FAM184 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XA02_LEIDO

TriTrypDb:

LdBPK_354930.1 , LdCL_350054300 , LDHU3_35.6460

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XA02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XA02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.573
CLV_C14_Caspase3-7	190	194	PF00656	0.586
CLV_C14_Caspase3-7	468	472	PF00656	0.553
CLV_C14_Caspase3-7	695	699	PF00656	0.664
CLV_NRD_NRD_1	263	265	PF00675	0.614
CLV_NRD_NRD_1	310	312	PF00675	0.475
CLV_NRD_NRD_1	617	619	PF00675	0.606
CLV_NRD_NRD_1	703	705	PF00675	0.661
CLV_NRD_NRD_1	854	856	PF00675	0.649
CLV_NRD_NRD_1	892	894	PF00675	0.677
CLV_PCSK_KEX2_1	145	147	PF00082	0.571
CLV_PCSK_KEX2_1	185	187	PF00082	0.604
CLV_PCSK_KEX2_1	263	265	PF00082	0.678
CLV_PCSK_KEX2_1	286	288	PF00082	0.648
CLV_PCSK_KEX2_1	310	312	PF00082	0.475
CLV_PCSK_KEX2_1	437	439	PF00082	0.606
CLV_PCSK_KEX2_1	617	619	PF00082	0.606
CLV_PCSK_KEX2_1	703	705	PF00082	0.661
CLV_PCSK_KEX2_1	841	843	PF00082	0.597
CLV_PCSK_KEX2_1	854	856	PF00082	0.583
CLV_PCSK_KEX2_1	892	894	PF00082	0.677
CLV_PCSK_KEX2_1	983	985	PF00082	0.784
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.571
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.604
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.598
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.707
CLV_PCSK_PC1ET2_1	841	843	PF00082	0.698
CLV_PCSK_PC1ET2_1	983	985	PF00082	0.674
CLV_PCSK_SKI1_1	167	171	PF00082	0.563
CLV_PCSK_SKI1_1	177	181	PF00082	0.572
CLV_PCSK_SKI1_1	223	227	PF00082	0.679
CLV_PCSK_SKI1_1	287	291	PF00082	0.649
CLV_PCSK_SKI1_1	329	333	PF00082	0.588
CLV_PCSK_SKI1_1	340	344	PF00082	0.678
CLV_PCSK_SKI1_1	384	388	PF00082	0.734
CLV_PCSK_SKI1_1	467	471	PF00082	0.608
CLV_PCSK_SKI1_1	650	654	PF00082	0.614
CLV_PCSK_SKI1_1	785	789	PF00082	0.685
CLV_PCSK_SKI1_1	868	872	PF00082	0.595
CLV_Separin_Metazoa	443	447	PF03568	0.645
CLV_Separin_Metazoa	711	715	PF03568	0.552
DOC_CYCLIN_RxL_1	933	941	PF00134	0.602
DOC_CYCLIN_yClb5_NLxxxL_5	819	827	PF00134	0.448
DOC_MAPK_gen_1	145	155	PF00069	0.669
DOC_MAPK_gen_1	667	676	PF00069	0.514
DOC_MAPK_gen_1	916	925	PF00069	0.578
DOC_MIT_MIM_1	275	283	PF04212	0.600
DOC_USP7_MATH_1	202	206	PF00917	0.628
DOC_USP7_MATH_1	297	301	PF00917	0.592
DOC_USP7_MATH_1	3	7	PF00917	0.759
DOC_USP7_MATH_1	410	414	PF00917	0.635
DOC_USP7_MATH_1	497	501	PF00917	0.649
DOC_USP7_MATH_1	572	576	PF00917	0.480
DOC_USP7_UBL2_3	16	20	PF12436	0.641
DOC_USP7_UBL2_3	23	27	PF12436	0.532
DOC_USP7_UBL2_3	581	585	PF12436	0.495
LIG_14-3-3_CanoR_1	223	228	PF00244	0.780
LIG_14-3-3_CanoR_1	279	284	PF00244	0.625
LIG_14-3-3_CanoR_1	411	415	PF00244	0.677
LIG_14-3-3_CanoR_1	446	454	PF00244	0.639
LIG_14-3-3_CanoR_1	650	659	PF00244	0.629
LIG_14-3-3_CanoR_1	903	907	PF00244	0.611
LIG_14-3-3_CanoR_1	984	989	PF00244	0.718
