PHD-zinc-finger like domain/PHD-like zinc-binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9X5_LEIDO

TriTrypDb:

LdBPK_354630.1 , LdCL_350051400 , LDHU3_35.6110

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9X5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.547
CLV_MEL_PAP_1	44	50	PF00089	0.603
CLV_NRD_NRD_1	160	162	PF00675	0.591
CLV_PCSK_KEX2_1	160	162	PF00082	0.591
CLV_PCSK_KEX2_1	436	438	PF00082	0.615
CLV_PCSK_KEX2_1	9	11	PF00082	0.528
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.615
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.528
CLV_PCSK_PC7_1	156	162	PF00082	0.588
CLV_PCSK_SKI1_1	156	160	PF00082	0.655
CLV_PCSK_SKI1_1	271	275	PF00082	0.572
CLV_PCSK_SKI1_1	3	7	PF00082	0.614
CLV_PCSK_SKI1_1	364	368	PF00082	0.260
CLV_PCSK_SKI1_1	414	418	PF00082	0.466
CLV_PCSK_SKI1_1	50	54	PF00082	0.652
CLV_PCSK_SKI1_1	9	13	PF00082	0.521
DEG_SCF_FBW7_1	129	136	PF00400	0.603
DEG_SPOP_SBC_1	133	137	PF00917	0.571
DEG_SPOP_SBC_1	211	215	PF00917	0.632
DOC_CKS1_1	149	154	PF01111	0.651
DOC_CKS1_1	203	208	PF01111	0.592
DOC_CKS1_1	240	245	PF01111	0.613
DOC_MAPK_gen_1	3	13	PF00069	0.542
DOC_MAPK_gen_1	396	403	PF00069	0.491
DOC_MAPK_gen_1	47	56	PF00069	0.708
DOC_PP1_RVXF_1	7	14	PF00149	0.522
DOC_PP2B_LxvP_1	292	295	PF13499	0.588
DOC_PP2B_LxvP_1	426	429	PF13499	0.574
DOC_PP4_FxxP_1	19	22	PF00568	0.585
DOC_PP4_FxxP_1	389	392	PF00568	0.456
DOC_USP7_MATH_1	133	137	PF00917	0.571
DOC_USP7_MATH_1	152	156	PF00917	0.644
DOC_USP7_MATH_1	211	215	PF00917	0.656
DOC_USP7_MATH_1	219	223	PF00917	0.555
DOC_USP7_MATH_1	230	234	PF00917	0.538
DOC_USP7_MATH_1	285	289	PF00917	0.627
DOC_USP7_MATH_1	397	401	PF00917	0.491
DOC_USP7_MATH_1	412	416	PF00917	0.407
DOC_USP7_MATH_1	444	448	PF00917	0.510
DOC_USP7_MATH_1	99	103	PF00917	0.630
DOC_WW_Pin1_4	121	126	PF00397	0.685
DOC_WW_Pin1_4	129	134	PF00397	0.585
DOC_WW_Pin1_4	148	153	PF00397	0.730
DOC_WW_Pin1_4	182	187	PF00397	0.649
DOC_WW_Pin1_4	202	207	PF00397	0.632
DOC_WW_Pin1_4	239	244	PF00397	0.616
LIG_14-3-3_CanoR_1	10	14	PF00244	0.531
LIG_14-3-3_CanoR_1	123	129	PF00244	0.551
LIG_14-3-3_CanoR_1	232	241	PF00244	0.569
LIG_14-3-3_CanoR_1	414	419	PF00244	0.458
LIG_14-3-3_CanoR_1	50	55	PF00244	0.588
LIG_Actin_WH2_2	341	356	PF00022	0.491
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	213	217	PF00533	0.547
LIG_BRCT_BRCA1_1	446	450	PF00533	0.514
LIG_CtBP_PxDLS_1	243	247	PF00389	0.577
LIG_eIF4E_1	18	24	PF01652	0.535
LIG_EVH1_1	239	243	PF00568	0.676
LIG_FHA_1	133	139	PF00498	0.654
LIG_FHA_1	320	326	PF00498	0.444
LIG_FHA_1	382	388	PF00498	0.456
LIG_FHA_1	403	409	PF00498	0.417
LIG_FHA_1	51	57	PF00498	0.591
LIG_FHA_1	84	90	PF00498	0.596
LIG_FHA_2	137	143	PF00498	0.623
LIG_FHA_2	149	155	PF00498	0.729
LIG_FHA_2	419	425	PF00498	0.497
LIG_FHA_2	436	442	PF00498	0.513
LIG_LIR_Apic_2	147	152	PF02991	0.640
LIG_LIR_Apic_2	17	22	PF02991	0.572
LIG_LIR_Apic_2	388	392	PF02991	0.456
LIG_LIR_Gen_1	305	314	PF02991	0.404
LIG_LIR_Nem_3	12	16	PF02991	0.559
LIG_LIR_Nem_3	305	309	PF02991	0.392
LIG_LIR_Nem_3	343	348	PF02991	0.532
LIG_LIR_Nem_3	405	409	PF02991	0.417
LIG_MLH1_MIPbox_1	446	450	PF16413	0.514
LIG_PCNA_yPIPBox_3	66	74	PF02747	0.609
LIG_Rb_LxCxE_1	335	352	PF01857	0.491
LIG_SH2_CRK	149	153	PF00017	0.658
LIG_SH2_STAP1	224	228	PF00017	0.624
LIG_SH2_STAP1	346	350	PF00017	0.540
LIG_SH2_STAT3	81	84	PF00017	0.612
LIG_SH2_STAT5	18	21	PF00017	0.684
LIG_SH2_STAT5	409	412	PF00017	0.495
LIG_SH3_3	123	129	PF00018	0.654
LIG_SH3_3	203	209	PF00018	0.752
LIG_SH3_3	237	243	PF00018	0.736
LIG_SH3_3	45	51	PF00018	0.655
LIG_SH3_3	90	96	PF00018	0.616
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.517
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.581
LIG_TRAF2_1	139	142	PF00917	0.644
LIG_WRC_WIRS_1	403	408	PF05994	0.417
MOD_CDK_SPK_2	202	207	PF00069	0.588
MOD_CK1_1	136	142	PF00069	0.587
MOD_CK1_1	202	208	PF00069	0.598
MOD_CK1_1	222	228	PF00069	0.646
MOD_CK1_1	233	239	PF00069	0.539
MOD_CK1_1	27	33	PF00069	0.553
MOD_CK2_1	136	142	PF00069	0.624
MOD_CK2_1	148	154	PF00069	0.727
MOD_CK2_1	177	183	PF00069	0.642
MOD_CK2_1	435	441	PF00069	0.690
MOD_GlcNHglycan	19	22	PF01048	0.712
MOD_GlcNHglycan	192	195	PF01048	0.514
MOD_GlcNHglycan	214	217	PF01048	0.623
MOD_GlcNHglycan	285	288	PF01048	0.751
MOD_GlcNHglycan	414	417	PF01048	0.449
MOD_GlcNHglycan	58	61	PF01048	0.761
MOD_GSK3_1	117	124	PF00069	0.660
MOD_GSK3_1	129	136	PF00069	0.562
MOD_GSK3_1	148	155	PF00069	0.657
MOD_GSK3_1	182	189	PF00069	0.742
MOD_GSK3_1	219	226	PF00069	0.601
MOD_GSK3_1	231	238	PF00069	0.527
MOD_GSK3_1	279	286	PF00069	0.563
MOD_GSK3_1	29	36	PF00069	0.559
MOD_GSK3_1	381	388	PF00069	0.456
MOD_GSK3_1	412	419	PF00069	0.580
MOD_GSK3_1	46	53	PF00069	0.596
MOD_N-GLC_1	296	301	PF02516	0.553
MOD_NEK2_1	199	204	PF00069	0.534
MOD_NEK2_1	210	215	PF00069	0.619
MOD_NEK2_1	435	440	PF00069	0.627
MOD_NEK2_2	219	224	PF00069	0.562
MOD_NEK2_2	385	390	PF00069	0.456
MOD_OFUCOSY	380	385	PF10250	0.256
MOD_PIKK_1	186	192	PF00454	0.479
MOD_PIKK_1	199	205	PF00454	0.555
MOD_PIKK_1	24	30	PF00454	0.567
MOD_PKA_1	9	15	PF00069	0.517
MOD_PKA_2	219	225	PF00069	0.675
MOD_PKA_2	231	237	PF00069	0.526
MOD_PKA_2	397	403	PF00069	0.491
MOD_PKA_2	46	52	PF00069	0.594
MOD_PKA_2	9	15	PF00069	0.615
MOD_Plk_1	279	285	PF00069	0.541
MOD_Plk_1	33	39	PF00069	0.621
MOD_Plk_4	14	20	PF00069	0.523
MOD_Plk_4	177	183	PF00069	0.688
MOD_Plk_4	402	408	PF00069	0.417
MOD_Plk_4	83	89	PF00069	0.596
MOD_ProDKin_1	121	127	PF00069	0.685
MOD_ProDKin_1	129	135	PF00069	0.587
MOD_ProDKin_1	148	154	PF00069	0.731
MOD_ProDKin_1	182	188	PF00069	0.642
MOD_ProDKin_1	202	208	PF00069	0.632
MOD_ProDKin_1	239	245	PF00069	0.618
TRG_DiLeu_BaEn_1	34	39	PF01217	0.570
TRG_DiLeu_BaEn_1	68	73	PF01217	0.609
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.595
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.574
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.491
TRG_ER_diArg_1	362	365	PF00400	0.491
TRG_ER_diArg_1	44	47	PF00400	0.778
TRG_NLS_MonoExtC_3	435	441	PF00514	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I986	Leptomonas seymouri	30%	93%
A4IBZ6	Leishmania infantum	98%	100%
E9AFT3	Leishmania major	81%	100%
E9B6Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%