Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA73_LEIDO

TriTrypDb:

LdBPK_355050.1 , LdCL_350059300 , LDHU3_35.7120

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.481
CLV_PCSK_KEX2_1	27	29	PF00082	0.461
CLV_PCSK_KEX2_1	87	89	PF00082	0.462
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.408
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.462
CLV_PCSK_SKI1_1	105	109	PF00082	0.375
CLV_PCSK_SKI1_1	144	148	PF00082	0.350
CLV_PCSK_SKI1_1	15	19	PF00082	0.442
CLV_PCSK_SKI1_1	167	171	PF00082	0.470
CLV_PCSK_SKI1_1	209	213	PF00082	0.455
CLV_PCSK_SKI1_1	224	228	PF00082	0.454
CLV_PCSK_SKI1_1	28	32	PF00082	0.386
DEG_APCC_KENBOX_2	43	47	PF00400	0.377
DEG_Nend_UBRbox_1	1	4	PF02207	0.664
DEG_SPOP_SBC_1	172	176	PF00917	0.450
DOC_CYCLIN_RxL_1	12	19	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	75	78	PF00134	0.490
DOC_MAPK_DCC_7	144	154	PF00069	0.341
DOC_PP2B_LxvP_1	54	57	PF13499	0.389
DOC_PP2B_LxvP_1	75	78	PF13499	0.446
DOC_PP4_FxxP_1	165	168	PF00568	0.445
DOC_USP7_MATH_1	13	17	PF00917	0.457
DOC_USP7_MATH_1	132	136	PF00917	0.449
DOC_USP7_MATH_1	172	176	PF00917	0.471
DOC_USP7_MATH_1	192	196	PF00917	0.486
DOC_USP7_MATH_1	198	202	PF00917	0.505
DOC_WW_Pin1_4	16	21	PF00397	0.477
DOC_WW_Pin1_4	48	53	PF00397	0.408
LIG_FHA_1	178	184	PF00498	0.569
LIG_FHA_1	37	43	PF00498	0.469
LIG_FHA_1	49	55	PF00498	0.483
LIG_FHA_1	88	94	PF00498	0.446
LIG_FHA_2	106	112	PF00498	0.503
LIG_FHA_2	125	131	PF00498	0.568
LIG_FHA_2	168	174	PF00498	0.505
LIG_HCF-1_HBM_1	94	97	PF13415	0.363
LIG_Integrin_RGD_1	217	219	PF01839	0.544
LIG_LIR_Apic_2	162	168	PF02991	0.437
LIG_LIR_Gen_1	135	146	PF02991	0.497
LIG_LIR_Nem_3	135	141	PF02991	0.451
LIG_LIR_Nem_3	234	239	PF02991	0.269
LIG_LIR_Nem_3	94	100	PF02991	0.313
LIG_PDZ_Class_1	254	259	PF00595	0.620
LIG_Pex14_1	161	165	PF04695	0.387
LIG_RPA_C_Fungi	191	203	PF08784	0.326
LIG_SH2_STAT5	101	104	PF00017	0.321
LIG_SH2_STAT5	145	148	PF00017	0.456
LIG_SH2_STAT5	159	162	PF00017	0.321
LIG_SH2_STAT5	215	218	PF00017	0.453
LIG_SH2_STAT5	97	100	PF00017	0.331
LIG_SH3_3	143	149	PF00018	0.477
LIG_SH3_3	73	79	PF00018	0.590
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.495
LIG_TRAF2_1	127	130	PF00917	0.529
LIG_UBA3_1	82	87	PF00899	0.523
MOD_CK1_1	16	22	PF00069	0.548
MOD_CK1_1	201	207	PF00069	0.527
MOD_CK1_1	252	258	PF00069	0.529
MOD_CK1_1	34	40	PF00069	0.372
MOD_CK2_1	105	111	PF00069	0.389
MOD_CK2_1	124	130	PF00069	0.417
MOD_GlcNHglycan	114	117	PF01048	0.456
MOD_GlcNHglycan	175	178	PF01048	0.597
MOD_GlcNHglycan	2	5	PF01048	0.638
MOD_GlcNHglycan	200	203	PF01048	0.538
MOD_GlcNHglycan	256	259	PF01048	0.569
MOD_GlcNHglycan	33	36	PF01048	0.597
MOD_GSK3_1	167	174	PF00069	0.535
MOD_NEK2_1	203	208	PF00069	0.405
MOD_NEK2_1	211	216	PF00069	0.391
MOD_NEK2_1	31	36	PF00069	0.484
MOD_NEK2_2	100	105	PF00069	0.404
MOD_PIKK_1	125	131	PF00454	0.688
MOD_PKA_1	87	93	PF00069	0.439
MOD_PKA_2	87	93	PF00069	0.439
MOD_Plk_1	231	237	PF00069	0.410
MOD_Plk_1	249	255	PF00069	0.407
MOD_Plk_4	211	217	PF00069	0.488
MOD_Plk_4	231	237	PF00069	0.233
MOD_ProDKin_1	16	22	PF00069	0.471
MOD_ProDKin_1	48	54	PF00069	0.403
TRG_DiLeu_BaEn_1	81	86	PF01217	0.387
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.460
TRG_ENDOCYTIC_2	101	104	PF00928	0.312
TRG_ENDOCYTIC_2	236	239	PF00928	0.362
TRG_ER_diArg_1	5	8	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE1	Leptomonas seymouri	50%	96%
A0A1X0NWL1	Trypanosomatidae	28%	92%
A0A422N815	Trypanosoma rangeli	21%	97%
A4HNJ9	Leishmania braziliensis	80%	100%
A4IC68	Leishmania infantum	100%	100%
E9AG11	Leishmania major	92%	100%
E9B764	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DS95	Trypanosoma cruzi	23%	97%