Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA10_LEIDO

TriTrypDb:

LdBPK_354580.1 , LdCL_350050900 , LDHU3_35.6030

Length:

231

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7XA10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.370
CLV_NRD_NRD_1	2	4	PF00675	0.456
CLV_NRD_NRD_1	80	82	PF00675	0.427
CLV_PCSK_KEX2_1	2	4	PF00082	0.438
CLV_PCSK_KEX2_1	80	82	PF00082	0.385
CLV_PCSK_SKI1_1	151	155	PF00082	0.516
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DOC_MAPK_DCC_7	132	140	PF00069	0.398
DOC_MAPK_MEF2A_6	132	140	PF00069	0.458
DOC_PP4_FxxP_1	139	142	PF00568	0.376
DOC_PP4_FxxP_1	56	59	PF00568	0.728
DOC_USP7_MATH_1	32	36	PF00917	0.759
DOC_USP7_UBL2_3	151	155	PF12436	0.441
DOC_WW_Pin1_4	49	54	PF00397	0.679
LIG_14-3-3_CanoR_1	66	71	PF00244	0.719
LIG_APCC_ABBAyCdc20_2	167	173	PF00400	0.462
LIG_EH1_1	115	123	PF00400	0.326
LIG_eIF4E_1	218	224	PF01652	0.455
LIG_FHA_1	84	90	PF00498	0.460
LIG_FHA_2	142	148	PF00498	0.440
LIG_FHA_2	37	43	PF00498	0.752
LIG_LIR_Apic_2	54	59	PF02991	0.722
LIG_LIR_Apic_2	69	73	PF02991	0.536
LIG_LIR_Gen_1	143	153	PF02991	0.368
LIG_LIR_Gen_1	219	229	PF02991	0.412
LIG_LIR_Nem_3	143	148	PF02991	0.369
LIG_LIR_Nem_3	215	221	PF02991	0.372
LIG_LIR_Nem_3	40	46	PF02991	0.741
LIG_PDZ_Class_2	226	231	PF00595	0.487
LIG_SH2_NCK_1	221	225	PF00017	0.429
LIG_SH2_PTP2	70	73	PF00017	0.646
LIG_SH2_SRC	70	73	PF00017	0.665
LIG_SH2_STAP1	145	149	PF00017	0.445
LIG_SH2_STAT5	100	103	PF00017	0.305
LIG_SH2_STAT5	70	73	PF00017	0.693
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.478
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.460
LIG_TYR_ITIM	98	103	PF00017	0.380
LIG_TYR_ITSM	39	46	PF00017	0.743
MOD_CK1_1	27	33	PF00069	0.746
MOD_CK1_1	34	40	PF00069	0.632
MOD_CK2_1	141	147	PF00069	0.365
MOD_CK2_1	216	222	PF00069	0.441
MOD_CK2_1	36	42	PF00069	0.735
MOD_CK2_1	66	72	PF00069	0.680
MOD_GlcNHglycan	190	193	PF01048	0.584
MOD_GlcNHglycan	218	221	PF01048	0.669
MOD_GSK3_1	16	23	PF00069	0.755
MOD_GSK3_1	161	168	PF00069	0.470
MOD_GSK3_1	212	219	PF00069	0.429
MOD_GSK3_1	27	34	PF00069	0.669
MOD_GSK3_1	45	52	PF00069	0.660
MOD_N-GLC_2	183	185	PF02516	0.561
MOD_NEK2_1	101	106	PF00069	0.433
MOD_NEK2_1	216	221	PF00069	0.439
MOD_NEK2_1	85	90	PF00069	0.329
MOD_NEK2_2	166	171	PF00069	0.462
MOD_NEK2_2	75	80	PF00069	0.667
MOD_PIKK_1	158	164	PF00454	0.461
MOD_PKA_2	131	137	PF00069	0.483
MOD_Plk_4	171	177	PF00069	0.388
MOD_Plk_4	66	72	PF00069	0.713
MOD_ProDKin_1	49	55	PF00069	0.677
MOD_SUMO_rev_2	69	76	PF00179	0.671
TRG_DiLeu_BaEn_2	71	77	PF01217	0.602
TRG_ENDOCYTIC_2	100	103	PF00928	0.302
TRG_ENDOCYTIC_2	145	148	PF00928	0.445
TRG_ENDOCYTIC_2	149	152	PF00928	0.447
TRG_ENDOCYTIC_2	221	224	PF00928	0.386
TRG_ENDOCYTIC_2	43	46	PF00928	0.746
TRG_ER_diArg_1	1	3	PF00400	0.663
TRG_ER_diArg_1	107	110	PF00400	0.474
TRG_ER_diArg_1	124	127	PF00400	0.382
TRG_ER_diArg_1	79	81	PF00400	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMV6	Leptomonas seymouri	61%	97%
A0A0S4JR13	Bodo saltans	32%	97%
A0A1X0P4Y8	Trypanosomatidae	43%	100%
A0A422P1A7	Trypanosoma rangeli	44%	100%
A4HNB8	Leishmania braziliensis	84%	100%
A4IBZ1	Leishmania infantum	100%	100%
C9ZYL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AFS8	Leishmania major	95%	100%
E9B6Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%