60Kd inner membrane protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XA08_LEIDO

TriTrypDb:

LdBPK_354650.1 , LdCL_350051600 , LDHU3_35.6130

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7XA08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA08

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0032978	protein insertion into membrane from inner side	6	1
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051205	protein insertion into membrane	5	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061024	membrane organization	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0090151	establishment of protein localization to mitochondrial membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	10
GO:0140104	molecular carrier activity	1	10
GO:0140597	protein carrier chaperone	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	490	494	PF00656	0.749
CLV_NRD_NRD_1	183	185	PF00675	0.359
CLV_NRD_NRD_1	319	321	PF00675	0.397
CLV_NRD_NRD_1	336	338	PF00675	0.543
CLV_PCSK_KEX2_1	183	185	PF00082	0.374
CLV_PCSK_KEX2_1	319	321	PF00082	0.397
CLV_PCSK_KEX2_1	336	338	PF00082	0.543
CLV_PCSK_KEX2_1	510	512	PF00082	0.610
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.610
CLV_PCSK_SKI1_1	145	149	PF00082	0.395
CLV_PCSK_SKI1_1	184	188	PF00082	0.360
CLV_PCSK_SKI1_1	263	267	PF00082	0.416
CLV_PCSK_SKI1_1	337	341	PF00082	0.521
CLV_PCSK_SKI1_1	349	353	PF00082	0.566
DEG_APCC_DBOX_1	144	152	PF00400	0.634
DEG_Nend_Nbox_1	1	3	PF02207	0.493
DEG_ODPH_VHL_1	54	67	PF01847	0.456
DEG_SCF_FBW7_1	27	34	PF00400	0.544
DEG_SCF_FBW7_1	333	338	PF00400	0.600
DEG_SPOP_SBC_1	225	229	PF00917	0.363
DEG_SPOP_SBC_1	473	477	PF00917	0.770
DOC_CDC14_PxL_1	242	250	PF14671	0.457
DOC_CDC14_PxL_1	282	290	PF14671	0.408
DOC_CKS1_1	465	470	PF01111	0.767
DOC_CYCLIN_RxL_1	314	328	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.344
DOC_MAPK_MEF2A_6	139	148	PF00069	0.617
DOC_MAPK_MEF2A_6	292	299	PF00069	0.308
DOC_PP1_RVXF_1	158	164	PF00149	0.658
DOC_PP1_RVXF_1	269	276	PF00149	0.531
DOC_PP1_RVXF_1	318	325	PF00149	0.611
DOC_PP2B_LxvP_1	146	149	PF13499	0.592
DOC_PP2B_LxvP_1	236	239	PF13499	0.343
DOC_PP2B_LxvP_1	54	57	PF13499	0.520
DOC_PP4_FxxP_1	11	14	PF00568	0.579
DOC_USP7_MATH_1	20	24	PF00917	0.557
DOC_USP7_MATH_1	335	339	PF00917	0.739
DOC_USP7_MATH_1	429	433	PF00917	0.808
DOC_USP7_MATH_1	451	455	PF00917	0.700
DOC_USP7_MATH_1	46	50	PF00917	0.586
DOC_USP7_MATH_1	474	478	PF00917	0.826
DOC_USP7_MATH_1	481	485	PF00917	0.739
DOC_USP7_MATH_1	487	491	PF00917	0.799
DOC_USP7_MATH_1	515	519	PF00917	0.764
DOC_USP7_MATH_1	95	99	PF00917	0.473
DOC_USP7_UBL2_3	412	416	PF12436	0.759
DOC_USP7_UBL2_3	510	514	PF12436	0.807
DOC_WW_Pin1_4	10	15	PF00397	0.560
DOC_WW_Pin1_4	27	32	PF00397	0.514
DOC_WW_Pin1_4	331	336	PF00397	0.708
