LeishMANIAdb
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SAC3/GANP/Nin1/mts3/eIF-3 p25 family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SAC3/GANP/Nin1/mts3/eIF-3 p25 family, putative
Gene product:
SAC3/GANP/Nin1/mts3/eIF-3 p25 family, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XA75_LEIDO
TriTrypDb:
LdBPK_355290.1 , LdCL_350058700 , LDHU3_35.7050
Length:
597

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7XA75
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA75

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 590 594 PF00656 0.560
CLV_NRD_NRD_1 109 111 PF00675 0.641
CLV_NRD_NRD_1 137 139 PF00675 0.482
CLV_NRD_NRD_1 163 165 PF00675 0.540
CLV_NRD_NRD_1 252 254 PF00675 0.694
CLV_NRD_NRD_1 517 519 PF00675 0.572
CLV_NRD_NRD_1 590 592 PF00675 0.539
CLV_PCSK_KEX2_1 109 111 PF00082 0.641
CLV_PCSK_KEX2_1 137 139 PF00082 0.463
CLV_PCSK_KEX2_1 163 165 PF00082 0.514
CLV_PCSK_KEX2_1 227 229 PF00082 0.644
CLV_PCSK_KEX2_1 241 243 PF00082 0.656
CLV_PCSK_KEX2_1 517 519 PF00082 0.623
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.731
CLV_PCSK_PC1ET2_1 241 243 PF00082 0.747
CLV_PCSK_PC1ET2_1 517 519 PF00082 0.651
CLV_PCSK_SKI1_1 128 132 PF00082 0.470
CLV_PCSK_SKI1_1 217 221 PF00082 0.745
CLV_PCSK_SKI1_1 256 260 PF00082 0.566
CLV_PCSK_SKI1_1 395 399 PF00082 0.475
CLV_PCSK_SKI1_1 461 465 PF00082 0.478
CLV_PCSK_SKI1_1 487 491 PF00082 0.337
CLV_PCSK_SKI1_1 518 522 PF00082 0.550
CLV_PCSK_SKI1_1 65 69 PF00082 0.531
DEG_APCC_DBOX_1 40 48 PF00400 0.533
DEG_APCC_DBOX_1 474 482 PF00400 0.396
DEG_APCC_DBOX_1 64 72 PF00400 0.504
DEG_SPOP_SBC_1 113 117 PF00917 0.695
DOC_CKS1_1 208 213 PF01111 0.742
DOC_CYCLIN_RxL_1 458 467 PF00134 0.398
DOC_CYCLIN_RxL_1 513 525 PF00134 0.614
DOC_MAPK_gen_1 163 170 PF00069 0.491
DOC_MAPK_gen_1 335 343 PF00069 0.319
DOC_MAPK_MEF2A_6 494 501 PF00069 0.413
DOC_MAPK_NFAT4_5 494 502 PF00069 0.475
DOC_PP1_RVXF_1 44 50 PF00149 0.548
DOC_PP1_RVXF_1 480 486 PF00149 0.344
DOC_PP1_RVXF_1 516 523 PF00149 0.615
DOC_PP4_FxxP_1 220 223 PF00568 0.690
DOC_USP7_MATH_1 113 117 PF00917 0.685
DOC_USP7_MATH_1 249 253 PF00917 0.636
DOC_USP7_MATH_1 432 436 PF00917 0.343
DOC_USP7_MATH_1 526 530 PF00917 0.508
DOC_USP7_MATH_1 53 57 PF00917 0.607
DOC_USP7_MATH_1 87 91 PF00917 0.547
DOC_USP7_UBL2_3 319 323 PF12436 0.370
DOC_USP7_UBL2_3 324 328 PF12436 0.371
DOC_USP7_UBL2_3 515 519 PF12436 0.552
DOC_WW_Pin1_4 182 187 PF00397 0.697
DOC_WW_Pin1_4 188 193 PF00397 0.751
DOC_WW_Pin1_4 207 212 PF00397 0.747
DOC_WW_Pin1_4 453 458 PF00397 0.437
DOC_WW_Pin1_4 506 511 PF00397 0.401
DOC_WW_Pin1_4 74 79 PF00397 0.561
DOC_WW_Pin1_4 94 99 PF00397 0.328
LIG_14-3-3_CanoR_1 138 144 PF00244 0.504
LIG_14-3-3_CanoR_1 16 24 PF00244 0.687
LIG_14-3-3_CanoR_1 46 50 PF00244 0.452
LIG_14-3-3_CanoR_1 461 467 PF00244 0.437
LIG_14-3-3_CanoR_1 52 58 PF00244 0.497
LIG_Actin_WH2_2 290 306 PF00022 0.413
LIG_Actin_WH2_2 471 489 PF00022 0.383
LIG_BIR_II_1 1 5 PF00653 0.794
LIG_BRCT_BRCA1_1 504 508 PF00533 0.387
