LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XA27_LEIDO
TriTrypDb:
LdBPK_355020.1 , LdCL_350055200 , LDHU3_35.6580
Length:
342

Annotations

LeishMANIAdb annotations

A Kinetoplastid-specific signal-anchored protein. Might be part of a bigger complex.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3S7XA27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA27

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 150 154 PF00656 0.565
CLV_NRD_NRD_1 217 219 PF00675 0.555
CLV_NRD_NRD_1 275 277 PF00675 0.599
CLV_NRD_NRD_1 292 294 PF00675 0.527
CLV_NRD_NRD_1 335 337 PF00675 0.591
CLV_PCSK_KEX2_1 217 219 PF00082 0.536
CLV_PCSK_KEX2_1 275 277 PF00082 0.604
CLV_PCSK_PC7_1 213 219 PF00082 0.482
CLV_PCSK_SKI1_1 6 10 PF00082 0.379
CLV_Separin_Metazoa 97 101 PF03568 0.416
DEG_SCF_FBW7_1 307 312 PF00400 0.354
DEG_SPOP_SBC_1 154 158 PF00917 0.529
DOC_CYCLIN_yClb5_NLxxxL_5 43 52 PF00134 0.330
DOC_MAPK_DCC_7 10 19 PF00069 0.482
DOC_MAPK_DCC_7 275 283 PF00069 0.340
DOC_MAPK_gen_1 275 283 PF00069 0.340
DOC_MAPK_gen_1 72 79 PF00069 0.336
DOC_MAPK_MEF2A_6 10 19 PF00069 0.485
DOC_MAPK_MEF2A_6 275 283 PF00069 0.340
DOC_PP4_FxxP_1 166 169 PF00568 0.313
DOC_USP7_MATH_1 154 158 PF00917 0.563
DOC_USP7_MATH_1 177 181 PF00917 0.278
DOC_USP7_MATH_1 220 224 PF00917 0.450
DOC_USP7_UBL2_3 6 10 PF12436 0.581
DOC_WW_Pin1_4 143 148 PF00397 0.493
DOC_WW_Pin1_4 164 169 PF00397 0.498
DOC_WW_Pin1_4 221 226 PF00397 0.377
DOC_WW_Pin1_4 250 255 PF00397 0.433
DOC_WW_Pin1_4 293 298 PF00397 0.385
DOC_WW_Pin1_4 305 310 PF00397 0.428
LIG_14-3-3_CanoR_1 221 225 PF00244 0.388
LIG_14-3-3_CanoR_1 92 96 PF00244 0.358
LIG_Actin_WH2_2 318 333 PF00022 0.407
LIG_APCC_ABBA_1 229 234 PF00400 0.322
LIG_BIR_II_1 1 5 PF00653 0.579
LIG_BRCT_BRCA1_1 162 166 PF00533 0.499
LIG_deltaCOP1_diTrp_1 298 304 PF00928 0.387
LIG_FHA_1 234 240 PF00498 0.412
LIG_FHA_1 306 312 PF00498 0.381
LIG_FHA_1 316 322 PF00498 0.319
LIG_FHA_1 52 58 PF00498 0.402
LIG_FHA_2 148 154 PF00498 0.559
LIG_FHA_2 25 31 PF00498 0.419
LIG_FHA_2 92 98 PF00498 0.467
LIG_LIR_Apic_2 163 169 PF02991 0.331
LIG_LIR_Apic_2 64 69 PF02991 0.377
LIG_LIR_Gen_1 130 139 PF02991 0.271
LIG_LIR_Gen_1 185 196 PF02991 0.381
LIG_LIR_Gen_1 94 103 PF02991 0.327
LIG_LIR_Nem_3 118 124 PF02991 0.334
LIG_LIR_Nem_3 130 134 PF02991 0.260
LIG_LIR_Nem_3 230 235 PF02991 0.339
LIG_LIR_Nem_3 94 98 PF02991 0.343
LIG_PCNA_yPIPBox_3 133 141 PF02747 0.335
LIG_Pex14_1 300 304 PF04695 0.346
LIG_Pex14_2 19 23 PF04695 0.319
LIG_Rb_LxCxE_1 328 342 PF01857 0.450
LIG_REV1ctd_RIR_1 261 270 PF16727 0.360
LIG_REV1ctd_RIR_1 6 14 PF16727 0.585
LIG_RPA_C_Fungi 208 220 PF08784 0.334
LIG_SH2_STAP1 235 239 PF00017 0.403
