TPR repeat/Tetratricopeptide repeat/Uncharacterized protein family (UPF0121), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9Z6_LEIDO

TriTrypDb:

LdBPK_354940.1 , LdCL_350054400 , LDHU3_35.6470

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0072379	ER membrane insertion complex	2	1
GO:0072380	TRC complex	3	1

Expansion

Sequence features

A0A3S7X9Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9Z6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006950	response to stress	2	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	3
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0015031	protein transport	4	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0050896	response to stimulus	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0051716	cellular response to stimulus	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1
GO:0006457	protein folding	2	2

Molecular functions
Term	Name	Level	Count
GO:0060090	molecular adaptor activity	1	1
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2
GO:0051879	Hsp90 protein binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.632
CLV_NRD_NRD_1	132	134	PF00675	0.529
CLV_PCSK_KEX2_1	132	134	PF00082	0.535
CLV_PCSK_KEX2_1	269	271	PF00082	0.618
CLV_PCSK_KEX2_1	64	66	PF00082	0.298
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.618
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.364
CLV_PCSK_SKI1_1	215	219	PF00082	0.358
CLV_PCSK_SKI1_1	299	303	PF00082	0.581
CLV_PCSK_SKI1_1	340	344	PF00082	0.341
CLV_PCSK_SKI1_1	90	94	PF00082	0.409
DOC_MAPK_gen_1	213	220	PF00069	0.654
DOC_MAPK_MEF2A_6	249	258	PF00069	0.533
DOC_PP1_RVXF_1	247	254	PF00149	0.480
DOC_PP1_RVXF_1	338	344	PF00149	0.567
DOC_PP2B_LxvP_1	188	191	PF13499	0.305
DOC_PP2B_LxvP_1	283	286	PF13499	0.368
DOC_USP7_MATH_1	122	126	PF00917	0.704
DOC_USP7_MATH_1	191	195	PF00917	0.292
DOC_USP7_MATH_1	63	67	PF00917	0.564
DOC_USP7_UBL2_3	106	110	PF12436	0.694
DOC_USP7_UBL2_3	340	344	PF12436	0.621
DOC_USP7_UBL2_3	54	58	PF12436	0.617
LIG_14-3-3_CanoR_1	299	308	PF00244	0.437
LIG_14-3-3_CanoR_1	352	360	PF00244	0.636
LIG_BRCT_BRCA1_1	233	237	PF00533	0.447
LIG_BRCT_BRCA1_1	36	40	PF00533	0.586
LIG_EH1_1	260	268	PF00400	0.420
LIG_eIF4E_1	261	267	PF01652	0.393
LIG_FHA_1	162	168	PF00498	0.580
LIG_FHA_1	196	202	PF00498	0.382
LIG_FHA_1	300	306	PF00498	0.381
LIG_FHA_1	36	42	PF00498	0.565
LIG_LIR_Gen_1	158	167	PF02991	0.649
LIG_LIR_Gen_1	194	205	PF02991	0.454
LIG_LIR_Gen_1	230	239	PF02991	0.558
LIG_LIR_Gen_1	336	346	PF02991	0.538
LIG_LIR_Nem_3	158	162	PF02991	0.664
LIG_LIR_Nem_3	194	200	PF02991	0.444
LIG_LIR_Nem_3	230	235	PF02991	0.542
LIG_LIR_Nem_3	319	324	PF02991	0.350
LIG_LIR_Nem_3	336	341	PF02991	0.527
LIG_LIR_Nem_3	37	43	PF02991	0.562