LIG_Clathr_ClatBox_1 463 467 PF01394 0.475
LIG_Clathr_ClatBox_1 520 524 PF01394 0.559
LIG_deltaCOP1_diTrp_1 42 49 PF00928 0.502
LIG_FHA_1 210 216 PF00498 0.694
LIG_FHA_1 349 355 PF00498 0.447
LIG_FHA_1 363 369 PF00498 0.475
LIG_FHA_1 414 420 PF00498 0.344
LIG_FHA_1 442 448 PF00498 0.272
LIG_FHA_1 454 460 PF00498 0.252
LIG_FHA_1 469 475 PF00498 0.336
LIG_FHA_1 538 544 PF00498 0.509
LIG_FHA_2 167 173 PF00498 0.462
LIG_FHA_2 264 270 PF00498 0.697
LIG_FHA_2 279 285 PF00498 0.382
LIG_FHA_2 286 292 PF00498 0.448
LIG_FHA_2 313 319 PF00498 0.475
LIG_FHA_2 53 59 PF00498 0.519
LIG_FHA_2 559 565 PF00498 0.667
LIG_FHA_2 588 594 PF00498 0.537
LIG_LIR_Apic_2 122 126 PF02991 0.527
LIG_LIR_Apic_2 218 223 PF02991 0.689
LIG_LIR_Gen_1 169 177 PF02991 0.446
LIG_LIR_Gen_1 204 213 PF02991 0.694
LIG_LIR_Gen_1 305 314 PF02991 0.475
LIG_LIR_Gen_1 348 357 PF02991 0.475
LIG_LIR_Gen_1 408 419 PF02991 0.449
LIG_LIR_Gen_1 536 546 PF02991 0.502
LIG_LIR_Gen_1 583 588 PF02991 0.503
LIG_LIR_Nem_3 204 208 PF02991 0.712
LIG_LIR_Nem_3 257 262 PF02991 0.570
LIG_LIR_Nem_3 284 290 PF02991 0.480
LIG_LIR_Nem_3 305 310 PF02991 0.449
LIG_LIR_Nem_3 408 414 PF02991 0.449
LIG_LIR_Nem_3 505 511 PF02991 0.437
LIG_LIR_Nem_3 536 541 PF02991 0.435
LIG_LIR_Nem_3 583 587 PF02991 0.438
LIG_LYPXL_yS_3 569 572 PF13949 0.557
LIG_NRBOX 458 464 PF00104 0.475
LIG_PCNA_PIPBox_1 375 384 PF02747 0.363
LIG_PCNA_PIPBox_1 391 400 PF02747 0.363
LIG_PCNA_yPIPBox_3 391 401 PF02747 0.475
LIG_Pex14_2 534 538 PF04695 0.494
LIG_REV1ctd_RIR_1 395 405 PF16727 0.344
LIG_SH2_CRK 205 209 PF00017 0.738
LIG_SH2_CRK 400 404 PF00017 0.410
LIG_SH2_CRK 411 415 PF00017 0.385
LIG_SH2_GRB2like 123 126 PF00017 0.694
LIG_SH2_NCK_1 123 127 PF00017 0.603
LIG_SH2_NCK_1 165 169 PF00017 0.459
LIG_SH2_NCK_1 307 311 PF00017 0.487
LIG_SH2_SRC 123 126 PF00017 0.687
LIG_SH2_SRC 307 310 PF00017 0.487
LIG_SH2_STAP1 154 158 PF00017 0.581
LIG_SH2_STAP1 355 359 PF00017 0.328
LIG_SH2_STAP1 382 386 PF00017 0.475
LIG_SH2_STAP1 63 67 PF00017 0.412
LIG_SH2_STAT5 287 290 PF00017 0.586
LIG_SH2_STAT5 329 332 PF00017 0.344
LIG_SH2_STAT5 404 407 PF00017 0.328
LIG_SH2_STAT5 472 475 PF00017 0.379
LIG_SH2_STAT5 477 480 PF00017 0.344
LIG_SH2_STAT5 584 587 PF00017 0.429
LIG_SH3_3 186 192 PF00018 0.753
LIG_SH3_3 194 200 PF00018 0.751
LIG_SH3_3 232 238 PF00018 0.795
LIG_SH3_3 267 273 PF00018 0.665
LIG_SH3_3 540 546 PF00018 0.517
LIG_SH3_3 72 78 PF00018 0.528
LIG_SH3_3 88 94 PF00018 0.344
LIG_SUMO_SIM_par_1 350 356 PF11976 0.421
LIG_TYR_ITIM 402 407 PF00017 0.344
LIG_UBA3_1 173 178 PF00899 0.551
LIG_UBA3_1 483 487 PF00899 0.403
LIG_UBA3_1 489 494 PF00899 0.425
LIG_UBA3_1 537 542 PF00899 0.472
LIG_WRC_WIRS_1 463 468 PF05994 0.475
LIG_WW_1 202 205 PF00397 0.731
MOD_CK1_1 116 122 PF00069 0.666
MOD_CK1_1 413 419 PF00069 0.428
MOD_CK2_1 166 172 PF00069 0.481
MOD_CK2_1 263 269 PF00069 0.694
MOD_CK2_1 278 284 PF00069 0.351
MOD_CK2_1 285 291 PF00069 0.435
MOD_CK2_1 312 318 PF00069 0.475
MOD_CK2_1 52 58 PF00069 0.574
