PHD-zinc-finger like domain/PHD-like zinc-binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9X5_LEIDO

TriTrypDb:

LdBPK_354630.1 , LdCL_350051400 , LDHU3_35.6110

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9X5

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.547
CLV_MEL_PAP_1	44	50	PF00089	0.603
CLV_NRD_NRD_1	160	162	PF00675	0.591
CLV_PCSK_KEX2_1	160	162	PF00082	0.591
CLV_PCSK_KEX2_1	436	438	PF00082	0.615
CLV_PCSK_KEX2_1	9	11	PF00082	0.528
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.615
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.528
CLV_PCSK_PC7_1	156	162	PF00082	0.588
CLV_PCSK_SKI1_1	156	160	PF00082	0.655

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I986	Leptomonas seymouri	30%	93%
A4IBZ6	Leishmania infantum	98%	100%
E9AFT3	Leishmania major	81%	100%
E9B6Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%

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