LIG_Pex14_1	155	159	PF04695	0.556
LIG_Pex14_1	228	232	PF04695	0.591
LIG_Pex14_2	237	241	PF04695	0.447
LIG_Pex14_2	253	257	PF04695	0.394
LIG_Pex14_2	311	315	PF04695	0.368
LIG_REV1ctd_RIR_1	318	326	PF16727	0.169
LIG_SH2_CRK	281	285	PF00017	0.439
LIG_SH2_GRB2like	129	132	PF00017	0.727
LIG_SH2_GRB2like	42	45	PF00017	0.562
LIG_SH2_NCK_1	141	145	PF00017	0.692
LIG_SH2_PTP2	199	202	PF00017	0.480
LIG_SH2_PTP2	338	341	PF00017	0.615
LIG_SH2_SRC	139	142	PF00017	0.700
LIG_SH2_STAP1	141	145	PF00017	0.692
LIG_SH2_STAP1	29	33	PF00017	0.493
LIG_SH2_STAP1	366	370	PF00017	0.634
LIG_SH2_STAP1	56	60	PF00017	0.581
LIG_SH2_STAT3	287	290	PF00017	0.449
LIG_SH2_STAT5	199	202	PF00017	0.428
LIG_SH2_STAT5	325	328	PF00017	0.389
LIG_SH2_STAT5	338	341	PF00017	0.535
LIG_SH3_3	132	138	PF00018	0.692
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.431
LIG_SUMO_SIM_anti_2	262	268	PF11976	0.377
LIG_SUMO_SIM_par_1	198	204	PF11976	0.448
MOD_CK1_1	105	111	PF00069	0.649
MOD_CK1_1	161	167	PF00069	0.660
MOD_CK1_1	227	233	PF00069	0.609
MOD_CK2_1	91	97	PF00069	0.520
MOD_GlcNHglycan	126	129	PF01048	0.520
MOD_GSK3_1	191	198	PF00069	0.360
MOD_GSK3_1	223	230	PF00069	0.627
MOD_GSK3_1	231	238	PF00069	0.573
MOD_GSK3_1	309	316	PF00069	0.356
MOD_GSK3_1	348	355	PF00069	0.602
MOD_GSK3_1	98	105	PF00069	0.610
MOD_NEK2_1	123	128	PF00069	0.693
MOD_NEK2_1	183	188	PF00069	0.387
MOD_NEK2_1	192	197	PF00069	0.385
MOD_NEK2_1	201	206	PF00069	0.328
MOD_NEK2_1	235	240	PF00069	0.495
MOD_NEK2_1	309	314	PF00069	0.315
MOD_NEK2_1	346	351	PF00069	0.570
MOD_PIKK_1	376	382	PF00454	0.606
MOD_PKA_2	346	352	PF00069	0.585
MOD_Plk_2-3	158	164	PF00069	0.655
MOD_Plk_2-3	91	97	PF00069	0.520
MOD_Plk_4	183	189	PF00069	0.379
MOD_Plk_4	192	198	PF00069	0.371
MOD_Plk_4	224	230	PF00069	0.587
MOD_Plk_4	231	237	PF00069	0.512
MOD_Plk_4	259	265	PF00069	0.339
MOD_Plk_4	272	278	PF00069	0.316
MOD_Plk_4	316	322	PF00069	0.368
MOD_Plk_4	354	360	PF00069	0.606
MOD_SUMO_for_1	92	95	PF00179	0.626
MOD_SUMO_rev_2	61	66	PF00179	0.520
MOD_SUMO_rev_2	7	11	PF00179	0.624
TRG_DiLeu_BaEn_4	23	29	PF01217	0.567
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.346
TRG_ENDOCYTIC_2	199	202	PF00928	0.480
TRG_ENDOCYTIC_2	261	264	PF00928	0.316
TRG_ENDOCYTIC_2	281	284	PF00928	0.419
TRG_ENDOCYTIC_2	338	341	PF00928	0.604
TRG_ENDOCYTIC_2	50	53	PF00928	0.562
TRG_ER_diArg_1	212	215	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGM1	Leptomonas seymouri	71%	100%
A0A0S4J3T8	Bodo saltans	30%	100%
A0A1X0P4V4	Trypanosomatidae	35%	100%
A0A422P159	Trypanosoma rangeli	36%	100%
A4HNF2	Leishmania braziliensis	83%	100%
A4IC24	Leishmania infantum	99%	100%
C9ZYH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AFW3	Leishmania major	93%	100%
E9B716	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%