LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XA10_LEIDO
TriTrypDb:
LdBPK_354580.1 , LdCL_350050900 , LDHU3_35.6030
Length:
231

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005739 mitochondrion 5 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7XA10
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 191 195 PF00656 0.370
CLV_NRD_NRD_1 2 4 PF00675 0.456
CLV_NRD_NRD_1 80 82 PF00675 0.427
CLV_PCSK_KEX2_1 2 4 PF00082 0.438
CLV_PCSK_KEX2_1 80 82 PF00082 0.385
CLV_PCSK_SKI1_1 151 155 PF00082 0.516
DEG_Nend_UBRbox_1 1 4 PF02207 0.714
DOC_MAPK_DCC_7 132 140 PF00069 0.398
DOC_MAPK_MEF2A_6 132 140 PF00069 0.458
DOC_PP4_FxxP_1 139 142 PF00568 0.376
DOC_PP4_FxxP_1 56 59 PF00568 0.728
DOC_USP7_MATH_1 32 36 PF00917 0.759
DOC_USP7_UBL2_3 151 155 PF12436 0.441
DOC_WW_Pin1_4 49 54 PF00397 0.679
LIG_14-3-3_CanoR_1 66 71 PF00244 0.719
LIG_APCC_ABBAyCdc20_2 167 173 PF00400 0.462
LIG_EH1_1 115 123 PF00400 0.326
LIG_eIF4E_1 218 224 PF01652 0.455
LIG_FHA_1 84 90 PF00498 0.460
LIG_FHA_2 142 148 PF00498 0.440
LIG_FHA_2 37 43 PF00498 0.752
LIG_LIR_Apic_2 54 59 PF02991 0.722
LIG_LIR_Apic_2 69 73 PF02991 0.536
LIG_LIR_Gen_1 143 153 PF02991 0.368
LIG_LIR_Gen_1 219 229 PF02991 0.412
LIG_LIR_Nem_3 143 148 PF02991 0.369
LIG_LIR_Nem_3 215 221 PF02991 0.372
LIG_LIR_Nem_3 40 46 PF02991 0.741
LIG_PDZ_Class_2 226 231 PF00595 0.487
LIG_SH2_NCK_1 221 225 PF00017 0.429
LIG_SH2_PTP2 70 73 PF00017 0.646
LIG_SH2_SRC 70 73 PF00017 0.665
LIG_SH2_STAP1 145 149 PF00017 0.445
LIG_SH2_STAT5 100 103 PF00017 0.305
LIG_SH2_STAT5 70 73 PF00017 0.693
LIG_SUMO_SIM_anti_2 131 137 PF11976 0.478
LIG_SUMO_SIM_anti_2 95 100 PF11976 0.460
LIG_TYR_ITIM 98 103 PF00017 0.380
LIG_TYR_ITSM 39 46 PF00017 0.743
MOD_CK1_1 27 33 PF00069 0.746
MOD_CK1_1 34 40 PF00069 0.632
MOD_CK2_1 141 147 PF00069 0.365
MOD_CK2_1 216 222 PF00069 0.441
MOD_CK2_1 36 42 PF00069 0.735
MOD_CK2_1 66 72 PF00069 0.680
MOD_GlcNHglycan 190 193 PF01048 0.584
MOD_GlcNHglycan 218 221 PF01048 0.669
MOD_GSK3_1 16 23 PF00069 0.755
MOD_GSK3_1 161 168 PF00069 0.470
MOD_GSK3_1 212 219 PF00069 0.429
MOD_GSK3_1 27 34 PF00069 0.669
MOD_GSK3_1 45 52 PF00069 0.660
MOD_N-GLC_2 183 185 PF02516 0.561
MOD_NEK2_1 101 106 PF00069 0.433
MOD_NEK2_1 216 221 PF00069 0.439
MOD_NEK2_1 85 90 PF00069 0.329
MOD_NEK2_2 166 171 PF00069 0.462
MOD_NEK2_2 75 80 PF00069 0.667
MOD_PIKK_1 158 164 PF00454 0.461
MOD_PKA_2 131 137 PF00069 0.483
MOD_Plk_4 171 177 PF00069 0.388
MOD_Plk_4 66 72 PF00069 0.713
MOD_ProDKin_1 49 55 PF00069 0.677
MOD_SUMO_rev_2 69 76 PF00179 0.671
TRG_DiLeu_BaEn_2 71 77 PF01217 0.602
TRG_ENDOCYTIC_2 100 103 PF00928 0.302
TRG_ENDOCYTIC_2 145 148 PF00928 0.445
TRG_ENDOCYTIC_2 149 152 PF00928 0.447
TRG_ENDOCYTIC_2 221 224 PF00928 0.386
TRG_ENDOCYTIC_2 43 46 PF00928 0.746
TRG_ER_diArg_1 1 3 PF00400 0.663
TRG_ER_diArg_1 107 110 PF00400 0.474
TRG_ER_diArg_1 124 127 PF00400 0.382
TRG_ER_diArg_1 79 81 PF00400 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMV6 Leptomonas seymouri 61% 97%
A0A0S4JR13 Bodo saltans 32% 97%
A0A1X0P4Y8 Trypanosomatidae 43% 100%
A0A422P1A7 Trypanosoma rangeli 44% 100%
A4HNB8 Leishmania braziliensis 84% 100%
A4IBZ1 Leishmania infantum 100% 100%
C9ZYL3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AFS8 Leishmania major 95% 100%
E9B6Y0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS