LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XA39_LEIDO
TriTrypDb:
LdBPK_355390.1 , LdCL_350056200 , LDHU3_35.6720
Length:
168

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA39

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 108 112 PF00082 0.582
CLV_PCSK_SKI1_1 55 59 PF00082 0.588
CLV_PCSK_SKI1_1 67 71 PF00082 0.566
DOC_MAPK_MEF2A_6 124 132 PF00069 0.665
DOC_PP1_RVXF_1 65 71 PF00149 0.661
DOC_USP7_MATH_1 100 104 PF00917 0.653
DOC_USP7_MATH_2 100 106 PF00917 0.641
DOC_USP7_UBL2_3 108 112 PF12436 0.655
LIG_14-3-3_CanoR_1 78 84 PF00244 0.697
LIG_BIR_II_1 1 5 PF00653 0.656
LIG_BRCT_BRCA1_1 76 80 PF00533 0.687
LIG_Clathr_ClatBox_1 131 135 PF01394 0.674
LIG_deltaCOP1_diTrp_1 85 89 PF00928 0.665
LIG_FHA_1 162 168 PF00498 0.596
LIG_FHA_2 47 53 PF00498 0.652
LIG_FHA_2 80 86 PF00498 0.548
LIG_LIR_Gen_1 85 92 PF02991 0.595
LIG_LIR_Nem_3 135 141 PF02991 0.586
LIG_LIR_Nem_3 157 161 PF02991 0.692
LIG_LIR_Nem_3 51 57 PF02991 0.584
LIG_LIR_Nem_3 77 83 PF02991 0.555
LIG_LIR_Nem_3 85 89 PF02991 0.525
LIG_REV1ctd_RIR_1 108 116 PF16727 0.608
LIG_SH2_CRK 158 162 PF00017 0.662
LIG_SH2_NCK_1 143 147 PF00017 0.642
LIG_SH2_STAP1 115 119 PF00017 0.618
LIG_SH2_STAT5 141 144 PF00017 0.616
LIG_SH2_STAT5 38 41 PF00017 0.592
LIG_SUMO_SIM_anti_2 5 15 PF11976 0.595
LIG_SUMO_SIM_par_1 127 133 PF11976 0.644
LIG_TRAF2_1 88 91 PF00917 0.723
MOD_CK1_1 2 8 PF00069 0.715
MOD_CK2_1 3 9 PF00069 0.671
MOD_CK2_1 46 52 PF00069 0.652
MOD_CK2_1 79 85 PF00069 0.651
MOD_GlcNHglycan 104 107 PF01048 0.658
MOD_GlcNHglycan 118 122 PF01048 0.674
MOD_GSK3_1 90 97 PF00069 0.703
MOD_N-GLC_1 34 39 PF02516 0.684
MOD_NEK2_1 161 166 PF00069 0.659
MOD_PKA_2 94 100 PF00069 0.709
MOD_Plk_1 34 40 PF00069 0.688
MOD_Plk_2-3 3 9 PF00069 0.677
MOD_Plk_2-3 94 100 PF00069 0.768
MOD_SUMO_for_1 111 114 PF00179 0.604
TRG_DiLeu_BaEn_1 157 162 PF01217 0.706
TRG_ENDOCYTIC_2 143 146 PF00928 0.645
TRG_ENDOCYTIC_2 158 161 PF00928 0.670

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC25 Leptomonas seymouri 76% 100%
A0A0S4JSV4 Bodo saltans 50% 99%
A0A1X0P4T8 Trypanosomatidae 56% 93%
A0A422ND44 Trypanosoma rangeli 51% 100%
A0A6L0Y1J4 Leishmania infantum 100% 100%
A4HNG9 Leishmania braziliensis 92% 100%
C9ZYE3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AFY0 Leishmania major 99% 100%
E9B733 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS