO_SIM_par_1	22	28	PF11976	0.371
LIG_SUMO_SIM_par_1	29	35	PF11976	0.365
LIG_TRAF2_1	227	230	PF00917	0.467
LIG_UBA3_1	219	224	PF00899	0.411
LIG_UBA3_1	357	364	PF00899	0.451
LIG_WRC_WIRS_1	241	246	PF05994	0.424
MOD_CK1_1	161	167	PF00069	0.514
MOD_CK1_1	174	180	PF00069	0.530
MOD_CK2_1	212	218	PF00069	0.448
MOD_CK2_1	224	230	PF00069	0.388
MOD_CK2_1	55	61	PF00069	0.465
MOD_CK2_1	85	91	PF00069	0.424
MOD_GlcNHglycan	307	310	PF01048	0.296
MOD_GSK3_1	101	108	PF00069	0.418
MOD_GSK3_1	247	254	PF00069	0.496
MOD_GSK3_1	287	294	PF00069	0.461
MOD_GSK3_1	301	308	PF00069	0.363
MOD_LATS_1	115	121	PF00433	0.492
MOD_LATS_1	210	216	PF00433	0.411
MOD_N-GLC_1	2	7	PF02516	0.442
MOD_N-GLC_1	239	244	PF02516	0.280
MOD_NEK2_1	111	116	PF00069	0.516
MOD_NEK2_1	171	176	PF00069	0.411
MOD_NEK2_1	233	238	PF00069	0.411
MOD_NEK2_1	251	256	PF00069	0.411
MOD_NEK2_1	29	34	PF00069	0.401
MOD_NEK2_1	333	338	PF00069	0.474
MOD_NEK2_1	47	52	PF00069	0.457
MOD_NEK2_2	90	95	PF00069	0.415
MOD_PKA_2	246	252	PF00069	0.494
MOD_PKA_2	320	326	PF00069	0.428
MOD_PKA_2	338	344	PF00069	0.372
MOD_Plk_1	161	167	PF00069	0.464
MOD_Plk_1	2	8	PF00069	0.443
MOD_Plk_1	239	245	PF00069	0.528
MOD_Plk_1	90	96	PF00069	0.438
MOD_Plk_2-3	403	409	PF00069	0.565
MOD_Plk_4	105	111	PF00069	0.411
MOD_Plk_4	2	8	PF00069	0.375
MOD_Plk_4	247	253	PF00069	0.411
MOD_Plk_4	287	293	PF00069	0.474
MOD_Plk_4	320	326	PF00069	0.453
MOD_Plk_4	346	352	PF00069	0.457
MOD_Plk_4	420	426	PF00069	0.332
MOD_Plk_4	55	61	PF00069	0.331
MOD_ProDKin_1	181	187	PF00069	0.411
MOD_SUMO_rev_2	152	161	PF00179	0.484
MOD_SUMO_rev_2	162	171	PF00179	0.442
MOD_SUMO_rev_2	228	233	PF00179	0.516
TRG_ENDOCYTIC_2	193	196	PF00928	0.440
TRG_ENDOCYTIC_2	422	425	PF00928	0.327
TRG_NES_CRM1_1	279	289	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.376
TRG_PTS1	429	432	PF00515	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM2	Leptomonas seymouri	78%	100%
A0A0S4JIK6	Bodo saltans	51%	98%
A0A1X0NNC6	Trypanosomatidae	59%	100%
A0A3R7KWA9	Trypanosoma rangeli	57%	100%
A4HNK9	Leishmania braziliensis	88%	100%
A4ICY4	Leishmania infantum	100%	100%
E9ASC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O34450	Bacillus subtilis (strain 168)	25%	100%
Q4Q275	Leishmania major	95%	100%
V5C012	Trypanosoma cruzi	56%	100%