Mitochondrial phosphate transporter, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial phosphate transporter, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X9Y0_LEIDO

TriTrypDb:

LdBPK_354490.1 , LdCL_350050000 , LDHU3_35.5930

Length:

317

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	14
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	14
GO:0031090	organelle membrane	3	14
GO:0031966	mitochondrial membrane	4	14
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7X9Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9Y0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0006811	monoatomic ion transport	4	16
GO:0006817	phosphate ion transport	7	16
GO:0006820	monoatomic anion transport	5	16
GO:0009987	cellular process	1	16
GO:0015698	inorganic anion transport	6	16
GO:0034220	monoatomic ion transmembrane transport	3	16
GO:0035435	phosphate ion transmembrane transport	6	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0055085	transmembrane transport	2	16
GO:0098656	monoatomic anion transmembrane transport	4	16
GO:0098660	inorganic ion transmembrane transport	4	16
GO:0098661	inorganic anion transmembrane transport	5	16
GO:1990542	mitochondrial transmembrane transport	3	16
GO:1990547	mitochondrial phosphate ion transmembrane transport	4	16

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	16
GO:0005315	inorganic phosphate transmembrane transporter activity	4	16
GO:0015291	secondary active transmembrane transporter activity	4	16
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	16
GO:0022804	active transmembrane transporter activity	3	16
GO:0022857	transmembrane transporter activity	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	201	205	PF00082	0.402
CLV_PCSK_SKI1_1	307	311	PF00082	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.453
DOC_AGCK_PIF_2	103	108	PF00069	0.437
DOC_MAPK_gen_1	123	131	PF00069	0.521
DOC_MAPK_MEF2A_6	226	234	PF00069	0.393
DOC_PP4_FxxP_1	217	220	PF00568	0.435
DOC_USP7_MATH_1	170	174	PF00917	0.371
DOC_USP7_MATH_1	176	180	PF00917	0.327
DOC_USP7_MATH_1	183	187	PF00917	0.224
DOC_USP7_MATH_1	245	249	PF00917	0.387
DOC_USP7_MATH_1	264	268	PF00917	0.451
DOC_WW_Pin1_4	155	160	PF00397	0.303
DOC_WW_Pin1_4	41	46	PF00397	0.325
DOC_WW_Pin1_4	56	61	PF00397	0.307
LIG_14-3-3_CanoR_1	62	67	PF00244	0.458
LIG_BRCT_BRCA1_1	135	139	PF00533	0.332
LIG_BRCT_BRCA1_1	178	182	PF00533	0.430
LIG_BRCT_BRCA1_1	230	234	PF00533	0.406
LIG_DLG_GKlike_1	62	70	PF00625	0.458
LIG_FHA_1	163	169	PF00498	0.436
LIG_FHA_1	285	291	PF00498	0.424
LIG_LIR_Apic_2	13	19	PF02991	0.459
LIG_LIR_Gen_1	111	117	PF02991	0.332
LIG_LIR_Gen_1	138	148	PF02991	0.316
LIG_LIR_Gen_1	274	285	PF02991	0.432
LIG_LIR_Nem_3	107	112	PF02991	0.343
LIG_LIR_Nem_3	267	271	PF02991	0.443
LIG_LIR_Nem_3	274	280	PF02991	0.388
LIG_LIR_Nem_3	61	66	PF02991	0.316
LIG_PCNA_yPIPBox_3	75	89	PF02747	0.390
LIG_Pex14_1	12	16	PF04695	0.443
LIG_REV1ctd_RIR_1	201	211	PF16727	0.319
LIG_SH2_CRK	184	188	PF00017	0.446
LIG_SH2_CRK	213	217	PF00017	0.311
LIG_SH2_CRK	268	272	PF00017	0.411
LIG_SH2_GRB2like	113	116	PF00017	0.332
LIG_SH2_GRB2like	16	19	PF00017	0.492
LIG_SH2_GRB2like	277	280	PF00017	0.454
LIG_SH2_NCK_1	224	228	PF00017	0.468
LIG_SH2_PTP2	16	19	PF00017	0.565
LIG_SH2_PTP2	277	280	PF00017	0.477
LIG_SH2_SRC	16	19	PF00017	0.492
LIG_SH2_SRC	213	216	PF00017	0.396
LIG_SH2_SRC	277	280	PF00017	0.345
LIG_SH2_STAP1	113	117	PF00017	0.332
LIG_SH2_STAT3	95	98	PF00017	0.316
LIG_SH2_STAT5	108	111	PF00017	0.458
LIG_SH2_STAT5	16	19	PF00017	0.496
LIG_SH2_STAT5	197	200	PF00017	0.316
LIG_SH2_STAT5	215	218	PF00017	0.433
LIG_SH2_STAT5	238	241	PF00017	0.366
LIG_SH2_STAT5	277	280	PF00017	0.360
LIG_SH3_1	16	22	PF00018	0.468
LIG_SH3_3	16	22	PF00018	0.468
LIG_SH3_3	244	250	PF00018	0.383
LIG_SH3_3	42	48	PF00018	0.335
LIG_SH3_4	219	226	PF00018	0.552
LIG_SUMO_SIM_par_1	287	294	PF11976	0.388
MOD_CDC14_SPxK_1	59	62	PF00782	0.331
MOD_CDK_SPK_2	155	160	PF00069	0.399
MOD_CDK_SPxK_1	56	62	PF00069	0.331
MOD_GlcNHglycan	133	136	PF01048	0.316
MOD_GlcNHglycan	179	182	PF01048	0.453
MOD_GlcNHglycan	2	5	PF01048	0.640
MOD_GlcNHglycan	235	238	PF01048	0.361
MOD_GlcNHglycan	255	258	PF01048	0.464
MOD_GlcNHglycan	314	317	PF01048	0.421
MOD_GlcNHglycan	95	98	PF01048	0.469
MOD_GSK3_1	155	162	PF00069	0.322
MOD_N-GLC_2	279	281	PF02516	0.437
MOD_NEK2_1	131	136	PF00069	0.316
MOD_NEK2_1	148	153	PF00069	0.316
MOD_NEK2_1	230	235	PF00069	0.457
MOD_NEK2_1	291	296	PF00069	0.383
MOD_NEK2_1	312	317	PF00069	0.428
MOD_NEK2_2	170	175	PF00069	0.419
MOD_PIKK_1	225	231	PF00454	0.412
MOD_Plk_1	23	29	PF00069	0.567
MOD_Plk_4	183	189	PF00069	0.296
MOD_Plk_4	23	29	PF00069	0.437
MOD_Plk_4	250	256	PF00069	0.441
MOD_ProDKin_1	155	161	PF00069	0.303
MOD_ProDKin_1	41	47	PF00069	0.325
MOD_ProDKin_1	56	62	PF00069	0.307
MOD_SUMO_for_1	74	77	PF00179	0.417
TRG_ENDOCYTIC_2	106	109	PF00928	0.316
TRG_ENDOCYTIC_2	113	116	PF00928	0.316
TRG_ENDOCYTIC_2	125	128	PF00928	0.402
TRG_ENDOCYTIC_2	184	187	PF00928	0.458
TRG_ENDOCYTIC_2	213	216	PF00928	0.316
TRG_ENDOCYTIC_2	268	271	PF00928	0.425
TRG_ENDOCYTIC_2	277	280	PF00928	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I993	Leptomonas seymouri	83%	100%
A0A0S4JBC4	Bodo saltans	39%	82%
A0A0S4JNX4	Bodo saltans	72%	94%
A0A0S4KJX8	Bodo saltans	26%	91%
A0A1X0P0K9	Trypanosomatidae	38%	100%
A0A1X0P561	Trypanosomatidae	75%	99%
A0A3S5IRV4	Trypanosoma rangeli	77%	100%
A0A3S7X9V4	Leishmania donovani	98%	100%
A0A422NF39	Trypanosoma rangeli	25%	100%
A4HNB1	Leishmania braziliensis	94%	100%
A4HNB2	Leishmania braziliensis	92%	100%
A4IBY2	Leishmania infantum	94%	100%
A4IBY3	Leishmania infantum	97%	100%
B0G143	Dictyostelium discoideum	25%	100%
C9ZYM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A4I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	83%
E9AFR9	Leishmania major	97%	100%
E9AFS0	Leishmania major	97%	100%
E9B6X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O61703	Choristoneura fumiferana	51%	91%
P12234	Bos taurus	51%	88%
P16036	Rattus norvegicus	50%	89%
P16260	Homo sapiens	25%	95%
P23641	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P40035	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P40614	Caenorhabditis elegans	55%	93%
Q00325	Homo sapiens	48%	88%
Q01888	Bos taurus	26%	96%
Q54BF6	Dictyostelium discoideum	40%	100%
Q5R7W2	Pongo abelii	50%	88%
Q7DNC3	Arabidopsis thaliana	40%	100%
Q8VEM8	Mus musculus	50%	89%
Q9FMU6	Arabidopsis thaliana	51%	85%
Q9M2Z8	Arabidopsis thaliana	49%	87%
Q9P7V8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
V5BT68	Trypanosoma cruzi	76%	100%