LeishMANIAdb
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Proteasome subunit beta

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proteasome subunit beta
Gene product:
proteasome subunit beta type-2, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XA80_LEIDO
TriTrypDb:
LdBPK_360340.1 , LdCL_360008400 , LDHU3_36.0460
Length:
206

Annotations

Annotations by Jardim et al.

Proteasome, proteasome beta 2 subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0005839 proteasome core complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0140535 intracellular protein-containing complex 2 12
GO:1902494 catalytic complex 2 12
GO:0019774 proteasome core complex, beta-subunit complex 2 1
GO:0016020 membrane 2 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7XA80
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA80

PDB structure(s): 6qm7_K , 6qm7_Y , 6qm8_K , 6qm8_Y

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009057 macromolecule catabolic process 4 12
GO:0010498 proteasomal protein catabolic process 5 12
GO:0019538 protein metabolic process 3 12
GO:0030163 protein catabolic process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044238 primary metabolic process 2 12
GO:0051603 proteolysis involved in protein catabolic process 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901565 organonitrogen compound catabolic process 4 12
GO:1901575 organic substance catabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0016787 hydrolase activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 180 182 PF00675 0.328
CLV_PCSK_KEX2_1 179 181 PF00082 0.265
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.229
CLV_PCSK_SKI1_1 192 196 PF00082 0.280
DOC_PP1_RVXF_1 52 58 PF00149 0.440
DOC_USP7_MATH_1 93 97 PF00917 0.466
DOC_USP7_UBL2_3 192 196 PF12436 0.296
LIG_BIR_II_1 1 5 PF00653 0.247
LIG_BRCT_BRCA1_1 186 190 PF00533 0.449
LIG_BRCT_BRCA1_2 186 192 PF00533 0.433
LIG_Clathr_ClatBox_1 126 130 PF01394 0.448
LIG_eIF4E_1 101 107 PF01652 0.440
LIG_eIF4E_1 60 66 PF01652 0.423
LIG_FHA_1 149 155 PF00498 0.431
LIG_FHA_1 39 45 PF00498 0.574
LIG_FHA_1 56 62 PF00498 0.389
LIG_FHA_2 161 167 PF00498 0.417
LIG_FHA_2 28 34 PF00498 0.428
LIG_FHA_2 35 41 PF00498 0.406
LIG_LIR_Gen_1 12 21 PF02991 0.425
LIG_LIR_Nem_3 12 16 PF02991 0.441
LIG_LIR_Nem_3 185 191 PF02991 0.420
LIG_MLH1_MIPbox_1 186 190 PF16413 0.438
LIG_PTB_Apo_2 183 190 PF02174 0.417
LIG_REV1ctd_RIR_1 187 196 PF16727 0.426
LIG_SH2_CRK 110 114 PF00017 0.457
LIG_SH2_PTP2 13 16 PF00017 0.480
LIG_SH2_PTP2 26 29 PF00017 0.376
LIG_SH2_STAT5 128 131 PF00017 0.468
LIG_SH2_STAT5 13 16 PF00017 0.480
LIG_SH2_STAT5 188 191 PF00017 0.222
LIG_SH2_STAT5 26 29 PF00017 0.376
LIG_SH2_STAT5 60 63 PF00017 0.427
LIG_SUMO_SIM_anti_2 166 172 PF11976 0.427
LIG_TRAF2_1 163 166 PF00917 0.427
MOD_CK1_1 78 84 PF00069 0.571
MOD_CK2_1 160 166 PF00069 0.417
MOD_CK2_1 27 33 PF00069 0.457
MOD_GlcNHglycan 91 94 PF01048 0.320
MOD_GSK3_1 34 41 PF00069 0.427
MOD_GSK3_1 74 81 PF00069 0.445
MOD_GSK3_1 89 96 PF00069 0.423
MOD_LATS_1 73 79 PF00433 0.457
MOD_N-GLC_1 55 60 PF02516 0.322
MOD_NEK2_1 1 6 PF00069 0.247
MOD_PIKK_1 160 166 PF00454 0.508
MOD_PIKK_1 34 40 PF00454 0.440
MOD_PKA_2 74 80 PF00069 0.472
MOD_Plk_4 184 190 PF00069 0.423
MOD_SUMO_rev_2 31 37 PF00179 0.417
TRG_DiLeu_BaEn_1 166 171 PF01217 0.417
TRG_ENDOCYTIC_2 13 16 PF00928 0.480
TRG_ENDOCYTIC_2 188 191 PF00928 0.222
TRG_ENDOCYTIC_2 26 29 PF00928 0.376
TRG_ER_diArg_1 180 182 PF00400 0.530
TRG_ER_diArg_1 94 97 PF00400 0.417

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILF0 Leptomonas seymouri 24% 83%
A0A0N1ILR7 Leptomonas seymouri 86% 100%
A0A0S4J7A1 Bodo saltans 25% 83%
A0A0S4JIF5 Bodo saltans 61% 100%
A0A1X0P8B0 Trypanosomatidae 64% 94%
A0A3S5ISK6 Trypanosoma rangeli 69% 100%
A4HNP0 Leishmania braziliensis 90% 100%
A4ICV5 Leishmania infantum 100% 100%
A5DB52 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 36% 100%
A5UM14 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 23% 100%
A9A2U7 Nitrosopumilus maritimus (strain SCM1) 22% 98%
C9REN7 Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) 25% 92%
D0A2J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9ASE9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O23714 Arabidopsis thaliana 40% 100%
O24633 Arabidopsis thaliana 40% 100%
O50110 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 28% 100%
P0CQ12 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 32% 92%
P0CQ13 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 32% 92%
P22141 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 100%
P40307 Rattus norvegicus 36% 100%
P49721 Homo sapiens 36% 100%
P91477 Caenorhabditis elegans 31% 100%
Q09720 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
Q2NI68 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 24% 100%
Q4Q246 Leishmania major 98% 100%
Q55DY7 Dictyostelium discoideum 40% 100%
Q5E9K0 Bos taurus 36% 100%
Q8SRF1 Encephalitozoon cuniculi (strain GB-M1) 25% 100%
Q8U125 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 26% 100%
Q8ZST5 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 25% 100%
Q9LST6 Oryza sativa subsp. japonica 40% 97%
Q9NHC6 Trypanosoma brucei brucei 69% 100%
Q9P6U7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 38% 100%
Q9R1P3 Mus musculus 36% 100%
Q9V0N9 Pyrococcus abyssi (strain GE5 / Orsay) 27% 100%
Q9VQE5 Drosophila melanogaster 33% 98%
V5C017 Trypanosoma cruzi 69% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS