IQ calmodulin-binding motif protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA50_LEIDO

TriTrypDb:

LdBPK_355100.1 , LdCL_350056700 , LDHU3_35.6790

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.465
CLV_NRD_NRD_1	245	247	PF00675	0.583
CLV_NRD_NRD_1	46	48	PF00675	0.642
CLV_PCSK_FUR_1	243	247	PF00082	0.600
CLV_PCSK_KEX2_1	170	172	PF00082	0.505
CLV_PCSK_KEX2_1	245	247	PF00082	0.591
CLV_PCSK_KEX2_1	46	48	PF00082	0.642
CLV_PCSK_SKI1_1	170	174	PF00082	0.475
CLV_PCSK_SKI1_1	180	184	PF00082	0.446
CLV_PCSK_SKI1_1	20	24	PF00082	0.644
DEG_Nend_UBRbox_2	1	3	PF02207	0.670
DEG_SPOP_SBC_1	205	209	PF00917	0.633
DEG_SPOP_SBC_1	339	343	PF00917	0.574
DOC_CYCLIN_RxL_1	167	177	PF00134	0.399
DOC_CYCLIN_RxL_1	308	319	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.712
DOC_MAPK_gen_1	185	193	PF00069	0.547
DOC_MAPK_MEF2A_6	188	195	PF00069	0.485
DOC_PP1_RVXF_1	171	177	PF00149	0.555
DOC_PP1_RVXF_1	18	25	PF00149	0.587
DOC_PP1_RVXF_1	309	316	PF00149	0.480
DOC_USP7_MATH_1	119	123	PF00917	0.734
DOC_USP7_MATH_1	222	226	PF00917	0.623
DOC_USP7_MATH_1	241	245	PF00917	0.355
DOC_USP7_MATH_1	283	287	PF00917	0.657
DOC_USP7_MATH_1	294	298	PF00917	0.513
DOC_USP7_MATH_1	328	332	PF00917	0.613
DOC_WW_Pin1_4	127	132	PF00397	0.715
DOC_WW_Pin1_4	290	295	PF00397	0.713
DOC_WW_Pin1_4	348	353	PF00397	0.748
LIG_14-3-3_CanoR_1	206	211	PF00244	0.669
LIG_14-3-3_CanoR_1	223	227	PF00244	0.496
LIG_BRCT_BRCA1_1	267	271	PF00533	0.665
LIG_CaM_IQ_9	232	248	PF13499	0.488
LIG_FHA_1	122	128	PF00498	0.770
LIG_FHA_1	135	141	PF00498	0.690
LIG_FHA_1	216	222	PF00498	0.504
LIG_FHA_1	226	232	PF00498	0.415
LIG_FHA_1	341	347	PF00498	0.576
LIG_FHA_1	74	80	PF00498	0.622
LIG_LIR_Apic_2	289	294	PF02991	0.707
LIG_LIR_Gen_1	21	31	PF02991	0.627
LIG_LIR_Nem_3	21	27	PF02991	0.627
LIG_MYND_1	257	261	PF01753	0.653
LIG_PCNA_yPIPBox_3	295	309	PF02747	0.615
LIG_Pex14_2	194	198	PF04695	0.522
LIG_Pex14_2	238	242	PF04695	0.591
LIG_SH2_NCK_1	276	280	PF00017	0.671
LIG_SH2_PTP2	291	294	PF00017	0.631
LIG_SH2_STAP1	56	60	PF00017	0.701
LIG_SH2_STAT5	291	294	PF00017	0.708
LIG_SH2_STAT5	301	304	PF00017	0.589
LIG_SH2_STAT5	314	317	PF00017	0.406
LIG_SH3_3	2	8	PF00018	0.749
LIG_SH3_3	251	257	PF00018	0.673
LIG_SH3_3	346	352	PF00018	0.652
LIG_TRAF2_1	264	267	PF00917	0.644
LIG_WRC_WIRS_1	195	200	PF05994	0.580
MOD_CDK_SPxxK_3	348	355	PF00069	0.694
MOD_CK1_1	121	127	PF00069	0.666
MOD_CK1_1	133	139	PF00069	0.664
MOD_CK1_1	225	231	PF00069	0.529
MOD_CK1_1	274	280	PF00069	0.620
MOD_CK1_1	290	296	PF00069	0.654
MOD_CK1_1	324	330	PF00069	0.629
MOD_CK1_1	333	339	PF00069	0.561
MOD_CK1_1	341	347	PF00069	0.421
MOD_CK1_1	351	357	PF00069	0.560
MOD_CK1_1	360	366	PF00069	0.508
MOD_CK1_1	40	46	PF00069	0.694
MOD_CK2_1	283	289	PF00069	0.694
MOD_CK2_1	38	44	PF00069	0.677
MOD_DYRK1A_RPxSP_1	348	352	PF00069	0.671
MOD_GlcNHglycan	155	158	PF01048	0.604
MOD_GlcNHglycan	277	280	PF01048	0.683
MOD_GlcNHglycan	326	329	PF01048	0.663
MOD_GlcNHglycan	330	333	PF01048	0.620
MOD_GSK3_1	129	136	PF00069	0.723
MOD_GSK3_1	153	160	PF00069	0.650
MOD_GSK3_1	200	207	PF00069	0.642
MOD_GSK3_1	227	234	PF00069	0.464
MOD_GSK3_1	271	278	PF00069	0.673
MOD_GSK3_1	283	290	PF00069	0.541
MOD_GSK3_1	324	331	PF00069	0.590
MOD_GSK3_1	338	345	PF00069	0.527
MOD_GSK3_1	347	354	PF00069	0.627
MOD_GSK3_1	360	367	PF00069	0.540
MOD_GSK3_1	60	67	PF00069	0.756
MOD_N-GLC_1	287	292	PF02516	0.679
MOD_N-GLC_1	294	299	PF02516	0.495
MOD_NEK2_1	194	199	PF00069	0.581
MOD_NEK2_1	204	209	PF00069	0.672
MOD_NEK2_1	215	220	PF00069	0.548
MOD_NEK2_1	231	236	PF00069	0.404
MOD_NEK2_1	271	276	PF00069	0.688
MOD_NEK2_1	338	343	PF00069	0.594
MOD_NEK2_1	75	80	PF00069	0.680
MOD_NEK2_1	9	14	PF00069	0.731
MOD_PK_1	206	212	PF00069	0.628
MOD_PKA_2	200	206	PF00069	0.665
MOD_PKA_2	222	228	PF00069	0.643
MOD_PKA_2	347	353	PF00069	0.761
MOD_PKB_1	62	70	PF00069	0.779
MOD_Plk_1	20	26	PF00069	0.666
MOD_Plk_1	283	289	PF00069	0.705
MOD_Plk_1	294	300	PF00069	0.541
MOD_Plk_1	305	311	PF00069	0.430
MOD_Plk_1	333	339	PF00069	0.659
MOD_Plk_1	357	363	PF00069	0.703
MOD_Plk_4	143	149	PF00069	0.723
MOD_Plk_4	194	200	PF00069	0.518
MOD_Plk_4	222	228	PF00069	0.509
MOD_Plk_4	271	277	PF00069	0.757
MOD_Plk_4	287	293	PF00069	0.551
MOD_Plk_4	333	339	PF00069	0.718
MOD_ProDKin_1	127	133	PF00069	0.714
MOD_ProDKin_1	290	296	PF00069	0.715
MOD_ProDKin_1	348	354	PF00069	0.747
MOD_SUMO_for_1	172	175	PF00179	0.486
MOD_SUMO_rev_2	84	92	PF00179	0.761
TRG_ER_diArg_1	170	172	PF00400	0.509
TRG_ER_diArg_1	242	245	PF00400	0.562
TRG_ER_diArg_1	97	100	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I004	Leptomonas seymouri	42%	96%
A0A1X0P4S3	Trypanosomatidae	32%	100%
A4HNH5	Leishmania braziliensis	60%	98%
A4IC31	Leishmania infantum	99%	100%
C9ZYD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFY6	Leishmania major	93%	100%
E9B739	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BTY5	Trypanosoma cruzi	27%	100%