DOC_WW_Pin1_4	42	47	PF00397	0.399
DOC_WW_Pin1_4	464	469	PF00397	0.780
DOC_WW_Pin1_4	477	482	PF00397	0.795
DOC_WW_Pin1_4	542	547	PF00397	0.781
DOC_WW_Pin1_4	548	553	PF00397	0.765
LIG_14-3-3_CanoR_1	127	132	PF00244	0.344
LIG_14-3-3_CanoR_1	336	342	PF00244	0.735
LIG_14-3-3_CanoR_1	349	354	PF00244	0.765
LIG_14-3-3_CanoR_1	427	435	PF00244	0.753
LIG_Actin_WH2_2	298	316	PF00022	0.346
LIG_AP2alpha_2	240	242	PF02296	0.351
LIG_APCC_ABBA_1	133	138	PF00400	0.403
LIG_BIR_III_2	493	497	PF00653	0.662
LIG_BRCT_BRCA1_1	73	77	PF00533	0.474
LIG_Clathr_ClatBox_1	254	258	PF01394	0.344
LIG_deltaCOP1_diTrp_1	69	77	PF00928	0.387
LIG_eIF4E_1	5	11	PF01652	0.480
LIG_FHA_1	115	121	PF00498	0.362
LIG_FHA_1	190	196	PF00498	0.592
LIG_FHA_1	247	253	PF00498	0.484
LIG_FHA_1	42	48	PF00498	0.484
LIG_FHA_2	235	241	PF00498	0.374
LIG_FHA_2	350	356	PF00498	0.759
LIG_FHA_2	61	67	PF00498	0.438
LIG_LIR_Gen_1	156	166	PF02991	0.580
LIG_LIR_Gen_1	240	248	PF02991	0.328
LIG_LIR_Gen_1	404	414	PF02991	0.692
LIG_LIR_Gen_1	63	71	PF02991	0.376
LIG_LIR_Gen_1	98	105	PF02991	0.353
LIG_LIR_Nem_3	130	136	PF02991	0.364
LIG_LIR_Nem_3	156	161	PF02991	0.555
LIG_LIR_Nem_3	240	245	PF02991	0.293
LIG_LIR_Nem_3	389	395	PF02991	0.690
LIG_LIR_Nem_3	404	409	PF02991	0.735
LIG_LIR_Nem_3	63	67	PF02991	0.429
LIG_LIR_Nem_3	74	80	PF02991	0.450
LIG_NRBOX	394	400	PF00104	0.679
LIG_Pex14_2	100	104	PF04695	0.344
LIG_SH2_CRK	5	9	PF00017	0.477
LIG_SH2_GRB2like	162	165	PF00017	0.610
LIG_SH2_STAT5	162	165	PF00017	0.671
LIG_SH2_STAT5	230	233	PF00017	0.435
LIG_SH2_STAT5	298	301	PF00017	0.369
LIG_SH2_STAT5	394	397	PF00017	0.630
LIG_SH2_STAT5	64	67	PF00017	0.418
LIG_SH3_3	50	56	PF00018	0.544
LIG_SH3_3	509	515	PF00018	0.753
LIG_SH3_3	543	549	PF00018	0.786
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.423
LIG_SUMO_SIM_par_1	309	315	PF11976	0.344
LIG_TRAF2_1	326	329	PF00917	0.537
LIG_WRC_WIRS_1	288	293	PF05994	0.531
MOD_CDK_SPK_2	10	15	PF00069	0.446
MOD_CDK_SPK_2	331	336	PF00069	0.676
MOD_CDK_SPxK_1	331	337	PF00069	0.698
MOD_CDK_SPxxK_3	10	17	PF00069	0.420
MOD_CDK_SPxxK_3	464	471	PF00069	0.784
MOD_CK1_1	290	296	PF00069	0.414
MOD_CK1_1	45	51	PF00069	0.491
MOD_CK1_1	477	483	PF00069	0.740
MOD_CK1_1	502	508	PF00069	0.748
MOD_CK1_1	542	548	PF00069	0.788
MOD_CK1_1	550	556	PF00069	0.779
MOD_CK1_1	98	104	PF00069	0.409
MOD_CK2_1	165	171	PF00069	0.602
MOD_CK2_1	323	329	PF00069	0.597
MOD_CK2_1	349	355	PF00069	0.763
MOD_CK2_1	477	483	PF00069	0.824
MOD_CK2_1	528	534	PF00069	0.680
MOD_GlcNHglycan	167	170	PF01048	0.374
MOD_GlcNHglycan	214	217	PF01048	0.570
MOD_GlcNHglycan	292	295	PF01048	0.543
MOD_GlcNHglycan	314	317	PF01048	0.405
MOD_GlcNHglycan	325	328	PF01048	0.322
MOD_GlcNHglycan	337	340	PF01048	0.558
MOD_GlcNHglycan	346	349	PF01048	0.554
