FPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X9Y3_LEIDO

TriTrypDb:

LdCL_350051200 , LDHU3_35.6070

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005765	lysosomal membrane	7	1
GO:0005774	vacuolar membrane	5	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0036020	endolysosome membrane	6	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098852	lytic vacuole membrane	6	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X9Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9Y3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0007041	lysosomal transport	5	1
GO:0008333	endosome to lysosome transport	5	1
GO:0009894	regulation of catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010506	regulation of autophagy	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016241	regulation of macroautophagy	7	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0033043	regulation of organelle organization	5	1
GO:0043244	regulation of protein-containing complex disassembly	5	1
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0065007	biological regulation	1	1
GO:1901096	regulation of autophagosome maturation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.498
CLV_C14_Caspase3-7	36	40	PF00656	0.525
CLV_C14_Caspase3-7	587	591	PF00656	0.511
CLV_MEL_PAP_1	828	834	PF00089	0.375
CLV_NRD_NRD_1	41	43	PF00675	0.431
CLV_NRD_NRD_1	493	495	PF00675	0.451
CLV_NRD_NRD_1	736	738	PF00675	0.511
CLV_NRD_NRD_1	844	846	PF00675	0.406
CLV_PCSK_KEX2_1	736	738	PF00082	0.511
CLV_PCSK_KEX2_1	843	845	PF00082	0.447
CLV_PCSK_PC1ET2_1	843	845	PF00082	0.447
CLV_PCSK_SKI1_1	222	226	PF00082	0.380
CLV_PCSK_SKI1_1	324	328	PF00082	0.388
CLV_PCSK_SKI1_1	434	438	PF00082	0.505
CLV_PCSK_SKI1_1	5	9	PF00082	0.599
CLV_PCSK_SKI1_1	55	59	PF00082	0.308
CLV_PCSK_SKI1_1	568	572	PF00082	0.496
CLV_PCSK_SKI1_1	730	734	PF00082	0.425
CLV_PCSK_SKI1_1	736	740	PF00082	0.436
CLV_PCSK_SKI1_1	817	821	PF00082	0.379
CLV_PCSK_SKI1_1	844	848	PF00082	0.395
CLV_PCSK_SKI1_1	86	90	PF00082	0.308
CLV_PCSK_SKI1_1	866	870	PF00082	0.443
CLV_PCSK_SKI1_1	919	923	PF00082	0.513
DEG_APCC_DBOX_1	221	229	PF00400	0.371
DEG_APCC_DBOX_1	843	851	PF00400	0.393
DEG_MDM2_SWIB_1	377	384	PF02201	0.366
DEG_Nend_UBRbox_2	1	3	PF02207	0.541
DEG_ODPH_VHL_1	796	807	PF01847	0.502
DEG_SIAH_1	257	265	PF03145	0.513
DEG_SPOP_SBC_1	443	447	PF00917	0.583
DOC_CDC14_PxL_1	112	120	PF14671	0.235
DOC_CKS1_1	799	804	PF01111	0.442
DOC_CYCLIN_RxL_1	148	158	PF00134	0.308
DOC_CYCLIN_RxL_1	564	572	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	822	828	PF00134	0.520