LIG_14-3-3_CterR_2	995	1000	PF00244	0.705
LIG_Actin_WH2_2	634	652	PF00022	0.684
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_CaM_IQ_9	71	87	PF13499	0.565
LIG_FHA_1	142	148	PF00498	0.644
LIG_FHA_1	30	36	PF00498	0.536
LIG_FHA_1	459	465	PF00498	0.722
LIG_FHA_1	47	53	PF00498	0.576
LIG_FHA_1	654	660	PF00498	0.637
LIG_FHA_2	272	278	PF00498	0.482
LIG_FHA_2	325	331	PF00498	0.685
LIG_FHA_2	399	405	PF00498	0.449
LIG_FHA_2	466	472	PF00498	0.667
LIG_FHA_2	693	699	PF00498	0.714
LIG_FHA_2	903	909	PF00498	0.625
LIG_LIR_Gen_1	66	74	PF02991	0.421
LIG_LIR_Gen_1	941	952	PF02991	0.654
LIG_LIR_Gen_1	958	969	PF02991	0.550
LIG_LIR_Gen_1	973	981	PF02991	0.694
LIG_LIR_Nem_3	66	70	PF02991	0.421
LIG_LIR_Nem_3	958	964	PF02991	0.619
LIG_LIR_Nem_3	973	977	PF02991	0.690
LIG_NRBOX	822	828	PF00104	0.662
LIG_RPA_C_Fungi	306	318	PF08784	0.495
LIG_SH2_CRK	961	965	PF00017	0.635
LIG_SH2_CRK	974	978	PF00017	0.695
LIG_SH2_NCK_1	961	965	PF00017	0.635
LIG_SH2_NCK_1	974	978	PF00017	0.695
LIG_SH2_STAP1	125	129	PF00017	0.672
LIG_SH2_STAP1	620	624	PF00017	0.679
LIG_SH2_STAP1	67	71	PF00017	0.531
LIG_SH2_STAP1	725	729	PF00017	0.590
LIG_SH2_STAP1	974	978	PF00017	0.719
LIG_SH2_STAT5	36	39	PF00017	0.528
LIG_SUMO_SIM_anti_2	673	678	PF11976	0.654
LIG_SUMO_SIM_anti_2	921	927	PF11976	0.576
LIG_TRAF2_1	102	105	PF00917	0.662
LIG_TRAF2_1	119	122	PF00917	0.383
LIG_TRAF2_1	179	182	PF00917	0.558
LIG_TRAF2_1	460	463	PF00917	0.643
LIG_TRAF2_1	818	821	PF00917	0.642
LIG_TRAF2_1	905	908	PF00917	0.650
LIG_UBA3_1	812	819	PF00899	0.659
LIG_UBA3_1	925	934	PF00899	0.570
MOD_CK1_1	234	240	PF00069	0.773
MOD_CK1_1	282	288	PF00069	0.644
MOD_CK1_1	324	330	PF00069	0.665
MOD_CK1_1	363	369	PF00069	0.670
MOD_CK1_1	413	419	PF00069	0.614
MOD_CK1_1	815	821	PF00069	0.552
MOD_CK2_1	116	122	PF00069	0.665
MOD_CK2_1	234	240	PF00069	0.773
MOD_CK2_1	271	277	PF00069	0.536
MOD_CK2_1	324	330	PF00069	0.686
MOD_CK2_1	398	404	PF00069	0.665
MOD_CK2_1	415	421	PF00069	0.592
MOD_CK2_1	492	498	PF00069	0.737
MOD_CK2_1	66	72	PF00069	0.636
MOD_CK2_1	815	821	PF00069	0.655
MOD_CK2_1	901	907	PF00069	0.619
MOD_CK2_1	915	921	PF00069	0.482
MOD_CK2_1	92	98	PF00069	0.525
MOD_Cter_Amidation	981	984	PF01082	0.729
MOD_GlcNHglycan	1	4	PF01048	0.724
MOD_GlcNHglycan	126	129	PF01048	0.454
MOD_GlcNHglycan	204	207	PF01048	0.694
MOD_GlcNHglycan	232	236	PF01048	0.788
MOD_GlcNHglycan	363	366	PF01048	0.610
MOD_GlcNHglycan	498	502	PF01048	0.650
MOD_GlcNHglycan	562	567	PF01048	0.714
MOD_GlcNHglycan	570	573	PF01048	0.568
MOD_GlcNHglycan	587	590	PF01048	0.525
MOD_GlcNHglycan	973	977	PF01048	0.690
MOD_GSK3_1	112	119	PF00069	0.626
MOD_GSK3_1	120	127	PF00069	0.570
MOD_GSK3_1	240	247	PF00069	0.622
MOD_GSK3_1	321	328	PF00069	0.680
MOD_GSK3_1	369	376	PF00069	0.684
MOD_GSK3_1	413	420	PF00069	0.610
MOD_GSK3_1	5	12	PF00069	0.698
MOD_GSK3_1	568	575	PF00069	0.488
MOD_GSK3_1	811	818	PF00069	0.593
MOD_GSK3_1	88	95	PF00069	0.514
MOD_GSK3_1	991	998	PF00069	0.758
MOD_N-GLC_1	416	421	PF02516	0.723
MOD_N-GLC_2	40	42	PF02516	0.644
MOD_NEK2_1	180	185	PF00069	0.658
MOD_NEK2_1	343	348	PF00069	0.695
MOD_NEK2_1	360	365	PF00069	0.453
MOD_NEK2_1	371	376	PF00069	0.526
MOD_NEK2_1	465	470	PF00069	0.703
MOD_NEK2_1	492	497	PF00069	0.721
MOD_NEK2_1	5	10	PF00069	0.574
MOD_NEK2_1	653	658	PF00069	0.681
MOD_NEK2_1	659	664	PF00069	0.673
MOD_NEK2_1	692	697	PF00069	0.685
MOD_NEK2_1	754	759	PF00069	0.667
MOD_NEK2_1	798	803	PF00069	0.649
MOD_NEK2_1	812	817	PF00069	0.417
MOD_NEK2_1	92	97	PF00069	0.588
MOD_NEK2_1	938	943	PF00069	0.557
MOD_NEK2_2	410	415	PF00069	0.538
MOD_PIKK_1	240	246	PF00454	0.626
MOD_PIKK_1	373	379	PF00454	0.751
MOD_PIKK_1	396	402	PF00454	0.682
MOD_PIKK_1	458	464	PF00454	0.575
MOD_PIKK_1	608	614	PF00454	0.509
MOD_PIKK_1	92	98	PF00454	0.588
MOD_PKA_1	430	436	PF00069	0.643
MOD_PKA_1	983	989	PF00069	0.721
MOD_PKA_2	147	153	PF00069	0.492
MOD_PKA_2	396	402	PF00069	0.741
MOD_PKA_2	410	416	PF00069	0.517
MOD_PKA_2	902	908	PF00069	0.617
MOD_PKA_2	915	921	PF00069	0.492
MOD_PKA_2	983	989	PF00069	0.721
MOD_PKB_1	264	272	PF00069	0.630
MOD_PKB_1	783	791	PF00069	0.606
MOD_Plk_1	180	186	PF00069	0.423
MOD_Plk_1	972	978	PF00069	0.711
MOD_Plk_2-3	116	122	PF00069	0.586
MOD_Plk_2-3	271	277	PF00069	0.656
MOD_Plk_2-3	66	72	PF00069	0.422
MOD_Plk_4	366	372	PF00069	0.685
MOD_Plk_4	637	643	PF00069	0.610
MOD_Plk_4	66	72	PF00069	0.422
MOD_SUMO_for_1	184	187	PF00179	0.679
MOD_SUMO_for_1	272	275	PF00179	0.609
MOD_SUMO_rev_2	105	109	PF00179	0.579
MOD_SUMO_rev_2	139	147	PF00179	0.574
MOD_SUMO_rev_2	269	274	PF00179	0.620
MOD_SUMO_rev_2	560	566	PF00179	0.623
MOD_SUMO_rev_2	800	809	PF00179	0.588
MOD_SUMO_rev_2	865	873	PF00179	0.595
TRG_DiLeu_BaEn_1	154	159	PF01217	0.556
TRG_DiLeu_BaEn_1	421	426	PF01217	0.637
TRG_DiLeu_BaEn_1	488	493	PF01217	0.732
TRG_DiLeu_BaEn_1	66	71	PF01217	0.422
TRG_DiLeu_BaEn_1	921	926	PF01217	0.576
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.660
TRG_DiLeu_BaLyEn_6	822	827	PF01217	0.584
TRG_DiLeu_LyEn_5	421	426	PF01217	0.603
TRG_ENDOCYTIC_2	166	169	PF00928	0.565
TRG_ENDOCYTIC_2	67	70	PF00928	0.418
TRG_ENDOCYTIC_2	944	947	PF00928	0.553
TRG_ENDOCYTIC_2	961	964	PF00928	0.630
TRG_ENDOCYTIC_2	974	977	PF00928	0.696
TRG_ER_diArg_1	263	266	PF00400	0.675
TRG_ER_diArg_1	616	618	PF00400	0.612
TRG_ER_diArg_1	713	716	PF00400	0.690
TRG_ER_diArg_1	722	725	PF00400	0.578
TRG_ER_diArg_1	782	785	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	825	829	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I973	Leptomonas seymouri	47%	99%
A4HNF1	Leishmania braziliensis	70%	99%
A4IC23	Leishmania infantum	100%	100%
E9AFW2	Leishmania major	92%	100%
E9B715	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%