BRCA1 C Terminus (BRCT) domain containing protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRCA1 C Terminus (BRCT) domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA18_LEIDO

TriTrypDb:

LdBPK_354870.1 , LdCL_350053700 , LDHU3_35.6390

Length:

366

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA18

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1

Previous1 2 3 4Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0005488	binding	1	2
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0043167	ion binding	2	2

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.600
CLV_NRD_NRD_1	227	229	PF00675	0.671
CLV_PCSK_KEX2_1	18	20	PF00082	0.600
CLV_PCSK_KEX2_1	282	284	PF00082	0.645
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.645
CLV_PCSK_PC7_1	14	20	PF00082	0.582
CLV_PCSK_SKI1_1	248	252	PF00082	0.436
DOC_CKS1_1	257	262	PF01111	0.395
DOC_CKS1_1	346	351	PF01111	0.520
DOC_MAPK_gen_1	228	236	PF00069	0.589

Previous1 2 3 4 5…10Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9H3	Leptomonas seymouri	70%	94%
A0A0S4J3S6	Bodo saltans	45%	94%
A0A1X0P4V1	Trypanosomatidae	51%	96%
A0A3R7RRN6	Trypanosoma rangeli	52%	95%
A4HNE5	Leishmania braziliensis	66%	100%
C9ZYI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	92%
E9AFV6	Leishmania major	90%	100%
E9AHW9	Leishmania infantum	100%	100%
E9B709	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B718	Trypanosoma cruzi	51%	95%

Previous1Next