LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X9Y7_LEIDO

TriTrypDb:

LdBPK_354450.1 , LdCL_350049600 , LDHU3_35.5880

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.614
CLV_NRD_NRD_1	155	157	PF00675	0.634
CLV_NRD_NRD_1	185	187	PF00675	0.561
CLV_NRD_NRD_1	240	242	PF00675	0.642
CLV_NRD_NRD_1	270	272	PF00675	0.613
CLV_NRD_NRD_1	325	327	PF00675	0.640
CLV_NRD_NRD_1	355	357	PF00675	0.599
CLV_NRD_NRD_1	41	43	PF00675	0.553
CLV_NRD_NRD_1	410	412	PF00675	0.562
CLV_NRD_NRD_1	70	72	PF00675	0.637
CLV_PCSK_KEX2_1	127	129	PF00082	0.626
CLV_PCSK_KEX2_1	212	214	PF00082	0.665
CLV_PCSK_KEX2_1	297	299	PF00082	0.644
CLV_PCSK_KEX2_1	382	384	PF00082	0.631
CLV_PCSK_KEX2_1	463	465	PF00082	0.642
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.626
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.665
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.644
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.631
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.642
CLV_PCSK_SKI1_1	102	106	PF00082	0.556
CLV_PCSK_SKI1_1	187	191	PF00082	0.543
CLV_PCSK_SKI1_1	272	276	PF00082	0.548
CLV_PCSK_SKI1_1	357	361	PF00082	0.517
CLV_PCSK_SKI1_1	36	40	PF00082	0.502
CLV_PCSK_SKI1_1	441	445	PF00082	0.559
CLV_Separin_Metazoa	153	157	PF03568	0.597
CLV_Separin_Metazoa	183	187	PF03568	0.504
CLV_Separin_Metazoa	238	242	PF03568	0.596
CLV_Separin_Metazoa	268	272	PF03568	0.576
CLV_Separin_Metazoa	323	327	PF03568	0.622
CLV_Separin_Metazoa	353	357	PF03568	0.566
CLV_Separin_Metazoa	408	412	PF03568	0.548
CLV_Separin_Metazoa	68	72	PF03568	0.625
CLV_Separin_Metazoa	98	102	PF03568	0.542
DEG_SPOP_SBC_1	111	115	PF00917	0.621
DEG_SPOP_SBC_1	196	200	PF00917	0.652
DEG_SPOP_SBC_1	281	285	PF00917	0.659
DEG_SPOP_SBC_1	366	370	PF00917	0.622
DOC_CKS1_1	622	627	PF01111	0.689
DOC_MAPK_MEF2A_6	614	622	PF00069	0.649
DOC_PP2B_LxvP_1	3	6	PF13499	0.487
DOC_USP7_MATH_1	111	115	PF00917	0.621
DOC_USP7_MATH_1	196	200	PF00917	0.652
DOC_USP7_MATH_1	281	285	PF00917	0.659
DOC_USP7_MATH_1	366	370	PF00917	0.622
DOC_USP7_MATH_1	450	454	PF00917	0.562
DOC_USP7_MATH_1	485	489	PF00917	0.660
DOC_USP7_MATH_1	59	63	PF00917	0.632
DOC_USP7_UBL2_3	123	127	PF12436	0.601
DOC_USP7_UBL2_3	132	136	PF12436	0.579
DOC_USP7_UBL2_3	157	161	PF12436	0.629
DOC_USP7_UBL2_3	162	166	PF12436	0.592
DOC_USP7_UBL2_3	208	212	PF12436	0.690
