Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 3 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 7 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | yes | yes: 14 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 15 |
NetGPI | no | yes: 0, no: 15 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005743 | mitochondrial inner membrane | 5 | 14 |
GO:0016020 | membrane | 2 | 14 |
GO:0019866 | organelle inner membrane | 4 | 14 |
GO:0031090 | organelle membrane | 3 | 14 |
GO:0031966 | mitochondrial membrane | 4 | 14 |
GO:0110165 | cellular anatomical entity | 1 | 16 |
GO:0005737 | cytoplasm | 2 | 2 |
GO:0005739 | mitochondrion | 5 | 2 |
GO:0020023 | kinetoplast | 2 | 2 |
GO:0043226 | organelle | 2 | 2 |
GO:0043227 | membrane-bounded organelle | 3 | 2 |
GO:0043229 | intracellular organelle | 3 | 2 |
GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
Related structures:
AlphaFold database: A0A3S7X9Y0
Term | Name | Level | Count |
---|---|---|---|
GO:0006810 | transport | 3 | 16 |
GO:0006811 | monoatomic ion transport | 4 | 16 |
GO:0006817 | phosphate ion transport | 7 | 16 |
GO:0006820 | monoatomic anion transport | 5 | 16 |
GO:0009987 | cellular process | 1 | 16 |
GO:0015698 | inorganic anion transport | 6 | 16 |
GO:0034220 | monoatomic ion transmembrane transport | 3 | 16 |
GO:0035435 | phosphate ion transmembrane transport | 6 | 16 |
GO:0051179 | localization | 1 | 16 |
GO:0051234 | establishment of localization | 2 | 16 |
GO:0055085 | transmembrane transport | 2 | 16 |
GO:0098656 | monoatomic anion transmembrane transport | 4 | 16 |
GO:0098660 | inorganic ion transmembrane transport | 4 | 16 |
GO:0098661 | inorganic anion transmembrane transport | 5 | 16 |
GO:1990542 | mitochondrial transmembrane transport | 3 | 16 |
GO:1990547 | mitochondrial phosphate ion transmembrane transport | 4 | 16 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005215 | transporter activity | 1 | 16 |
GO:0005315 | inorganic phosphate transmembrane transporter activity | 4 | 16 |
GO:0015291 | secondary active transmembrane transporter activity | 4 | 16 |
GO:0015318 | inorganic molecular entity transmembrane transporter activity | 3 | 16 |
GO:0022804 | active transmembrane transporter activity | 3 | 16 |
GO:0022857 | transmembrane transporter activity | 2 | 16 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_PCSK_SKI1_1 | 201 | 205 | PF00082 | 0.402 |
CLV_PCSK_SKI1_1 | 307 | 311 | PF00082 | 0.471 |
DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.453 |
DOC_AGCK_PIF_2 | 103 | 108 | PF00069 | 0.437 |
DOC_MAPK_gen_1 | 123 | 131 | PF00069 | 0.521 |
DOC_MAPK_MEF2A_6 | 226 | 234 | PF00069 | 0.393 |
DOC_PP4_FxxP_1 | 217 | 220 | PF00568 | 0.435 |
DOC_USP7_MATH_1 | 170 | 174 | PF00917 | 0.371 |
DOC_USP7_MATH_1 | 176 | 180 | PF00917 | 0.327 |
DOC_USP7_MATH_1 | 183 | 187 | PF00917 | 0.224 |
DOC_USP7_MATH_1 | 245 | 249 | PF00917 | 0.387 |
DOC_USP7_MATH_1 | 264 | 268 | PF00917 | 0.451 |
DOC_WW_Pin1_4 | 155 | 160 | PF00397 | 0.303 |
DOC_WW_Pin1_4 | 41 | 46 | PF00397 | 0.325 |
DOC_WW_Pin1_4 | 56 | 61 | PF00397 | 0.307 |
LIG_14-3-3_CanoR_1 | 62 | 67 | PF00244 | 0.458 |
LIG_BRCT_BRCA1_1 | 135 | 139 | PF00533 | 0.332 |
LIG_BRCT_BRCA1_1 | 178 | 182 | PF00533 | 0.430 |
LIG_BRCT_BRCA1_1 | 230 | 234 | PF00533 | 0.406 |
LIG_DLG_GKlike_1 | 62 | 70 | PF00625 | 0.458 |
LIG_FHA_1 | 163 | 169 | PF00498 | 0.436 |
LIG_FHA_1 | 285 | 291 | PF00498 | 0.424 |
LIG_LIR_Apic_2 | 13 | 19 | PF02991 | 0.459 |
LIG_LIR_Gen_1 | 111 | 117 | PF02991 | 0.332 |
LIG_LIR_Gen_1 | 138 | 148 | PF02991 | 0.316 |
LIG_LIR_Gen_1 | 274 | 285 | PF02991 | 0.432 |
LIG_LIR_Nem_3 | 107 | 112 | PF02991 | 0.343 |
LIG_LIR_Nem_3 | 267 | 271 | PF02991 | 0.443 |
LIG_LIR_Nem_3 | 274 | 280 | PF02991 | 0.388 |
LIG_LIR_Nem_3 | 61 | 66 | PF02991 | 0.316 |
LIG_PCNA_yPIPBox_3 | 75 | 89 | PF02747 | 0.390 |
LIG_Pex14_1 | 12 | 16 | PF04695 | 0.443 |
LIG_REV1ctd_RIR_1 | 201 | 211 | PF16727 | 0.319 |
LIG_SH2_CRK | 184 | 188 | PF00017 | 0.446 |
LIG_SH2_CRK | 213 | 217 | PF00017 | 0.311 |
LIG_SH2_CRK | 268 | 272 | PF00017 | 0.411 |
LIG_SH2_GRB2like | 113 | 116 | PF00017 | 0.332 |
LIG_SH2_GRB2like | 16 | 19 | PF00017 | 0.492 |
LIG_SH2_GRB2like | 277 | 280 | PF00017 | 0.454 |
LIG_SH2_NCK_1 | 224 | 228 | PF00017 | 0.468 |
LIG_SH2_PTP2 | 16 | 19 | PF00017 | 0.565 |
LIG_SH2_PTP2 | 277 | 280 | PF00017 | 0.477 |
LIG_SH2_SRC | 16 | 19 | PF00017 | 0.492 |
LIG_SH2_SRC | 213 | 216 | PF00017 | 0.396 |
LIG_SH2_SRC | 277 | 280 | PF00017 | 0.345 |
LIG_SH2_STAP1 | 113 | 117 | PF00017 | 0.332 |
LIG_SH2_STAT3 | 95 | 98 | PF00017 | 0.316 |
LIG_SH2_STAT5 | 108 | 111 | PF00017 | 0.458 |
LIG_SH2_STAT5 | 16 | 19 | PF00017 | 0.496 |
LIG_SH2_STAT5 | 197 | 200 | PF00017 | 0.316 |
LIG_SH2_STAT5 | 215 | 218 | PF00017 | 0.433 |
LIG_SH2_STAT5 | 238 | 241 | PF00017 | 0.366 |
LIG_SH2_STAT5 | 277 | 280 | PF00017 | 0.360 |
LIG_SH3_1 | 16 | 22 | PF00018 | 0.468 |
LIG_SH3_3 | 16 | 22 | PF00018 | 0.468 |
LIG_SH3_3 | 244 | 250 | PF00018 | 0.383 |
LIG_SH3_3 | 42 | 48 | PF00018 | 0.335 |
LIG_SH3_4 | 219 | 226 | PF00018 | 0.552 |
LIG_SUMO_SIM_par_1 | 287 | 294 | PF11976 | 0.388 |
MOD_CDC14_SPxK_1 | 59 | 62 | PF00782 | 0.331 |
MOD_CDK_SPK_2 | 155 | 160 | PF00069 | 0.399 |
MOD_CDK_SPxK_1 | 56 | 62 | PF00069 | 0.331 |
MOD_GlcNHglycan | 133 | 136 | PF01048 | 0.316 |
MOD_GlcNHglycan | 179 | 182 | PF01048 | 0.453 |
MOD_GlcNHglycan | 2 | 5 | PF01048 | 0.640 |
MOD_GlcNHglycan | 235 | 238 | PF01048 | 0.361 |
MOD_GlcNHglycan | 255 | 258 | PF01048 | 0.464 |
MOD_GlcNHglycan | 314 | 317 | PF01048 | 0.421 |
MOD_GlcNHglycan | 95 | 98 | PF01048 | 0.469 |
MOD_GSK3_1 | 155 | 162 | PF00069 | 0.322 |
MOD_N-GLC_2 | 279 | 281 | PF02516 | 0.437 |
MOD_NEK2_1 | 131 | 136 | PF00069 | 0.316 |
MOD_NEK2_1 | 148 | 153 | PF00069 | 0.316 |
MOD_NEK2_1 | 230 | 235 | PF00069 | 0.457 |
MOD_NEK2_1 | 291 | 296 | PF00069 | 0.383 |
MOD_NEK2_1 | 312 | 317 | PF00069 | 0.428 |
MOD_NEK2_2 | 170 | 175 | PF00069 | 0.419 |
MOD_PIKK_1 | 225 | 231 | PF00454 | 0.412 |
MOD_Plk_1 | 23 | 29 | PF00069 | 0.567 |
MOD_Plk_4 | 183 | 189 | PF00069 | 0.296 |
MOD_Plk_4 | 23 | 29 | PF00069 | 0.437 |
MOD_Plk_4 | 250 | 256 | PF00069 | 0.441 |
MOD_ProDKin_1 | 155 | 161 | PF00069 | 0.303 |
MOD_ProDKin_1 | 41 | 47 | PF00069 | 0.325 |
MOD_ProDKin_1 | 56 | 62 | PF00069 | 0.307 |
MOD_SUMO_for_1 | 74 | 77 | PF00179 | 0.417 |
TRG_ENDOCYTIC_2 | 106 | 109 | PF00928 | 0.316 |
TRG_ENDOCYTIC_2 | 113 | 116 | PF00928 | 0.316 |
TRG_ENDOCYTIC_2 | 125 | 128 | PF00928 | 0.402 |
TRG_ENDOCYTIC_2 | 184 | 187 | PF00928 | 0.458 |
TRG_ENDOCYTIC_2 | 213 | 216 | PF00928 | 0.316 |
TRG_ENDOCYTIC_2 | 268 | 271 | PF00928 | 0.425 |
TRG_ENDOCYTIC_2 | 277 | 280 | PF00928 | 0.408 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N1I993 | Leptomonas seymouri | 83% | 100% |
A0A0S4JBC4 | Bodo saltans | 39% | 82% |
A0A0S4JNX4 | Bodo saltans | 72% | 94% |
A0A0S4KJX8 | Bodo saltans | 26% | 91% |
A0A1X0P0K9 | Trypanosomatidae | 38% | 100% |
A0A1X0P561 | Trypanosomatidae | 75% | 99% |
A0A3S5IRV4 | Trypanosoma rangeli | 77% | 100% |
A0A3S7X9V4 | Leishmania donovani | 98% | 100% |
A0A422NF39 | Trypanosoma rangeli | 25% | 100% |
A4HNB1 | Leishmania braziliensis | 94% | 100% |
A4HNB2 | Leishmania braziliensis | 92% | 100% |
A4IBY2 | Leishmania infantum | 94% | 100% |
A4IBY3 | Leishmania infantum | 97% | 100% |
B0G143 | Dictyostelium discoideum | 25% | 100% |
C9ZYM2 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 75% | 100% |
D0A4I3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 83% |
E9AFR9 | Leishmania major | 97% | 100% |
E9AFS0 | Leishmania major | 97% | 100% |
E9B6X2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
O61703 | Choristoneura fumiferana | 51% | 91% |
P12234 | Bos taurus | 51% | 88% |
P16036 | Rattus norvegicus | 50% | 89% |
P16260 | Homo sapiens | 25% | 95% |
P23641 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 38% | 100% |
P40035 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 44% | 100% |
P40614 | Caenorhabditis elegans | 55% | 93% |
Q00325 | Homo sapiens | 48% | 88% |
Q01888 | Bos taurus | 26% | 96% |
Q54BF6 | Dictyostelium discoideum | 40% | 100% |
Q5R7W2 | Pongo abelii | 50% | 88% |
Q7DNC3 | Arabidopsis thaliana | 40% | 100% |
Q8VEM8 | Mus musculus | 50% | 89% |
Q9FMU6 | Arabidopsis thaliana | 51% | 85% |
Q9M2Z8 | Arabidopsis thaliana | 49% | 87% |
Q9P7V8 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 46% | 100% |
V5BT68 | Trypanosoma cruzi | 76% | 100% |