RNA polymerase III RPC4, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase III RPC4, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA21_LEIDO

TriTrypDb:

LdBPK_354240.1 , LdCL_350047500 , LDHU3_35.5460

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	6
GO:0005666	RNA polymerase III complex	4	6
GO:0030880	RNA polymerase complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	6
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	6
GO:0140513	nuclear protein-containing complex	2	6
GO:0140535	intracellular protein-containing complex	2	6
GO:1902494	catalytic complex	2	6
GO:1990234	transferase complex	3	6

Expansion

Sequence features

A0A3S7XA21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA21

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006351	DNA-templated transcription	7	6
GO:0006383	transcription by RNA polymerase III	8	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009059	macromolecule biosynthetic process	4	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0032774	RNA biosynthetic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0097659	nucleic acid-templated transcription	6	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003677	DNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.577
CLV_NRD_NRD_1	139	141	PF00675	0.694
CLV_NRD_NRD_1	354	356	PF00675	0.380
CLV_PCSK_KEX2_1	139	141	PF00082	0.672
CLV_PCSK_SKI1_1	13	17	PF00082	0.690
CLV_PCSK_SKI1_1	300	304	PF00082	0.555
DEG_SCF_FBW7_1	207	214	PF00400	0.565
DEG_SPOP_SBC_1	51	55	PF00917	0.705
DEG_SPOP_SBC_1	67	71	PF00917	0.746
DEG_SPOP_SBC_1	85	89	PF00917	0.613
DOC_CKS1_1	358	363	PF01111	0.453
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.706
DOC_MAPK_gen_1	294	303	PF00069	0.463
DOC_MAPK_gen_1	9	16	PF00069	0.710
DOC_MAPK_MEF2A_6	297	305	PF00069	0.573
DOC_MAPK_MEF2A_6	9	16	PF00069	0.710
DOC_PP2B_LxvP_1	178	181	PF13499	0.714
DOC_PP4_FxxP_1	283	286	PF00568	0.589
DOC_USP7_MATH_1	114	118	PF00917	0.723
DOC_USP7_MATH_1	155	159	PF00917	0.714
DOC_USP7_MATH_1	173	177	PF00917	0.586
DOC_USP7_MATH_1	211	215	PF00917	0.681
DOC_USP7_MATH_1	336	340	PF00917	0.598
DOC_USP7_MATH_1	52	56	PF00917	0.729
DOC_USP7_MATH_1	67	71	PF00917	0.823
DOC_USP7_MATH_1	84	88	PF00917	0.761
DOC_USP7_MATH_2	84	90	PF00917	0.609
DOC_USP7_UBL2_3	9	13	PF12436	0.701
DOC_WW_Pin1_4	207	212	PF00397	0.680
DOC_WW_Pin1_4	214	219	PF00397	0.706
DOC_WW_Pin1_4	357	362	PF00397	0.431
DOC_WW_Pin1_4	68	73	PF00397	0.809
LIG_14-3-3_CanoR_1	24	34	PF00244	0.636
LIG_FHA_1	222	228	PF00498	0.620
LIG_FHA_1	29	35	PF00498	0.687
LIG_FHA_1	358	364	PF00498	0.472
LIG_FHA_2	215	221	PF00498	0.594
LIG_LIR_Apic_2	281	286	PF02991	0.615
LIG_LIR_Nem_3	145	150	PF02991	0.648
LIG_LIR_Nem_3	176	182	PF02991	0.713
LIG_LIR_Nem_3	281	285	PF02991	0.586
LIG_LYPXL_yS_3	147	150	PF13949	0.547
LIG_SH2_CRK	179	183	PF00017	0.678
LIG_SH2_NCK_1	317	321	PF00017	0.606
LIG_SH2_SRC	245	248	PF00017	0.605
LIG_SH2_SRC	317	320	PF00017	0.653
LIG_SH2_STAP1	238	242	PF00017	0.552
LIG_SH2_STAP1	245	249	PF00017	0.589
LIG_SH2_STAP1	310	314	PF00017	0.438
LIG_SH2_STAT5	46	49	PF00017	0.690
LIG_SH3_3	147	153	PF00018	0.657
LIG_SH3_3	335	341	PF00018	0.601
LIG_SH3_3	358	364	PF00018	0.518
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.656
LIG_TRAF2_1	133	136	PF00917	0.666
LIG_TRAF2_1	193	196	PF00917	0.742
LIG_TRFH_1	283	287	PF08558	0.618
LIG_WW_2	152	155	PF00397	0.690
MOD_CK1_1	158	164	PF00069	0.662
MOD_CK1_1	187	193	PF00069	0.627
MOD_CK1_1	214	220	PF00069	0.541
MOD_CK1_1	255	261	PF00069	0.666
MOD_CK1_1	339	345	PF00069	0.556
MOD_CK2_1	343	349	PF00069	0.557
MOD_CK2_1	50	56	PF00069	0.705
MOD_GlcNHglycan	128	131	PF01048	0.695
MOD_GlcNHglycan	165	168	PF01048	0.799
MOD_GlcNHglycan	175	178	PF01048	0.756
MOD_GlcNHglycan	200	203	PF01048	0.677
MOD_GlcNHglycan	207	210	PF01048	0.705
MOD_GlcNHglycan	213	216	PF01048	0.735
MOD_GlcNHglycan	257	260	PF01048	0.654
MOD_GlcNHglycan	297	300	PF01048	0.493
MOD_GlcNHglycan	334	337	PF01048	0.601
MOD_GSK3_1	122	129	PF00069	0.741
MOD_GSK3_1	207	214	PF00069	0.707
MOD_GSK3_1	28	35	PF00069	0.622
MOD_GSK3_1	332	339	PF00069	0.584
MOD_GSK3_1	98	105	PF00069	0.714
MOD_N-GLC_1	101	106	PF02516	0.734
MOD_N-GLC_1	126	131	PF02516	0.716
MOD_NEK2_1	184	189	PF00069	0.658
MOD_NEK2_1	252	257	PF00069	0.683
MOD_NEK2_2	245	250	PF00069	0.592
MOD_PIKK_1	142	148	PF00454	0.712
MOD_PIKK_1	25	31	PF00454	0.780
MOD_PIKK_1	329	335	PF00454	0.524
MOD_PKA_2	98	104	PF00069	0.643
MOD_PKB_1	120	128	PF00069	0.553
MOD_Plk_1	142	148	PF00069	0.742
MOD_Plk_1	184	190	PF00069	0.601
MOD_Plk_1	245	251	PF00069	0.660
MOD_Plk_1	32	38	PF00069	0.559
MOD_Plk_4	114	120	PF00069	0.792
MOD_Plk_4	158	164	PF00069	0.655
MOD_Plk_4	32	38	PF00069	0.570
MOD_ProDKin_1	207	213	PF00069	0.681
MOD_ProDKin_1	214	220	PF00069	0.700
MOD_ProDKin_1	357	363	PF00069	0.446
MOD_ProDKin_1	68	74	PF00069	0.812
TRG_ENDOCYTIC_2	147	150	PF00928	0.547
TRG_ENDOCYTIC_2	179	182	PF00928	0.659
TRG_ER_diArg_1	119	122	PF00400	0.572
TRG_NES_CRM1_1	38	49	PF08389	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD4	Leptomonas seymouri	57%	93%
A4HN89	Leishmania braziliensis	74%	100%
A4IBV7	Leishmania infantum	99%	100%
C9ZYQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AFP4	Leishmania major	92%	100%
E9B6U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BXW4	Trypanosoma cruzi	35%	100%