DOC_USP7_UBL2_3	217	221	PF12436	0.592
DOC_USP7_UBL2_3	242	246	PF12436	0.627
DOC_USP7_UBL2_3	247	251	PF12436	0.617
DOC_USP7_UBL2_3	293	297	PF12436	0.782
DOC_USP7_UBL2_3	302	306	PF12436	0.630
DOC_USP7_UBL2_3	327	331	PF12436	0.642
DOC_USP7_UBL2_3	332	336	PF12436	0.595
DOC_USP7_UBL2_3	378	382	PF12436	0.664
DOC_USP7_UBL2_3	387	391	PF12436	0.591
DOC_USP7_UBL2_3	412	416	PF12436	0.587
DOC_USP7_UBL2_3	417	421	PF12436	0.560
DOC_USP7_UBL2_3	72	76	PF12436	0.686
DOC_USP7_UBL2_3	77	81	PF12436	0.655
DOC_WW_Pin1_4	127	132	PF00397	0.601
DOC_WW_Pin1_4	161	166	PF00397	0.582
DOC_WW_Pin1_4	212	217	PF00397	0.654
DOC_WW_Pin1_4	246	251	PF00397	0.578
DOC_WW_Pin1_4	297	302	PF00397	0.644
DOC_WW_Pin1_4	331	336	PF00397	0.588
DOC_WW_Pin1_4	382	387	PF00397	0.604
DOC_WW_Pin1_4	416	421	PF00397	0.579
DOC_WW_Pin1_4	621	626	PF00397	0.616
DOC_WW_Pin1_4	76	81	PF00397	0.648
LIG_14-3-3_CanoR_1	22	30	PF00244	0.468
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_FHA_1	44	50	PF00498	0.549
LIG_FHA_1	622	628	PF00498	0.689
LIG_SH2_NCK_1	23	27	PF00017	0.508
LIG_SH2_STAP1	23	27	PF00017	0.508
LIG_SH2_STAT5	15	18	PF00017	0.408
LIG_SH2_STAT5	23	26	PF00017	0.432
LIG_SH3_3	118	124	PF00018	0.698
LIG_SH3_3	152	158	PF00018	0.755
LIG_SH3_3	182	188	PF00018	0.745
LIG_SH3_3	203	209	PF00018	0.740
LIG_SH3_3	237	243	PF00018	0.758
LIG_SH3_3	267	273	PF00018	0.736
LIG_SH3_3	288	294	PF00018	0.768
LIG_SH3_3	322	328	PF00018	0.761
LIG_SH3_3	352	358	PF00018	0.714
LIG_SH3_3	373	379	PF00018	0.703
LIG_SH3_3	407	413	PF00018	0.761
LIG_SH3_3	67	73	PF00018	0.627
LIG_SH3_3	97	103	PF00018	0.712
LIG_SH3_4	123	130	PF00018	0.619
LIG_SH3_4	132	139	PF00018	0.572
LIG_SH3_4	157	164	PF00018	0.666
LIG_SH3_4	208	215	PF00018	0.701
LIG_SH3_4	217	224	PF00018	0.626
LIG_SH3_4	242	249	PF00018	0.664
LIG_SH3_4	293	300	PF00018	0.640
LIG_SH3_4	302	309	PF00018	0.583
LIG_SH3_4	327	334	PF00018	0.694
LIG_SH3_4	378	385	PF00018	0.626
LIG_SH3_4	387	394	PF00018	0.569
LIG_SH3_4	412	419	PF00018	0.572
LIG_SH3_4	72	79	PF00018	0.712
LIG_TRAF2_1	115	118	PF00917	0.622
LIG_TRAF2_1	200	203	PF00917	0.625
LIG_TRAF2_1	285	288	PF00917	0.612
LIG_TRAF2_1	29	32	PF00917	0.539
LIG_TRAF2_1	370	373	PF00917	0.593
LIG_TRAF2_1	454	457	PF00917	0.559
MOD_CDK_SPK_2	127	132	PF00069	0.601
MOD_CDK_SPK_2	161	166	PF00069	0.582
MOD_CDK_SPK_2	212	217	PF00069	0.654
MOD_CDK_SPK_2	246	251	PF00069	0.578
MOD_CDK_SPK_2	297	302	PF00069	0.644
MOD_CDK_SPK_2	331	336	PF00069	0.588
MOD_CDK_SPK_2	382	387	PF00069	0.604
MOD_CDK_SPK_2	416	421	PF00069	0.579
MOD_CDK_SPK_2	76	81	PF00069	0.648
MOD_CK1_1	21	27	PF00069	0.489
MOD_CK1_1	451	457	PF00069	0.529
MOD_CK1_1	47	53	PF00069	0.634
MOD_CK1_1	488	494	PF00069	0.656
MOD_CK1_1	62	68	PF00069	0.520
MOD_CK1_1	623	629	PF00069	0.634
MOD_CK2_1	111	117	PF00069	0.621
MOD_CK2_1	196	202	PF00069	0.653
MOD_CK2_1	281	287	PF00069	0.656
MOD_CK2_1	366	372	PF00069	0.623
MOD_CK2_1	431	437	PF00069	0.586
MOD_CK2_1	450	456	PF00069	0.515
MOD_CK2_1	478	484	PF00069	0.674
MOD_CK2_1	62	68	PF00069	0.607
MOD_GlcNHglycan	24	27	PF01048	0.458
MOD_GlcNHglycan	46	49	PF01048	0.548
MOD_GSK3_1	127	134	PF00069	0.608
MOD_GSK3_1	18	25	PF00069	0.456
MOD_GSK3_1	212	219	PF00069	0.647
MOD_GSK3_1	297	304	PF00069	0.630
MOD_GSK3_1	382	389	PF00069	0.618
MOD_GSK3_1	43	50	PF00069	0.583
MOD_GSK3_1	480	487	PF00069	0.719
MOD_GSK3_1	626	633	PF00069	0.681
MOD_N-GLC_1	488	493	PF02516	0.686
MOD_N-GLC_1	630	635	PF02516	0.606
MOD_NEK2_1	18	23	PF00069	0.405
MOD_NEK2_1	443	448	PF00069	0.556
MOD_PKA_1	441	447	PF00069	0.557
MOD_PKA_2	21	27	PF00069	0.448
MOD_Plk_1	630	636	PF00069	0.607
MOD_Plk_2-3	112	118	PF00069	0.594
MOD_Plk_2-3	146	152	PF00069	0.598
MOD_Plk_2-3	176	182	PF00069	0.591
MOD_Plk_2-3	197	203	PF00069	0.612
MOD_Plk_2-3	231	237	PF00069	0.640
MOD_Plk_2-3	261	267	PF00069	0.615
MOD_Plk_2-3	282	288	PF00069	0.652
MOD_Plk_2-3	316	322	PF00069	0.627
MOD_Plk_2-3	346	352	PF00069	0.604
MOD_Plk_2-3	367	373	PF00069	0.596
MOD_Plk_2-3	401	407	PF00069	0.637
MOD_Plk_2-3	91	97	PF00069	0.638
MOD_ProDKin_1	127	133	PF00069	0.600
MOD_ProDKin_1	161	167	PF00069	0.585
MOD_ProDKin_1	212	218	PF00069	0.649
MOD_ProDKin_1	246	252	PF00069	0.581
MOD_ProDKin_1	297	303	PF00069	0.642
MOD_ProDKin_1	331	337	PF00069	0.592
MOD_ProDKin_1	382	388	PF00069	0.602
MOD_ProDKin_1	416	422	PF00069	0.579
MOD_ProDKin_1	621	627	PF00069	0.616
MOD_ProDKin_1	76	82	PF00069	0.649
MOD_SUMO_for_1	6	9	PF00179	0.433
TRG_ENDOCYTIC_2	15	18	PF00928	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HNA7	Leishmania braziliensis	58%	100%
A4IBX8	Leishmania infantum	75%	100%
C9ZYM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AFR5	Leishmania major	66%	100%
E9B6W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%