Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA38_LEIDO

TriTrypDb:

LdBPK_355270.1 , LdCL_350058500 , LDHU3_35.7030

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XA38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.641
CLV_NRD_NRD_1	232	234	PF00675	0.565
CLV_NRD_NRD_1	253	255	PF00675	0.599
CLV_PCSK_FUR_1	251	255	PF00082	0.635
CLV_PCSK_KEX2_1	114	116	PF00082	0.626
CLV_PCSK_KEX2_1	251	253	PF00082	0.546
CLV_PCSK_KEX2_1	264	266	PF00082	0.319
CLV_PCSK_KEX2_1	63	65	PF00082	0.580
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.648
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.662
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.652
CLV_PCSK_PC7_1	110	116	PF00082	0.643
CLV_PCSK_SKI1_1	2	6	PF00082	0.650
CLV_PCSK_SKI1_1	79	83	PF00082	0.521
DEG_Nend_UBRbox_1	1	4	PF02207	0.717
DOC_CKS1_1	109	114	PF01111	0.601
DOC_PP2B_LxvP_1	55	58	PF13499	0.537
DOC_USP7_MATH_1	147	151	PF00917	0.595
DOC_USP7_MATH_1	176	180	PF00917	0.631
DOC_USP7_UBL2_3	287	291	PF12436	0.652
DOC_WW_Pin1_4	108	113	PF00397	0.583
DOC_WW_Pin1_4	245	250	PF00397	0.531
DOC_WW_Pin1_4	305	310	PF00397	0.691
DOC_WW_Pin1_4	311	316	PF00397	0.771
LIG_14-3-3_CanoR_1	115	125	PF00244	0.671
LIG_14-3-3_CanoR_1	238	245	PF00244	0.592
LIG_14-3-3_CanoR_1	251	257	PF00244	0.616
LIG_BRCT_BRCA1_1	25	29	PF00533	0.499
LIG_CSL_BTD_1	246	249	PF09270	0.515
LIG_deltaCOP1_diTrp_1	156	160	PF00928	0.526
LIG_eIF4E_1	220	226	PF01652	0.472
LIG_FHA_1	134	140	PF00498	0.436
LIG_FHA_1	237	243	PF00498	0.676
LIG_FHA_1	305	311	PF00498	0.691
LIG_FHA_2	191	197	PF00498	0.730
LIG_FHA_2	225	231	PF00498	0.577
LIG_FHA_2	257	263	PF00498	0.542
LIG_FHA_2	66	72	PF00498	0.476
LIG_IRF3_LxIS_1	42	49	PF10401	0.473
LIG_LIR_Gen_1	15	24	PF02991	0.435
LIG_LIR_Gen_1	223	231	PF02991	0.577
LIG_LIR_Gen_1	26	33	PF02991	0.461
LIG_LIR_Gen_1	89	99	PF02991	0.497
LIG_LIR_Nem_3	15	19	PF02991	0.446
LIG_LIR_Nem_3	156	161	PF02991	0.460
LIG_LIR_Nem_3	223	229	PF02991	0.567
LIG_LIR_Nem_3	246	250	PF02991	0.501
LIG_LIR_Nem_3	289	293	PF02991	0.589
LIG_LIR_Nem_3	294	299	PF02991	0.605
LIG_LIR_Nem_3	41	47	PF02991	0.471
LIG_LIR_Nem_3	89	94	PF02991	0.507
LIG_NRBOX	224	230	PF00104	0.448
LIG_PDZ_Class_1	311	316	PF00595	0.678
LIG_Pex14_2	91	95	PF04695	0.504
LIG_SH2_CRK	126	130	PF00017	0.568
LIG_SH2_PTP2	128	131	PF00017	0.560
LIG_SH2_SRC	128	131	PF00017	0.439
LIG_SH2_STAP1	135	139	PF00017	0.424
LIG_SH2_STAT3	258	261	PF00017	0.666
LIG_SH2_STAT5	128	131	PF00017	0.467
LIG_SH2_STAT5	135	138	PF00017	0.427
LIG_SH2_STAT5	161	164	PF00017	0.432
LIG_SH2_STAT5	220	223	PF00017	0.473
LIG_SH2_STAT5	258	261	PF00017	0.631
LIG_SH2_STAT5	44	47	PF00017	0.462
LIG_SH2_STAT5	77	80	PF00017	0.643
LIG_SH3_2	58	63	PF14604	0.569
LIG_SH3_3	55	61	PF00018	0.528
LIG_SUMO_SIM_par_1	134	141	PF11976	0.450
LIG_TRAF2_1	259	262	PF00917	0.553
LIG_UBA3_1	105	114	PF00899	0.623
LIG_UBA3_1	225	234	PF00899	0.558
MOD_CDK_SPK_2	108	113	PF00069	0.583
MOD_CDK_SPxK_1	108	114	PF00069	0.595
MOD_CDK_SPxK_1	245	251	PF00069	0.528
MOD_CDK_SPxxK_3	108	115	PF00069	0.602
MOD_CDK_SPxxK_3	245	252	PF00069	0.510
MOD_CK1_1	138	144	PF00069	0.444
MOD_CK1_1	165	171	PF00069	0.470
MOD_CK1_1	17	23	PF00069	0.551
MOD_CK1_1	179	185	PF00069	0.466
MOD_CK1_1	200	206	PF00069	0.765
MOD_CK1_1	277	283	PF00069	0.621
MOD_CK1_1	308	314	PF00069	0.693
MOD_CK1_1	38	44	PF00069	0.530
MOD_CK2_1	190	196	PF00069	0.673
MOD_CK2_1	224	230	PF00069	0.569
MOD_CK2_1	256	262	PF00069	0.553
MOD_GlcNHglycan	131	134	PF01048	0.468
MOD_GlcNHglycan	178	181	PF01048	0.566
MOD_GlcNHglycan	19	22	PF01048	0.509
MOD_GlcNHglycan	202	205	PF01048	0.757
MOD_GlcNHglycan	207	210	PF01048	0.649
MOD_GlcNHglycan	310	313	PF01048	0.674
MOD_GlcNHglycan	48	51	PF01048	0.490
MOD_GSK3_1	129	136	PF00069	0.451
MOD_GSK3_1	165	172	PF00069	0.558
MOD_GSK3_1	200	207	PF00069	0.764
MOD_GSK3_1	220	227	PF00069	0.260
MOD_GSK3_1	252	259	PF00069	0.687
MOD_GSK3_1	300	307	PF00069	0.648
MOD_GSK3_1	31	38	PF00069	0.557
MOD_N-GLC_1	200	205	PF02516	0.745
MOD_N-GLC_2	73	75	PF02516	0.523
MOD_NEK2_1	23	28	PF00069	0.469
MOD_NEK2_1	256	261	PF00069	0.625
MOD_NEK2_1	46	51	PF00069	0.516
MOD_NEK2_2	135	140	PF00069	0.423
MOD_PIKK_1	165	171	PF00454	0.490
MOD_PIKK_1	237	243	PF00454	0.671
MOD_PKA_1	113	119	PF00069	0.670
MOD_PKA_1	252	258	PF00069	0.687
MOD_PKA_1	286	292	PF00069	0.592
MOD_PKA_2	116	122	PF00069	0.637
MOD_PKA_2	237	243	PF00069	0.638
MOD_PKA_2	252	258	PF00069	0.531
MOD_PKA_2	65	71	PF00069	0.489
MOD_PKB_1	113	121	PF00069	0.698
MOD_Plk_1	133	139	PF00069	0.468
MOD_Plk_1	210	216	PF00069	0.528
MOD_Plk_4	135	141	PF00069	0.423
MOD_Plk_4	220	226	PF00069	0.558
MOD_ProDKin_1	108	114	PF00069	0.595
MOD_ProDKin_1	245	251	PF00069	0.532
MOD_ProDKin_1	305	311	PF00069	0.685
MOD_SUMO_rev_2	172	177	PF00179	0.633
MOD_SUMO_rev_2	187	195	PF00179	0.695
TRG_ENDOCYTIC_2	126	129	PF00928	0.540
TRG_ER_diArg_1	112	115	PF00400	0.613
TRG_ER_diArg_1	151	154	PF00400	0.536
TRG_ER_diArg_1	250	253	PF00400	0.537
TRG_ER_diArg_1	64	67	PF00400	0.532
TRG_NLS_MonoExtC_3	112	117	PF00514	0.671
TRG_NLS_MonoExtC_3	62	67	PF00514	0.599
TRG_NLS_MonoExtN_4	110	117	PF00514	0.653
TRG_NLS_MonoExtN_4	61	67	PF00514	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L9	Leptomonas seymouri	82%	79%
A0A0S4JQD1	Bodo saltans	44%	72%
A0A1X0P4Q6	Trypanosomatidae	55%	78%
A0A422N5V3	Trypanosoma rangeli	52%	79%
A4HNJ1	Leishmania braziliensis	87%	100%
A4IC48	Leishmania infantum	99%	100%
C9ZYC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	78%
E9AG03	Leishmania major	97%	100%
E9B756	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BTX9	Trypanosoma cruzi	52%	71%