Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 5

Species:

Leishmania donovani

UniProt:

A0A3S7XA59_LEIDO

TriTrypDb:

LdBPK_355250.1 , LdCL_350058300 , LDHU3_35.7010

Length:

255

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 5 (POMP5) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XA59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.403
CLV_PCSK_KEX2_1	93	95	PF00082	0.418
CLV_PCSK_SKI1_1	127	131	PF00082	0.354
CLV_PCSK_SKI1_1	139	143	PF00082	0.566
CLV_PCSK_SKI1_1	204	208	PF00082	0.406
CLV_PCSK_SKI1_1	230	234	PF00082	0.338
CLV_PCSK_SKI1_1	239	243	PF00082	0.280
DOC_ANK_TNKS_1	194	201	PF00023	0.523
DOC_CKS1_1	174	179	PF01111	0.367
DOC_CYCLIN_RxL_1	201	212	PF00134	0.370
DOC_MAPK_gen_1	202	210	PF00069	0.489
DOC_MAPK_MEF2A_6	202	210	PF00069	0.368
DOC_MAPK_RevD_3	79	94	PF00069	0.520
DOC_PP1_RVXF_1	125	131	PF00149	0.503
DOC_PP1_RVXF_1	205	211	PF00149	0.523
DOC_PP1_RVXF_1	36	43	PF00149	0.352
DOC_USP7_MATH_1	102	106	PF00917	0.395
DOC_USP7_MATH_1	163	167	PF00917	0.407
DOC_USP7_UBL2_3	127	131	PF12436	0.505
DOC_USP7_UBL2_3	145	149	PF12436	0.445
DOC_WW_Pin1_4	110	115	PF00397	0.366
DOC_WW_Pin1_4	173	178	PF00397	0.371
DOC_WW_Pin1_4	43	48	PF00397	0.365
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_BRCT_BRCA1_1	38	42	PF00533	0.345
LIG_eIF4E_1	35	41	PF01652	0.375
LIG_FHA_1	145	151	PF00498	0.523
LIG_FHA_1	8	14	PF00498	0.393
LIG_LIR_Gen_1	170	178	PF02991	0.363
LIG_LIR_Gen_1	39	48	PF02991	0.317
LIG_LIR_Gen_1	73	81	PF02991	0.367
LIG_LIR_Gen_1	85	95	PF02991	0.243
LIG_LIR_LC3C_4	10	13	PF02991	0.378
LIG_LIR_Nem_3	125	129	PF02991	0.325
LIG_LIR_Nem_3	170	174	PF02991	0.514
LIG_LIR_Nem_3	39	45	PF02991	0.330
LIG_LIR_Nem_3	73	78	PF02991	0.359
LIG_LIR_Nem_3	85	91	PF02991	0.240
LIG_PCNA_yPIPBox_3	5	16	PF02747	0.399
LIG_Pex14_2	126	130	PF04695	0.352
LIG_Pex14_2	189	193	PF04695	0.409
LIG_PTB_Apo_2	26	33	PF02174	0.377
LIG_SH2_CRK	251	255	PF00017	0.420
LIG_SH2_CRK	88	92	PF00017	0.379
LIG_SH2_SRC	251	254	PF00017	0.492
LIG_SH3_1	59	65	PF00018	0.416
LIG_SH3_3	41	47	PF00018	0.413
LIG_SH3_3	59	65	PF00018	0.430
LIG_SUMO_SIM_par_1	68	74	PF11976	0.370
LIG_TRFH_1	88	92	PF08558	0.373
LIG_WRC_WIRS_1	168	173	PF05994	0.340
MOD_CK1_1	110	116	PF00069	0.396
MOD_CK2_1	110	116	PF00069	0.555
MOD_CK2_1	209	215	PF00069	0.398
MOD_CK2_1	71	77	PF00069	0.431
MOD_GlcNHglycan	104	107	PF01048	0.318
MOD_GlcNHglycan	109	112	PF01048	0.345
MOD_GlcNHglycan	165	168	PF01048	0.343
MOD_GlcNHglycan	17	21	PF01048	0.380
MOD_GlcNHglycan	56	59	PF01048	0.563
MOD_GSK3_1	16	23	PF00069	0.342
MOD_GSK3_1	163	170	PF00069	0.363
MOD_GSK3_1	3	10	PF00069	0.443
MOD_N-GLC_1	20	25	PF02516	0.438
MOD_N-GLC_1	4	9	PF02516	0.457
MOD_NEK2_1	208	213	PF00069	0.383
MOD_NEK2_1	221	226	PF00069	0.301
MOD_NEK2_1	3	8	PF00069	0.484
MOD_NEK2_1	71	76	PF00069	0.520
MOD_NEK2_2	167	172	PF00069	0.358
MOD_PIKK_1	129	135	PF00454	0.392
MOD_PIKK_1	20	26	PF00454	0.403
MOD_PKB_1	14	22	PF00069	0.398
MOD_Plk_1	4	10	PF00069	0.444
MOD_Plk_4	150	156	PF00069	0.371
MOD_Plk_4	209	215	PF00069	0.447
MOD_Plk_4	36	42	PF00069	0.374
MOD_Plk_4	7	13	PF00069	0.395
MOD_ProDKin_1	110	116	PF00069	0.368
MOD_ProDKin_1	173	179	PF00069	0.367
MOD_ProDKin_1	43	49	PF00069	0.363
MOD_SUMO_rev_2	122	129	PF00179	0.356
MOD_SUMO_rev_2	33	40	PF00179	0.370
TRG_DiLeu_BaEn_1	36	41	PF01217	0.381
TRG_ENDOCYTIC_2	101	104	PF00928	0.318
TRG_ENDOCYTIC_2	251	254	PF00928	0.405
TRG_ENDOCYTIC_2	88	91	PF00928	0.363
TRG_ER_diArg_1	13	16	PF00400	0.360
TRG_ER_diArg_1	92	94	PF00400	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX2	Leptomonas seymouri	72%	100%
A0A0S4JR49	Bodo saltans	60%	96%
A0A1X0NWC4	Trypanosomatidae	21%	93%
A0A1X0P5U7	Trypanosomatidae	67%	100%
A0A3S5IRL1	Trypanosoma rangeli	23%	92%
A0A422N5Y6	Trypanosoma rangeli	66%	100%
A4HNI9	Leishmania braziliensis	91%	100%
A4IC46	Leishmania infantum	100%	100%
C9ZIA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	94%
C9ZYC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AG01	Leishmania major	98%	100%
E9AUM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	74%
E9B754	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BVF1	Trypanosoma cruzi	25%	93%
V5BYQ0	Trypanosoma cruzi	66%	100%