DUF962-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF962), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9Y4_LEIDO

TriTrypDb:

LdBPK_354590.1 , LdCL_350051000 , LDHU3_35.6040

Length:

178

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X9Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9Y4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0030149	sphingolipid catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046466	membrane lipid catabolic process	5	1
GO:0046519	sphingoid metabolic process	5	1
GO:0046521	sphingoid catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.501
CLV_PCSK_SKI1_1	167	171	PF00082	0.327
DEG_Nend_Nbox_1	1	3	PF02207	0.354
DOC_CKS1_1	79	84	PF01111	0.200
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.336
DOC_PP2B_PxIxI_1	81	87	PF00149	0.200
DOC_WW_Pin1_4	78	83	PF00397	0.238
LIG_14-3-3_CanoR_1	12	16	PF00244	0.287
LIG_14-3-3_CanoR_1	167	172	PF00244	0.463
LIG_BRCT_BRCA1_1	13	17	PF00533	0.253
LIG_FHA_1	79	85	PF00498	0.414
LIG_LIR_Gen_1	68	76	PF02991	0.263
LIG_LIR_Nem_3	14	18	PF02991	0.275
LIG_LIR_Nem_3	6	11	PF02991	0.298
LIG_PCNA_PIPBox_1	83	92	PF02747	0.200
LIG_SH2_STAP1	65	69	PF00017	0.266
LIG_SH2_STAT5	4	7	PF00017	0.312
LIG_SH2_STAT5	8	11	PF00017	0.221
LIG_SH2_STAT5	80	83	PF00017	0.292
LIG_SH2_STAT5	89	92	PF00017	0.293
LIG_SUMO_SIM_par_1	81	88	PF11976	0.217
MOD_CK1_1	75	81	PF00069	0.471
MOD_GlcNHglycan	73	77	PF01048	0.449
MOD_GSK3_1	37	44	PF00069	0.308
MOD_GSK3_1	55	62	PF00069	0.226
MOD_N-GLC_1	55	60	PF02516	0.284
MOD_NEK2_1	11	16	PF00069	0.253
MOD_PKA_2	11	17	PF00069	0.291
MOD_PKA_2	152	158	PF00069	0.425
MOD_Plk_1	55	61	PF00069	0.247
MOD_Plk_4	11	17	PF00069	0.248
MOD_Plk_4	41	47	PF00069	0.318
MOD_Plk_4	65	71	PF00069	0.377
MOD_Plk_4	75	81	PF00069	0.377
MOD_ProDKin_1	78	84	PF00069	0.238
MOD_SUMO_for_1	156	159	PF00179	0.536
MOD_SUMO_for_1	70	73	PF00179	0.266
TRG_DiLeu_BaEn_2	144	150	PF01217	0.360
TRG_ENDOCYTIC_2	8	11	PF00928	0.253
TRG_ENDOCYTIC_2	80	83	PF00928	0.266
TRG_ER_diLys_1	175	178	PF00400	0.485
TRG_NES_CRM1_1	133	145	PF08389	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGQ0	Leptomonas seymouri	68%	92%
A0A0S4JU62	Bodo saltans	54%	100%
A0A1X0P4Z2	Trypanosomatidae	51%	89%
A4HNB9	Leishmania braziliensis	78%	100%
A4IBZ2	Leishmania infantum	100%	100%
E9AFS9	Leishmania major	92%	100%
E9B6Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O13737	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	80%
P25338	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%