SAS-6_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal protein 6 homolog

Species:

Leishmania donovani

UniProt:

A0A3S7X9W8_LEIDO

TriTrypDb:

LdBPK_354350.1 , LdCL_350048600 , LDHU3_35.5760

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	11
GO:0043229	intracellular organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X9W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9W8

PDB structure(s): 4ckm_A , 4ckm_B , 4ckm_C , 4ckn_A , 4ckn_B , 4ckn_C , 4ckn_D , 4ckp_A , 4ckp_B , 4ckp_C , 4ckp_D , 4ckp_E , 4ckp_F

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007099	centriole replication	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0098534	centriole assembly	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.516
CLV_C14_Caspase3-7	696	700	PF00656	0.696
CLV_NRD_NRD_1	32	34	PF00675	0.780
CLV_NRD_NRD_1	320	322	PF00675	0.551
CLV_NRD_NRD_1	551	553	PF00675	0.632
CLV_NRD_NRD_1	568	570	PF00675	0.614
CLV_NRD_NRD_1	73	75	PF00675	0.763
CLV_NRD_NRD_1	747	749	PF00675	0.717
CLV_PCSK_KEX2_1	274	276	PF00082	0.416
CLV_PCSK_KEX2_1	31	33	PF00082	0.780
CLV_PCSK_KEX2_1	551	553	PF00082	0.632
CLV_PCSK_KEX2_1	73	75	PF00082	0.730
CLV_PCSK_KEX2_1	773	775	PF00082	0.709
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.416
CLV_PCSK_PC1ET2_1	773	775	PF00082	0.741
CLV_PCSK_PC7_1	27	33	PF00082	0.778
CLV_PCSK_SKI1_1	169	173	PF00082	0.496
CLV_PCSK_SKI1_1	523	527	PF00082	0.528
CLV_PCSK_SKI1_1	789	793	PF00082	0.596
CLV_Separin_Metazoa	566	570	PF03568	0.613
DEG_APCC_DBOX_1	112	120	PF00400	0.719
DEG_APCC_DBOX_1	168	176	PF00400	0.484
DEG_APCC_DBOX_1	243	251	PF00400	0.473
DEG_Nend_Nbox_1	1	3	PF02207	0.715
DOC_ANK_TNKS_1	218	225	PF00023	0.562
DOC_ANK_TNKS_1	72	79	PF00023	0.761
DOC_MAPK_gen_1	321	329	PF00069	0.547
DOC_MAPK_gen_1	585	594	PF00069	0.591
DOC_MAPK_MEF2A_6	198	207	PF00069	0.459
DOC_MAPK_MEF2A_6	256	265	PF00069	0.459
DOC_MAPK_NFAT4_5	198	206	PF00069	0.459
DOC_PP4_FxxP_1	23	26	PF00568	0.747
DOC_PP4_MxPP_1	762	765	PF00568	0.532
DOC_USP7_MATH_1	122	126	PF00917	0.763
DOC_USP7_MATH_1	356	360	PF00917	0.599
DOC_USP7_MATH_1	394	398	PF00917	0.574
DOC_USP7_MATH_1	465	469	PF00917	0.693
DOC_USP7_MATH_1	619	623	PF00917	0.697
DOC_USP7_MATH_1	628	632	PF00917	0.714
DOC_USP7_MATH_1	697	701	PF00917	0.714
DOC_USP7_MATH_1	715	719	PF00917	0.676
DOC_USP7_MATH_1	720	724	PF00917	0.705
DOC_USP7_MATH_1	757	761	PF00917	0.673
DOC_USP7_MATH_1	787	791	PF00917	0.632
DOC_USP7_MATH_1	808	812	PF00917	0.616
DOC_USP7_MATH_1	98	102	PF00917	0.654
DOC_USP7_UBL2_3	506	510	PF12436	0.642
DOC_WD40_RPTOR_TOS_1	185	191	PF00400	0.473
DOC_WW_Pin1_4	118	123	PF00397	0.704
DOC_WW_Pin1_4	42	47	PF00397	0.719
DOC_WW_Pin1_4	673	678	PF00397	0.708
DOC_WW_Pin1_4	713	718	PF00397	0.709
DOC_WW_Pin1_4	742	747	PF00397	0.784
DOC_WW_Pin1_4	767	772	PF00397	0.782
DOC_WW_Pin1_4	778	783	PF00397	0.504
LIG_14-3-3_CanoR_1	110	119	PF00244	0.721
LIG_14-3-3_CanoR_1	174	178	PF00244	0.459
LIG_14-3-3_CanoR_1	317	321	PF00244	0.596
LIG_14-3-3_CanoR_1	395	403	PF00244	0.559
LIG_14-3-3_CanoR_1	51	58	PF00244	0.774
LIG_14-3-3_CanoR_1	569	578	PF00244	0.632
LIG_14-3-3_CanoR_1	668	672	PF00244	0.739
LIG_14-3-3_CanoR_1	673	677	PF00244	0.731
LIG_14-3-3_CanoR_1	726	735	PF00244	0.733
LIG_14-3-3_CanoR_1	741	746	PF00244	0.731
LIG_14-3-3_CanoR_1	748	752	PF00244	0.728
LIG_14-3-3_CanoR_1	800	809	PF00244	0.691
LIG_Actin_WH2_2	251	269	PF00022	0.473
LIG_Actin_WH2_2	302	319	PF00022	0.534
LIG_Actin_WH2_2	364	381	PF00022	0.584
LIG_Actin_WH2_2	396	413	PF00022	0.485
LIG_Actin_WH2_2	446	462	PF00022	0.602
LIG_AP2alpha_2	180	182	PF02296	0.459
LIG_BRCT_BRCA1_1	19	23	PF00533	0.745
LIG_BRCT_BRCA1_1	810	814	PF00533	0.573
LIG_CaM_IQ_9	561	577	PF13499	0.652
LIG_Clathr_ClatBox_1	184	188	PF01394	0.473
LIG_FHA_1	134	140	PF00498	0.468
LIG_FHA_1	166	172	PF00498	0.519
LIG_FHA_1	244	250	PF00498	0.459
LIG_FHA_1	297	303	PF00498	0.455
LIG_FHA_1	373	379	PF00498	0.590
LIG_FHA_1	394	400	PF00498	0.618
LIG_FHA_1	414	420	PF00498	0.591
LIG_FHA_1	454	460	PF00498	0.545
LIG_FHA_1	559	565	PF00498	0.611
LIG_FHA_1	603	609	PF00498	0.709
LIG_FHA_1	639	645	PF00498	0.729
LIG_FHA_1	650	656	PF00498	0.639
LIG_FHA_1	730	736	PF00498	0.725
LIG_FHA_1	742	748	PF00498	0.660
LIG_FHA_2	330	336	PF00498	0.513
LIG_FHA_2	379	385	PF00498	0.591
LIG_FHA_2	424	430	PF00498	0.613
LIG_FHA_2	452	458	PF00498	0.642
LIG_FHA_2	60	66	PF00498	0.605
LIG_FHA_2	694	700	PF00498	0.749
LIG_Integrin_isoDGR_2	609	611	PF01839	0.610
LIG_LIR_Apic_2	20	26	PF02991	0.729
LIG_LIR_Gen_1	191	201	PF02991	0.562
LIG_LIR_Gen_1	449	459	PF02991	0.607
LIG_LIR_Gen_1	484	491	PF02991	0.516
LIG_LIR_Gen_1	781	791	PF02991	0.652
LIG_LIR_Nem_3	179	185	PF02991	0.461
LIG_LIR_Nem_3	191	197	PF02991	0.456
LIG_LIR_Nem_3	206	210	PF02991	0.459
LIG_LIR_Nem_3	253	258	PF02991	0.451
LIG_LIR_Nem_3	279	284	PF02991	0.402
LIG_LIR_Nem_3	449	455	PF02991	0.605
LIG_LIR_Nem_3	484	489	PF02991	0.514
LIG_LIR_Nem_3	781	786	PF02991	0.714
LIG_MLH1_MIPbox_1	810	814	PF16413	0.573
LIG_PCNA_PIPBox_1	473	482	PF02747	0.620
LIG_SH2_CRK	660	664	PF00017	0.606
LIG_SH2_PTP2	452	455	PF00017	0.602
LIG_SH2_PTP2	486	489	PF00017	0.515
LIG_SH2_STAP1	228	232	PF00017	0.490
LIG_SH2_STAP1	284	288	PF00017	0.465
LIG_SH2_STAT3	480	483	PF00017	0.528
LIG_SH2_STAT5	156	159	PF00017	0.483
LIG_SH2_STAT5	213	216	PF00017	0.459
LIG_SH2_STAT5	276	279	PF00017	0.387
LIG_SH2_STAT5	452	455	PF00017	0.602
LIG_SH2_STAT5	486	489	PF00017	0.515
LIG_SH3_1	142	148	PF00018	0.604
LIG_SH3_2	768	773	PF14604	0.568
LIG_SH3_3	100	106	PF00018	0.699
LIG_SH3_3	142	148	PF00018	0.551
LIG_SH3_3	175	181	PF00018	0.473
LIG_SH3_3	762	768	PF00018	0.580
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.462
