Lsm12_protein_putative/GeneDB:LmjF.35.5290

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p21 antigen protein

Species:

Leishmania donovani

UniProt:

A0A3S7XA44_LEIDO

TriTrypDb:

LdBPK_355260.1 , LdCL_350058400 , LDHU3_35.7020

Length:

191

Annotations

Annotations by Jardim et al.

Membrane associated proteins, p21 antigen

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	164	168	PF00082	0.669
CLV_PCSK_SKI1_1	91	95	PF00082	0.669
DOC_CKS1_1	160	165	PF01111	0.630
DOC_CKS1_1	53	58	PF01111	0.601
DOC_MAPK_MEF2A_6	34	43	PF00069	0.621
DOC_USP7_MATH_1	75	79	PF00917	0.738
DOC_USP7_UBL2_3	91	95	PF12436	0.752
DOC_WW_Pin1_4	116	121	PF00397	0.569
DOC_WW_Pin1_4	159	164	PF00397	0.586
DOC_WW_Pin1_4	52	57	PF00397	0.592
LIG_APCC_ABBA_1	133	138	PF00400	0.626
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BIR_III_4	8	12	PF00653	0.675
LIG_eIF4E_1	13	19	PF01652	0.642
LIG_FHA_1	13	19	PF00498	0.608
LIG_FHA_1	149	155	PF00498	0.632
LIG_FHA_1	53	59	PF00498	0.549
LIG_FHA_2	15	21	PF00498	0.590
LIG_GBD_Chelix_1	178	186	PF00786	0.622
LIG_LIR_Apic_2	157	163	PF02991	0.580
LIG_LIR_Gen_1	109	120	PF02991	0.714
LIG_LIR_Gen_1	125	135	PF02991	0.636
LIG_LIR_Gen_1	77	87	PF02991	0.787
LIG_LIR_Nem_3	109	115	PF02991	0.712
LIG_LIR_Nem_3	125	130	PF02991	0.428
LIG_LIR_Nem_3	77	82	PF02991	0.789
LIG_LYPXL_S_1	133	137	PF13949	0.552
LIG_LYPXL_yS_3	134	137	PF13949	0.545
LIG_SH2_CRK	13	17	PF00017	0.661
LIG_SH2_STAT5	127	130	PF00017	0.590
LIG_SH2_STAT5	57	60	PF00017	0.682
LIG_SH3_3	152	158	PF00018	0.609
LIG_SUMO_SIM_anti_2	149	157	PF11976	0.602
LIG_SUMO_SIM_anti_2	15	22	PF11976	0.647
LIG_SUMO_SIM_anti_2	35	42	PF11976	0.531
LIG_SUMO_SIM_par_1	14	22	PF11976	0.569
LIG_SUMO_SIM_par_1	149	157	PF11976	0.602
LIG_SUMO_SIM_par_1	35	42	PF11976	0.630
LIG_WRC_WIRS_1	76	81	PF05994	0.791
MOD_CDK_SPK_2	159	164	PF00069	0.678
MOD_CDK_SPxxK_3	52	59	PF00069	0.592
MOD_CK1_1	114	120	PF00069	0.700
MOD_CK2_1	19	25	PF00069	0.678
MOD_CK2_1	61	67	PF00069	0.670
MOD_CK2_1	75	81	PF00069	0.632
MOD_Cter_Amidation	188	191	PF01082	0.803
MOD_GSK3_1	116	123	PF00069	0.671
MOD_NEK2_1	14	19	PF00069	0.633
MOD_NEK2_1	61	66	PF00069	0.682
MOD_PIKK_1	96	102	PF00454	0.686
MOD_PK_1	59	65	PF00069	0.679
MOD_PK_1	89	95	PF00069	0.766
MOD_Plk_1	59	65	PF00069	0.653
MOD_Plk_1	89	95	PF00069	0.661
MOD_Plk_2-3	138	144	PF00069	0.600
MOD_Plk_4	14	20	PF00069	0.573
MOD_Plk_4	148	154	PF00069	0.629
MOD_Plk_4	24	30	PF00069	0.442
MOD_Plk_4	89	95	PF00069	0.764
MOD_ProDKin_1	116	122	PF00069	0.560
MOD_ProDKin_1	159	165	PF00069	0.580
MOD_ProDKin_1	52	58	PF00069	0.588
MOD_SUMO_rev_2	20	24	PF00179	0.686
TRG_DiLeu_BaEn_4	67	73	PF01217	0.762
TRG_ENDOCYTIC_2	127	130	PF00928	0.544
TRG_ENDOCYTIC_2	13	16	PF00928	0.629
TRG_ENDOCYTIC_2	134	137	PF00928	0.515
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ22	Leptomonas seymouri	80%	100%
A0A0S4JPM5	Bodo saltans	35%	99%
A0A1X0P513	Trypanosomatidae	44%	100%
A0A422N5Z2	Trypanosoma rangeli	45%	100%
A4HNJ0	Leishmania braziliensis	93%	100%
A4IC47	Leishmania infantum	100%	100%
C9ZYC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B755	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q38E83	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	45%	100%
Q9U8C2	Leishmania major	97%	100%