Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA10_LEIDO

TriTrypDb:

LdBPK_354580.1 , LdCL_350050900 , LDHU3_35.6030

Length:

231

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	6
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A0A3S7XA10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA10

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.370
CLV_NRD_NRD_1	2	4	PF00675	0.456
CLV_NRD_NRD_1	80	82	PF00675	0.427
CLV_PCSK_KEX2_1	2	4	PF00082	0.438
CLV_PCSK_KEX2_1	80	82	PF00082	0.385
CLV_PCSK_SKI1_1	151	155	PF00082	0.516
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DOC_MAPK_DCC_7	132	140	PF00069	0.398
DOC_MAPK_MEF2A_6	132	140	PF00069	0.458
DOC_PP4_FxxP_1	139	142	PF00568	0.376

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMV6	Leptomonas seymouri	61%	97%
A0A0S4JR13	Bodo saltans	32%	97%
A0A1X0P4Y8	Trypanosomatidae	43%	100%
A0A422P1A7	Trypanosoma rangeli	44%	100%
A4HNB8	Leishmania braziliensis	84%	100%
A4IBZ1	Leishmania infantum	100%	100%
C9ZYL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AFS8	Leishmania major	95%	100%
E9B6Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%

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