C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9X8_LEIDO

TriTrypDb:

LdBPK_354670.1 , LdCL_350051800 , LDHU3_35.6150

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.697
CLV_C14_Caspase3-7	396	400	PF00656	0.697
CLV_C14_Caspase3-7	455	459	PF00656	0.574
CLV_C14_Caspase3-7	88	92	PF00656	0.590
CLV_NRD_NRD_1	21	23	PF00675	0.545
CLV_NRD_NRD_1	426	428	PF00675	0.681
CLV_NRD_NRD_1	462	464	PF00675	0.603
CLV_PCSK_FUR_1	324	328	PF00082	0.488
CLV_PCSK_KEX2_1	127	129	PF00082	0.646
CLV_PCSK_KEX2_1	23	25	PF00082	0.482
CLV_PCSK_KEX2_1	326	328	PF00082	0.586
CLV_PCSK_KEX2_1	461	463	PF00082	0.637
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.646
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.482
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.586
CLV_PCSK_PC7_1	457	463	PF00082	0.484
CLV_PCSK_SKI1_1	110	114	PF00082	0.715
CLV_PCSK_SKI1_1	127	131	PF00082	0.446
CLV_PCSK_SKI1_1	200	204	PF00082	0.614
CLV_PCSK_SKI1_1	462	466	PF00082	0.666
CLV_PCSK_SKI1_1	75	79	PF00082	0.624
DEG_APCC_DBOX_1	74	82	PF00400	0.603
DEG_SPOP_SBC_1	506	510	PF00917	0.686
DOC_CYCLIN_RxL_1	197	207	PF00134	0.618
DOC_MAPK_gen_1	262	271	PF00069	0.588
DOC_USP7_MATH_1	105	109	PF00917	0.643
DOC_USP7_MATH_1	256	260	PF00917	0.676
DOC_USP7_MATH_1	282	286	PF00917	0.658
DOC_USP7_MATH_1	293	297	PF00917	0.700
DOC_USP7_MATH_1	346	350	PF00917	0.772
DOC_USP7_MATH_1	393	397	PF00917	0.569
DOC_USP7_MATH_1	506	510	PF00917	0.703
DOC_USP7_MATH_1	86	90	PF00917	0.706
DOC_USP7_UBL2_3	372	376	PF12436	0.586
DOC_USP7_UBL2_3	394	398	PF12436	0.673
DOC_WW_Pin1_4	285	290	PF00397	0.640
DOC_WW_Pin1_4	336	341	PF00397	0.679
DOC_WW_Pin1_4	403	408	PF00397	0.679
DOC_WW_Pin1_4	412	417	PF00397	0.705
DOC_WW_Pin1_4	95	100	PF00397	0.727
LIG_14-3-3_CanoR_1	327	335	PF00244	0.592
LIG_14-3-3_CanoR_1	498	504	PF00244	0.603
LIG_Actin_WH2_2	70	85	PF00022	0.670
LIG_APCC_ABBA_1	71	76	PF00400	0.601
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_eIF4E_1	26	32	PF01652	0.566
LIG_FHA_1	124	130	PF00498	0.583
LIG_FHA_1	210	216	PF00498	0.573
LIG_FHA_1	230	236	PF00498	0.596
LIG_FHA_1	286	292	PF00498	0.641
LIG_FHA_2	350	356	PF00498	0.697
LIG_FHA_2	55	61	PF00498	0.588
LIG_LIR_Apic_2	500	504	PF02991	0.510
LIG_LIR_Nem_3	41	46	PF02991	0.586
LIG_NRBOX	112	118	PF00104	0.663
LIG_NRBOX	16	22	PF00104	0.580
LIG_NRBOX	187	193	PF00104	0.605
LIG_SH2_CRK	43	47	PF00017	0.672
LIG_SH2_CRK	501	505	PF00017	0.521
LIG_SH2_NCK_1	501	505	PF00017	0.521
LIG_SH2_STAT5	19	22	PF00017	0.551
LIG_SH3_3	117	123	PF00018	0.641
LIG_SH3_3	163	169	PF00018	0.556
LIG_SH3_3	287	293	PF00018	0.766
LIG_SH3_3	337	343	PF00018	0.695
LIG_SH3_3	417	423	PF00018	0.705
LIG_SH3_3	74	80	PF00018	0.560
LIG_TRAF2_1	252	255	PF00917	0.638
LIG_TRAF2_1	38	41	PF00917	0.602
LIG_TRAF2_1	45	48	PF00917	0.627
LIG_TRAF2_1	98	101	PF00917	0.582
LIG_UBA3_1	112	119	PF00899	0.606
LIG_UBA3_1	191	200	PF00899	0.680
LIG_UBA3_1	78	83	PF00899	0.589
MOD_CDC14_SPxK_1	415	418	PF00782	0.538
MOD_CDK_SPxK_1	412	418	PF00069	0.721
MOD_CK1_1	194	200	PF00069	0.569
MOD_CK1_1	222	228	PF00069	0.696
MOD_CK1_1	285	291	PF00069	0.553
MOD_CK1_1	349	355	PF00069	0.668
MOD_CK1_1	401	407	PF00069	0.701
MOD_CK1_1	497	503	PF00069	0.697
MOD_CK1_1	85	91	PF00069	0.567
MOD_CK2_1	293	299	PF00069	0.675
MOD_CK2_1	327	333	PF00069	0.666
MOD_CK2_1	349	355	PF00069	0.646
MOD_CK2_1	54	60	PF00069	0.622
MOD_CK2_1	95	101	PF00069	0.726
MOD_GlcNHglycan	143	146	PF01048	0.778
MOD_GlcNHglycan	177	180	PF01048	0.609
MOD_GlcNHglycan	284	287	PF01048	0.653
MOD_GlcNHglycan	336	339	PF01048	0.543
MOD_GlcNHglycan	343	346	PF01048	0.781
MOD_GlcNHglycan	403	406	PF01048	0.706
MOD_GlcNHglycan	501	504	PF01048	0.614
MOD_GlcNHglycan	84	87	PF01048	0.711
MOD_GlcNHglycan	88	91	PF01048	0.727
MOD_GSK3_1	101	108	PF00069	0.782
MOD_GSK3_1	418	425	PF00069	0.753
MOD_GSK3_1	82	89	PF00069	0.690
MOD_GSK3_1	91	98	PF00069	0.708
MOD_N-GLC_1	101	106	PF02516	0.777
MOD_N-GLC_1	152	157	PF02516	0.788
MOD_NEK2_1	129	134	PF00069	0.660
MOD_NEK2_1	177	182	PF00069	0.624
MOD_NEK2_1	191	196	PF00069	0.570
MOD_NEK2_1	499	504	PF00069	0.597
MOD_NEK2_1	82	87	PF00069	0.613
MOD_NEK2_2	393	398	PF00069	0.602
MOD_PIKK_1	194	200	PF00454	0.597
MOD_PIKK_1	219	225	PF00454	0.547
MOD_PIKK_1	327	333	PF00454	0.631
MOD_PKA_2	141	147	PF00069	0.788
MOD_PKA_2	263	269	PF00069	0.533
MOD_PKA_2	497	503	PF00069	0.639
MOD_Plk_1	101	107	PF00069	0.788
MOD_Plk_1	152	158	PF00069	0.652
MOD_Plk_1	293	299	PF00069	0.716
MOD_Plk_1	398	404	PF00069	0.758
MOD_Plk_4	152	158	PF00069	0.648
MOD_Plk_4	177	183	PF00069	0.663
MOD_Plk_4	293	299	PF00069	0.639
MOD_ProDKin_1	285	291	PF00069	0.641
MOD_ProDKin_1	336	342	PF00069	0.683
MOD_ProDKin_1	403	409	PF00069	0.682
MOD_ProDKin_1	412	418	PF00069	0.702
MOD_ProDKin_1	95	101	PF00069	0.726
MOD_SUMO_rev_2	124	129	PF00179	0.626
MOD_SUMO_rev_2	421	429	PF00179	0.672
TRG_DiLeu_BaEn_1	125	130	PF01217	0.666
TRG_DiLeu_BaEn_4	299	305	PF01217	0.596
TRG_DiLeu_LyEn_5	125	130	PF01217	0.613
TRG_ENDOCYTIC_2	43	46	PF00928	0.651
TRG_ER_diArg_1	21	24	PF00400	0.547
TRG_ER_diArg_1	461	463	PF00400	0.599
TRG_ER_diArg_1	472	475	PF00400	0.509
TRG_NES_CRM1_1	380	395	PF08389	0.564
TRG_NES_CRM1_1	442	456	PF08389	0.607
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P962	Leptomonas seymouri	48%	91%
A0A1X0P582	Trypanosomatidae	25%	100%
A4HNC7	Leishmania braziliensis	67%	100%
A4IC00	Leishmania infantum	100%	100%
E9AFT7	Leishmania major	91%	100%
E9B6Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C2K9	Trypanosoma cruzi	25%	100%