DOC_MAPK_gen_1	654	661	PF00069	0.558
DOC_MAPK_gen_1	843	852	PF00069	0.389
DOC_MAPK_gen_1	98	107	PF00069	0.196
DOC_MAPK_MEF2A_6	55	64	PF00069	0.308
DOC_MAPK_MEF2A_6	654	661	PF00069	0.647
DOC_MAPK_MEF2A_6	817	826	PF00069	0.410
DOC_MAPK_MEF2A_6	845	854	PF00069	0.383
DOC_MAPK_NFAT4_5	654	662	PF00069	0.642
DOC_MAPK_NFAT4_5	817	825	PF00069	0.399
DOC_PIKK_1	298	306	PF02985	0.439
DOC_PP1_RVXF_1	322	328	PF00149	0.402
DOC_PP1_RVXF_1	597	603	PF00149	0.571
DOC_PP1_RVXF_1	815	822	PF00149	0.467
DOC_PP1_RVXF_1	842	849	PF00149	0.407
DOC_PP2B_LxvP_1	822	825	PF13499	0.574
DOC_PP4_FxxP_1	398	401	PF00568	0.475
DOC_SPAK_OSR1_1	410	414	PF12202	0.455
DOC_USP7_MATH_1	264	268	PF00917	0.525
DOC_USP7_MATH_1	364	368	PF00917	0.451
DOC_USP7_MATH_1	401	405	PF00917	0.498
DOC_USP7_MATH_1	406	410	PF00917	0.511
DOC_USP7_MATH_1	444	448	PF00917	0.613
DOC_USP7_UBL2_3	491	495	PF12436	0.501
DOC_WW_Pin1_4	155	160	PF00397	0.308
DOC_WW_Pin1_4	269	274	PF00397	0.559
DOC_WW_Pin1_4	306	311	PF00397	0.381
DOC_WW_Pin1_4	402	407	PF00397	0.426
DOC_WW_Pin1_4	446	451	PF00397	0.780
DOC_WW_Pin1_4	465	470	PF00397	0.373
DOC_WW_Pin1_4	496	501	PF00397	0.527
DOC_WW_Pin1_4	639	644	PF00397	0.519
DOC_WW_Pin1_4	714	719	PF00397	0.493
DOC_WW_Pin1_4	756	761	PF00397	0.478
DOC_WW_Pin1_4	798	803	PF00397	0.457
LIG_14-3-3_CanoR_1	181	190	PF00244	0.235
LIG_14-3-3_CanoR_1	21	29	PF00244	0.460
LIG_14-3-3_CanoR_1	253	258	PF00244	0.575
LIG_14-3-3_CanoR_1	410	414	PF00244	0.455
LIG_14-3-3_CanoR_1	455	461	PF00244	0.523
LIG_14-3-3_CanoR_1	530	538	PF00244	0.399
LIG_14-3-3_CanoR_1	599	603	PF00244	0.569
LIG_14-3-3_CanoR_1	716	726	PF00244	0.478
LIG_14-3-3_CanoR_1	831	838	PF00244	0.613
LIG_14-3-3_CanoR_1	845	851	PF00244	0.301
LIG_14-3-3_CanoR_1	907	912	PF00244	0.407
LIG_Actin_WH2_2	140	158	PF00022	0.308
LIG_APCC_ABBA_1	135	140	PF00400	0.284
LIG_APCC_ABBA_1	162	167	PF00400	0.325
LIG_APCC_ABBAyCdc20_2	817	823	PF00400	0.458
LIG_BRCT_BRCA1_1	103	107	PF00533	0.320
LIG_BRCT_BRCA1_1	764	768	PF00533	0.551
LIG_BRCT_BRCA1_1	909	913	PF00533	0.422
LIG_Clathr_ClatBox_1	61	65	PF01394	0.308
LIG_Clathr_ClatBox_1	819	823	PF01394	0.385
LIG_CSL_BTD_1	678	681	PF09270	0.541
LIG_DLG_GKlike_1	114	121	PF00625	0.325
LIG_DLG_GKlike_1	907	915	PF00625	0.418
LIG_EH1_1	410	418	PF00400	0.493
LIG_eIF4E_1	729	735	PF01652	0.488
LIG_EVH1_2	452	456	PF00568	0.550
LIG_FHA_1	104	110	PF00498	0.308
LIG_FHA_1	159	165	PF00498	0.332
LIG_FHA_1	284	290	PF00498	0.469
LIG_FHA_1	443	449	PF00498	0.637
LIG_FHA_1	471	477	PF00498	0.515