MOD_GlcNHglycan	39	42	PF01048	0.746
MOD_GlcNHglycan	421	425	PF01048	0.604
MOD_GlcNHglycan	445	448	PF01048	0.512
MOD_GlcNHglycan	483	486	PF01048	0.574
MOD_GlcNHglycan	489	493	PF01048	0.580
MOD_GlcNHglycan	501	504	PF01048	0.458
MOD_GlcNHglycan	522	525	PF01048	0.545
MOD_GlcNHglycan	542	545	PF01048	0.558
MOD_GlcNHglycan	81	85	PF01048	0.679
MOD_GlcNHglycan	93	96	PF01048	0.706
MOD_GSK3_1	123	130	PF00069	0.359
MOD_GSK3_1	174	181	PF00069	0.609
MOD_GSK3_1	246	253	PF00069	0.369
MOD_GSK3_1	27	34	PF00069	0.522
MOD_GSK3_1	286	293	PF00069	0.540
MOD_GSK3_1	331	338	PF00069	0.686
MOD_GSK3_1	37	44	PF00069	0.466
MOD_GSK3_1	370	377	PF00069	0.705
MOD_GSK3_1	473	480	PF00069	0.740
MOD_GSK3_1	498	505	PF00069	0.760
MOD_GSK3_1	515	522	PF00069	0.748
MOD_GSK3_1	524	531	PF00069	0.714
MOD_GSK3_1	540	547	PF00069	0.772
MOD_GSK3_1	76	83	PF00069	0.499
MOD_GSK3_1	91	98	PF00069	0.384
MOD_N-GLC_1	219	224	PF02516	0.612
MOD_NEK2_1	103	108	PF00069	0.410
MOD_NEK2_1	131	136	PF00069	0.331
MOD_NEK2_1	231	236	PF00069	0.383
MOD_NEK2_1	257	262	PF00069	0.531
MOD_NEK2_1	312	317	PF00069	0.436
MOD_NEK2_1	384	389	PF00069	0.690
MOD_NEK2_1	443	448	PF00069	0.741
MOD_NEK2_1	520	525	PF00069	0.734
MOD_NEK2_1	71	76	PF00069	0.478
MOD_NEK2_2	31	36	PF00069	0.495
MOD_NEK2_2	370	375	PF00069	0.668
MOD_NEK2_2	515	520	PF00069	0.652
MOD_PIKK_1	525	531	PF00454	0.710
MOD_PIKK_1	551	557	PF00454	0.752
MOD_PIKK_1	98	104	PF00454	0.446
MOD_PKA_2	335	341	PF00069	0.732
MOD_PKA_2	497	503	PF00069	0.752
MOD_PKB_1	425	433	PF00069	0.666
MOD_Plk_1	219	225	PF00069	0.435
MOD_Plk_1	257	263	PF00069	0.541
MOD_Plk_2-3	219	225	PF00069	0.405
MOD_Plk_4	114	120	PF00069	0.155
MOD_Plk_4	127	133	PF00069	0.250
MOD_Plk_4	174	180	PF00069	0.585
MOD_Plk_4	226	232	PF00069	0.343
MOD_Plk_4	515	521	PF00069	0.651
MOD_Plk_4	60	66	PF00069	0.465
MOD_Plk_4	95	101	PF00069	0.447
MOD_ProDKin_1	10	16	PF00069	0.560
MOD_ProDKin_1	27	33	PF00069	0.515
MOD_ProDKin_1	331	337	PF00069	0.716
MOD_ProDKin_1	42	48	PF00069	0.387
MOD_ProDKin_1	464	470	PF00069	0.791
MOD_ProDKin_1	477	483	PF00069	0.796
MOD_ProDKin_1	542	548	PF00069	0.783
MOD_SUMO_rev_2	258	267	PF00179	0.647
TRG_DiLeu_BaEn_1	114	119	PF01217	0.324
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.344
TRG_ENDOCYTIC_2	406	409	PF00928	0.689
TRG_ENDOCYTIC_2	64	67	PF00928	0.418
TRG_ER_diArg_1	143	146	PF00400	0.576
TRG_ER_diArg_1	318	320	PF00400	0.585
TRG_ER_diArg_1	335	337	PF00400	0.738

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFR8	Leptomonas seymouri	55%	100%
A0A0S4JMC8	Bodo saltans	35%	100%
A0A422P166	Trypanosoma rangeli	39%	100%
A4HNC5	Leishmania braziliensis	76%	100%
A4IBZ8	Leishmania infantum	100%	100%
E9AFT5	Leishmania major	91%	100%
E9B6Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BT14	Trypanosoma cruzi	39%	100%