Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7XA33_LEIDO

TriTrypDb:

LdBPK_355210.1 , LdCL_350057900 , LDHU3_35.6950

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7XA33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.424
CLV_NRD_NRD_1	145	147	PF00675	0.608
CLV_NRD_NRD_1	25	27	PF00675	0.544
CLV_PCSK_SKI1_1	136	140	PF00082	0.513
CLV_PCSK_SKI1_1	243	247	PF00082	0.642
DOC_CKS1_1	168	173	PF01111	0.383
DOC_CYCLIN_yCln2_LP_2	118	121	PF00134	0.465
DOC_MAPK_HePTP_8	198	210	PF00069	0.408
DOC_MAPK_MEF2A_6	201	210	PF00069	0.423
DOC_PP2B_LxvP_1	118	121	PF13499	0.465
DOC_PP2B_LxvP_1	18	21	PF13499	0.619
DOC_PP2B_LxvP_1	193	196	PF13499	0.364
DOC_PP2B_LxvP_1	93	96	PF13499	0.331
DOC_PP4_FxxP_1	180	183	PF00568	0.402
DOC_PP4_FxxP_1	203	206	PF00568	0.257
DOC_USP7_MATH_1	183	187	PF00917	0.427
DOC_USP7_MATH_1	248	252	PF00917	0.283
DOC_WW_Pin1_4	167	172	PF00397	0.352
DOC_WW_Pin1_4	179	184	PF00397	0.390
DOC_WW_Pin1_4	235	240	PF00397	0.347
LIG_14-3-3_CanoR_1	133	139	PF00244	0.307
LIG_14-3-3_CanoR_1	81	87	PF00244	0.352
LIG_BIR_III_2	32	36	PF00653	0.378
LIG_BRCT_BRCA1_1	196	200	PF00533	0.361
LIG_deltaCOP1_diTrp_1	129	138	PF00928	0.312
LIG_FHA_1	121	127	PF00498	0.415
LIG_FHA_1	129	135	PF00498	0.279
LIG_FHA_1	213	219	PF00498	0.422
LIG_FHA_1	244	250	PF00498	0.302
LIG_GBD_Chelix_1	261	269	PF00786	0.332
LIG_LIR_Apic_2	179	183	PF02991	0.411
LIG_LIR_Gen_1	220	226	PF02991	0.367
LIG_LIR_Gen_1	63	70	PF02991	0.467
LIG_LIR_Nem_3	197	203	PF02991	0.264
LIG_LIR_Nem_3	220	224	PF02991	0.371
LIG_LIR_Nem_3	63	68	PF02991	0.473
LIG_NRBOX	2	8	PF00104	0.435
LIG_NRBOX	262	268	PF00104	0.382
LIG_PDZ_Class_2	264	269	PF00595	0.605
LIG_PDZ_Wminus1_1	267	269	PF00595	0.662
LIG_SH2_CRK	65	69	PF00017	0.405
LIG_SH2_CRK	83	87	PF00017	0.262
LIG_SH2_STAP1	65	69	PF00017	0.372
LIG_SH2_STAP1	83	87	PF00017	0.373
LIG_SH2_STAT5	83	86	PF00017	0.407
LIG_SH2_STAT5	92	95	PF00017	0.291
LIG_SH3_3	32	38	PF00018	0.328
LIG_SH3_3	93	99	PF00018	0.290
LIG_SH3_5	231	235	PF00018	0.429
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.283
LIG_SUMO_SIM_par_1	222	230	PF11976	0.365
LIG_SUMO_SIM_par_1	5	11	PF11976	0.456
MOD_CK1_1	122	128	PF00069	0.425
MOD_CK1_1	166	172	PF00069	0.422
MOD_CK1_1	179	185	PF00069	0.359
MOD_CK1_1	212	218	PF00069	0.411
MOD_GlcNHglycan	250	253	PF01048	0.469
MOD_GlcNHglycan	254	257	PF01048	0.403
MOD_GlcNHglycan	258	261	PF01048	0.304
MOD_GlcNHglycan	65	68	PF01048	0.609
MOD_GSK3_1	162	169	PF00069	0.379
MOD_GSK3_1	179	186	PF00069	0.315
MOD_GSK3_1	248	255	PF00069	0.494
MOD_N-GLC_1	173	178	PF02516	0.614
MOD_N-GLC_1	226	231	PF02516	0.579
MOD_N-GLC_2	50	52	PF02516	0.576
MOD_NEK2_1	173	178	PF00069	0.414
MOD_NEK2_1	8	13	PF00069	0.586
MOD_NEK2_2	196	201	PF00069	0.428
MOD_OFUCOSY	160	167	PF10250	0.560
MOD_PIKK_1	212	218	PF00454	0.378
MOD_PIKK_1	76	82	PF00454	0.414
MOD_PK_1	105	111	PF00069	0.377
MOD_Plk_1	128	134	PF00069	0.322
MOD_Plk_4	209	215	PF00069	0.363
MOD_Plk_4	8	14	PF00069	0.586
MOD_Plk_4	82	88	PF00069	0.373
MOD_ProDKin_1	167	173	PF00069	0.350
MOD_ProDKin_1	179	185	PF00069	0.398
MOD_ProDKin_1	235	241	PF00069	0.341
TRG_ENDOCYTIC_2	65	68	PF00928	0.409
TRG_ENDOCYTIC_2	83	86	PF00928	0.250
TRG_ENDOCYTIC_2	92	95	PF00928	0.260
TRG_NES_CRM1_1	216	230	PF08389	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL7	Leptomonas seymouri	70%	100%
A0A0S4JP52	Bodo saltans	41%	97%
A4IC42	Leishmania infantum	99%	100%
E9AFZ7	Leishmania major	95%	100%
E9B750	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%