LIG_FHA_1	533	539	PF00498	0.396
LIG_FHA_1	56	62	PF00498	0.308
LIG_FHA_1	772	778	PF00498	0.435
LIG_FHA_1	87	93	PF00498	0.340
LIG_FHA_2	22	28	PF00498	0.459
LIG_FHA_2	419	425	PF00498	0.498
LIG_FHA_2	582	588	PF00498	0.643
LIG_FHA_2	893	899	PF00498	0.496
LIG_LIR_Apic_2	396	401	PF02991	0.403
LIG_LIR_Apic_2	870	874	PF02991	0.428
LIG_LIR_Gen_1	139	150	PF02991	0.308
LIG_LIR_Gen_1	241	249	PF02991	0.578
LIG_LIR_Gen_1	554	563	PF02991	0.448
LIG_LIR_Gen_1	6	16	PF02991	0.490
LIG_LIR_Gen_1	656	666	PF02991	0.494
LIG_LIR_Gen_1	697	708	PF02991	0.488
LIG_LIR_Gen_1	70	80	PF02991	0.311
LIG_LIR_Gen_1	818	829	PF02991	0.494
LIG_LIR_Gen_1	83	92	PF02991	0.317
LIG_LIR_Nem_3	139	145	PF02991	0.308
LIG_LIR_Nem_3	219	224	PF02991	0.328
LIG_LIR_Nem_3	241	245	PF02991	0.552
LIG_LIR_Nem_3	554	558	PF02991	0.465
LIG_LIR_Nem_3	6	11	PF02991	0.588
LIG_LIR_Nem_3	601	605	PF02991	0.522
LIG_LIR_Nem_3	656	661	PF02991	0.485
LIG_LIR_Nem_3	663	667	PF02991	0.508
LIG_LIR_Nem_3	677	682	PF02991	0.491
LIG_LIR_Nem_3	697	703	PF02991	0.497
LIG_LIR_Nem_3	70	75	PF02991	0.311
LIG_LIR_Nem_3	818	824	PF02991	0.455
LIG_LIR_Nem_3	83	87	PF02991	0.317
LIG_LIR_Nem_3	851	857	PF02991	0.374
LIG_MAD2	866	874	PF02301	0.410
LIG_NRBOX	537	543	PF00104	0.458
LIG_Pex14_1	555	559	PF04695	0.440
LIG_Pex14_1	696	700	PF04695	0.565
LIG_Pex14_2	377	381	PF04695	0.354
LIG_Pex14_2	660	664	PF04695	0.540
LIG_Rb_LxCxE_1	177	192	PF01857	0.235
LIG_RPA_C_Fungi	732	744	PF08784	0.446
LIG_SH2_CRK	357	361	PF00017	0.494
LIG_SH2_CRK	520	524	PF00017	0.475
LIG_SH2_CRK	700	704	PF00017	0.424
LIG_SH2_CRK	871	875	PF00017	0.445
LIG_SH2_GRB2like	302	305	PF00017	0.367
LIG_SH2_NCK_1	357	361	PF00017	0.494
LIG_SH2_SRC	368	371	PF00017	0.422
LIG_SH2_STAP1	577	581	PF00017	0.464
LIG_SH2_STAT3	380	383	PF00017	0.369
LIG_SH2_STAT5	120	123	PF00017	0.349
LIG_SH2_STAT5	146	149	PF00017	0.308
LIG_SH2_STAT5	302	305	PF00017	0.367
LIG_SH2_STAT5	465	468	PF00017	0.423
LIG_SH2_STAT5	520	523	PF00017	0.417
LIG_SH2_STAT5	525	528	PF00017	0.444
LIG_SH2_STAT5	559	562	PF00017	0.490
LIG_SH2_STAT5	658	661	PF00017	0.488
LIG_SH3_2	450	455	PF14604	0.546
LIG_SH3_2	861	866	PF14604	0.496
LIG_SH3_3	270	276	PF00018	0.577
LIG_SH3_3	322	328	PF00018	0.454
LIG_SH3_3	445	451	PF00018	0.639
LIG_SH3_3	507	513	PF00018	0.376
LIG_SH3_3	616	622	PF00018	0.506
LIG_SH3_3	659	665	PF00018	0.478
LIG_SH3_3	792	798	PF00018	0.546
LIG_SH3_3	858	864	PF00018	0.493
LIG_SUMO_SIM_anti_2	537	543	PF11976	0.369
LIG_SUMO_SIM_par_1	129	134	PF11976	0.284
LIG_SUMO_SIM_par_1	280	286	PF11976	0.513
LIG_SUMO_SIM_par_1	663	671	PF11976	0.535
LIG_SUMO_SIM_par_1	680	686	PF11976	0.509
LIG_SUMO_SIM_par_1	823	830	PF11976	0.493
LIG_TRAF2_1	584	587	PF00917	0.517
LIG_TRAF2_1	833	836	PF00917	0.410
LIG_TRFH_1	397	401	PF08558	0.411
LIG_TYR_ITIM	698	703	PF00017	0.498
LIG_UBA3_1	623	628	PF00899	0.482
LIG_WRC_WIRS_1	146	151	PF05994	0.308
LIG_WRC_WIRS_1	81	86	PF05994	0.286
MOD_CDK_SPK_2	496	501	PF00069	0.491
MOD_CDK_SPxxK_3	272	279	PF00069	0.578
MOD_CK1_1	101	107	PF00069	0.308
MOD_CK1_1	241	247	PF00069	0.559
MOD_CK1_1	252	258	PF00069	0.535
MOD_CK1_1	348	354	PF00069	0.568
MOD_CK1_1	405	411	PF00069	0.588
MOD_CK1_1	446	452	PF00069	0.595
MOD_CK1_1	499	505	PF00069	0.559
MOD_CK1_1	532	538	PF00069	0.389
MOD_CK1_1	598	604	PF00069	0.551
MOD_CK1_1	714	720	PF00069	0.488
MOD_CK2_1	21	27	PF00069	0.457
MOD_CK2_1	581	587	PF00069	0.513
MOD_CK2_1	604	610	PF00069	0.541
MOD_CK2_1	717	723	PF00069	0.493
MOD_CK2_1	824	830	PF00069	0.541
MOD_CK2_1	892	898	PF00069	0.490
MOD_GlcNHglycan	209	212	PF01048	0.405
MOD_GlcNHglycan	257	261	PF01048	0.534
MOD_GlcNHglycan	339	342	PF01048	0.491
MOD_GlcNHglycan	347	350	PF01048	0.521
MOD_GlcNHglycan	364	367	PF01048	0.448
MOD_GlcNHglycan	546	549	PF01048	0.535
MOD_GlcNHglycan	578	581	PF01048	0.428
MOD_GlcNHglycan	606	609	PF01048	0.484
MOD_GlcNHglycan	676	679	PF01048	0.548
MOD_GlcNHglycan	808	811	PF01048	0.444
MOD_GlcNHglycan	919	922	PF01048	0.509
MOD_GSK3_1	110	117	PF00069	0.308
MOD_GSK3_1	141	148	PF00069	0.308
MOD_GSK3_1	241	248	PF00069	0.559
MOD_GSK3_1	249	256	PF00069	0.695
MOD_GSK3_1	379	386	PF00069	0.406
MOD_GSK3_1	401	408	PF00069	0.504
MOD_GSK3_1	442	449	PF00069	0.642
MOD_GSK3_1	481	488	PF00069	0.473
MOD_GSK3_1	532	539	PF00069	0.403
MOD_GSK3_1	666	673	PF00069	0.538
MOD_GSK3_1	756	763	PF00069	0.569
MOD_GSK3_1	768	775	PF00069	0.430
MOD_GSK3_1	782	789	PF00069	0.397
MOD_LATS_1	53	59	PF00433	0.325
MOD_N-GLC_1	110	115	PF02516	0.308
MOD_N-GLC_1	402	407	PF02516	0.583
MOD_N-GLC_1	768	773	PF02516	0.485
MOD_N-GLC_2	902	904	PF02516	0.422
MOD_NEK2_1	145	150	PF00069	0.311
MOD_NEK2_1	189	194	PF00069	0.313
MOD_NEK2_1	204	209	PF00069	0.481
MOD_NEK2_1	283	288	PF00069	0.410
MOD_NEK2_1	379	384	PF00069	0.402
MOD_NEK2_1	418	423	PF00069	0.474
MOD_NEK2_1	644	649	PF00069	0.584
MOD_NEK2_1	674	679	PF00069	0.569
MOD_NEK2_1	683	688	PF00069	0.565
MOD_NEK2_1	703	708	PF00069	0.475
MOD_NEK2_1	711	716	PF00069	0.485
MOD_NEK2_1	751	756	PF00069	0.457
MOD_NEK2_1	768	773	PF00069	0.467
MOD_NEK2_1	882	887	PF00069	0.411
MOD_PIKK_1	379	385	PF00454	0.440
MOD_PIKK_1	518	524	PF00454	0.395
MOD_PIKK_1	760	766	PF00454	0.491
