Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X9X6_LEIDO

TriTrypDb:

LdBPK_354280.1 , LdCL_350047900 , LDHU3_35.5670

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.650
CLV_C14_Caspase3-7	198	202	PF00656	0.698
CLV_C14_Caspase3-7	579	583	PF00656	0.591
CLV_NRD_NRD_1	238	240	PF00675	0.722
CLV_NRD_NRD_1	513	515	PF00675	0.694
CLV_NRD_NRD_1	653	655	PF00675	0.727
CLV_NRD_NRD_1	87	89	PF00675	0.716
CLV_NRD_NRD_1	95	97	PF00675	0.640
CLV_PCSK_KEX2_1	204	206	PF00082	0.662
CLV_PCSK_KEX2_1	219	221	PF00082	0.630
CLV_PCSK_KEX2_1	238	240	PF00082	0.534
CLV_PCSK_KEX2_1	653	655	PF00082	0.727
CLV_PCSK_KEX2_1	95	97	PF00082	0.655
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.662
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.630
CLV_PCSK_SKI1_1	140	144	PF00082	0.789
CLV_PCSK_SKI1_1	219	223	PF00082	0.677
CLV_PCSK_SKI1_1	228	232	PF00082	0.690
CLV_PCSK_SKI1_1	515	519	PF00082	0.772
CLV_PCSK_SKI1_1	523	527	PF00082	0.735
CLV_PCSK_SKI1_1	634	638	PF00082	0.746
CLV_PCSK_SKI1_1	731	735	PF00082	0.602
DEG_APCC_DBOX_1	513	521	PF00400	0.692
DEG_SPOP_SBC_1	301	305	PF00917	0.714
DEG_SPOP_SBC_1	561	565	PF00917	0.716
DOC_CDC14_PxL_1	478	486	PF14671	0.681
DOC_CKS1_1	1	6	PF01111	0.674
DOC_CKS1_1	455	460	PF01111	0.645
DOC_MAPK_MEF2A_6	604	613	PF00069	0.686
DOC_PP2B_LxvP_1	311	314	PF13499	0.605
DOC_PP2B_LxvP_1	665	668	PF13499	0.709
DOC_USP7_MATH_1	130	134	PF00917	0.684
DOC_USP7_MATH_1	142	146	PF00917	0.652
DOC_USP7_MATH_1	158	162	PF00917	0.534
DOC_USP7_MATH_1	176	180	PF00917	0.550
DOC_USP7_MATH_1	182	186	PF00917	0.691
DOC_USP7_MATH_1	192	196	PF00917	0.620
DOC_USP7_MATH_1	237	241	PF00917	0.731
DOC_USP7_MATH_1	245	249	PF00917	0.746
DOC_USP7_MATH_1	251	255	PF00917	0.654
DOC_USP7_MATH_1	301	305	PF00917	0.690
DOC_USP7_MATH_1	316	320	PF00917	0.619
DOC_USP7_MATH_1	324	328	PF00917	0.726
DOC_USP7_MATH_1	379	383	PF00917	0.616
DOC_USP7_MATH_1	414	418	PF00917	0.723
DOC_USP7_MATH_1	429	433	PF00917	0.550
DOC_USP7_MATH_1	43	47	PF00917	0.668
DOC_USP7_MATH_1	434	438	PF00917	0.491
DOC_USP7_MATH_1	456	460	PF00917	0.720
DOC_USP7_MATH_1	461	465	PF00917	0.668
DOC_USP7_MATH_1	545	549	PF00917	0.644
DOC_USP7_MATH_1	561	565	PF00917	0.688
DOC_USP7_MATH_1	578	582	PF00917	0.565
DOC_USP7_MATH_1	648	652	PF00917	0.637
DOC_USP7_MATH_1	718	722	PF00917	0.668
DOC_USP7_UBL2_3	554	558	PF12436	0.638
DOC_WW_Pin1_4	210	215	PF00397	0.642
