Histidine phosphatase (Branch 1) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA60_LEIDO

TriTrypDb:

LdBPK_360160.1 , LdCL_360006400 , LDHU3_36.0230

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XA60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA60

Function

Biological processes
Term	Name	Level	Count
GO:0006003	fructose 2,6-bisphosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	8	5
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0017076	purine nucleotide binding	4	12
GO:0019203	carbohydrate phosphatase activity	6	5
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050308	sugar-phosphatase activity	7	5
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003873	6-phosphofructo-2-kinase activity	6	5
GO:0008443	phosphofructokinase activity	5	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0019200	carbohydrate kinase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.508
CLV_NRD_NRD_1	132	134	PF00675	0.521
CLV_NRD_NRD_1	329	331	PF00675	0.417
CLV_NRD_NRD_1	400	402	PF00675	0.355
CLV_PCSK_KEX2_1	132	134	PF00082	0.525
CLV_PCSK_KEX2_1	329	331	PF00082	0.343
CLV_PCSK_KEX2_1	400	402	PF00082	0.356
CLV_PCSK_SKI1_1	168	172	PF00082	0.508
CLV_PCSK_SKI1_1	179	183	PF00082	0.593
CLV_PCSK_SKI1_1	209	213	PF00082	0.642
CLV_PCSK_SKI1_1	299	303	PF00082	0.390
CLV_PCSK_SKI1_1	348	352	PF00082	0.337
CLV_PCSK_SKI1_1	400	404	PF00082	0.388
CLV_PCSK_SKI1_1	426	430	PF00082	0.351
CLV_Separin_Metazoa	38	42	PF03568	0.753
DEG_APCC_DBOX_1	167	175	PF00400	0.492
DEG_SCF_FBW7_1	117	122	PF00400	0.550
DOC_CKS1_1	151	156	PF01111	0.600
DOC_CYCLIN_yCln2_LP_2	174	177	PF00134	0.506
DOC_MAPK_FxFP_2	387	390	PF00069	0.328
DOC_MAPK_gen_1	299	307	PF00069	0.398
DOC_MAPK_gen_1	378	387	PF00069	0.442
DOC_MAPK_MEF2A_6	255	262	PF00069	0.557
DOC_PP1_RVXF_1	145	151	PF00149	0.593
DOC_PP1_RVXF_1	182	189	PF00149	0.467
DOC_PP1_RVXF_1	382	388	PF00149	0.344
DOC_PP2B_LxvP_1	174	177	PF13499	0.506
DOC_PP4_FxxP_1	387	390	PF00568	0.328
DOC_USP7_MATH_1	108	112	PF00917	0.524
DOC_USP7_MATH_1	170	174	PF00917	0.523
DOC_USP7_MATH_1	177	181	PF00917	0.446
DOC_USP7_MATH_1	214	218	PF00917	0.680
DOC_USP7_MATH_1	349	353	PF00917	0.435
DOC_USP7_MATH_1	55	59	PF00917	0.722
DOC_WW_Pin1_4	115	120	PF00397	0.565
DOC_WW_Pin1_4	150	155	PF00397	0.594
DOC_WW_Pin1_4	400	405	PF00397	0.449
DOC_WW_Pin1_4	466	471	PF00397	0.612
DOC_WW_Pin1_4	66	71	PF00397	0.561
LIG_14-3-3_CanoR_1	132	142	PF00244	0.538
LIG_14-3-3_CanoR_1	196	201	PF00244	0.651
LIG_14-3-3_CanoR_1	213	222	PF00244	0.587
LIG_14-3-3_CanoR_1	264	272	PF00244	0.337
LIG_14-3-3_CanoR_1	311	315	PF00244	0.451
LIG_14-3-3_CanoR_1	329	337	PF00244	0.342
LIG_14-3-3_CanoR_1	378	387	PF00244	0.369
LIG_14-3-3_CanoR_1	426	432	PF00244	0.328
LIG_14-3-3_CanoR_1	471	478	PF00244	0.664
LIG_14-3-3_CanoR_1	80	84	PF00244	0.466
LIG_Actin_WH2_2	198	215	PF00022	0.609
LIG_BRCT_BRCA1_1	108	112	PF00533	0.498
LIG_BRCT_BRCA1_1	198	202	PF00533	0.672
LIG_CtBP_PxDLS_1	43	47	PF00389	0.772
LIG_deltaCOP1_diTrp_1	479	485	PF00928	0.626
LIG_EVH1_2	258	262	PF00568	0.413
LIG_FHA_1	225	231	PF00498	0.435
LIG_FHA_1	283	289	PF00498	0.475
LIG_FHA_1	336	342	PF00498	0.413
LIG_FHA_1	380	386	PF00498	0.385
LIG_FHA_1	401	407	PF00498	0.443
LIG_FHA_1	66	72	PF00498	0.498
LIG_FHA_1	88	94	PF00498	0.381
LIG_FHA_2	120	126	PF00498	0.593
LIG_FHA_2	158	164	PF00498	0.530
LIG_FHA_2	311	317	PF00498	0.407
LIG_FHA_2	33	39	PF00498	0.760
LIG_FHA_2	363	369	PF00498	0.349
LIG_FHA_2	471	477	PF00498	0.640
LIG_LIR_Gen_1	199	207	PF02991	0.529
LIG_LIR_Gen_1	393	402	PF02991	0.385
LIG_LIR_Nem_3	199	205	PF02991	0.540
LIG_LIR_Nem_3	236	241	PF02991	0.558
LIG_LIR_Nem_3	256	260	PF02991	0.448
LIG_LIR_Nem_3	371	376	PF02991	0.437
LIG_LIR_Nem_3	393	398	PF02991	0.328
LIG_LIR_Nem_3	90	95	PF02991	0.485
LIG_LYPXL_S_1	372	376	PF13949	0.363
LIG_LYPXL_yS_3	373	376	PF13949	0.344
LIG_OCRL_FandH_1	180	192	PF00620	0.504
LIG_PCNA_yPIPBox_3	366	380	PF02747	0.364
LIG_PCNA_yPIPBox_3	422	435	PF02747	0.449
LIG_Pex14_2	188	192	PF04695	0.480
LIG_Pex14_2	257	261	PF04695	0.436
LIG_Pex14_2	375	379	PF04695	0.434
LIG_Pex14_2	88	92	PF04695	0.493
LIG_REV1ctd_RIR_1	259	268	PF16727	0.328
LIG_REV1ctd_RIR_1	294	303	PF16727	0.321
LIG_REV1ctd_RIR_1	429	435	PF16727	0.449
LIG_REV1ctd_RIR_1	85	95	PF16727	0.396
LIG_RPA_C_Fungi	127	139	PF08784	0.530
LIG_SH2_PTP2	395	398	PF00017	0.475
LIG_SH2_STAT3	120	123	PF00017	0.638
LIG_SH2_STAT3	33	36	PF00017	0.676
LIG_SH2_STAT5	141	144	PF00017	0.507
LIG_SH2_STAT5	395	398	PF00017	0.449
LIG_SH2_STAT5	95	98	PF00017	0.403
LIG_SH3_3	148	154	PF00018	0.622
LIG_SH3_3	343	349	PF00018	0.475
LIG_SH3_3	36	42	PF00018	0.650
LIG_SH3_3	438	444	PF00018	0.344
LIG_SUMO_SIM_anti_2	153	161	PF11976	0.546
LIG_SUMO_SIM_anti_2	393	400	PF11976	0.449
LIG_TRAF2_1	365	368	PF00917	0.353
LIG_TRAF2_1	436	439	PF00917	0.363
LIG_TRAF2_1	76	79	PF00917	0.618
LIG_TRAF2_2	470	475	PF00917	0.710
LIG_UBA3_1	405	414	PF00899	0.350
LIG_WRC_WIRS_1	226	231	PF05994	0.521
LIG_WRC_WIRS_1	428	433	PF05994	0.363
MOD_CDK_SPK_2	466	471	PF00069	0.619
MOD_CK1_1	215	221	PF00069	0.595
MOD_CK1_1	224	230	PF00069	0.393
MOD_CK1_1	65	71	PF00069	0.504
MOD_CK2_1	310	316	PF00069	0.439
MOD_CK2_1	32	38	PF00069	0.738
MOD_CK2_1	349	355	PF00069	0.367
MOD_CK2_1	362	368	PF00069	0.286
MOD_CK2_1	470	476	PF00069	0.623
MOD_CK2_1	73	79	PF00069	0.608