MOD_PIKK_1	788	794	PF00454	0.579
MOD_PIKK_1	831	837	PF00454	0.577
MOD_PKA_2	252	258	PF00069	0.598
MOD_PKA_2	409	415	PF00069	0.461
MOD_PKA_2	529	535	PF00069	0.410
MOD_PKA_2	598	604	PF00069	0.610
MOD_PKA_2	830	836	PF00069	0.396
MOD_PKB_1	905	913	PF00069	0.416
MOD_Plk_1	213	219	PF00069	0.493
MOD_Plk_1	29	35	PF00069	0.577
MOD_Plk_1	418	424	PF00069	0.484
MOD_Plk_1	47	53	PF00069	0.334
MOD_Plk_1	670	676	PF00069	0.531
MOD_Plk_1	775	781	PF00069	0.551
MOD_Plk_2-3	12	18	PF00069	0.413
MOD_Plk_4	103	109	PF00069	0.376
MOD_Plk_4	114	120	PF00069	0.265
MOD_Plk_4	141	147	PF00069	0.313
MOD_Plk_4	238	244	PF00069	0.487
MOD_Plk_4	29	35	PF00069	0.429
MOD_Plk_4	412	418	PF00069	0.474
MOD_Plk_4	481	487	PF00069	0.465
MOD_Plk_4	536	542	PF00069	0.388
MOD_Plk_4	590	596	PF00069	0.503
MOD_Plk_4	670	676	PF00069	0.531
MOD_Plk_4	703	709	PF00069	0.455
MOD_ProDKin_1	155	161	PF00069	0.308
MOD_ProDKin_1	269	275	PF00069	0.559
MOD_ProDKin_1	306	312	PF00069	0.392
MOD_ProDKin_1	402	408	PF00069	0.429
MOD_ProDKin_1	446	452	PF00069	0.772
MOD_ProDKin_1	465	471	PF00069	0.416
MOD_ProDKin_1	496	502	PF00069	0.534
MOD_ProDKin_1	639	645	PF00069	0.518
MOD_ProDKin_1	714	720	PF00069	0.488
MOD_ProDKin_1	756	762	PF00069	0.473
MOD_ProDKin_1	798	804	PF00069	0.448
TRG_DiLeu_BaEn_1	561	566	PF01217	0.405
TRG_DiLeu_BaEn_1	815	820	PF01217	0.475
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.308
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.490
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.357
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.476
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.572
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.557
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.458
TRG_ENDOCYTIC_2	146	149	PF00928	0.308
TRG_ENDOCYTIC_2	520	523	PF00928	0.417
TRG_ENDOCYTIC_2	559	562	PF00928	0.490
TRG_ENDOCYTIC_2	620	623	PF00928	0.427
TRG_ENDOCYTIC_2	658	661	PF00928	0.488
TRG_ENDOCYTIC_2	700	703	PF00928	0.439
TRG_ENDOCYTIC_2	729	732	PF00928	0.422
TRG_ER_diArg_1	439	442	PF00400	0.504
TRG_ER_diArg_1	735	737	PF00400	0.520
TRG_ER_diArg_1	844	846	PF00400	0.406
TRG_NES_CRM1_1	52	65	PF08389	0.277
TRG_NES_CRM1_1	561	572	PF08389	0.481
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	756	761	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F5	Leptomonas seymouri	52%	95%
A4HNC1	Leishmania braziliensis	75%	100%
A4IBZ4	Leishmania infantum	100%	100%
E9AFT1	Leishmania major	93%	100%
E9B6Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%