Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA65_LEIDO

TriTrypDb:

LdBPK_355190.1 , LdCL_350057700 , LDHU3_35.6920

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	276	278	PF00675	0.463
CLV_NRD_NRD_1	38	40	PF00675	0.434
CLV_PCSK_KEX2_1	38	40	PF00082	0.434
CLV_PCSK_SKI1_1	33	37	PF00082	0.409
CLV_PCSK_SKI1_1	98	102	PF00082	0.472
DEG_APCC_DBOX_1	97	105	PF00400	0.493
DOC_CKS1_1	119	124	PF01111	0.589
DOC_USP7_MATH_1	2	6	PF00917	0.553
DOC_USP7_MATH_1	210	214	PF00917	0.618
DOC_USP7_MATH_1	242	246	PF00917	0.398
DOC_USP7_MATH_1	49	53	PF00917	0.334
DOC_WW_Pin1_4	118	123	PF00397	0.650
DOC_WW_Pin1_4	206	211	PF00397	0.565
DOC_WW_Pin1_4	219	224	PF00397	0.566
DOC_WW_Pin1_4	81	86	PF00397	0.476
LIG_14-3-3_CanoR_1	196	206	PF00244	0.615
LIG_14-3-3_CanoR_1	292	296	PF00244	0.416
LIG_14-3-3_CanoR_1	63	69	PF00244	0.419
LIG_Actin_WH2_2	191	209	PF00022	0.555
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	51	55	PF00533	0.344
LIG_FHA_1	165	171	PF00498	0.440
LIG_FHA_1	193	199	PF00498	0.538
LIG_FHA_1	201	207	PF00498	0.534
LIG_FHA_1	260	266	PF00498	0.475
LIG_FHA_1	72	78	PF00498	0.385
LIG_FHA_2	206	212	PF00498	0.543
LIG_FHA_2	5	11	PF00498	0.423
LIG_FHA_2	65	71	PF00498	0.461
LIG_GBD_Chelix_1	50	58	PF00786	0.417
LIG_LIR_Gen_1	252	260	PF02991	0.406
LIG_LIR_Gen_1	52	61	PF02991	0.408
LIG_LIR_Nem_3	124	128	PF02991	0.514
LIG_LIR_Nem_3	252	257	PF02991	0.437
LIG_LIR_Nem_3	52	58	PF02991	0.420
LIG_NRBOX	72	78	PF00104	0.385
LIG_SH2_CRK	254	258	PF00017	0.405
LIG_SH2_STAP1	236	240	PF00017	0.483
LIG_SH2_STAP1	64	68	PF00017	0.374
LIG_SH2_STAT5	18	21	PF00017	0.427
LIG_SH2_STAT5	64	67	PF00017	0.377
LIG_SH3_3	113	119	PF00018	0.523
LIG_SUMO_SIM_anti_2	245	252	PF11976	0.433
LIG_SUMO_SIM_par_1	18	25	PF11976	0.435
LIG_TRAF2_1	67	70	PF00917	0.352
MOD_CDK_SPK_2	118	123	PF00069	0.577
MOD_CK1_1	137	143	PF00069	0.481
MOD_CK1_1	200	206	PF00069	0.573
MOD_CK1_1	222	228	PF00069	0.511
MOD_CK2_1	205	211	PF00069	0.540
MOD_CK2_1	39	45	PF00069	0.606
MOD_CK2_1	63	69	PF00069	0.489
MOD_GlcNHglycan	125	128	PF01048	0.697
MOD_GlcNHglycan	139	142	PF01048	0.433
MOD_GlcNHglycan	211	215	PF01048	0.634
MOD_GlcNHglycan	4	7	PF01048	0.538
MOD_GSK3_1	2	9	PF00069	0.536
MOD_GSK3_1	206	213	PF00069	0.709
MOD_GSK3_1	255	262	PF00069	0.462
MOD_GSK3_1	72	79	PF00069	0.442
MOD_N-GLC_1	198	203	PF02516	0.454
MOD_N-GLC_1	2	7	PF02516	0.548
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	12	17	PF00069	0.481
MOD_NEK2_1	205	210	PF00069	0.556
MOD_NEK2_1	76	81	PF00069	0.548
MOD_PIKK_1	12	18	PF00454	0.464
MOD_PIKK_1	39	45	PF00454	0.424
MOD_PK_1	112	118	PF00069	0.569
MOD_PKA_1	38	44	PF00069	0.426
MOD_PKA_2	164	170	PF00069	0.462
MOD_PKA_2	291	297	PF00069	0.415
MOD_PKA_2	311	317	PF00069	0.394
MOD_PKA_2	38	44	PF00069	0.426
MOD_PKA_2	62	68	PF00069	0.416
MOD_PKB_1	31	39	PF00069	0.409
MOD_Plk_1	112	118	PF00069	0.580
MOD_Plk_1	192	198	PF00069	0.452
MOD_Plk_1	236	242	PF00069	0.520
MOD_Plk_4	112	118	PF00069	0.532
MOD_Plk_4	72	78	PF00069	0.409
MOD_ProDKin_1	118	124	PF00069	0.653
MOD_ProDKin_1	206	212	PF00069	0.565
MOD_ProDKin_1	219	225	PF00069	0.559
MOD_ProDKin_1	81	87	PF00069	0.471
TRG_DiLeu_BaEn_1	113	118	PF01217	0.524
TRG_DiLeu_BaEn_1	296	301	PF01217	0.417
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.563
TRG_ENDOCYTIC_2	254	257	PF00928	0.408
TRG_ER_diArg_1	105	108	PF00400	0.658
TRG_ER_diArg_1	187	190	PF00400	0.469
TRG_ER_diArg_1	38	40	PF00400	0.434
TRG_ER_diArg_1	94	97	PF00400	0.421
TRG_NES_CRM1_1	17	30	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE8	Leptomonas seymouri	49%	96%
A4HNI4	Leishmania braziliensis	62%	100%
A4IC40	Leishmania infantum	100%	100%
E9AFZ5	Leishmania major	84%	100%
E9B748	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%