DOC_WW_Pin1_4	23	28	PF00397	0.607
DOC_WW_Pin1_4	302	307	PF00397	0.693
DOC_WW_Pin1_4	312	317	PF00397	0.680
DOC_WW_Pin1_4	334	339	PF00397	0.724
DOC_WW_Pin1_4	367	372	PF00397	0.804
DOC_WW_Pin1_4	375	380	PF00397	0.742
DOC_WW_Pin1_4	39	44	PF00397	0.531
DOC_WW_Pin1_4	454	459	PF00397	0.692
DOC_WW_Pin1_4	492	497	PF00397	0.611
DOC_WW_Pin1_4	534	539	PF00397	0.721
DOC_WW_Pin1_4	658	663	PF00397	0.720
DOC_WW_Pin1_4	675	680	PF00397	0.693
DOC_WW_Pin1_4	684	689	PF00397	0.606
DOC_WW_Pin1_4	698	703	PF00397	0.524
LIG_14-3-3_CanoR_1	129	139	PF00244	0.693
LIG_14-3-3_CanoR_1	160	166	PF00244	0.589
LIG_14-3-3_CanoR_1	181	189	PF00244	0.678
LIG_14-3-3_CanoR_1	351	360	PF00244	0.730
LIG_14-3-3_CanoR_1	407	411	PF00244	0.740
LIG_14-3-3_CanoR_1	44	48	PF00244	0.658
LIG_14-3-3_CanoR_1	447	455	PF00244	0.708
LIG_14-3-3_CanoR_1	469	476	PF00244	0.724
LIG_14-3-3_CanoR_1	514	518	PF00244	0.630
LIG_14-3-3_CanoR_1	707	714	PF00244	0.630
LIG_14-3-3_CanoR_1	719	724	PF00244	0.554
LIG_14-3-3_CanoR_1	80	87	PF00244	0.662
LIG_Actin_WH2_2	502	520	PF00022	0.598
LIG_Actin_WH2_2	620	636	PF00022	0.783
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_CtBP_PxDLS_1	662	666	PF00389	0.712
LIG_Dynein_DLC8_1	292	298	PF01221	0.624
LIG_FHA_1	1	7	PF00498	0.672
LIG_FHA_1	141	147	PF00498	0.711
LIG_FHA_1	244	250	PF00498	0.817
LIG_FHA_1	306	312	PF00498	0.587
LIG_FHA_1	361	367	PF00498	0.573
LIG_FHA_1	455	461	PF00498	0.684
LIG_FHA_1	618	624	PF00498	0.689
LIG_FHA_1	69	75	PF00498	0.671
LIG_FHA_1	99	105	PF00498	0.702
LIG_FHA_2	339	345	PF00498	0.711
LIG_FHA_2	535	541	PF00498	0.676
LIG_LIR_Nem_3	318	323	PF02991	0.705
LIG_LIR_Nem_3	722	728	PF02991	0.583
LIG_Pex14_2	47	51	PF04695	0.646
LIG_SH2_STAT3	59	62	PF00017	0.667
LIG_SH2_STAT5	589	592	PF00017	0.676
LIG_SH3_1	84	90	PF00018	0.684
LIG_SH3_2	482	487	PF14604	0.633
LIG_SH3_3	133	139	PF00018	0.777
LIG_SH3_3	144	150	PF00018	0.606
LIG_SH3_3	186	192	PF00018	0.741
LIG_SH3_3	24	30	PF00018	0.598
LIG_SH3_3	283	289	PF00018	0.719
LIG_SH3_3	368	374	PF00018	0.817
LIG_SH3_3	428	434	PF00018	0.697
LIG_SH3_3	452	458	PF00018	0.646
LIG_SH3_3	479	485	PF00018	0.670
LIG_SH3_3	610	616	PF00018	0.684
LIG_SH3_3	673	679	PF00018	0.697
LIG_SH3_3	696	702	PF00018	0.685
LIG_SH3_3	721	727	PF00018	0.613
LIG_SH3_3	84	90	PF00018	0.684
LIG_SUMO_SIM_anti_2	548	554	PF11976	0.722
LIG_SUMO_SIM_par_1	661	666	PF11976	0.713
LIG_WRC_WIRS_1	317	322	PF05994	0.569
LIG_WW_3	235	239	PF00397	0.645
LIG_WW_3	666	670	PF00397	0.712
MOD_CDC14_SPxK_1	337	340	PF00782	0.705
MOD_CDC14_SPxK_1	342	345	PF00782	0.659
MOD_CDK_SPK_2	39	44	PF00069	0.665
MOD_CDK_SPK_2	492	497	PF00069	0.611
MOD_CDK_SPK_2	534	539	PF00069	0.707
MOD_CDK_SPK_2	675	680	PF00069	0.586
MOD_CDK_SPxK_1	334	340	PF00069	0.714
MOD_CDK_SPxK_1	663	669	PF00069	0.712
MOD_CK1_1	195	201	PF00069	0.604
MOD_CK1_1	2	8	PF00069	0.668
MOD_CK1_1	240	246	PF00069	0.684
MOD_CK1_1	305	311	PF00069	0.723
MOD_CK1_1	312	318	PF00069	0.661
MOD_CK1_1	319	325	PF00069	0.596
MOD_CK1_1	327	333	PF00069	0.622
MOD_CK1_1	352	358	PF00069	0.744
MOD_CK1_1	370	376	PF00069	0.578
MOD_CK1_1	393	399	PF00069	0.740
MOD_CK1_1	42	48	PF00069	0.638
MOD_CK1_1	437	443	PF00069	0.625
MOD_CK1_1	459	465	PF00069	0.619
MOD_CK1_1	566	572	PF00069	0.745
MOD_CK1_1	617	623	PF00069	0.685
MOD_CK1_1	656	662	PF00069	0.720
MOD_CK1_1	678	684	PF00069	0.610
MOD_CK1_1	701	707	PF00069	0.592
MOD_CK1_1	75	81	PF00069	0.702
MOD_CK1_1	82	88	PF00069	0.634
MOD_CK1_1	9	15	PF00069	0.587
MOD_CK2_1	174	180	PF00069	0.752
MOD_CK2_1	2	8	PF00069	0.592
MOD_CK2_1	338	344	PF00069	0.704
MOD_CK2_1	534	540	PF00069	0.601
MOD_GlcNHglycan	118	121	PF01048	0.749
MOD_GlcNHglycan	133	136	PF01048	0.629
MOD_GlcNHglycan	176	179	PF01048	0.756
MOD_GlcNHglycan	184	187	PF01048	0.691
MOD_GlcNHglycan	194	197	PF01048	0.537
MOD_GlcNHglycan	201	204	PF01048	0.569
MOD_GlcNHglycan	239	242	PF01048	0.699
MOD_GlcNHglycan	253	256	PF01048	0.554
MOD_GlcNHglycan	311	314	PF01048	0.760
MOD_GlcNHglycan	354	357	PF01048	0.702
MOD_GlcNHglycan	392	395	PF01048	0.705
MOD_GlcNHglycan	463	466	PF01048	0.705
MOD_GlcNHglycan	568	571	PF01048	0.766
MOD_GlcNHglycan	620	623	PF01048	0.685
MOD_GlcNHglycan	629	632	PF01048	0.593
MOD_GlcNHglycan	658	661	PF01048	0.722
MOD_GlcNHglycan	694	697	PF01048	0.765
MOD_GlcNHglycan	703	706	PF01048	0.645
MOD_GlcNHglycan	8	11	PF01048	0.635
MOD_GSK3_1	166	173	PF00069	0.709
MOD_GSK3_1	195	202	PF00069	0.642
MOD_GSK3_1	2	9	PF00069	0.668
MOD_GSK3_1	210	217	PF00069	0.600
MOD_GSK3_1	224	231	PF00069	0.726
MOD_GSK3_1	301	308	PF00069	0.694
MOD_GSK3_1	312	319	PF00069	0.573
MOD_GSK3_1	334	341	PF00069	0.699
MOD_GSK3_1	375	382	PF00069	0.762
MOD_GSK3_1	39	46	PF00069	0.659
MOD_GSK3_1	415	422	PF00069	0.687
MOD_GSK3_1	437	444	PF00069	0.671
MOD_GSK3_1	446	453	PF00069	0.665
MOD_GSK3_1	461	468	PF00069	0.587
MOD_GSK3_1	562	569	PF00069	0.774
MOD_GSK3_1	614	621	PF00069	0.688
MOD_GSK3_1	671	678	PF00069	0.734
MOD_GSK3_1	68	75	PF00069	0.680
MOD_GSK3_1	680	687	PF00069	0.684
MOD_GSK3_1	688	695	PF00069	0.645
MOD_N-GLC_1	390	395	PF02516	0.644
MOD_N-GLC_1	401	406	PF02516	0.689
MOD_N-GLC_1	465	470	PF02516	0.622
MOD_N-GLC_1	68	73	PF02516	0.675
MOD_NEK2_1	166	171	PF00069	0.691
MOD_NEK2_1	690	695	PF00069	0.608
MOD_NEK2_2	316	321	PF00069	0.577
MOD_NEK2_2	513	518	PF00069	0.553
MOD_PIKK_1	108	114	PF00454	0.757
MOD_PIKK_1	170	176	PF00454	0.719
MOD_PIKK_1	293	299	PF00454	0.723
MOD_PIKK_1	448	454	PF00454	0.644
MOD_PIKK_1	563	569	PF00454	0.764
MOD_PIKK_1	79	85	PF00454	0.631
MOD_PKA_1	219	225	PF00069	0.724
MOD_PKA_1	653	659	PF00069	0.723
MOD_PKA_2	159	165	PF00069	0.587
MOD_PKA_2	219	225	PF00069	0.724
MOD_PKA_2	237	243	PF00069	0.548
MOD_PKA_2	352	358	PF00069	0.650
MOD_PKA_2	406	412	PF00069	0.742
MOD_PKA_2	43	49	PF00069	0.657
MOD_PKA_2	446	452	PF00069	0.709
MOD_PKA_2	468	474	PF00069	0.728
MOD_PKA_2	513	519	PF00069	0.632
MOD_PKA_2	614	620	PF00069	0.687
MOD_PKA_2	627	633	PF00069	0.561
MOD_PKA_2	653	659	PF00069	0.723
MOD_PKA_2	706	712	PF00069	0.631
MOD_PKA_2	718	724	PF00069	0.554
MOD_PKA_2	79	85	PF00069	0.661
MOD_Plk_1	228	234	PF00069	0.700
MOD_Plk_4	450	456	PF00069	0.691
MOD_Plk_4	568	574	PF00069	0.630
MOD_Plk_4	614	620	PF00069	0.687
MOD_ProDKin_1	210	216	PF00069	0.643
MOD_ProDKin_1	23	29	PF00069	0.603
MOD_ProDKin_1	302	308	PF00069	0.694
MOD_ProDKin_1	312	318	PF00069	0.678
MOD_ProDKin_1	334	340	PF00069	0.723
MOD_ProDKin_1	367	373	PF00069	0.804
MOD_ProDKin_1	375	381	PF00069	0.735
MOD_ProDKin_1	39	45	PF00069	0.532
MOD_ProDKin_1	454	460	PF00069	0.692
MOD_ProDKin_1	492	498	PF00069	0.611
MOD_ProDKin_1	534	540	PF00069	0.721
MOD_ProDKin_1	658	664	PF00069	0.718
MOD_ProDKin_1	675	681	PF00069	0.692
MOD_ProDKin_1	684	690	PF00069	0.606
MOD_ProDKin_1	698	704	PF00069	0.525
MOD_SUMO_rev_2	225	230	PF00179	0.622
MOD_SUMO_rev_2	630	639	PF00179	0.663
MOD_SUMO_rev_2	726	733	PF00179	0.608
TRG_DiLeu_BaLyEn_6	685	690	PF01217	0.587
TRG_ER_diArg_1	237	239	PF00400	0.723
TRG_ER_diArg_1	623	626	PF00400	0.531
TRG_ER_diArg_1	652	654	PF00400	0.785
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4IBW1	Leishmania infantum	99%	100%
E9AFP8	Leishmania major	79%	100%
E9B6V1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%