LIG_SH2_STAP1 53 57 PF00017 0.451
LIG_SH2_STAT5 110 113 PF00017 0.399
LIG_SH2_STAT5 121 124 PF00017 0.325
LIG_SH2_STAT5 235 238 PF00017 0.418
LIG_SH2_STAT5 53 56 PF00017 0.533
LIG_SH3_1 141 147 PF00018 0.513
LIG_SH3_3 141 147 PF00018 0.507
LIG_SH3_3 248 254 PF00018 0.593
LIG_SH3_3 280 286 PF00018 0.489
LIG_SH3_3 9 15 PF00018 0.326
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.533
LIG_SUMO_SIM_par_1 226 234 PF11976 0.462
LIG_SUMO_SIM_par_1 75 81 PF11976 0.533
LIG_TRAF2_1 115 118 PF00917 0.531
LIG_TRAF2_1 253 256 PF00917 0.363
LIG_TYR_ITIM 119 124 PF00017 0.376
LIG_UBA3_1 76 82 PF00899 0.546
LIG_WRC_WIRS_1 136 141 PF05994 0.505
MOD_CDC14_SPxK_1 224 227 PF00782 0.416
MOD_CDK_SPxK_1 221 227 PF00069 0.426
MOD_CK1_1 157 163 PF00069 0.696
MOD_CK1_1 233 239 PF00069 0.536
MOD_CK2_1 143 149 PF00069 0.621
MOD_CK2_1 183 189 PF00069 0.324
MOD_CK2_1 220 226 PF00069 0.554
MOD_CK2_1 24 30 PF00069 0.339
MOD_CK2_1 250 256 PF00069 0.499
MOD_CK2_1 58 64 PF00069 0.458
MOD_CK2_1 72 78 PF00069 0.401
MOD_CK2_1 91 97 PF00069 0.609
MOD_GlcNHglycan 1 4 PF01048 0.448
MOD_GlcNHglycan 162 165 PF01048 0.737
MOD_GSK3_1 143 150 PF00069 0.649
MOD_GSK3_1 153 160 PF00069 0.675
MOD_GSK3_1 305 312 PF00069 0.485
MOD_N-GLC_1 305 310 PF02516 0.482
MOD_N-GLC_1 84 89 PF02516 0.625
MOD_NEK2_1 183 188 PF00069 0.499
MOD_NEK2_1 198 203 PF00069 0.418
MOD_PIKK_1 51 57 PF00454 0.442
MOD_PK_1 72 78 PF00069 0.410
MOD_PKA_2 220 226 PF00069 0.462
MOD_PKA_2 91 97 PF00069 0.500
MOD_Plk_1 198 204 PF00069 0.343
MOD_Plk_1 269 275 PF00069 0.497
MOD_Plk_2-3 113 119 PF00069 0.383
MOD_Plk_2-3 91 97 PF00069 0.475
MOD_Plk_4 135 141 PF00069 0.397
MOD_Plk_4 183 189 PF00069 0.506
MOD_Plk_4 258 264 PF00069 0.444
MOD_Plk_4 58 64 PF00069 0.516
MOD_ProDKin_1 143 149 PF00069 0.639
MOD_ProDKin_1 164 170 PF00069 0.622
MOD_ProDKin_1 221 227 PF00069 0.470
MOD_ProDKin_1 250 256 PF00069 0.537
MOD_ProDKin_1 293 299 PF00069 0.481
MOD_ProDKin_1 305 311 PF00069 0.537
TRG_DiLeu_BaEn_1 30 35 PF01217 0.414
TRG_DiLeu_BaLyEn_6 276 281 PF01217 0.644
TRG_ENDOCYTIC_2 121 124 PF00928 0.392
TRG_ER_diArg_1 217 219 PF00400 0.492
TRG_ER_diArg_1 275 277 PF00400 0.502
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2I6 Leptomonas seymouri 62% 97%
A0A0S4J6X6 Bodo saltans 32% 100%
A0A0S4J7W0 Bodo saltans 32% 100%
A0A1X0P4T2 Trypanosomatidae 37% 100%
A0A3R7MCD3 Trypanosoma rangeli 42% 100%
A4HNG0 Leishmania braziliensis 79% 100%
A4IC71 Leishmania infantum 100% 100%
C9ZYG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AFX1 Leishmania major 94% 100%
E9B724 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5B4K6 Trypanosoma cruzi 40% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS