Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA13_LEIDO

TriTrypDb:

LdBPK_355350.1 , LdCL_350055800 , LDHU3_35.6670

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XA13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	505	509	PF00656	0.422
CLV_NRD_NRD_1	149	151	PF00675	0.511
CLV_NRD_NRD_1	159	161	PF00675	0.489
CLV_NRD_NRD_1	305	307	PF00675	0.486
CLV_NRD_NRD_1	42	44	PF00675	0.570
CLV_NRD_NRD_1	457	459	PF00675	0.634
CLV_NRD_NRD_1	64	66	PF00675	0.638
CLV_NRD_NRD_1	73	75	PF00675	0.530
CLV_PCSK_FUR_1	303	307	PF00082	0.490
CLV_PCSK_KEX2_1	149	151	PF00082	0.511
CLV_PCSK_KEX2_1	158	160	PF00082	0.497
CLV_PCSK_KEX2_1	215	217	PF00082	0.464
CLV_PCSK_KEX2_1	305	307	PF00082	0.486
CLV_PCSK_KEX2_1	457	459	PF00082	0.637
CLV_PCSK_KEX2_1	64	66	PF00082	0.522
CLV_PCSK_KEX2_1	73	75	PF00082	0.520
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.464
CLV_PCSK_PC7_1	154	160	PF00082	0.530
CLV_PCSK_SKI1_1	202	206	PF00082	0.553
CLV_PCSK_SKI1_1	278	282	PF00082	0.516
CLV_PCSK_SKI1_1	338	342	PF00082	0.479
CLV_PCSK_SKI1_1	97	101	PF00082	0.493
DEG_APCC_DBOX_1	305	313	PF00400	0.675
DEG_Nend_Nbox_1	1	3	PF02207	0.718
DOC_CKS1_1	363	368	PF01111	0.760
DOC_CKS1_1	374	379	PF01111	0.593
DOC_CKS1_1	526	531	PF01111	0.391
DOC_CYCLIN_RxL_1	199	206	PF00134	0.726
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.707
DOC_MAPK_gen_1	164	172	PF00069	0.670
DOC_MAPK_gen_1	93	101	PF00069	0.721
DOC_MAPK_MEF2A_6	164	172	PF00069	0.767
DOC_PP1_RVXF_1	328	334	PF00149	0.677
DOC_PP1_RVXF_1	42	49	PF00149	0.757
DOC_PP2B_LxvP_1	205	208	PF13499	0.776
DOC_PP2B_LxvP_1	50	53	PF13499	0.724
DOC_USP7_MATH_1	128	132	PF00917	0.841
DOC_USP7_MATH_1	192	196	PF00917	0.646
DOC_USP7_MATH_1	290	294	PF00917	0.640
DOC_USP7_MATH_1	386	390	PF00917	0.733
DOC_USP7_MATH_1	489	493	PF00917	0.465
DOC_USP7_MATH_1	509	513	PF00917	0.327
DOC_USP7_MATH_1	514	518	PF00917	0.378
DOC_USP7_UBL2_3	177	181	PF12436	0.794
DOC_WW_Pin1_4	122	127	PF00397	0.816
DOC_WW_Pin1_4	283	288	PF00397	0.727
DOC_WW_Pin1_4	355	360	PF00397	0.816
DOC_WW_Pin1_4	362	367	PF00397	0.736
DOC_WW_Pin1_4	373	378	PF00397	0.532
DOC_WW_Pin1_4	396	401	PF00397	0.743
DOC_WW_Pin1_4	525	530	PF00397	0.370
LIG_14-3-3_CanoR_1	136	141	PF00244	0.820
LIG_14-3-3_CanoR_1	158	164	PF00244	0.739
LIG_14-3-3_CanoR_1	235	243	PF00244	0.804
LIG_14-3-3_CanoR_1	79	87	PF00244	0.724
LIG_Actin_WH2_2	267	283	PF00022	0.628
LIG_APCC_ABBA_1	472	477	PF00400	0.361
LIG_BIR_III_2	508	512	PF00653	0.416
LIG_CSL_BTD_1	459	462	PF09270	0.432
LIG_DLG_GKlike_1	136	144	PF00625	0.684
LIG_FHA_1	215	221	PF00498	0.742
LIG_FHA_1	374	380	PF00498	0.698
LIG_FHA_1	446	452	PF00498	0.529
LIG_FHA_1	489	495	PF00498	0.470
LIG_FHA_1	75	81	PF00498	0.782
LIG_FHA_2	100	106	PF00498	0.736
LIG_FHA_2	180	186	PF00498	0.721
LIG_FHA_2	33	39	PF00498	0.778
LIG_LIR_Gen_1	102	110	PF02991	0.635
LIG_LIR_Gen_1	477	487	PF02991	0.400
LIG_LIR_Nem_3	102	107	PF02991	0.638
LIG_LIR_Nem_3	232	237	PF02991	0.725
LIG_LIR_Nem_3	276	280	PF02991	0.687
LIG_LIR_Nem_3	40	45	PF02991	0.721
LIG_LIR_Nem_3	477	482	PF02991	0.399
LIG_LIR_Nem_3	515	521	PF02991	0.388
LIG_NRBOX	426	432	PF00104	0.411
LIG_REV1ctd_RIR_1	1	10	PF16727	0.734
LIG_SH2_CRK	104	108	PF00017	0.629
LIG_SH2_CRK	277	281	PF00017	0.731
LIG_SH2_CRK	42	46	PF00017	0.745
LIG_SH2_STAP1	403	407	PF00017	0.689
LIG_SH2_STAP1	521	525	PF00017	0.402
LIG_SH2_STAT5	106	109	PF00017	0.781
LIG_SH3_3	145	151	PF00018	0.770
LIG_SH3_3	240	246	PF00018	0.757
LIG_SH3_3	281	287	PF00018	0.788
LIG_SH3_3	353	359	PF00018	0.751
LIG_SH3_3	360	366	PF00018	0.731
LIG_SH3_3	394	400	PF00018	0.766
LIG_SH3_3	456	462	PF00018	0.434
LIG_SUMO_SIM_par_1	502	508	PF11976	0.451
LIG_TRAF2_1	182	185	PF00917	0.658
LIG_TRAF2_1	447	450	PF00917	0.394
LIG_WRC_WIRS_1	431	436	PF05994	0.513
MOD_CDC14_SPxK_1	286	289	PF00782	0.746
MOD_CDK_SPxK_1	283	289	PF00069	0.743
MOD_CK1_1	122	128	PF00069	0.823
MOD_CK1_1	14	20	PF00069	0.744
MOD_CK1_1	162	168	PF00069	0.795
MOD_CK1_1	203	209	PF00069	0.768
MOD_CK1_1	221	227	PF00069	0.672
MOD_CK1_1	238	244	PF00069	0.606
MOD_CK1_1	273	279	PF00069	0.624
MOD_CK1_1	409	415	PF00069	0.735
MOD_CK2_1	179	185	PF00069	0.744
MOD_CK2_1	509	515	PF00069	0.402
MOD_Cter_Amidation	156	159	PF01082	0.532
MOD_GlcNHglycan	237	240	PF01048	0.534
MOD_GlcNHglycan	300	303	PF01048	0.572
MOD_GlcNHglycan	338	341	PF01048	0.508
MOD_GlcNHglycan	345	348	PF01048	0.466
MOD_GlcNHglycan	438	441	PF01048	0.513
MOD_GlcNHglycan	491	494	PF01048	0.644
MOD_GSK3_1	105	112	PF00069	0.727
MOD_GSK3_1	159	166	PF00069	0.793
MOD_GSK3_1	214	221	PF00069	0.766
MOD_GSK3_1	357	364	PF00069	0.790
MOD_GSK3_1	386	393	PF00069	0.660
MOD_GSK3_1	430	437	PF00069	0.513
MOD_GSK3_1	441	448	PF00069	0.332
MOD_GSK3_1	60	67	PF00069	0.786
MOD_GSK3_1	74	81	PF00069	0.809
MOD_GSK3_1	93	100	PF00069	0.634
MOD_LATS_1	134	140	PF00433	0.778
MOD_N-GLC_2	115	117	PF02516	0.509
MOD_N-GLC_2	335	337	PF02516	0.467
MOD_NEK2_1	11	16	PF00069	0.701
MOD_NEK2_1	170	175	PF00069	0.779
MOD_NEK2_1	2	7	PF00069	0.772
MOD_NEK2_1	200	205	PF00069	0.788
MOD_NEK2_1	229	234	PF00069	0.806
MOD_NEK2_1	270	275	PF00069	0.626
MOD_NEK2_1	32	37	PF00069	0.732
MOD_NEK2_1	430	435	PF00069	0.513
MOD_NEK2_2	497	502	PF00069	0.486
MOD_PIKK_1	409	415	PF00454	0.665
MOD_PIKK_1	509	515	PF00454	0.420
MOD_PIKK_1	80	86	PF00454	0.762
MOD_PK_1	159	165	PF00069	0.763
MOD_PKA_1	159	165	PF00069	0.720
MOD_PKA_1	64	70	PF00069	0.794
MOD_PKA_1	73	79	PF00069	0.703
MOD_PKA_2	159	165	PF00069	0.730
MOD_PKA_2	229	235	PF00069	0.679
MOD_PKA_2	64	70	PF00069	0.733
MOD_PKA_2	73	79	PF00069	0.746
MOD_PKB_1	334	342	PF00069	0.745
MOD_PKB_1	95	103	PF00069	0.810
MOD_Plk_1	200	206	PF00069	0.781
MOD_Plk_1	422	428	PF00069	0.601
MOD_Plk_1	514	520	PF00069	0.457
MOD_Plk_1	97	103	PF00069	0.777
MOD_Plk_4	200	206	PF00069	0.762
MOD_Plk_4	291	297	PF00069	0.735
MOD_Plk_4	406	412	PF00069	0.727
MOD_Plk_4	430	436	PF00069	0.465
MOD_ProDKin_1	122	128	PF00069	0.815
MOD_ProDKin_1	283	289	PF00069	0.728
MOD_ProDKin_1	355	361	PF00069	0.816
MOD_ProDKin_1	362	368	PF00069	0.734
MOD_ProDKin_1	373	379	PF00069	0.532
MOD_ProDKin_1	396	402	PF00069	0.740
MOD_ProDKin_1	525	531	PF00069	0.384
MOD_SUMO_rev_2	178	188	PF00179	0.788
MOD_SUMO_rev_2	326	331	PF00179	0.749
TRG_AP2beta_CARGO_1	477	486	PF09066	0.401
TRG_DiLeu_BaEn_1	423	428	PF01217	0.649
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.710
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.704
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.710
TRG_ENDOCYTIC_2	104	107	PF00928	0.632
TRG_ENDOCYTIC_2	277	280	PF00928	0.695
TRG_ENDOCYTIC_2	42	45	PF00928	0.746
TRG_ENDOCYTIC_2	523	526	PF00928	0.401
TRG_ER_diArg_1	148	150	PF00400	0.780
TRG_ER_diArg_1	158	160	PF00400	0.763
TRG_ER_diArg_1	303	306	PF00400	0.692
TRG_ER_diArg_1	333	336	PF00400	0.743
TRG_ER_diArg_1	456	458	PF00400	0.438
TRG_ER_diArg_1	68	71	PF00400	0.750
TRG_ER_diArg_1	72	74	PF00400	0.722
TRG_ER_diArg_1	92	95	PF00400	0.806
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3L4	Leptomonas seymouri	34%	92%
A4HNG5	Leishmania braziliensis	58%	100%
A4IC56	Leishmania infantum	99%	100%
E9AFX6	Leishmania major	85%	100%
E9B729	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%