Archaic_translocase_outer_mitochondrial_membrane_ 40_putative/GeneDB:LmjF.35.4860

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM40, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA15_LEIDO

TriTrypDb:

LdBPK_354920.1 , LdCL_350054200 , LDHU3_35.6450

Length:

349

Annotations

Annotations by Jardim et al.

Mitochondrial protein, Mitochondrial import receptor subunit ATOM40 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7XA15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA15

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.324
CLV_NRD_NRD_1	288	290	PF00675	0.329
CLV_NRD_NRD_1	44	46	PF00675	0.454
CLV_NRD_NRD_1	73	75	PF00675	0.485
CLV_PCSK_KEX2_1	236	238	PF00082	0.468
CLV_PCSK_KEX2_1	43	45	PF00082	0.478
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.426
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.563
CLV_PCSK_SKI1_1	281	285	PF00082	0.463
CLV_PCSK_SKI1_1	65	69	PF00082	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DEG_SCF_SKP2-CKS1_1	242	249	PF00560	0.368
DOC_MAPK_gen_1	20	28	PF00069	0.517
DOC_MAPK_gen_1	74	81	PF00069	0.457
DOC_MAPK_MEF2A_6	309	316	PF00069	0.332
DOC_MAPK_NFAT4_5	309	317	PF00069	0.448
DOC_PP1_RVXF_1	325	331	PF00149	0.376
DOC_PP2B_LxvP_1	312	315	PF13499	0.375
DOC_USP7_MATH_1	114	118	PF00917	0.345
DOC_USP7_MATH_1	61	65	PF00917	0.483
DOC_USP7_UBL2_3	249	253	PF12436	0.309
DOC_WW_Pin1_4	243	248	PF00397	0.378
LIG_14-3-3_CanoR_1	148	157	PF00244	0.365
LIG_14-3-3_CanoR_1	289	293	PF00244	0.454
LIG_14-3-3_CanoR_1	327	331	PF00244	0.365
LIG_Actin_WH2_2	313	329	PF00022	0.547
LIG_FHA_1	249	255	PF00498	0.406
LIG_FHA_1	297	303	PF00498	0.364
LIG_FHA_1	91	97	PF00498	0.377
LIG_FHA_2	255	261	PF00498	0.282
LIG_LIR_Gen_1	106	116	PF02991	0.413
LIG_LIR_Gen_1	135	144	PF02991	0.296
LIG_LIR_Gen_1	172	180	PF02991	0.362
LIG_LIR_Nem_3	106	112	PF02991	0.395
LIG_LIR_Nem_3	135	139	PF02991	0.281
LIG_LIR_Nem_3	68	72	PF02991	0.374
LIG_PCNA_yPIPBox_3	164	177	PF02747	0.330
LIG_PDZ_Class_2	344	349	PF00595	0.289
LIG_SH2_CRK	146	150	PF00017	0.351
LIG_SH2_CRK	69	73	PF00017	0.362
LIG_SH2_SRC	334	337	PF00017	0.341
LIG_SH2_STAP1	334	338	PF00017	0.390
LIG_SH2_STAP1	48	52	PF00017	0.483
LIG_SH2_STAT5	191	194	PF00017	0.310
LIG_SH2_STAT5	225	228	PF00017	0.442
LIG_SH3_1	57	63	PF00018	0.414
LIG_SH3_2	60	65	PF14604	0.424
LIG_SH3_3	57	63	PF00018	0.414
LIG_TRAF2_1	16	19	PF00917	0.591
LIG_TYR_ITIM	144	149	PF00017	0.307
LIG_TYR_ITIM	67	72	PF00017	0.377
MOD_CDK_SPxK_1	243	249	PF00069	0.379
MOD_CK1_1	135	141	PF00069	0.297
MOD_CK1_1	169	175	PF00069	0.422
MOD_CK1_1	224	230	PF00069	0.405
MOD_CK1_1	231	237	PF00069	0.413
MOD_CK1_1	248	254	PF00069	0.370
MOD_CK1_1	39	45	PF00069	0.577
MOD_CK2_1	114	120	PF00069	0.334
MOD_CK2_1	52	58	PF00069	0.420
MOD_CK2_1	6	12	PF00069	0.665
MOD_GlcNHglycan	281	284	PF01048	0.392
MOD_GlcNHglycan	38	41	PF01048	0.563
MOD_GlcNHglycan	54	57	PF01048	0.437
MOD_GSK3_1	103	110	PF00069	0.339
MOD_GSK3_1	193	200	PF00069	0.316
MOD_GSK3_1	224	231	PF00069	0.327
MOD_GSK3_1	61	68	PF00069	0.455
MOD_N-GLC_1	213	218	PF02516	0.398
MOD_NEK2_1	104	109	PF00069	0.343
MOD_NEK2_1	155	160	PF00069	0.412
MOD_NEK2_1	197	202	PF00069	0.307
MOD_NEK2_1	254	259	PF00069	0.325
MOD_NEK2_1	298	303	PF00069	0.375
MOD_NEK2_1	326	331	PF00069	0.438
MOD_NEK2_1	52	57	PF00069	0.425
MOD_NEK2_1	6	11	PF00069	0.663
MOD_PIKK_1	155	161	PF00454	0.348
MOD_PIKK_1	166	172	PF00454	0.304
MOD_PIKK_1	184	190	PF00454	0.324
MOD_PKA_2	147	153	PF00069	0.348
MOD_PKA_2	288	294	PF00069	0.446
MOD_PKA_2	326	332	PF00069	0.369
MOD_PKA_2	36	42	PF00069	0.541
MOD_PKA_2	6	12	PF00069	0.636
MOD_Plk_1	193	199	PF00069	0.324
MOD_Plk_1	213	219	PF00069	0.218
MOD_Plk_4	169	175	PF00069	0.302
MOD_Plk_4	221	227	PF00069	0.468
MOD_Plk_4	288	294	PF00069	0.403
MOD_Plk_4	298	304	PF00069	0.406
MOD_ProDKin_1	243	249	PF00069	0.379
MOD_SUMO_rev_2	12	22	PF00179	0.649
MOD_SUMO_rev_2	46	53	PF00179	0.481
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.349
TRG_ENDOCYTIC_2	142	145	PF00928	0.326
TRG_ENDOCYTIC_2	146	149	PF00928	0.330
TRG_ENDOCYTIC_2	69	72	PF00928	0.324
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE17	Leptomonas seymouri	82%	100%
A0A0S4J3Y4	Bodo saltans	47%	100%
A0A1X0P556	Trypanosomatidae	54%	100%
A0A3R7KX50	Trypanosoma rangeli	55%	100%
A4HNF0	Leishmania braziliensis	93%	100%
A4IC22	Leishmania infantum	100%	100%
C9ZYH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9AFW1	Leishmania major	98%	100%
E9B714	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5D7G9	Trypanosoma cruzi	54%	100%