MOD_Cter_Amidation 321 324 PF01082 0.475
MOD_Cter_Amidation 513 516 PF01082 0.652
MOD_GlcNHglycan 116 119 PF01048 0.694
MOD_GlcNHglycan 407 410 PF01048 0.475
MOD_GlcNHglycan 527 531 PF01048 0.462
MOD_GSK3_1 112 119 PF00069 0.538
MOD_GSK3_1 209 216 PF00069 0.670
MOD_GSK3_1 308 315 PF00069 0.466
MOD_GSK3_1 502 509 PF00069 0.372
MOD_GSK3_1 8 15 PF00069 0.687
MOD_GSK3_1 94 101 PF00069 0.643
MOD_N-GLC_1 348 353 PF02516 0.451
MOD_N-GLC_1 441 446 PF02516 0.439
MOD_N-GLC_1 8 13 PF02516 0.590
MOD_N-GLC_2 12 14 PF02516 0.680
MOD_N-GLC_2 372 374 PF02516 0.328
MOD_NEK2_1 1 6 PF00069 0.820
MOD_NEK2_1 132 137 PF00069 0.566
MOD_NEK2_1 405 410 PF00069 0.463
MOD_NEK2_1 493 498 PF00069 0.407
MOD_NEK2_1 502 507 PF00069 0.385
MOD_NEK2_1 537 542 PF00069 0.496
MOD_NEK2_1 587 592 PF00069 0.529
MOD_NEK2_2 495 500 PF00069 0.363
MOD_NEK2_2 547 552 PF00069 0.584
MOD_PIKK_1 1 7 PF00454 0.734
MOD_PIKK_1 15 21 PF00454 0.743
MOD_PIKK_1 195 201 PF00454 0.757
MOD_PIKK_1 387 393 PF00454 0.398
MOD_PKA_2 15 21 PF00069 0.657
MOD_PKA_2 45 51 PF00069 0.456
MOD_Plk_1 254 260 PF00069 0.588
MOD_Plk_1 348 354 PF00069 0.475
MOD_Plk_1 441 447 PF00069 0.449
MOD_Plk_1 468 474 PF00069 0.474
MOD_Plk_1 547 553 PF00069 0.509
MOD_Plk_2-3 166 172 PF00069 0.508
MOD_Plk_4 166 172 PF00069 0.467
MOD_Plk_4 254 260 PF00069 0.636
MOD_Plk_4 45 51 PF00069 0.456
MOD_Plk_4 468 474 PF00069 0.451
MOD_Plk_4 87 93 PF00069 0.540
MOD_ProDKin_1 182 188 PF00069 0.707
MOD_ProDKin_1 207 213 PF00069 0.734
MOD_ProDKin_1 453 459 PF00069 0.437
MOD_ProDKin_1 506 512 PF00069 0.414
MOD_ProDKin_1 74 80 PF00069 0.556
MOD_ProDKin_1 94 100 PF00069 0.330
MOD_SUMO_for_1 541 544 PF00179 0.522
MOD_SUMO_rev_2 318 325 PF00179 0.475
MOD_SUMO_rev_2 388 397 PF00179 0.459
TRG_DiLeu_BaEn_1 469 474 PF01217 0.449
TRG_DiLeu_BaEn_2 165 171 PF01217 0.564
TRG_DiLeu_BaEn_4 527 533 PF01217 0.545
TRG_DiLeu_BaLyEn_6 458 463 PF01217 0.396
TRG_ENDOCYTIC_2 165 168 PF00928 0.443
TRG_ENDOCYTIC_2 205 208 PF00928 0.710
TRG_ENDOCYTIC_2 290 293 PF00928 0.449
TRG_ENDOCYTIC_2 307 310 PF00928 0.449
TRG_ENDOCYTIC_2 400 403 PF00928 0.407
TRG_ENDOCYTIC_2 404 407 PF00928 0.315
TRG_ENDOCYTIC_2 411 414 PF00928 0.385
TRG_ENDOCYTIC_2 569 572 PF00928 0.541
TRG_ENDOCYTIC_2 584 587 PF00928 0.354
TRG_ER_diArg_1 136 138 PF00400 0.497
TRG_ER_diArg_1 163 165 PF00400 0.543
TRG_NES_CRM1_1 332 344 PF08389 0.328
TRG_NLS_MonoCore_2 514 519 PF00514 0.664
TRG_NLS_MonoExtC_3 514 519 PF00514 0.372
TRG_NLS_MonoExtN_4 512 519 PF00514 0.652

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL40 Leptomonas seymouri 58% 98%
A0A0S4JV64 Bodo saltans 34% 100%
A0A1X0P4X7 Trypanosomatidae 39% 96%
A0A3S5IQK8 Trypanosoma rangeli 38% 98%
A4HNJ3 Leishmania braziliensis 86% 100%
A4IC50 Leishmania infantum 99% 100%
C9ZYC4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AG05 Leishmania major 96% 100%
E9B758 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5B8T1 Trypanosoma cruzi 38% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS