Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA57_LEIDO

TriTrypDb:

LdBPK_360120.1 , LdCL_360006000 , LDHU3_36.0180

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7XA57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.464
CLV_C14_Caspase3-7	186	190	PF00656	0.481
CLV_C14_Caspase3-7	659	663	PF00656	0.637
CLV_NRD_NRD_1	106	108	PF00675	0.550
CLV_NRD_NRD_1	134	136	PF00675	0.480
CLV_NRD_NRD_1	182	184	PF00675	0.498
CLV_NRD_NRD_1	219	221	PF00675	0.459
CLV_NRD_NRD_1	340	342	PF00675	0.521
CLV_NRD_NRD_1	347	349	PF00675	0.558
CLV_NRD_NRD_1	372	374	PF00675	0.477
CLV_NRD_NRD_1	44	46	PF00675	0.478
CLV_NRD_NRD_1	590	592	PF00675	0.558
CLV_NRD_NRD_1	616	618	PF00675	0.482
CLV_NRD_NRD_1	620	622	PF00675	0.444
CLV_PCSK_FUR_1	180	184	PF00082	0.427
CLV_PCSK_FUR_1	216	220	PF00082	0.497
CLV_PCSK_FUR_1	42	46	PF00082	0.502
CLV_PCSK_KEX2_1	106	108	PF00082	0.550
CLV_PCSK_KEX2_1	134	136	PF00082	0.480
CLV_PCSK_KEX2_1	182	184	PF00082	0.498
CLV_PCSK_KEX2_1	218	220	PF00082	0.478
CLV_PCSK_KEX2_1	256	258	PF00082	0.590
CLV_PCSK_KEX2_1	340	342	PF00082	0.477
CLV_PCSK_KEX2_1	346	348	PF00082	0.479
CLV_PCSK_KEX2_1	366	368	PF00082	0.357
CLV_PCSK_KEX2_1	372	374	PF00082	0.457
CLV_PCSK_KEX2_1	44	46	PF00082	0.486
CLV_PCSK_KEX2_1	590	592	PF00082	0.564
CLV_PCSK_KEX2_1	616	618	PF00082	0.458
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.595
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.505
CLV_PCSK_SKI1_1	107	111	PF00082	0.543
CLV_PCSK_SKI1_1	15	19	PF00082	0.652
CLV_PCSK_SKI1_1	165	169	PF00082	0.461
CLV_PCSK_SKI1_1	305	309	PF00082	0.584
CLV_PCSK_SKI1_1	320	324	PF00082	0.395
CLV_PCSK_SKI1_1	513	517	PF00082	0.595
CLV_PCSK_SKI1_1	576	580	PF00082	0.582
CLV_PCSK_SKI1_1	590	594	PF00082	0.423
DEG_APCC_DBOX_1	14	22	PF00400	0.628
DEG_APCC_DBOX_1	164	172	PF00400	0.567
DEG_APCC_DBOX_1	347	355	PF00400	0.499
DEG_APCC_DBOX_1	562	570	PF00400	0.561
DEG_APCC_DBOX_1	639	647	PF00400	0.545
DEG_MDM2_SWIB_1	311	318	PF02201	0.537
DEG_SPOP_SBC_1	21	25	PF00917	0.573
DOC_CYCLIN_RxL_1	142	153	PF00134	0.531
DOC_MAPK_gen_1	180	187	PF00069	0.493
DOC_MAPK_gen_1	256	262	PF00069	0.570
DOC_MAPK_gen_1	471	479	PF00069	0.486
DOC_MAPK_gen_1	491	499	PF00069	0.397
DOC_MAPK_gen_1	616	627	PF00069	0.439
DOC_MAPK_MEF2A_6	234	242	PF00069	0.449
DOC_MAPK_MEF2A_6	471	479	PF00069	0.559
DOC_MAPK_MEF2A_6	491	499	PF00069	0.374
DOC_MAPK_MEF2A_6	830	839	PF00069	0.573
DOC_MAPK_RevD_3	335	348	PF00069	0.475
DOC_PP1_RVXF_1	217	224	PF00149	0.567
DOC_PP1_RVXF_1	35	42	PF00149	0.626
DOC_PP1_RVXF_1	779	786	PF00149	0.656
DOC_PP2B_LxvP_1	835	838	PF13499	0.524
DOC_PP4_FxxP_1	6	9	PF00568	0.500
DOC_PP4_FxxP_1	785	788	PF00568	0.572
DOC_USP7_MATH_1	152	156	PF00917	0.576
DOC_USP7_MATH_1	58	62	PF00917	0.484
DOC_USP7_MATH_1	580	584	PF00917	0.571
DOC_USP7_MATH_1	639	643	PF00917	0.603
DOC_USP7_MATH_1	7	11	PF00917	0.505
DOC_USP7_MATH_1	725	729	PF00917	0.594
DOC_USP7_MATH_1	829	833	PF00917	0.567
DOC_USP7_MATH_1	838	842	PF00917	0.504
DOC_USP7_UBL2_3	320	324	PF12436	0.452
DOC_USP7_UBL2_3	618	622	PF12436	0.506
DOC_WW_Pin1_4	634	639	PF00397	0.646
LIG_14-3-3_CanoR_1	134	138	PF00244	0.499
LIG_14-3-3_CanoR_1	234	239	PF00244	0.546
LIG_14-3-3_CanoR_1	267	275	PF00244	0.531
LIG_14-3-3_CanoR_1	291	297	PF00244	0.509
LIG_14-3-3_CanoR_1	372	376	PF00244	0.441
LIG_14-3-3_CanoR_1	413	417	PF00244	0.580
LIG_14-3-3_CanoR_1	513	521	PF00244	0.482
LIG_14-3-3_CanoR_1	536	542	PF00244	0.601
LIG_14-3-3_CanoR_1	576	585	PF00244	0.539
LIG_14-3-3_CanoR_1	591	601	PF00244	0.454
LIG_14-3-3_CanoR_1	645	653	PF00244	0.626
LIG_14-3-3_CanoR_1	679	688	PF00244	0.516
LIG_14-3-3_CanoR_1	781	786	PF00244	0.654
LIG_Actin_WH2_2	279	295	PF00022	0.499
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	2	6	PF00533	0.517
LIG_BRCT_BRCA1_1	629	633	PF00533	0.488
LIG_CaM_IQ_9	477	493	PF13499	0.460
LIG_Clathr_ClatBox_1	496	500	PF01394	0.529
LIG_Clathr_ClatBox_1	566	570	PF01394	0.563
LIG_deltaCOP1_diTrp_1	610	614	PF00928	0.494
LIG_deltaCOP1_diTrp_1	651	660	PF00928	0.553
LIG_eIF4E_1	698	704	PF01652	0.521
LIG_FHA_1	268	274	PF00498	0.473
LIG_FHA_1	360	366	PF00498	0.488
LIG_FHA_1	515	521	PF00498	0.520
LIG_FHA_1	577	583	PF00498	0.513
LIG_FHA_1	77	83	PF00498	0.494
LIG_FHA_1	791	797	PF00498	0.666
LIG_FHA_1	820	826	PF00498	0.584
LIG_FHA_2	158	164	PF00498	0.484
LIG_FHA_2	293	299	PF00498	0.527
LIG_FHA_2	538	544	PF00498	0.485
LIG_LIR_Apic_2	3	9	PF02991	0.597
LIG_LIR_Apic_2	782	788	PF02991	0.574
LIG_LIR_Gen_1	472	480	PF02991	0.606
LIG_LIR_Gen_1	683	693	PF02991	0.562
LIG_LIR_Gen_1	711	716	PF02991	0.620
LIG_LIR_Nem_3	110	116	PF02991	0.504
LIG_LIR_Nem_3	143	148	PF02991	0.550
LIG_LIR_Nem_3	302	307	PF02991	0.419
LIG_LIR_Nem_3	329	335	PF02991	0.531
LIG_LIR_Nem_3	472	477	PF02991	0.531
LIG_LIR_Nem_3	650	656	PF02991	0.714
LIG_LIR_Nem_3	683	688	PF02991	0.570
LIG_LIR_Nem_3	711	715	PF02991	0.543
LIG_MYND_1	28	32	PF01753	0.603
LIG_NRBOX	239	245	PF00104	0.491
LIG_NRBOX	350	356	PF00104	0.496
LIG_OCRL_FandH_1	120	132	PF00620	0.458
LIG_PCNA_PIPBox_1	198	207	PF02747	0.515
LIG_Pex14_1	315	319	PF04695	0.458
LIG_Pex14_2	311	315	PF04695	0.538
LIG_Pex14_2	763	767	PF04695	0.571
LIG_PTB_Apo_2	80	87	PF02174	0.583
LIG_PTB_Phospho_1	80	86	PF10480	0.581
LIG_Rb_LxCxE_1	133	153	PF01857	0.550
LIG_Rb_LxCxE_1	279	300	PF01857	0.468
LIG_Rb_LxCxE_1	446	464	PF01857	0.509
LIG_Rb_LxCxE_1	48	65	PF01857	0.476
LIG_RPA_C_Fungi	336	348	PF08784	0.544
LIG_SH2_CRK	319	323	PF00017	0.471
LIG_SH2_CRK	685	689	PF00017	0.569
LIG_SH2_PTP2	474	477	PF00017	0.673
LIG_SH2_SRC	474	477	PF00017	0.455
LIG_SH2_STAP1	236	240	PF00017	0.470
LIG_SH2_STAT5	379	382	PF00017	0.546
LIG_SH2_STAT5	443	446	PF00017	0.551
LIG_SH2_STAT5	474	477	PF00017	0.516
LIG_SH2_STAT5	698	701	PF00017	0.527
LIG_SH3_2	32	37	PF14604	0.562
LIG_SH3_3	114	120	PF00018	0.562
LIG_SH3_3	28	34	PF00018	0.587
LIG_SH3_3	635	641	PF00018	0.587
LIG_SH3_3	762	768	PF00018	0.646
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.418
LIG_SUMO_SIM_par_1	183	189	PF11976	0.538
LIG_SUMO_SIM_par_1	240	246	PF11976	0.468
LIG_SUMO_SIM_par_1	258	264	PF11976	0.623
LIG_SUMO_SIM_par_1	415	421	PF11976	0.535
LIG_SUMO_SIM_par_1	495	502	PF11976	0.531
LIG_TRAF2_1	170	173	PF00917	0.568
LIG_TRAF2_1	295	298	PF00917	0.512
LIG_TRAF2_1	387	390	PF00917	0.554
LIG_TRAF2_1	418	421	PF00917	0.588
LIG_TRAF2_1	460	463	PF00917	0.561
LIG_TRAF2_1	540	543	PF00917	0.508
LIG_WRC_WIRS_1	59	64	PF05994	0.418
MOD_CDC14_SPxK_1	637	640	PF00782	0.530
MOD_CDK_SPxK_1	634	640	PF00069	0.520
MOD_CK1_1	326	332	PF00069	0.490
MOD_CK1_1	519	525	PF00069	0.537
MOD_CK1_1	644	650	PF00069	0.574
MOD_CK1_1	720	726	PF00069	0.563
MOD_CK1_1	759	765	PF00069	0.645
MOD_CK2_1	172	178	PF00069	0.533
MOD_CK2_1	292	298	PF00069	0.525
MOD_CK2_1	384	390	PF00069	0.556
MOD_CK2_1	526	532	PF00069	0.531
MOD_CK2_1	537	543	PF00069	0.430
MOD_CK2_1	57	63	PF00069	0.451
MOD_CK2_1	580	586	PF00069	0.573
MOD_CK2_1	592	598	PF00069	0.536
MOD_CK2_1	721	727	PF00069	0.629
MOD_GlcNHglycan	152	155	PF01048	0.499
MOD_GlcNHglycan	500	504	PF01048	0.574
MOD_GlcNHglycan	582	585	PF01048	0.571
MOD_GlcNHglycan	595	598	PF01048	0.428
MOD_GlcNHglycan	723	726	PF01048	0.600
MOD_GlcNHglycan	727	731	PF01048	0.560
MOD_GlcNHglycan	831	834	PF01048	0.612
MOD_GSK3_1	22	29	PF00069	0.647
MOD_GSK3_1	323	330	PF00069	0.545
MOD_GSK3_1	576	583	PF00069	0.685
MOD_GSK3_1	627	634	PF00069	0.591
MOD_GSK3_1	662	669	PF00069	0.642
MOD_GSK3_1	680	687	PF00069	0.437
MOD_GSK3_1	716	723	PF00069	0.595
MOD_GSK3_1	72	79	PF00069	0.570
MOD_GSK3_1	759	766	PF00069	0.590
MOD_N-GLC_1	759	764	PF02516	0.596
MOD_NEK2_1	150	155	PF00069	0.536
MOD_NEK2_1	22	27	PF00069	0.615