LIG_SUMO_SIM_anti_2	186	193	PF11976	0.357
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.459
LIG_SUMO_SIM_par_1	134	141	PF11976	0.502
LIG_TRAF2_1	125	128	PF00917	0.714
LIG_TRAF2_1	323	326	PF00917	0.497
LIG_TRAF2_1	370	373	PF00917	0.573
LIG_TRAF2_1	468	471	PF00917	0.633
LIG_TRAF2_1	722	725	PF00917	0.721
LIG_TYR_ITIM	450	455	PF00017	0.603
LIG_WRC_WIRS_1	788	793	PF05994	0.709
MOD_CDC14_SPxK_1	676	679	PF00782	0.579
MOD_CDC14_SPxK_1	745	748	PF00782	0.563
MOD_CDC14_SPxK_1	770	773	PF00782	0.569
MOD_CDK_SPK_2	118	123	PF00069	0.763
MOD_CDK_SPxK_1	673	679	PF00069	0.581
MOD_CDK_SPxK_1	742	748	PF00069	0.568
MOD_CDK_SPxK_1	767	773	PF00069	0.567
MOD_CDK_SPxxK_3	742	749	PF00069	0.568
MOD_CDK_SPxxK_3	767	774	PF00069	0.571
MOD_CK1_1	10	16	PF00069	0.700
MOD_CK1_1	18	24	PF00069	0.679
MOD_CK1_1	291	297	PF00069	0.531
MOD_CK1_1	405	411	PF00069	0.561
MOD_CK1_1	59	65	PF00069	0.780
MOD_CK1_1	667	673	PF00069	0.726
MOD_CK1_1	729	735	PF00069	0.695
MOD_CK1_1	775	781	PF00069	0.737
MOD_CK2_1	122	128	PF00069	0.655
MOD_CK2_1	329	335	PF00069	0.510
MOD_CK2_1	378	384	PF00069	0.590
MOD_CK2_1	394	400	PF00069	0.467
MOD_CK2_1	423	429	PF00069	0.524
MOD_CK2_1	443	449	PF00069	0.480
MOD_CK2_1	451	457	PF00069	0.551
MOD_CK2_1	465	471	PF00069	0.500
MOD_CK2_1	719	725	PF00069	0.703
MOD_DYRK1A_RPxSP_1	673	677	PF00069	0.576
MOD_GlcNHglycan	100	103	PF01048	0.610
MOD_GlcNHglycan	124	127	PF01048	0.728
MOD_GlcNHglycan	191	197	PF01048	0.332
MOD_GlcNHglycan	225	228	PF01048	0.368
MOD_GlcNHglycan	235	238	PF01048	0.318
MOD_GlcNHglycan	411	414	PF01048	0.565
MOD_GlcNHglycan	617	620	PF01048	0.652
MOD_GlcNHglycan	630	633	PF01048	0.582
MOD_GlcNHglycan	683	686	PF01048	0.723
MOD_GlcNHglycan	699	702	PF01048	0.703
MOD_GlcNHglycan	728	731	PF01048	0.748
MOD_GlcNHglycan	753	756	PF01048	0.715
MOD_GlcNHglycan	759	762	PF01048	0.685
MOD_GlcNHglycan	810	813	PF01048	0.589
MOD_GSK3_1	118	125	PF00069	0.729
MOD_GSK3_1	133	140	PF00069	0.456
MOD_GSK3_1	228	235	PF00069	0.453
MOD_GSK3_1	239	246	PF00069	0.470
MOD_GSK3_1	250	257	PF00069	0.462
MOD_GSK3_1	284	291	PF00069	0.562
MOD_GSK3_1	389	396	PF00069	0.578
MOD_GSK3_1	405	412	PF00069	0.408
MOD_GSK3_1	439	446	PF00069	0.543
MOD_GSK3_1	461	468	PF00069	0.657
MOD_GSK3_1	52	59	PF00069	0.743
MOD_GSK3_1	6	13	PF00069	0.693
MOD_GSK3_1	615	622	PF00069	0.668
MOD_GSK3_1	649	656	PF00069	0.701
MOD_GSK3_1	667	674	PF00069	0.562
MOD_GSK3_1	689	696	PF00069	0.648
MOD_GSK3_1	715	722	PF00069	0.665
MOD_GSK3_1	725	732	PF00069	0.607
MOD_GSK3_1	747	754	PF00069	0.701
MOD_GSK3_1	795	802	PF00069	0.573
MOD_LATS_1	739	745	PF00433	0.683
MOD_N-GLC_1	7	12	PF02516	0.718
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	132	137	PF00069	0.575
MOD_NEK2_1	138	143	PF00069	0.538
MOD_NEK2_1	232	237	PF00069	0.537
MOD_NEK2_1	316	321	PF00069	0.495
MOD_NEK2_1	378	383	PF00069	0.573
MOD_NEK2_1	389	394	PF00069	0.504
MOD_NEK2_1	459	464	PF00069	0.586
MOD_NEK2_1	52	57	PF00069	0.751
MOD_NEK2_1	578	583	PF00069	0.616
MOD_NEK2_1	602	607	PF00069	0.588
MOD_NEK2_1	719	724	PF00069	0.772
MOD_NEK2_2	284	289	PF00069	0.530
MOD_NEK2_2	787	792	PF00069	0.654
MOD_PIKK_1	394	400	PF00454	0.593
MOD_PIKK_1	405	411	PF00454	0.434
MOD_PIKK_1	535	541	PF00454	0.490
MOD_PIKK_1	592	598	PF00454	0.552
MOD_PIKK_1	653	659	PF00454	0.649
MOD_PIKK_1	720	726	PF00454	0.708
MOD_PIKK_1	795	801	PF00454	0.745
MOD_PIKK_1	88	94	PF00454	0.681
MOD_PKA_1	569	575	PF00069	0.606
MOD_PKA_2	173	179	PF00069	0.459
MOD_PKA_2	243	249	PF00069	0.486
MOD_PKA_2	288	294	PF00069	0.568
MOD_PKA_2	316	322	PF00069	0.547
MOD_PKA_2	356	362	PF00069	0.472
MOD_PKA_2	378	384	PF00069	0.601
MOD_PKA_2	394	400	PF00069	0.483
MOD_PKA_2	459	465	PF00069	0.647
MOD_PKA_2	50	56	PF00069	0.778
MOD_PKA_2	667	673	PF00069	0.738
MOD_PKA_2	705	711	PF00069	0.726
MOD_PKA_2	725	731	PF00069	0.774
MOD_PKA_2	740	746	PF00069	0.683
MOD_PKA_2	747	753	PF00069	0.737
MOD_PKA_2	799	805	PF00069	0.647
MOD_PKB_1	458	466	PF00069	0.611
MOD_Plk_1	133	139	PF00069	0.464
MOD_Plk_1	192	198	PF00069	0.488
MOD_Plk_1	284	290	PF00069	0.532
MOD_Plk_1	7	13	PF00069	0.718
MOD_Plk_2-3	254	260	PF00069	0.459
MOD_Plk_2-3	423	429	PF00069	0.613
MOD_Plk_4	133	139	PF00069	0.506
MOD_Plk_4	18	24	PF00069	0.751
MOD_Plk_4	228	234	PF00069	0.480
MOD_Plk_4	667	673	PF00069	0.712
MOD_Plk_4	699	705	PF00069	0.720
MOD_Plk_4	7	13	PF00069	0.711
MOD_Plk_4	787	793	PF00069	0.612
MOD_ProDKin_1	118	124	PF00069	0.703
MOD_ProDKin_1	42	48	PF00069	0.720
MOD_ProDKin_1	673	679	PF00069	0.710
MOD_ProDKin_1	713	719	PF00069	0.711
MOD_ProDKin_1	742	748	PF00069	0.786
MOD_ProDKin_1	767	773	PF00069	0.785
MOD_ProDKin_1	778	784	PF00069	0.502
MOD_SUMO_for_1	437	440	PF00179	0.644
MOD_SUMO_rev_2	251	258	PF00179	0.539
MOD_SUMO_rev_2	358	364	PF00179	0.572
MOD_SUMO_rev_2	368	375	PF00179	0.579
MOD_SUMO_rev_2	397	404	PF00179	0.635
MOD_SUMO_rev_2	468	474	PF00179	0.663
MOD_SUMO_rev_2	586	595	PF00179	0.551
TRG_DiLeu_BaEn_1	128	133	PF01217	0.504
TRG_DiLeu_BaEn_1	259	264	PF01217	0.459
TRG_DiLeu_BaEn_1	335	340	PF01217	0.587
TRG_DiLeu_BaEn_3	324	330	PF01217	0.561
TRG_ENDOCYTIC_2	194	197	PF00928	0.452
TRG_ENDOCYTIC_2	452	455	PF00928	0.602
TRG_ENDOCYTIC_2	486	489	PF00928	0.515
TRG_ENDOCYTIC_2	49	52	PF00928	0.686
TRG_ENDOCYTIC_2	660	663	PF00928	0.722
TRG_ER_diArg_1	31	33	PF00400	0.780
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL2	Leptomonas seymouri	58%	96%
A0A1X0NEU3	Trypanosomatidae	39%	100%
A0A422NU91	Trypanosoma rangeli	41%	100%
A4HN97	Leishmania braziliensis	79%	99%
A4IBW8	Leishmania infantum	99%	100%
C9ZYP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AFQ5	Leishmania major	92%	100%
E9B6V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q6NRG6	Xenopus laevis	23%	100%
V5C2P0	Trypanosoma cruzi	40%	100%