MOD_CMANNOS	482	485	PF00535	0.579
MOD_GlcNHglycan	135	138	PF01048	0.509
MOD_GlcNHglycan	217	220	PF01048	0.647
MOD_GlcNHglycan	241	244	PF01048	0.558
MOD_GSK3_1	115	122	PF00069	0.549
MOD_GSK3_1	217	224	PF00069	0.520
MOD_GSK3_1	225	232	PF00069	0.422
MOD_GSK3_1	331	338	PF00069	0.315
MOD_GSK3_1	42	49	PF00069	0.689
MOD_GSK3_1	466	473	PF00069	0.586
MOD_GSK3_1	62	69	PF00069	0.587
MOD_N-GLC_1	65	70	PF02516	0.568
MOD_N-GLC_2	410	412	PF02516	0.449
MOD_NEK2_1	106	111	PF00069	0.460
MOD_NEK2_1	212	217	PF00069	0.575
MOD_NEK2_1	229	234	PF00069	0.430
MOD_NEK2_1	282	287	PF00069	0.449
MOD_NEK2_1	328	333	PF00069	0.322
MOD_NEK2_1	46	51	PF00069	0.709
MOD_NEK2_1	6	11	PF00069	0.592
MOD_NEK2_1	87	92	PF00069	0.432
MOD_NEK2_2	250	255	PF00069	0.488
MOD_PIKK_1	119	125	PF00454	0.559
MOD_PIKK_1	32	38	PF00454	0.666
MOD_PIKK_1	323	329	PF00454	0.328
MOD_PIKK_1	470	476	PF00454	0.676
MOD_PKA_2	123	129	PF00069	0.528
MOD_PKA_2	212	218	PF00069	0.540
MOD_PKA_2	310	316	PF00069	0.410
MOD_PKA_2	328	334	PF00069	0.230
MOD_PKA_2	379	385	PF00069	0.363
MOD_PKA_2	470	476	PF00069	0.631
MOD_PKA_2	6	12	PF00069	0.728
MOD_PKA_2	62	68	PF00069	0.646
MOD_PKA_2	79	85	PF00069	0.355
MOD_Plk_1	177	183	PF00069	0.646
MOD_Plk_1	203	209	PF00069	0.563
MOD_Plk_2-3	19	25	PF00069	0.672
MOD_Plk_2-3	391	397	PF00069	0.475
MOD_Plk_4	123	129	PF00069	0.511
MOD_Plk_4	170	176	PF00069	0.453
MOD_Plk_4	217	223	PF00069	0.549
MOD_Plk_4	225	231	PF00069	0.400
MOD_Plk_4	233	239	PF00069	0.342
MOD_Plk_4	310	316	PF00069	0.428
MOD_Plk_4	368	374	PF00069	0.398
MOD_Plk_4	391	397	PF00069	0.449
MOD_Plk_4	427	433	PF00069	0.319
MOD_ProDKin_1	115	121	PF00069	0.575
MOD_ProDKin_1	150	156	PF00069	0.588
MOD_ProDKin_1	400	406	PF00069	0.449
MOD_ProDKin_1	466	472	PF00069	0.623
MOD_ProDKin_1	66	72	PF00069	0.559
MOD_SUMO_rev_2	362	372	PF00179	0.363
TRG_DiLeu_BaEn_1	178	183	PF01217	0.633
TRG_DiLeu_BaEn_4	367	373	PF01217	0.376
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.413
TRG_ENDOCYTIC_2	200	203	PF00928	0.531
TRG_ENDOCYTIC_2	373	376	PF00928	0.344
TRG_ENDOCYTIC_2	395	398	PF00928	0.322
TRG_ER_diArg_1	328	330	PF00400	0.417
TRG_ER_diArg_1	399	401	PF00400	0.364
TRG_NES_CRM1_1	408	422	PF08389	0.300
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S9	Leptomonas seymouri	66%	100%
A0A0S4JII5	Bodo saltans	46%	74%
A0A1X0P8D4	Trypanosomatidae	52%	100%
A0A422NB33	Trypanosoma rangeli	53%	100%
A4HNM2	Leishmania braziliensis	88%	100%
A4ICX2	Leishmania infantum	100%	100%
D0A2H6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ASD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q263	Leishmania major	97%	100%
V5C004	Trypanosoma cruzi	51%	100%