MOD_NEK2_1	516	521	PF00069	0.556
MOD_NEK2_1	592	597	PF00069	0.528
MOD_NEK2_1	631	636	PF00069	0.585
MOD_NEK2_1	716	721	PF00069	0.512
MOD_NEK2_1	72	77	PF00069	0.454
MOD_NEK2_1	763	768	PF00069	0.621
MOD_NEK2_2	680	685	PF00069	0.618
MOD_PIKK_1	22	28	PF00454	0.590
MOD_PIKK_1	267	273	PF00454	0.515
MOD_PIKK_1	305	311	PF00454	0.543
MOD_PIKK_1	767	773	PF00454	0.566
MOD_PK_1	616	622	PF00069	0.488
MOD_PK_1	750	756	PF00069	0.547
MOD_PKA_1	616	622	PF00069	0.488
MOD_PKA_2	133	139	PF00069	0.496
MOD_PKA_2	150	156	PF00069	0.646
MOD_PKA_2	266	272	PF00069	0.517
MOD_PKA_2	292	298	PF00069	0.510
MOD_PKA_2	371	377	PF00069	0.440
MOD_PKA_2	412	418	PF00069	0.580
MOD_PKA_2	537	543	PF00069	0.642
MOD_PKA_2	616	622	PF00069	0.512
MOD_PKA_2	639	645	PF00069	0.577
MOD_PKA_2	678	684	PF00069	0.523
MOD_PKA_2	7	13	PF00069	0.597
MOD_PKA_2	798	804	PF00069	0.626
MOD_Plk_1	140	146	PF00069	0.508
MOD_Plk_1	326	332	PF00069	0.490
MOD_Plk_1	726	732	PF00069	0.643
MOD_Plk_1	759	765	PF00069	0.588
MOD_Plk_1	779	785	PF00069	0.450
MOD_Plk_4	26	32	PF00069	0.597
MOD_Plk_4	327	333	PF00069	0.607
MOD_Plk_4	350	356	PF00069	0.604
MOD_Plk_4	412	418	PF00069	0.592
MOD_Plk_4	505	511	PF00069	0.524
MOD_Plk_4	516	522	PF00069	0.497
MOD_Plk_4	813	819	PF00069	0.520
MOD_ProDKin_1	634	640	PF00069	0.650
MOD_SUMO_rev_2	48	53	PF00179	0.526
TRG_DiLeu_BaEn_1	350	355	PF01217	0.544
TRG_DiLeu_BaEn_1	546	551	PF01217	0.515
TRG_DiLeu_BaEn_1	598	603	PF01217	0.518
TRG_DiLeu_BaEn_1	65	70	PF01217	0.530
TRG_DiLeu_BaEn_1	94	99	PF01217	0.515
TRG_DiLeu_BaEn_4	462	468	PF01217	0.560
TRG_DiLeu_BaEn_4	48	54	PF01217	0.531
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.572
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.449
TRG_ENDOCYTIC_2	319	322	PF00928	0.469
TRG_ENDOCYTIC_2	474	477	PF00928	0.631
TRG_ENDOCYTIC_2	685	688	PF00928	0.570
TRG_ER_diArg_1	179	182	PF00400	0.491
TRG_ER_diArg_1	216	219	PF00400	0.575
TRG_ER_diArg_1	291	294	PF00400	0.598
TRG_ER_diArg_1	339	341	PF00400	0.471
TRG_ER_diArg_1	346	348	PF00400	0.479
TRG_ER_diArg_1	41	44	PF00400	0.520
TRG_ER_diArg_1	456	459	PF00400	0.598
TRG_ER_diArg_1	535	538	PF00400	0.581
TRG_ER_diArg_1	590	592	PF00400	0.588
TRG_NES_CRM1_1	233	246	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	219	224	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC9	Leptomonas seymouri	43%	100%
A4HNL8	Leishmania braziliensis	72%	100%
A4ICX6	Leishmania infantum	99%	100%
E9ASC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q267	Leishmania major	90%	100%