BRCA1 C Terminus (BRCT) domain containing protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRCA1 C Terminus (BRCT) domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA18_LEIDO

TriTrypDb:

LdBPK_354870.1 , LdCL_350053700 , LDHU3_35.6390

Length:

366

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA18

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016311	dephosphorylation	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.600
CLV_NRD_NRD_1	227	229	PF00675	0.671
CLV_PCSK_KEX2_1	18	20	PF00082	0.600
CLV_PCSK_KEX2_1	282	284	PF00082	0.645
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.645
CLV_PCSK_PC7_1	14	20	PF00082	0.582
CLV_PCSK_SKI1_1	248	252	PF00082	0.436
DOC_CKS1_1	257	262	PF01111	0.395
DOC_CKS1_1	346	351	PF01111	0.520
DOC_MAPK_gen_1	228	236	PF00069	0.589
DOC_MAPK_gen_1	304	310	PF00069	0.417
DOC_MAPK_MEF2A_6	228	236	PF00069	0.636
DOC_MAPK_RevD_3	267	283	PF00069	0.452
DOC_PP4_FxxP_1	12	15	PF00568	0.533
DOC_USP7_MATH_1	163	167	PF00917	0.741
DOC_USP7_MATH_1	43	47	PF00917	0.454
DOC_USP7_MATH_1	66	70	PF00917	0.460
DOC_USP7_UBL2_3	161	165	PF12436	0.755
DOC_USP7_UBL2_3	278	282	PF12436	0.586
DOC_USP7_UBL2_3	359	363	PF12436	0.534
DOC_WW_Pin1_4	256	261	PF00397	0.413
DOC_WW_Pin1_4	345	350	PF00397	0.518
LIG_14-3-3_CanoR_1	196	203	PF00244	0.595
LIG_14-3-3_CanoR_1	291	299	PF00244	0.435
LIG_14-3-3_CanoR_1	54	63	PF00244	0.460
LIG_APCC_ABBA_1	186	191	PF00400	0.669
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_eIF4E_1	116	122	PF01652	0.488
LIG_FHA_1	117	123	PF00498	0.577
LIG_FHA_1	213	219	PF00498	0.596
LIG_FHA_1	257	263	PF00498	0.404
LIG_FHA_1	264	270	PF00498	0.427
LIG_FHA_1	293	299	PF00498	0.407
LIG_FHA_1	348	354	PF00498	0.467
LIG_FHA_2	59	65	PF00498	0.556
LIG_FHA_2	83	89	PF00498	0.546
LIG_GBD_Chelix_1	98	106	PF00786	0.447
LIG_LIR_Apic_2	147	152	PF02991	0.529
LIG_LIR_Gen_1	3	13	PF02991	0.505
LIG_NBox_RRM_1	203	213	PF00076	0.411
LIG_NRBOX	101	107	PF00104	0.395
LIG_SH2_CRK	149	153	PF00017	0.536
LIG_SH2_NCK_1	149	153	PF00017	0.489
LIG_SH2_STAT5	347	350	PF00017	0.431
LIG_SH2_STAT5	361	364	PF00017	0.456
LIG_SH2_STAT5	6	9	PF00017	0.521
LIG_SH3_3	121	127	PF00018	0.484
LIG_SH3_3	254	260	PF00018	0.483
LIG_SH3_3	69	75	PF00018	0.416
LIG_SH3_3	88	94	PF00018	0.272
LIG_UBA3_1	353	360	PF00899	0.461
MOD_CDK_SPxxK_3	345	352	PF00069	0.560
MOD_CK1_1	147	153	PF00069	0.585
MOD_CK2_1	82	88	PF00069	0.475
MOD_GlcNHglycan	165	168	PF01048	0.761
MOD_GlcNHglycan	25	28	PF01048	0.549
MOD_GlcNHglycan	251	254	PF01048	0.441
MOD_GSK3_1	101	108	PF00069	0.488
MOD_GSK3_1	125	132	PF00069	0.673
MOD_GSK3_1	147	154	PF00069	0.558
MOD_GSK3_1	208	215	PF00069	0.609
MOD_GSK3_1	282	289	PF00069	0.510
MOD_GSK3_1	359	366	PF00069	0.610
MOD_GSK3_1	55	62	PF00069	0.520
MOD_N-GLC_1	144	149	PF02516	0.389
MOD_N-GLC_1	292	297	PF02516	0.341
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	101	106	PF00069	0.414
MOD_NEK2_1	195	200	PF00069	0.535
MOD_NEK2_1	286	291	PF00069	0.493
MOD_NEK2_1	315	320	PF00069	0.551
MOD_NEK2_1	325	330	PF00069	0.368
MOD_NEK2_1	353	358	PF00069	0.421
MOD_PKA_1	282	288	PF00069	0.528
MOD_PKA_1	359	365	PF00069	0.525
MOD_PKA_2	116	122	PF00069	0.542
MOD_PKA_2	195	201	PF00069	0.585
MOD_PKA_2	227	233	PF00069	0.660
MOD_PKA_2	282	288	PF00069	0.606
MOD_Plk_1	147	153	PF00069	0.546
MOD_Plk_1	2	8	PF00069	0.620
MOD_Plk_1	286	292	PF00069	0.488
MOD_Plk_4	101	107	PF00069	0.446
MOD_Plk_4	111	117	PF00069	0.468
MOD_Plk_4	198	204	PF00069	0.603
MOD_Plk_4	66	72	PF00069	0.519
MOD_ProDKin_1	256	262	PF00069	0.412
MOD_ProDKin_1	345	351	PF00069	0.523
MOD_SUMO_for_1	213	216	PF00179	0.635
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.554
TRG_ENDOCYTIC_2	6	9	PF00928	0.505
TRG_NLS_MonoExtC_3	227	232	PF00514	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9H3	Leptomonas seymouri	70%	94%
A0A0S4J3S6	Bodo saltans	45%	94%
A0A1X0P4V1	Trypanosomatidae	51%	96%
A0A3R7RRN6	Trypanosoma rangeli	52%	95%
A4HNE5	Leishmania braziliensis	66%	100%
C9ZYI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	92%
E9AFV6	Leishmania major	90%	100%
E9AHW9	Leishmania infantum	100%	100%
E9B709	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B718	Trypanosoma cruzi	51%	95%